Datasets:

ncats

/

EpiSet4NER-v2

like 0

Follow

National Center for Advancing Translational Sciences 6

[ "RESULTS", ":", "Of", "2", "107", "124", "births", "from", "2009", "to", "2015", ",", "900", "neonates", "were", "identified", "with", "HSV", "infection", ",", "with", "a", "corrected", "incidence", "rate", "of", "4.5", "(", "95", "%", "confidence", "interval", "[", "CI", "]", ":", "4.2", "-", "4.8", ")", "per", "10", "000", "births", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 11, 12, 12, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 5, 6, 6, 0, 7, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 8, 8, 8, 8, 0 ]

[ "The", "yearly", "disease", "incidence", "increased", "by", "56", "%", ",", "from", "3.4", "(", "95", "%", "CI", ":", "2.8", "-", "4.2", ")", "per", "10", "000", "births", "(", "or", "1", "in", "2941", "births", ")", "in", "2009", "to", "5.3", "(", "95", "%", "CI", ":", "4.6", "-", "6.1", ")", "per", "10", "000", "births", "(", "or", "1", "in", "1886", "births", ")", "in", "2015", "(", "P", "<", ".001", ")", "." ]

[ 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 11, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 0, 0, 11, 0, 0, 0, 0, 0, 0 ]

[ "Of", "the", "900", "neonates", "with", "HSV", "infection", ",", "54", "(", "6.0", "%", "[", "95", "%", "CI", ":", "4.4%-7.6", "%", "]", ")", "died", "during", "the", "index", "hospitalization", ";", "there", "was", "no", "increase", "in", "the", "yearly", "mortality", "rate", "." ]

[ 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Of", "the", "692", "(", "81.2", "%", ")", "infants", "with", "follow", "-", "up", "data", ",", "316", "(", "45.7", "%", ")", "had", "an", "emergency", "department", "visit", ",", "and", "112", "(", "16.2", "%", ")", "had", "a", "hospital", "readmission", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Total", "payments", "at", "6", "months", "amounted", "to", "$", "60", "620", "431", ",", "a", "median", "of", "$", "87", "602", "per", "case", "of", "neonatal", "HSV", "infection", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0 ]

[ "CONCLUSIONS", ":", "We", "observed", "an", "increase", "in", "neonatal", "HSV", "infection", "incidence", "over", "a", "recent", "7", "-", "year", "period", "in", "a", "Medicaid", "population", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 5, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Associated", "health", "care", "use", "and", "payments", "were", "substantial", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Public", "health", "interventions", "targeting", "disease", "prevention", "and", "early", "diagnosis", "are", "needed", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Despite", "the", "prevalence", "of", "preterm", "brain", "injury", ",", "there", "are", "no", "established", "neuroprotective", "strategies", "to", "prevent", "or", "alleviate", "mild", "-", "to", "-", "moderate", "inflammation", "-", "related", "brain", "injury", "." ]

[ 0, 0, 5, 0, 1, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Perinatal", "infection", "and", "inflammation", "have", "been", "shown", "to", "trigger", "acute", "neuroinflammation", ",", "including", "proinflammatory", "cytokine", "release", "and", "gliosis", ",", "which", "are", "associated", "with", "acute", "and", "chronic", "disturbances", "in", "brain", "cell", "survival", "and", "maturation", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 1, 2, 2, 0, 1, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "findings", "suggest", "the", "hypothesis", "that", "the", "inhibition", "of", "peripheral", "immune", "responses", "following", "infection", "or", "nonspecific", "inflammation", "may", "be", "a", "therapeutic", "strategy", "to", "reduce", "the", "associated", "brain", "injury", "and", "neurobehavioral", "deficits", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "review", "provides", "an", "overview", "of", "the", "neonatal", "immunity", ",", "neuroinflammation", ",", "and", "mechanisms", "of", "inflammation", "-", "related", "brain", "injury", "in", "preterm", "infants", "and", "explores", "the", "safety", "and", "efficacy", "of", "anti", "-", "inflammatory", "agents", "as", "potentially", "neurotherapeutics", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Inferior", "vena", "cava", "(", "IVC", ")", "agenesis", "is", "a", "rare", "congenital", "abnormality", "affecting", "the", "infrarenal", "segment", ",", "the", "suprarenal", "or", "the", "whole", "of", "the", "IVC", "." ]

