id
stringlengths 1
4
| tokens
sequence | ner_tags
sequence |
---|---|---|
3200 | [
"The",
"recent",
"discovery",
"of",
"genes",
"involved",
"in",
"familial",
"forms",
"of",
"nephrotic",
"syndrome",
"represents",
"a",
"break",
"-",
"through",
"in",
"nephrology",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0
] |
3201 | [
"To",
"date",
",",
"15",
"genes",
"have",
"been",
"characterized",
"and",
"several",
"new",
"loci",
"have",
"been",
"identified",
",",
"with",
"a",
"potential",
"for",
"discovery",
"of",
"new",
"genes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3202 | [
"Overall",
",",
"these",
"genes",
"account",
"for",
"a",
"large",
"fraction",
"of",
"familial",
"forms",
"of",
"nephrotic",
"syndrome",
",",
"but",
"they",
"can",
"also",
"be",
"recognized",
"in",
"10",
"-",
"20",
"%",
"of",
"sporadic",
"cases",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3203 | [
"These",
"advances",
"increase",
"diagnostic",
"and",
"therapeutic",
"potentials",
",",
"but",
"also",
"add",
"higher",
"complexity",
"to",
"the",
"scenario",
",",
"requiring",
"clear",
"definitions",
"of",
"clinical",
",",
"histopathological",
"and",
"molecular",
"signatures",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3204 | [
"In",
"general",
",",
"genetic",
"forms",
"of",
"nephrotic",
"syndrome",
"are",
"resistant",
"to",
"common",
"therapeutic",
"approaches",
"(",
"that",
"include",
"steroids",
"and",
"calcineurin",
"inhibitors",
")",
"but",
",",
"in",
"a",
"few",
"cases",
",",
"drug",
"response",
"or",
"spontaneous",
"remission",
"suggest",
"a",
"complex",
"pathogenesis",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3205 | [
"Finally",
",",
"syndromic",
"variants",
"can",
"be",
"recognized",
"on",
"the",
"basis",
"of",
"the",
"associated",
"extra",
"-",
"renal",
"manifestations",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3206 | [
"In",
"this",
"educational",
"review",
",",
"clinical",
",",
"histological",
"and",
"molecular",
"aspects",
"of",
"various",
"forms",
"of",
"familial",
"nephrotic",
"syndrome",
"have",
"been",
"reviewed",
"in",
"an",
"attempt",
"to",
"define",
"a",
"rational",
"diagnostic",
"approach",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3207 | [
"The",
"proposed",
"model",
"focuses",
"on",
"practical",
"and",
"economic",
"issues",
",",
"taking",
"into",
"consideration",
"the",
"impossibility",
"of",
"using",
"genetic",
"testing",
"as",
"starting",
"diagnostic",
"tool",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3208 | [
"The",
"final",
"objective",
"of",
"this",
"review",
"is",
"to",
"outline",
"a",
"diagnostic",
"flow",
"-",
"chart",
"for",
"clinicians",
"and",
"geneticists",
"and",
"to",
"generate",
"a",
"rational",
"scheme",
"for",
"molecular",
"testing",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3209 | [
"Pyridoxine",
"-",
"dependent",
"epilepsy",
"(",
"PDE",
")",
"is",
"a",
"recessive",
"genetic",
"disease",
"characterized",
"by",
"epileptic",
"encephalopathy",
"with",
"therapeutic",
"response",
"to",
"pharmacological",
"doses",
"of",
"pyridoxine",
"and",
"resistance",
"to",
"anti",
"-",
"epileptic",
"treatments",
"."
] | [
1,
2,
2,
2,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3210 | [
"The",
"recent",
"discovery",
"in",
"2006",
"of",
"the",
"genetic",
"defect",
"antiquitin",
"(",
"ALDH7A1",
",",
"OMIM",
"#",
"266100",
")",
"has",
"helped",
"to",
"understand",
"the",
"underlying",
"mechanism",
",",
"which",
"is",
"the",
"accumulation",
"of",
"neurotoxic",
"intermediates",
"in",
"the",
"lysine",
"catabolic",
"pathway",
"."
