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3200
[ "The", "recent", "discovery", "of", "genes", "involved", "in", "familial", "forms", "of", "nephrotic", "syndrome", "represents", "a", "break", "-", "through", "in", "nephrology", "." ]
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3201
[ "To", "date", ",", "15", "genes", "have", "been", "characterized", "and", "several", "new", "loci", "have", "been", "identified", ",", "with", "a", "potential", "for", "discovery", "of", "new", "genes", "." ]
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3202
[ "Overall", ",", "these", "genes", "account", "for", "a", "large", "fraction", "of", "familial", "forms", "of", "nephrotic", "syndrome", ",", "but", "they", "can", "also", "be", "recognized", "in", "10", "-", "20", "%", "of", "sporadic", "cases", "." ]
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3203
[ "These", "advances", "increase", "diagnostic", "and", "therapeutic", "potentials", ",", "but", "also", "add", "higher", "complexity", "to", "the", "scenario", ",", "requiring", "clear", "definitions", "of", "clinical", ",", "histopathological", "and", "molecular", "signatures", "." ]
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3204
[ "In", "general", ",", "genetic", "forms", "of", "nephrotic", "syndrome", "are", "resistant", "to", "common", "therapeutic", "approaches", "(", "that", "include", "steroids", "and", "calcineurin", "inhibitors", ")", "but", ",", "in", "a", "few", "cases", ",", "drug", "response", "or", "spontaneous", "remission", "suggest", "a", "complex", "pathogenesis", "." ]
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3205
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3206
[ "In", "this", "educational", "review", ",", "clinical", ",", "histological", "and", "molecular", "aspects", "of", "various", "forms", "of", "familial", "nephrotic", "syndrome", "have", "been", "reviewed", "in", "an", "attempt", "to", "define", "a", "rational", "diagnostic", "approach", "." ]
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3207
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3208
[ "The", "final", "objective", "of", "this", "review", "is", "to", "outline", "a", "diagnostic", "flow", "-", "chart", "for", "clinicians", "and", "geneticists", "and", "to", "generate", "a", "rational", "scheme", "for", "molecular", "testing", "." ]
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3209
[ "Pyridoxine", "-", "dependent", "epilepsy", "(", "PDE", ")", "is", "a", "recessive", "genetic", "disease", "characterized", "by", "epileptic", "encephalopathy", "with", "therapeutic", "response", "to", "pharmacological", "doses", "of", "pyridoxine", "and", "resistance", "to", "anti", "-", "epileptic", "treatments", "." ]
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3210
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3211
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3212
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3213
[ "The", "TT", "was", "well", "-", "tolerated", "with", "good", "compliance", "." ]
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3214
[ "No", "adverse", "events", "were", "reported", "." ]
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3215
[ "We", "observed", "a", "neurodevelopmental", "improvement", ",", "significantly", "fewer", "seizures", ",", "and", "a", "reduction", "of", "pipecolic", "acid", "(", "PA", ")", "as", "a", "biomarker", "of", "the", "illness", "." ]
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3216
[ "Our", "results", "show", "an", "improving", "clinical", "evolution", ",", "supporting", "and", "extending", "previous", "studies", "reporting", "efficacy", "of", "TT", "." ]
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3217
[ "Objectives", "To", "review", "the", "data", "of", "infants", "and", "children", "with", "suspected", "monogenic", "diabetes", "who", "underwent", "genetic", "testing", "." ]
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3218
[ "Methods", "Monogenic", "diabetes", "is", "a", "rare", "form", "of", "diabetes", "resulting", "from", "mutations", "in", "a", "single", "gene", "." ]
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3219
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3220
[ "In", "a", "country", "like", "Pakistan", "where", "interfamily", "marriages", "are", "common", "the", "incidence", "of", "genetic", "disorders", "is", "increased", "." ]
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3221
[ "As", "Pakistan", "a", "resource", "-", "poor", "country", ",", "the", "diagnosis", "of", "insulin", "-", "dependent", "diabetes", "is", "often", "delayed", "and", "a", "genetic", "diagnosis", "of", "monogenic", "diabetes", "is", "extremely", "difficult", "." ]
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3222
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3223
[ "Results", "One", "thousand", "sixty", "four", "new", "cases", "diagnosed", "with", "type", "1", "diabetes", "were", "registered", "at", "the", "National", "Institute", "of", "Child", "Health", ",", "Karachi", ",", "in", "the", "last", "10", "years", "." ]
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3224
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3225
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3226
[ "The", "most", "common", "genetic", "subtype", "was", "WolcottRallison", "syndrome", "caused", "by", "EIF2AK3", "mutations", "(", "seven", "cases", ")", "." ]
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3227
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3228
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3229
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3230
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3231
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3232
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3233
[ "It", "most", "commonly", "occurs", "in", "post", "-", "menopausal", "White", "women", "." ]
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3234
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3235
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3236
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3237
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3238
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3239
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3240
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3241
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3242
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3243
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3244
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3245
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3246
[ "The", "boy", "met", "the", "diagnostic", "criteria", "for", "LFS", "." ]
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3247
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3248
[ "Additionally", ",", "leukemia", "and", "lymphoma", "are", "also", "involved", "." ]
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3249
[ "LFS", "patients", "have", "a", "high", "risk", "to", "suffer", "secondary", "or", "even", "multiple", "cancers", "." ]
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3250
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3251
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3252
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3253
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3254
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3255
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3256
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3257
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