[ 1, 2, 2, 0, 3, 0, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "It", "has", "an", "estimated", "prevalence", "of", "up", "to", "1", "%", "in", "the", "general", "population", "that", "can", "rise", "to", "8.7", "%", "when", "abnormalities", "of", "the", "left", "renal", "vein", "are", "considered", "." ]

[ 0, 0, 0, 5, 6, 0, 7, 8, 8, 8, 0, 0, 0, 0, 0, 0, 0, 0, 7, 8, 8, 8, 8, 8, 8, 8, 8, 8, 8, 0 ]

[ "Most", "IVC", "malformations", "are", "asymptomatic", "but", "may", "be", "associated", "with", "nonspecific", "symptoms", "or", "present", "as", "deep", "vein", "thrombosis", "(", "DVT", ")", "." ]

[ 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 3, 0, 0 ]

[ "Up", "to", "5", "%", "of", "young", "individuals", "under", "30", "years", "of", "age", "with", "unprovoked", "DVT", "are", "found", "to", "have", "this", "condition", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0 ]

[ "Regarding", "the", "treatment", "of", "IVC", "agenesis", "-", "associated", "DVT", ",", "there", "are", "no", "standard", "guidelines", "." ]

[ 0, 0, 0, 0, 1, 2, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0 ]

[ "Treatment", "is", "directed", "towards", "preventing", "thrombosis", "or", "its", "recurrence", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Low", "molecular", "weight", "heparin", "and", "oral", "anticoagulation", "medication", ",", "in", "particular", "vitamin", "K", "antagonists", "(", "VKAs", ")", "are", "the", "mainstay", "of", "therapy", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Given", "the", "high", "risk", "of", "DVT", "recurrence", "in", "these", "patients", ",", "oral", "anticoagulation", "therapy", "is", "suggested", "to", "be", "pursued", "indefinitely", "." ]

[ 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "As", "far", "as", "we", "know", ",", "this", "is", "the", "first", "case", "reporting", "the", "use", "of", "a", "direct", "factor", "Xa", "inhibitor", "in", "IVC", "agenesis", "-", "associated", "DVT", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 0 ]

[ "Given", "VKA", "monitoring", "limitations", ",", "the", "use", "of", "a", "direct", "Xa", "inhibitor", "could", "be", "an", "alternative", "in", "young", "individuals", "with", "anatomical", "defects", "without", "thrombophilia", ",", "but", "further", "studies", "will", "be", "needed", "to", "confirm", "its", "efficacy", "and", "safety", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "LEARNING", "POINTS", ":", "Up", "to", "5", "%", "of", "young", "individuals", "under", "30", "years", "of", "age", "with", "unprovoked", "deep", "vein", "thrombosis", "(", "DVT", ")", "are", "found", "to", "have", "this", "condition", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Therefore", ",", "these", "types", "of", "anomalies", "should", "be", "actively", "looked", "for", ",", "particularly", "in", "young", "patients", "with", "DVT.Treatment", "with", "low", "molecular", "weight", "heparin", "or", "oral", "anticoagulation", "medication", "is", "the", "mainstay", "of", "therapy", ",", "directed", "towards", "preventing", "thrombosis", "or", "its", "recurrence", ".", "A", "direct", "factor", "Xa", "inhibitor", "could", "be", "a", "possible", "alternative", "to", "vitamin", "K", "antagonists", "in", "these", "patients", ",", "despite", "the", "lack", "of", "clinical", "evidence", "supporting", "its", "use", "at", "the", "moment", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "BACKGROUND", ":", "Lesch", "-", "Nyhan", "syndrome", "(", "LNS", ")", "is", "a", "congenital", "X", "-", "linked", "recessive", "neurogenetic", "disorder", "caused", "by", "mutations", "in", "the", "hypoxanthine", "-", "guanine", "phosphoribosyltransferase", "(", "HPRT", ")", "gene", "." ]