] | [
0,
0,
0,
0,
11,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3211 | [
"The",
"goal",
"of",
"the",
"new",
"therapeutic",
"approach",
",",
"termed",
"triple",
"therapy",
"(",
"TT",
")",
"(",
"pyridoxine",
",",
"lysine",
"-",
"restricted",
"diet",
"and",
"arginine",
"supplementation",
")",
",",
"is",
"to",
"improve",
"epilepsy",
"control",
"and",
"neurocognitive",
"development",
"in",
"patients",
"with",
"PDE",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] |
3212 | [
"We",
"present",
"the",
"3",
"-",
"year",
"treatment",
"outcome",
"for",
"a",
"child",
"with",
"PDE",
"on",
"pyridoxine",
"treatment",
"(",
"started",
"at",
"age",
"5",
"months",
")",
",",
"lysine",
"-",
"restricted",
"diet",
"(",
"started",
"at",
"age",
"17",
"months",
")",
"and",
"arginine",
"supplementation",
"therapy",
"(",
"started",
"at",
"age",
"19",
"months",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3213 | [
"The",
"TT",
"was",
"well",
"-",
"tolerated",
"with",
"good",
"compliance",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3214 | [
"No",
"adverse",
"events",
"were",
"reported",
"."
] | [
0,
0,
0,
0,
0,
0
] |
3215 | [
"We",
"observed",
"a",
"neurodevelopmental",
"improvement",
",",
"significantly",
"fewer",
"seizures",
",",
"and",
"a",
"reduction",
"of",
"pipecolic",
"acid",
"(",
"PA",
")",
"as",
"a",
"biomarker",
"of",
"the",
"illness",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3216 | [
"Our",
"results",
"show",
"an",
"improving",
"clinical",
"evolution",
",",
"supporting",
"and",
"extending",
"previous",
"studies",
"reporting",
"efficacy",
"of",
"TT",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3217 | [
"Objectives",
"To",
"review",
"the",
"data",
"of",
"infants",
"and",
"children",
"with",
"suspected",
"monogenic",
"diabetes",
"who",
"underwent",
"genetic",
"testing",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3218 | [
"Methods",
"Monogenic",
"diabetes",
"is",
"a",
"rare",
"form",
"of",
"diabetes",
"resulting",
"from",
"mutations",
"in",
"a",
"single",
"gene",
"."
] | [
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3219 | [
"It",
"can",
"be",
"caused",
"by",
"dominant",
"as",
"well",
"as",
"recessive",
"modes",
"of",
"inheritance",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3220 | [
"In",
"a",
"country",
"like",
"Pakistan",
"where",
"interfamily",
"marriages",
"are",
"common",
"the",
"incidence",
"of",
"genetic",
"disorders",
"is",
"increased",
"."
] | [
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0
] |
3221 | [
"As",
"Pakistan",
"a",
"resource",
"-",
"poor",
"country",
",",
"the",
"diagnosis",
"of",
"insulin",
"-",
"dependent",
"diabetes",
"is",
"often",
"delayed",
"and",
"a",
"genetic",
"diagnosis",
"of",
"monogenic",
"diabetes",
"is",
"extremely",
"difficult",
"."