[ 0, 0, 1, 2, 2, 2, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "main", "clinical", "manifestation", "includes", "hyperuricemia", ",", "juvenile", "-", "onset", "gouty", "arthritis", ",", "and", "neurological", "developmental", "disorders", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Studies", "have", "reported", "more", "than", "400", "HPRT", "gene", "mutation", "sites", ",", "but", "the", "incidence", "of", "LNS", "in", "the", "Chinese", "population", "is", "extremely", "low", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 3, 0, 0, 15, 0, 0, 0, 0, 0 ]

[ "METHODS", ":", "Here", "we", "report", "a", "16", "-", "year", "-", "old", "male", "patient", "who", "suffered", "neurological", "dysfunction", "at", "an", "early", "age", "and", "gouty", "arthritis", "in", "his", "youth", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 13, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0 ]

[ "RESULTS", ":", "No", "activity", "of", "the", "HPRT", "enzyme", "was", "detected", "in", "the", "erythrocytes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Furthermore", ",", "we", "found", "a", "mutation", "on", "exon", "3", "of", "the", "HPRT", "gene", "in", "the", "patient", "and", "his", "mother", "(", "exon", "3", ":", "c.143G", ">", "A", ")", ",", "which", "resulted", "in", "arginine", "to", "histidine", "(", "p.", "R48H", ")", "substitution", "in", "the", "encoded", "protein", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "same", "mutation", "was", "reported", "in", "several", "European", "families", ",", "but", "was", "found", "for", "the", "first", "time", "in", "a", "Chinese", "family", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0 ]

[ "CONCLUSIONS", ":", "Clinicians", "in", "China", "have", "poor", "experience", "in", "diagnosing", "LNS", "cases", "due", "to", "the", "low", "incidence", "in", "China", "." ]

[ 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 5, 0, 9, 0 ]

[ "Therefore", ",", "LNS", "screening", "for", "infants", "or", "adolescents", "with", "hyperuricemia", ",", "gouty", "arthritis", ",", "and", "neurological", "dysfunction", "should", "be", "performed", "." ]

[ 0, 0, 3, 0, 0, 0, 0, 0, 0, 1, 0, 1, 2, 0, 0, 1, 2, 0, 0, 0, 0 ]

[ "Objectives", "Few", "studies", "have", "investigated", "the", "prognostic", "factors", "for", "idiopathic", "inflammatory", "myopathy", "-", "associated", "interstitial", "lung", "disease", "(", "IIM", "-", "ILD", ")", "across", "different", "clinical", "/", "serological", "phenotypes", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 2, 2, 2, 2, 2, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Methods", "We", "conducted", "a", "retrospective", "analysis", "of", "patients", "diagnosed", "with", "IIM", "between", "January", "2012", "and", "December", "2017", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 11, 12, 12, 12, 12, 12, 0 ]

[ "Results", "Of", "the", "760", "IIM", "cases", "registered", ",", "679", "adult", "cases", "were", "included", "in", "this", "study", "." ]

[ 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "ILD", "was", "present", "in", "508", "cases", ",", "and", "the", "presence", "of", "ILD", "in", "the", "clinically", "amyopathic", "DM", ",", "DM", "and", "PM", "groups", "was", "92.7", ",", "73.6", "and", "55.1", "%", ",", "respectively", "(", "P", "<", "0.01", ")", "." ]

[ 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 1, 2, 0, 3, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "prevalence", "of", "ILD", "in", "the", "anti", "-", "synthetase", "antibody", "(", "ASA)+-IIM", "group", "was", "higher", "than", "that", "in", "ASA", "--", "IIM", "group", "(", "95.2", "vs", "72.4", "%", ",", "P", "<", "0.01", ")", ";", "no", "such", "difference", "was", "found", "between", "the", "anti", "-", "histidyl", "-", "tRNA", "synthetase", "(", "Jo-1)+-IIM", "and", "Jo-1", "-", "ASA+-IIM", "groups", "(", "93.0", "vs", "98.5", "%", ",", "P", ">", "0.05", ")", "." ]

[ 0, 5, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "prevalence", "of", "ILD", "in", "the", "melanoma", "differentiation", "-", "associated", "protein-5", "(", "MDA-5)+-IIM", "group", "was", "higher", "than", "that", "in", "MDA-5", "-", "-IIM", "group", "(", "97.8", "vs", "72.1", "%", ",", "P", "<", "0.01", ")", "." ]

[ 0, 5, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Among", "adults", "with", "IIM", ",", "men", "with", "concurrent", "ILD", ",", "who", "were", "older", "than", "50", "years", ",", "were", "most", "likely", "to", "die", "." ]

[ 0, 0, 0, 3, 0, 13, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "No", "significant", "difference", "was", "found", "in", "the", "all", "-", "cause", "mortality", "rates", "between", "DM", "-", "ILD", "and", "clinically", "amyopathic", "DM", "-", "ILD", "groups", "(", "33.3", "vs", "23", "%", ",", "P", ">", "0.05", ")", ",", "although", "both", "were", "higher", "than", "that", "in", "PM", "group", "(", "13.2", "%", ",", "P", "=", "0.01", "and", "P", "<", "0.05", ",", "respectively", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 0, 1, 2, 2, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "No", "difference", "was", "found", "in", "the", "all", "-", "cause", "mortality", "rates", "between", "MDA5", "-", "ASA", "--", "IM", "-", "ILD", "and", "MDA5", "-", "ASA+-IM", "-", "ILD", "groups", "(", "17.2", "vs", "12.8", "%", ",", "P", ">", "0.05", ")", ",", "and", "both", "were", "lower", "than", "that", "in", "MDA5+ASA", "--", "IM", "-", "ILD", "group", "(", "33.7", "%", ",", "P", "<", "0.05", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Conclusion", "The", "prevalence", "of", "ILD", "in", "IIM", "and", "the", "prognosis", "of", "IIM", "-", "ILD", "patients", "may", "vary", "depending", "on", "the", "statuses", "of", "the", "ASA", "and", "MDA-5", "antibodies", "." ]

[ 0, 0, 5, 0, 3, 0, 3, 0, 0, 0, 0, 3, 4, 4, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Background", ":", "Little", "is", "known", "about", "the", "surgical", "conditions", "affecting", "the", "pediatric", "population", "in", "low", "-", "income", "countries", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "In", "this", "article", "we", "describe", "the", "epidemiology", "of", "pediatric", "surgical", "diseases", "observed", "in", "Mutoyi", "hospital", ",", "a", "first", "-", "level", "hospital", "in", "Burundi", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0, 0, 0, 0, 0, 0, 0, 0, 9, 0 ]

[ "Methods", "and", "Findings", ":", "We", "retrospectively", "reviewed", "the", "records", "of", "all", "children", "(", "0", "-", "14", "years", ")", "admitted", "to", "the", "Surgery", "ward", "from", "January", "2017", "to", "December", "2017", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 12, 12, 12, 12, 0 ]

[ "We", "also", "reviewed", "the", "records", "of", "all", "the", "patients", "admitted", "to", "the", "Neonatology", "ward", "in", "2017", "and", "among", "them", "we", "selected", "the", "ones", "in", "which", "a", "surgical", "diagnosis", "was", "present", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Five", "hundred", "twenty", "-", "eight", "children", "were", "admitted", "to", "the", "surgical", "ward", "during", "the", "study", "period", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "most", "common", "conditions", "requiring", "hospitalization", "were", "abscesses", "(", "29.09", "%", ")", ",", "fractures", "(", "13.59", "%", ")", ",", "osteomyelitis", "(", "9.76", "%", ")", ",", "burns", "(", "5.40", "%", ")", "and", "head", "injuries", "(", "4.36", "%", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0 ]

[ "The", "average", "length", "of", "stay", "was", "16", "days", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Fifty", "-", "six", "newborns", "were", "admitted", "to", "the", "Neonatology", "ward", "for", "a", "surgical", "condition", ";", "29", "%", "of", "them", "had", "an", "abscess", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 0 ]

[ "Conclusions", ":", "Conditions", "requiring", "surgical", "care", "are", "frequent", "in", "Burundian", "children", "and", "have", "a", "completely", "different", "spectrum", "from", "the", "western", "ones", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "is", "due", "on", "one", "side", "to", "an", "under", "-", "diagnosis", "of", "certain", "conditions", "caused", "by", "the", "lack", "of", "diagnostic", "tools", "and", "on", "the", "other", "to", "the", "living", "conditions", "of", "the", "population", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "This", "difference", "should", "lead", "to", "intervention", "plans", "tailored", "on", "the", "actual", "necessities", "of", "the", "country", "and", "not", "on", "the", "western", "ones", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Introduction", "Tinea", "capitis", "is", "the", "most", "common", "form", "of", "dermatophytosis", "among", "children", ",", "contributing", "significantly", "to", "the", "global", "burden", "of", "skin", "and", "hair", "infections", "." ]