] | [
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0
] |
3222 | [
"Children",
"with",
"clinical",
"diagnosis",
"of",
"monogenic",
"and",
"syndromic",
"diabates",
"were",
"recruited",
"and",
"blood",
"samples",
"were",
"sent",
"for",
"genetic",
"analysis",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3223 | [
"Results",
"One",
"thousand",
"sixty",
"four",
"new",
"cases",
"diagnosed",
"with",
"type",
"1",
"diabetes",
"were",
"registered",
"at",
"the",
"National",
"Institute",
"of",
"Child",
"Health",
",",
"Karachi",
",",
"in",
"the",
"last",
"10",
"years",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0
] |
3224 | [
"Of",
"these",
"39",
"patients",
"were",
"selected",
"for",
"genetic",
"testing",
"who",
"were",
"diagnosed",
"with",
"diabetes",
"/",
"had",
"a",
"sibling",
"diagnosed",
"with",
"diabetes",
"before",
"the",
"age",
"of",
"nine",
"months",
"(",
"n",
"=",
"27",
")",
"or",
"had",
"extra",
"pancreatic",
"features",
"(",
"n=",
"12",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3225 | [
"We",
"identified",
"mutations",
"in",
"18/27",
"cases",
"diagnosed",
"with",
"diabetes",
"before",
"nine",
"months",
"of",
"age",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3226 | [
"The",
"most",
"common",
"genetic",
"subtype",
"was",
"WolcottRallison",
"syndrome",
"caused",
"by",
"EIF2AK3",
"mutations",
"(",
"seven",
"cases",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3227 | [
"KCNJ11",
"mutations",
"were",
"identified",
"in",
"two",
"cases",
",",
"ABCC8",
"mutations",
"were",
"identified",
"in",
"four",
"cases",
"from",
"three",
"families",
",",
"GCK",
"and",
"INS",
"mutations",
"were",
"each",
"identified",
"in",
"two",
"cases",
",",
"and",
"one",
"SLC2A2",
"mutation",
"was",
"identified",
"in",
"one",
"case",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3228 | [
"A",
"genetic",
"diagnosis",
"was",
"made",
"in",
"12/12",
"children",
"from",
"six",
"families",
"with",
"diabetes",
"diagnosed",
"after",
"the",
"age",
"of",
"nine",
"months",
"who",
"had",
"extrapancreatic",
"features",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3229 | [
"Six",
"patients",
"had",
"genetically",
"confirmed",
"Wolfram",
"syndrome",
"(",
"WFS1",
")",
",",
"three",
"had",
"thiamine",
"-",
"responsive",
"megaloblastic",
"anemia",
"(",
"SLC19A2",
")",
"and",
"three",
"were",
"diagnosed",
"with",
"histocytosis",
"lymphadenopathy",
"plus",
"syndrome",
"(",
"SLC29A3",
")",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
0,
3,
0,
0,
0,
0,
1,
2,
2,
2,
0,
0,
3,
0,
0,
0,
0,
0,
0,
1,
2,
2,
2,
0,
3,
0,
0
] |
3230 | [
"Conclusions",
"Genetic",
"testing",
"is",
"essential",
"to",
"confirm",
"a",
"diagnosis",
"of",
"monogenic",
"diabetes",
"which",
"guides",
"clinical",
"management",
"and",
"future",
"counselling",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3231 | [
"Our",
"study",
"highlights",
"the",
"importance",
"of",
"diagnosing",
"monogenic",
"diabetes",
"in",
"the",
"largely",
"consanguineously",
"-",
"married",
"population",
"of",
"Pakistan",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
3232 | [
"Frontal",
"fibrosing",
"alopecia",
"(",
"FFA",
")",
"is",
"a",
"variant",
"of",
"lichen",
"planopilaris",
"(",
"LPP",
")",
"with",
"characteristic",
"band",
"-",
"like",
"frontotemporal",
"hairline",
"involvement",
"and",
"eyebrow",
"loss",
"."
] | [
1,
2,
2,
0,
3,
0,
0,
0,
0,
0,
1,
2,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3233 | [
"It",
"most",
"commonly",
"occurs",
"in",
"post",
"-",
"menopausal",
"White",
"women",
"."
] | [
0,
0,
0,
5,
0,
0,
0,
0,
15,
13,
0
] |
3234 | [
"1",
"In",
"skin",
"of",
"color",
"(",
"SOC",
")",
"individuals",
",",
"FFA",
"is",
"often",
"misdiagnosed",
"as",
"traction",
"alopecia",
"(",
"TA",
")",
",",
"2",
"and",
"little",
"data",
"exists",
"regarding",
"the",
"presentation",
"of",
"FFA",
"in",
"the",
"SOC",
"patient",
"population",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
1,
2,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0
] |
3235 | [
"3",
"As",
"FFA",
"incidence",
"continues",
"to",
"increase",
",",
"4",
"we",
"aim",
"to",
"understand",
"differences",
"in",
"the",
"presentation",
"of",
"FFA",
"between",
"White",
"and",
"Black",
"women",
"in",
"order",
"to",
"aid",
"in",
"the",
"accurate",
"and",
"timely",
"diagnosis",
"as",
"well",
"as",
"help",
"inform",
"prognosis",
"and",
"management",
"."