[ 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "However", ",", "an", "accurate", "account", "of", "its", "burden", "in", "Africa", ",", "where", "most", "cases", "are", "thought", "to", "occur", ",", "is", "lacking", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "aim", "to", "systematically", "evaluate", "the", "burden", ",", "aetiology", "and", "epidemiological", "trend", "of", "tinea", "capitis", "among", "children", "over", "a", "30", "-", "year", "period", "in", "Africa", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 0, 0, 15, 0 ]

[ "Methods", "and", "analysis", "A", "systematic", "review", "will", "be", "conducted", "using", "Embase", ",", "PubMed", ",", "African", "Journals", "Online", ",", "Web", "of", "Science", "and", "the", "Cochrane", "Library", "of", "Systematic", "Review", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "These", "resources", "will", "be", "used", "to", "identify", "studies", "published", "between", "1990", "and", "December", "2020", ",", "which", "report", "the", "prevalence", ",", "aetiology", "and", "trend", "of", "tinea", "capitis", "among", "children", "younger", "than", "18", "years", "in", "Africa", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 11, 12, 12, 12, 12, 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 1, 2, 0, 0, 0, 0, 0, 0, 0, 15, 0 ]

[ "Articles", "in", "English", "and", "French", "will", "be", "considered", "." ]

[ 0, 0, 15, 0, 15, 0, 0, 0, 0 ]

[ "Two", "independent", "reviewers", "will", "screen", "the", "articles", "for", "eligibility", ",", "and", "any", "discrepancies", "will", "be", "resolved", "by", "discussion", "and", "consensus", "between", "the", "authors", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Methodological", "quality", "of", "all", "studies", "will", "be", "assessed", "and", "critically", "appraised", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "We", "will", "perform", "a", "metaregression", "to", "assess", "the", "impact", "of", "study", "characteristics", "on", "heterogeneity", "and", "also", "to", "correct", "the", "meta", "-", "analytical", "estimates", "for", "biases", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "A", "qualitative", "synthesis", "will", "be", "performed", ",", "and", "STATA", "V.16.0", "software", "will", "be", "used", "to", "estimate", "the", "pooled", "prevalence", "and", "aetiology", "of", "tinea", "capitis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 1, 2, 0 ]

[ "The", "Mann", "-", "Kendall", "trend", "test", "will", "be", "use", "to", "evaluate", "the", "trend", "in", "the", "prevalence", "of", "tinea", "capitis", "over", "the", "study", "period", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 5, 0, 1, 2, 0, 0, 0, 0, 0 ]

[ "Ethics", "and", "dissemination", "Ethical", "approval", "from", "an", "institutional", "review", "board", "or", "research", "ethics", "committee", "is", "not", "required", "for", "this", "systematic", "review", "and", "meta", "-", "analysis", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "results", "will", "be", "published", "in", "a", "peer", "-", "reviewed", "journal", "and", "presented", "in", "conferences", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Background", ":", "Previous", "research", "has", "suggested", "that", "vigorous", "physical", "activity", "(", "VPA", ")", "during", "adolescence", "and", "early", "adulthood", "is", "associated", "with", "ALS", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0 ]

[ "The", "National", "ALS", "Registry", "(", "Registry", ")", "collects", "physical", "activity", "data", "from", "persons", "with", "ALS", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0 ]

[ "Objective", ":", "To", "examine", "the", "association", "between", "vigorous", "VPA", "and", "early", "onset", "ALS", ",", "defined", "as", "a", "diagnosis", "before", "age", "60", ",", "among", "patients", "enrolled", "in", "the", "Registry", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "VPA", "was", "defined", "as", "engaging", "in", "dynamic", "exercise", "for", "at", "least", "10", "minutes", "in", "a", "session", "that", "caused", "heavy", "sweating", "or", "large", "increases", "in", "breathing", "or", "heart", "rate", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Methods", ":", "A", "cross", "-", "sectional", "study", "was", "conducted", "of", "5463", "ALS", "patients", "with", "VPA", "history", "and", "956", "ALS", "patients", "who", "never", "engaged", "in", "VPA", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0 ]