] | [
0,
0,
3,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
15,
0,
15,
13,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3236 | [
"Unilateral",
"lung",
"agenesis",
"is",
"a",
"relatively",
"rare",
"congenital",
"anomaly",
"with",
"a",
"reported",
"incidence",
"of",
"1",
"in",
"15",
"000",
"births",
"."
] | [
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0,
7,
8,
8,
8,
8,
0
] |
3237 | [
"It",
"is",
"frequently",
"associated",
"with",
"other",
"congenital",
"malformations",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3238 | [
"Some",
"of",
"the",
"sequelae",
"of",
"lung",
"agenesis",
"are",
"potentially",
"life",
"-",
"threatening",
"."
] | [
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0
] |
3239 | [
"Here",
",",
"we",
"report",
"a",
"case",
"of",
"left",
"lung",
"agenesis",
"in",
"association",
"with",
"hiatal",
"hernia",
"and",
"atrioventricular",
"septal",
"defect",
",",
"a",
"rare",
"combination",
"of",
"anomalies",
"which",
"have",
"not",
"been",
"described",
"previously",
"in",
"the",
"literature",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
1,
2,
0,
1,
2,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3240 | [
"Li",
"-",
"Fraumeni",
"syndrome",
"(",
"LFS",
")",
"is",
"a",
"hereditary",
"cancer",
"predisposition",
"syndrome",
",",
"with",
"the",
"characteristics",
"of",
"early",
"onset",
"of",
"cancer",
"and",
"high",
"cancer",
"incidence",
"."
] | [
1,
2,
2,
2,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
5,
0
] |
3241 | [
"TP53",
"is",
"widely",
"accepted",
"as",
"a",
"pathogenic",
"gene",
"of",
"LFS",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] |
3242 | [
"A",
"2",
"years",
"and",
"6",
"months",
"old",
"boy",
"is",
"reported",
"in",
"this",
"article",
",",
"who",
"was",
"diagnosed",
"with",
"embryonal",
"rhabdomyosarcoma",
"(",
"RMS",
")",
"in",
"the",
"left",
"submandibular",
"region",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
13,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
3,
0,
0,
0,
0,
0,
0,
0
] |
3243 | [
"His",
"brother",
"died",
"of",
"RMS",
",",
"and",
"his",
"grandmother",
"was",
"diagnosed",
"with",
"breast",
"cancer",
"."
] | [
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0
] |
3244 | [
"TP53",
"gene",
"mutation",
"detection",
"was",
"performed",
"in",
"this",
"patient",
"and",
"some",
"family",
"members",
",",
"indicating",
"a",
"missense",
"mutation",
"in",
"exon",
"8",
"of",
"the",
"patient",
":",
"c.844C",
">",
"T",
"(",
"p.",
"Arg282Trp",
",",
"heterozygous",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3245 | [
"TP53",
"mutation",
"was",
"also",
"found",
"in",
"his",
"mother",
"and",
"sister",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
13,
0,
13,
0
] |
3246 | [
"The",
"boy",
"met",
"the",
"diagnostic",
"criteria",
"for",
"LFS",
"."
] | [
0,
13,
0,
0,
0,
0,
0,
3,
0
] |
3247 | [
"Among",
"pediatric",
"patients",
",",
"the",
"most",
"common",
"LFS",
"diseases",
"include",
"osteosarcoma",
",",
"adrenocortical",
"cancer",
",",
"central",
"nervous",
"system",
"tumor",
",",
"and",
"soft",
"tissue",
"tumor",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
1,
0,
1,
2,
0,
1,
2,
2,
2,
0,
0,
1,
2,
2,
0
] |
3248 | [
"Additionally",
",",
"leukemia",
"and",
"lymphoma",
"are",
"also",
"involved",
"."
] | [
0,
0,
1,
0,
1,
0,
0,
0,
0
] |
3249 | [
"LFS",
"patients",
"have",
"a",
"high",
"risk",
"to",
"suffer",
"secondary",
"or",
"even",
"multiple",
"cancers",
"."