[ "Patient", "characteristics", "were", "collected", "via", "online", "surveys", "in", "the", "following", "areas", ":", "demographic", ",", "lifetime", "VPA", "history", ",", "and", "initial", "onset", "of", "symptoms", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "General", "linear", "modeling", "was", "used", "to", "estimate", "mean", "age", "of", "diagnosis", "and", "to", "compute", "95", "%", "confidence", "intervals", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Results", ":", "Patients", "who", "reported", "engaging", "in", "VPA", "at", "least", "moderately", "(", "three", "times", "a", "week", ")", "during", "early", "adulthood", "were", "more", "likely", "to", "have", "an", "ALS", "diagnosis", "earlier", "compared", "to", "patients", "who", "did", "not", "(", "p", "<", "0.0001", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "After", "controlling", "for", "year", "of", "birth", ",", "statistically", "significant", "associations", "between", "those", "reporting", "VPA", "at", "age", "15", "-", "24", "and", "25", "-", "34", "and", "diagnosis", "of", "ALS", "earlier", "(", "p", "=", "0.0009", ",", "p", "=", "0.0144", "respectively", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Conclusion", ":", "Patients", "with", "ALS", "who", "had", "a", "history", "of", "VPA", "before", "age", "35", ",", "were", "significantly", "more", "likely", "to", "be", "diagnosed", "with", "ALS", "before", "age", "60", "compared", "to", "patients", "with", "ALS", "who", "never", "engaged", "vigorously", "." ]

[ 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0 ]

[ "More", "research", "is", "needed", "in", "the", "relationship", "between", "VPA", "and", "early", "onset", "ALS", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0 ]

[ "Despite", "numerous", "studies", "in", "the", "field", "of", "congenital", "adrenal", "hyperplasia", "(", "CAH", ")", "due", "to", "21", "-", "hydroxylase", "deficiency", ",", "some", "clinical", "variability", "of", "the", "presentation", "and", "discrepancies", "in", "the", "genotype", "/", "phenotype", "correlation", "are", "still", "unexplained", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 1, 2, 2, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Some", ",", "but", "not", "all", ",", "discordant", "phenotypes", "caused", "by", "mutations", "with", "known", "enzyme", "activity", "have", "been", "explained", "by", "in", "silico", "structural", "changes", "in", "the", "21", "-", "hydroxylase", "protein", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "incidence", "of", "P30L", "mutation", "varies", "in", "different", "populations", "and", "is", "most", "frequently", "found", "in", "several", "Central", "and", "Southeast", "European", "countries", "as", "well", "as", "Mexico", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 9, 10, 10, 10, 10, 0, 0, 0, 9, 0 ]

[ "Patients", "carrying", "P30L", "mutation", "present", "predominantly", "as", "non", "-", "classical", "CAH", ";", "however", ",", "simple", "virilizing", "forms", "are", "found", "in", "up", "to", "50", "%", "of", "patients", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Taking", "into", "consideration", "the", "residual", "21", "-", "hydroxulase", "activity", "present", "with", "P30L", "mutation", "this", "is", "unexpected", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Different", "mechanisms", "for", "increased", "androgenization", "in", "patients", "carrying", "P30L", "mutation", "have", "been", "proposed", "including", "influence", "of", "different", "residues", ",", "accompanying", "promotor", "allele", "variability", "or", "mutations", ",", "and", "individual", "androgene", "sensitivity", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Early", "diagnosis", "of", "patients", "who", "would", "present", "with", "SV", "is", "important", "in", "order", "to", "improve", "outcome", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Outcome", "studies", "of", "CAH", "have", "confirmed", "the", "uniqueness", "of", "this", "mutation", "such", "as", "difficulties", "in", "phenotype", "classification", ",", "different", "fertility", ",", "growth", ",", "and", "psychologic", "issues", "in", "comparison", "with", "other", "genotypes", "." ]

[ 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Additional", "studies", "of", "P30L", "mutation", "are", "warranted", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Background", "Charcot", "-", "Marie", "-", "Tooth", "disease", "type", "1A", "(", "CMT1A", ")", "is", "the", "most", "common", "form", "of", "hereditary", "neuropathy", "." ]