] | [
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3250 | [
"Therefore",
",",
"it",
"is",
"necessary",
"to",
"perform",
"genetic",
"detection",
"for",
"pediatric",
"cancer",
"patients",
",",
"especially",
"those",
"with",
"hereditary",
"predisposition",
"cancers",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3251 | [
"TP53",
"mutation",
"often",
"indicates",
"poor",
"prognosis",
",",
"so",
"it",
"is",
"important",
"to",
"take",
"active",
"treatment",
"and",
"systematic",
"monitoring",
"for",
"LFS",
"family",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0
] |
3252 | [
"The",
"escalating",
"prevalence",
"of",
"coronavirus",
"disease",
"2019",
"(",
"COVID-19",
")",
"worldwide",
",",
"with",
"an",
"increased",
"rate",
"of",
"morbidity",
"and",
"mortality",
",",
"highlights",
"an",
"urgent",
"need",
"to",
"develop",
"more",
"effective",
"therapeutic",
"interventions",
"."
] | [
0,
0,
5,
0,
1,
2,
11,
0,
3,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3253 | [
"Despite",
"the",
"authorized",
"treatment",
"against",
"COVID-19",
"by",
"the",
"European",
"Union",
"(",
"EU",
")",
",",
"the",
"safety",
"and",
"effectiveness",
"of",
"this",
"therapeutic",
"strategy",
"for",
"a",
"wide",
"variety",
"of",
"patients",
"have",
"remained",
"a",
"significant",
"challenge",
"."
] | [
0,
0,
0,
0,
0,
3,
0,
0,
9,
10,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3254 | [
"In",
"this",
"respect",
",",
"micronutrients",
"such",
"as",
"vitamins",
"and",
"minerals",
",",
"as",
"essential",
"factors",
",",
"can",
"be",
"considered",
"for",
"improving",
"the",
"function",
"of",
"the",
"immune",
"system",
"and",
"accelerating",
"the",
"treatment",
"procedure",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3255 | [
"Dietary",
"supplements",
"can",
"attenuate",
"vascular",
"and",
"inflammatory",
"manifestations",
"related",
"to",
"infectious",
"diseases",
"in",
"large",
"part",
"due",
"to",
"their",
"anti",
"-",
"inflammatory",
"and",
"antioxidant",
"properties",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3256 | [
"Recently",
",",
"it",
"has",
"been",
"revealed",
"that",
"poor",
"nutritional",
"status",
"may",
"be",
"one",
"of",
"the",
"notable",
"risk",
"factors",
"in",
"severe",
"COVID-19",
"infections",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0
] |
3257 | [
"In",
"the",
"current",
"review",
",",
"we",
"focus",
"on",
"the",
"micronutrient",
"therapy",
"of",
"COVID-19",
"patients",
"and",
"provide",
"a",
"comprehensive",
"insight",
"into",
"the",
"essential",
"vitamins",
"/",
"minerals",
"and",
"their",
"role",
"in",
"controlling",
"the",
"severity",
"of",
"the",
"COVID-19",
"infection",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0
] |
3258 | [
"We",
"also",
"discuss",
"the",
"recent",
"advancements",
",",
"challenges",
",",
"negative",
"and",
"positive",
"outcomes",
"in",
"relevance",
"to",
"this",
"approach",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3259 | [
"The",
"Xp22.31",
"segment",
"of",
"the",
"short",
"arm",
"of",
"the",
"human",
"X",
"chromosome",
"is",
"a",
"region",
"of",
"high",
"instability",
"with",
"frequent",
"rearrangement",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3260 | [
"The",
"duplication",
"of",
"this",
"region",
"has",
"been",
"found",
"in",
"healthy",
"people",
"as",
"well",
"as",
"in",
"individuals",
"with",
"varying",
"degrees",
"of",
"neurological",
"impairment",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3261 | [
"The",
"incidence",
"has",
"been",
"reported",
"in",
"a",
"range",
"of",
"0.4",
"-",
"0.44",
"%",
"of",
"the",
"patients",
"with",
"neurological",
"impairment",
"."