[ 0, 0, 0, 1, 2, 2, 2, 2, 2, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Objective", "To", "investigate", "the", "prevalence", "and", "characteristics", "of", "pain", "in", "patients", "with", "CMT1A." ]

[ 0, 0, 0, 0, 5, 0, 0, 0, 0, 0, 0, 0, 3 ]

[ "Methods", "Nineteen", "patients", "with", "a", "diagnosis", "of", "CMT1A", "were", "evaluated", "between", "September", "2018", "and", "October", "2019", ",", "and", "other", "causes", "of", "neuropathy", "were", "ruled", "out", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 11, 12, 12, 12, 12, 12, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "following", "tools", "were", "used", "for", "the", "pain", "assessment", ":", "neurological", "assessment", ",", "LANSS", ",", "DN4", ",", "clinical", "evaluation", ",", "VAS", ",", "CMTNS2", "and", "SF-36", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Statistical", "analysis", "was", "performed", "using", "prevalence", "analysis", ",", "t", "test", ",", "chi", "-", "square", "test", "and", "Spearman", "'s", "rho", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Results", "The", "prevalence", "of", "pain", "was", "84.2", "%", "in", "the", "sample", "of", "this", "study", ",", "with", "moderate", "intensity", "and", "nociceptive", "characteristics", "according", "to", "the", "LANSS", "scale", "(", "75", "%", ")", "and", "clinical", "evaluation", "(", "50", "%", ")", ",", "but", "differing", "from", "DN4", ",", "which", "found", "neuropathic", "pain", "in", "the", "majority", "of", "the", "patients", "(", "56.2", "%", ")", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Mixed", "pain", "was", "also", "observed", "in", "43.7", "%", "of", "the", "patients", ",", "according", "to", "clinical", "criteria", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "There", "was", "a", "statistically", "significant", "correlation", "between", "pain", "intensity", "and", "SF-36", ",", "thus", "demonstrating", "that", "the", "lower", "the", "pain", "was", ",", "the", "lower", "the", "impairment", "was", ",", "in", "all", "domains", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Conclusion", "Pain", "is", "a", "prevalent", "and", "important", "symptom", "in", "CMT1A", ",", "with", "moderate", "intensity", "and", "nociceptive", "characteristics", "according", "to", "two", "tools", ",", "but", "neuropathic", "pain", "is", "also", "present", ",", "and", "there", "may", "even", "be", "a", "mixed", "pattern", "of", "pain", "." ]

[ 0, 0, 0, 0, 5, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "The", "correlation", "of", "the", "pain", "with", "SF-36", "suggests", "that", "pain", "relief", "could", "provide", "improvements", "to", "the", "quality", "of", "life", "of", "these", "individuals", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Auditory", "neuropathy", "spectrum", "disorder", "(", "ANSD", ")", "refers", "to", "a", "range", "of", "hearing", "impairments", "characterized", "by", "deteriorated", "speech", "perception", ",", "despite", "relatively", "preserved", "pure", "-", "tone", "detection", "thresholds", "." ]

[ 1, 2, 2, 2, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]

[ "Affected", "individuals", "usually", "present", "with", "abnormal", "auditory", "brainstem", "responses", "(", "ABRs", ")", ",", "but", "normal", "otoacoustic", "emissions", "(", "OAEs", ")", "." ]

[ 0, 0, 0, 0, 0, 1, 2, 2, 2, 0, 3, 0, 0, 0, 0, 1, 2, 0, 3, 0, 0 ]

[ "These", "electrophysiological", "characteristics", "have", "led", "to", "the", "hypothesis", "that", "ANSD", "may", "be", "caused", "by", "various", "dysfunctions", "at", "the", "cochlear", "inner", "hair", "cell", "(", "IHC", ")", "and", "spiral", "ganglion", "neuron", "(", "SGN", ")", "levels", ",", "while", "the", "activity", "of", "outer", "hair", "cells", "(", "OHCs", ")", "is", "preserved", ",", "resulting", "in", "discrepancies", "between", "pure", "-", "tone", "and", "speech", "comprehension", "thresholds", "." ]

[ 0, 0, 0, 0, 0, 0, 0, 0, 0, 3, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0, 0 ]