] | [
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3262 | [
"Moreover",
",",
"there",
"is",
"evidence",
"that",
"Xp22.31",
"duplication",
"may",
"cause",
"a",
"common",
"phenotype",
"including",
"developmental",
"delay",
",",
"intellectual",
"disability",
",",
"feeding",
"difficulty",
",",
"autistic",
"spectrum",
"disorders",
",",
"hypotonia",
",",
"seizures",
",",
"and",
"talipes",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3263 | [
"We",
"report",
"on",
"a",
"patient",
"with",
"microcephaly",
"and",
"trigonocephaly",
",",
"moderate",
"intellectual",
"disability",
",",
"speech",
"and",
"language",
"delay",
",",
"and",
"poor",
"social",
"interaction",
"in",
"addition",
"to",
"minor",
"but",
"atypical",
"dysmorphic",
"features",
"."
] | [
0,
0,
0,
0,
0,
0,
1,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3264 | [
"This",
"report",
"provides",
"further",
"insight",
"into",
"the",
"pathogenicity",
"of",
"the",
"Xp22.31",
"duplication",
"by",
"extending",
"knowledge",
"of",
"its",
"clinical",
"features",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0
] |
3265 | [
"This",
"case",
",",
"in",
"association",
"with",
"those",
"reported",
"in",
"the",
"literature",
",",
"indicates",
"that",
"the",
"Xp22.31",
"duplication",
"may",
"contribute",
"to",
"cause",
"pathological",
"phenotypes",
"with",
"minor",
"facial",
"dysmorphisms",
",",
"microcephaly",
",",
"and",
"intellectual",
"disability",
"as",
"main",
"features",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0
] |
3266 | [
"We",
"examined",
"the",
"potential",
"benefits",
"of",
"neuroimaging",
"measurements",
"across",
"the",
"first",
"5",
"years",
"of",
"life",
"in",
"detecting",
"early",
"comorbid",
"or",
"etiological",
"signs",
"of",
"autism",
"spectrum",
"disorder",
"(",
"ASD",
")",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0,
3,
0,
0
] |
3267 | [
"In",
"particular",
",",
"we",
"analyzed",
"the",
"prevalence",
"of",
"neuroradiologic",
"findings",
"in",
"routine",
"magnetic",
"resonance",
"imaging",
"(",
"MRI",
")",
"scans",
"of",
"a",
"group",
"of",
"117",
"ASD",
"children",
"younger",
"than",
"5",
"years",
"old",
"."
] | [
0,
0,
0,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0
] |
3268 | [
"These",
"data",
"were",
"compared",
"to",
"those",
"reported",
"in",
"typically",
"developing",
"(",
"TD",
")",
"children",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3269 | [
"MRI",
"findings",
"in",
"children",
"with",
"ASD",
"were",
"analyzed",
"in",
"relation",
"to",
"their",
"cognitive",
"level",
",",
"severity",
"of",
"autistic",
"symptoms",
",",
"and",
"the",
"presence",
"of",
"electroencephalogram",
"(",
"EEG",
")",
"abnormalities",
"."
] | [
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3270 | [
"The",
"MRI",
"was",
"rated",
"abnormal",
"in",
"55",
"%",
"of",
"children",
"with",
"ASD",
"with",
"a",
"significant",
"prevalence",
"in",
"the",
"high",
"-",
"functioning",
"subgroup",
"compared",
"to",
"TD",
"children",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3271 | [
"We",
"report",
"significant",
"incidental",
"findings",
"of",
"mega",
"cisterna",
"magna",
",",
"ventricular",
"anomalies",
"and",
"abnormal",
"white",
"matter",
"signal",
"intensity",
"in",
"ASD",
"without",
"significant",
"associations",
"between",
"these",
"MRI",
"findings",
"and",
"EEG",
"features",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3272 | [
"Based",
"on",
"these",
"results",
"we",
"discuss",
"the",
"role",
"that",
"brain",
"MRI",
"may",
"play",
"in",
"the",
"diagnostic",
"procedure",
"of",
"ASD",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
3,
0
] |
3273 | [
"Diabetes",
"is",
"a",
"chronic",
"illness",
"."
] | [
1,
0,
0,
0,
0,
0
] |
3274 | [
"Hyperglycemia",
"is",
"the",
"characteristic",
"of",
"this",
"disorder",
"."
] | [
1,
0,
0,
0,
0,
0,
0,
0
] |
3275 | [
"Diabetes",
"is",
"a",
"global",
"crisis",
"which",
"affects",
"the",
"economy",
"and",
"health",
"of",
"all",
"nations",
"."
] | [
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3276 | [
"Over",
"the",
"last",
"decades",
",",
"the",
"number",
"of",
"individuals",
"living",
"with",
"diabetes",
"has",
"significantly",
"increased",
"worldwide",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
3277 | [
"Asia",
"is",
"a",
"key",
"epicenter",
"of",
"the",
"emerging",
"diabetes",
"epidemic",
",",
"with",
"China",
"and",
"India",
"the",
"two",
"nations",
"having",
"the",
"highest",
"number",
"of",
"diabetic",
"people",
"."
] | [
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3278 | [
"Economic",
"development",
",",
"modernization",
",",
"unhealthy",
"diet",
",",
"population",
"aging",
",",
"and",
"sedentary",
"lifestyles",
"are",
"the",
"major",
"factors",
"responsible",
"for",
"the",
"increasing",
"diabetes",
"epidemic",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0
] |
3279 | [
"Diabetes",
"is",
"associated",
"with",
"several",
"complications",
",",
"and",
"cardiovascular",
"disease",
"is",
"the",
"most",
"important",
"cause",
"of",
"morbidity",
"and",
"mortality",
"among",
"people",
"with",
"diabetes",
"."
] | [
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3280 | [
"These",
"life",
"-",
"threatening",
"problems",
"can",
"be",
"prevented",
"or",
"delayed",
"by",
"proper",
"management",
"of",
"diabetes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0
] |
3281 | [
"Lifestyle",
"modification",
"is",
"an",
"important",
"factor",
"to",
"decrease",
"the",
"diabetes",
"risk",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
0,
0
] |
3282 | [
"The",
"frequency",
"of",
"diabetic",
"complications",
"will",
"rise",
"if",
"there",
"is",
"a",
"lack",
"of",
"cost",
"-",
"effective",
"and",
"sustainable",
"interventions",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3283 | [
"Hence",
",",
"prevention",
"of",
"diabetes",
"and",
"its",
"complications",
"such",
"as",
"diabetic",
"retinopathy",
"and",
"cardiovascular",
"disease",
"should",
"be",
"a",
"crucial",
"part",
"of",
"all",
"future",
"health",
"-",
"related",
"public",
"policies",
"among",
"all",
"nations",
"."
] | [
0,
0,
0,
0,
1,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3284 | [
"This",
"review",
"summarizes",
"current",
"epidemiological",
"aspects",
"of",
"diabetes",
"in",
"the",
"world",
"along",
"with",
"its",
"complications",
",",
"preventive",
"measures",
",",
"and",
"treatment",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
1,
0,
0,
9,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3285 | [
"Purpose",
"of",
"review",
"The",
"goal",
"of",
"the",
"review",
"is",
"to",
"provide",
"a",
"comprehensive",
"overview",
"of",
"the",
"current",
"understanding",
"of",
"the",
"mechanisms",
"underlying",
"variation",
"in",
"human",
"stature",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3286 | [
"Recent",
"findings",
"Human",
"height",
"is",
"an",
"anthropometric",
"trait",
"that",
"varies",
"considerably",
"within",
"human",
"populations",
"as",
"well",
"as",
"across",
"the",
"globe",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
9,
0
] |
3287 | [
"Historically",
",",
"much",
"research",
"focus",
"was",
"placed",
"on",
"understanding",
"the",
"biology",
"of",
"growth",
"plate",
"chondrocytes",
"and",
"how",
"modifications",
"to",
"core",
"chondrocyte",
"proliferation",
"and",
"differentiation",
"pathways",
"potentially",
"shaped",
"height",
"attainment",
"in",
"normal",
"as",
"well",
"as",
"pathological",
"contexts",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3288 | [
"Recently",
",",
"much",
"progress",
"has",
"been",
"made",
"to",
"improve",
"our",
"understanding",
"regarding",
"the",
"mechanisms",
"underlying",
"the",
"normal",
"and",
"pathological",
"range",
"of",
"height",
"variation",
"within",
"as",
"well",
"as",
"between",
"human",
"populations",
",",
"and",
"today",
",",
"it",
"is",
"understood",
"to",
"reflect",
"complex",
"interactions",
"among",
"a",
"myriad",
"of",
"genetic",
",",
"environmental",
",",
"and",
"evolutionary",
"factors",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3289 | [
"Indeed",
",",
"recent",
"improvements",
"in",
"genetics",
"(",
"e.g.",
",",
"GWAS",
")",
"and",
"breakthroughs",
"in",
"functional",
"genomics",
"(",
"e.g.",
",",
"whole",
"exome",
"sequencing",
",",
"DNA",
"methylation",
"analysis",
",",
"ATAC",
"-",
"sequencing",
",",
"and",
"CRISPR",
")",
"have",
"shed",
"light",
"on",
"previously",
"unknown",
"pathways",
"/",
"mechanisms",
"governing",
"pathological",
"and",
"common",
"height",
"variation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3290 | [
"Additionally",
",",
"the",
"use",
"of",
"an",
"evolutionary",
"perspective",
"has",
"also",
"revealed",
"important",
"mechanisms",
"that",
"have",
"shaped",
"height",
"variation",
"across",
"the",
"planet",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3291 | [
"This",
"review",
"provides",
"an",
"overview",
"of",
"the",
"current",
"knowledge",
"of",
"the",
"biological",
"mechanisms",
"underlying",
"height",
"variation",
"by",
"highlighting",
"new",
"research",
"findings",
"on",
"skeletal",
"growth",
"control",
"with",
"an",
"emphasis",
"on",
"previously",
"unknown",
"pathways",
"/",
"mechanisms",
"influencing",
"pathological",
"and",
"common",
"height",
"variation",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3292 | [
"In",
"this",
"context",
",",
"this",
"review",
"also",
"discusses",
"how",
"evolutionary",
"forces",
"likely",
"shaped",
"the",
"genomic",
"architecture",
"of",
"height",
"across",
"the",
"globe",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3293 | [
"Background",
"21",
"-",
"Hydroxylase",
"deficiency",
"(",
"21",
"-",
"OHD",
")",
"caused",
"by",
"the",
"CYP21A2",
"gene",
"mutations",
"is",
"the",
"most",
"common",
"form",
"of",
"congenital",
"adrenal",
"hyperplasia",
"."
] | [
0,
1,
2,
2,
2,
0,
3,
4,
4,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
1,
2,
2,
0
] |
3294 | [
"It",
"is",
"an",
"autosomal",
"recessive",
"disorder",
"that",
"results",
"in",
"defective",
"synthesis",
"of",
"cortisol",
"and",
"aldosterone",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3295 | [
"The",
"incidences",
"of",
"various",
"CYP21A2",
"gene",
"mutations",
"and",
"the",
"genotype",
"-",
"phenotype",
"correlations",
"vary",
"among",
"different",
"populations",
"."
] | [
0,
5,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3296 | [
"Materials",
"and",
"methods",
"The",
"clinical",
"and",
"molecular",
"data",
"of",
"22",
"patients",
"were",
"analyzed",
"in",
"this",
"study",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3297 | [
"All",
"patients",
"were",
"recruited",
"from",
"the",
"neonatal",
"intensive",
"care",
"unit",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3298 | [
"Locus",
"-",
"specific",
"polymerase",
"chain",
"reaction",
"and",
"Sanger",
"sequencing",
"were",
"applied",
"to",
"identify",
"gene",
"micro",
"-",
"conversions",
",",
"and",
"multiplex",
"ligation",
"-",
"dependent",
"probe",
"amplification",
"was",
"used",
"to",
"detect",
"large",
"fragment",
"deletions",
"/",
"conversions",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |
3299 | [
"Then",
",",
"the",
"genotypes",
"were",
"categorized",
"in",
"to",
"Null",
",",
"A",
",",
"B",
",",
"C",
",",
"and",
"D",
"groups",
"to",
"analyze",
"the",
"relationships",
"between",
"genotypes",
"and",
"phenotypes",
"."
] | [
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0,
0
] |