Name
stringlengths 14
548
| Synonym
stringlengths 14
790
⌀ | CAS RN
stringlengths 7
12
| GHS
class label 2
classes | Detailed Page
stringlengths 57
580
| Evidence
stringlengths 40
2.31k
⌀ | OECD TG 404
stringclasses 1
value | Data Source
stringclasses 34
values | Frequency
int64 1
6
| SMILES
stringlengths 2
255
| SMILES URL
stringlengths 45
101
| SMILES Source
stringclasses 4
values | Canonical SMILES
stringlengths 2
248
| Split
stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NZ_CCID:
2-Ethylhexyl dihydrogen phosphate | NZ_CCID:
Phosphoric acid, mono(2-ethylhexyl)ester | 1070-03-7 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A3281E22-D4D1-4A1F-96F3-9985FD308231 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CCCCC(CC)COP(=O)(O)O | https://pubchem.ncbi.nlm.nih.gov/compound/14050 | PubChem | CCCCC(CC)COP(=O)(O)O | Train |
JP_CHRIP:
Acrylaldehyde
KR_NCIS:
Acrolein
NZ_CCID:
Acrolein
US_HSDB:
ACROLEIN | JP_CHRIP:
2-Propen-1-al
2-Propenal
Acrolein
acrolein (synonym:acrylaldehyde)
acrylaldehyde (synonym:acrolein)
Acrylic aldehyde
Prop-2-enal
KR_NCIS:
2-Propenal
NZ_CCID:
2-Propenal, Acraldehyde, Acrylaldehyde, Acrylic aldehyde, Allyl aldehyde, Aqualin, Ethylene aldehyde, Prop-2-en-1-al | 107-02-8 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2004.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/891B07E1-8729-43BF-B83A-41008FE6788B
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/177 | JP_CHRIP:
【分類根拠】
（１）、（２）より、区分1とした。
【根拠データ】
（１）本物質0.01～10％溶液をボランティアの皮膚に適用したパッチテストにおいて、0.01％溶液を適用した8名及び0.1％溶液を適用した10名では陽性反応はみられなかった。1％溶液を適用した48名では12.5％（6/48名）が陽性反応を示し、うち4名で水疱形成を伴う重度の浮腫、2名で紅斑と重度浮腫がみられた。10％溶液では全例（20/20名）の皮膚に水疱、壊死、炎症細胞の浸潤、乳頭状の水腫がみられたとの報告がある（NITE 初期 リスク評価書 (2007)、ECHA RAC Opinion (2012)、CLH Report (2011)、EU RAR (2001)、ATSDR (2007)、AICIS IMAP (2017)、CICAD (2002)、CEPA PSAR (2000)、REACH登録情報（Accessed Juｌｙ 2021)）。
（２）ウサギ（n=6）を用いた皮膚刺激性試験（14日観察）において、試験期間中に死亡（原因不明）した2例を除いた4例の24/72h後の紅斑スコアの平均は1、浮腫スコアの平均は3であり、3例でみられた影響は14日以内に回復しなかったとの報告がある（ECHA RAC Opinion (2012)、CLH Reoort (2011)、AICIS IMAP (2017)）。
【参考データ等】
（３）本物質は、平成8年労働省告示第33号（平成25年厚生労働省告示第316号により改正）において、労働基準法施行規則別表第一の二第四号1の厚生労働大臣が指定する単体たる化学物質及び化合物（合金を含む。）に「アクロレイン」として指定されており、本物質にさらされる業務による、特定の症状又は障害を主たる症状又は障害とする疾病（皮膚障害、前眼部障害又は気道・肺障害）が、業務上の疾病として定められている。
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [ECB]
Eye Irritation
R PHRASE: R 34 [ECB] | null | JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 4 | C=CC=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.045B | J-GLOBAL | C=CC=O | Train |
EU_REACH:
4-({6-chloro-2-[(4-cyanophenyl)amino]pyrimidin-4-yl}oxy)-3,5-dimethylbenzonitrile | null | 1070377-34-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/25836/7/4/2/?documentUUID=a53cfa2c-052b-454b-b56b-9105893c8cf7 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CC(=CC(=C1OC2=CC(=NC(=N2)NC3=CC=C(C=C3)C#N)Cl)C)C#N | https://pubchem.ncbi.nlm.nih.gov/compound/50914946 | PubChem | Cc1cc(C#N)cc(C)c1Oc1cc(Cl)nc(Nc2ccc(C#N)cc2)n1 | Train |
EU_REACH:
ethyl 6,8-dichlorooctanoate | null | 1070-64-0 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/31429/7/4/2/?documentUUID=f951c697-40c9-420a-abc9-853d27afa43c | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC(=O)CCCCC(CCCl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/14053 | PubChem | CCOC(=O)CCCCC(Cl)CCCl | Train |
NZ_CCID:
1,4-Butanediol diacrylate | null | 1070-70-8 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A1F7A1E7-05D3-4A6B-80EA-FDE3BDD1D11A | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C=CC(=O)OCCCCOC(=O)C=C | https://pubchem.ncbi.nlm.nih.gov/compound/70613 | PubChem | C=CC(=O)OCCCCOC(=O)C=C | Train |
NZ_CCID:
3,3-Dimethylbutyric acid | null | 1070-83-3 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2844A019-798A-44CB-A2BF-E83D5F4C2D18 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CC(C)(C)CC(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/14057 | PubChem | CC(C)(C)CC(=O)O | Train |
JP_CHRIP:
Propylamine
NZ_CCID:
1-Propanamine | JP_CHRIP:
1-Aminopropane
n-Propylamine
Propanamine
NZ_CCID:
1-Aminopropane, Monopropylamine, Propylamine | 107-10-8 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0047e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EA72A93B-D31E-4C3F-B537-DF250ECC1B3A | JP_CHRIP:
Based on a report of grade 6 (maximum grade 8) in rabbit test (PATTY (5th, 2001)), a report of "contact can severely irritate and burn the skin" (HSFS (2001)), and information of pH 12.6 (20 degC, 100 g/L) (GESTIS (access on Aug. 2009)), the substance was classified into Category 1. As relevant information, another report is noted "irritating to skin, eyes, and respiratory system in human" (HSDB (2008)).
NZ_CCID:
Skin Irritation
SPECIES: Guinea pig
RESULT: Severe
REFERENCE SOURCE: [Peer Reviewed] [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2053] HSDB.
UN CLASS: 8 PG II
Eye Irritation
SPECIES: Rabbit
RESULT: Severe. Graded 9 on a scale of 1 to 10.
REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 768]**PEER REVIEWED** [HSDB]
UN CLASS: 8 PG II | null | JP_CHRIP, NZ_CCID | 2 | CCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.052E | J-GLOBAL | CCCN | Train |
JP_CHRIP:
3-Amino-1-propene; Allylamine | JP_CHRIP:
2-Propenylamine
3-Aminopropene
monoallylamine | 107-11-9 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2018e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1), it was classified in Category 1. Besides, since new data were obtained, the category was changed.
[Evidence Data]
(1) In an in vitro skin corrosion test using an artificial skin model (EpiDerm) in accordance with OECD TG 431, after 3 or 60 minutes of exposure, the viability was 12.8% or 8.4%, respectively (REACH registration dossier (Access on July 2019)).
[Reference Data, etc.]
(2) This substance is a severe eye and skin irritant (PATTY (6th, 2012)).
(3) This substance is a severe skin and eye irritant in humans (HSDB (Access on June 2019)). | null | JP_CHRIP | 1 | NCC=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.053C | J-GLOBAL | C=CCN | Train |
NZ_CCID:
Phosphorylethanolamine | NZ_CCID:
2-Aminoethyl dihydrogen phosphate, Colamine phosphate, Ethanol, 2-amino-, phosphate, Ethanolamine O-phosphate, Ethanolamine phosphate, Mono(2-aminoethyl) phosphate, O-Phosphoethanolamine, O-Phosphorylethanolamine, Phosphoethanolamine, Phosphonoethanolamine, Phosphoric acid, 2-aminoethyl phenyl ester, Phosphoryethanolamine, Ethanol, 2-amino-, dihydrogen phosphate (ester) | 1071-23-4 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CA18F847-CF01-40E1-82B5-58941D64F351 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Chemwatch]
Eye Irritation
R PHRASE: R 41 [Chemwatch] | null | NZ_CCID | 1 | C(COP(=O)(O)O)N | https://pubchem.ncbi.nlm.nih.gov/compound/1015 | PubChem | NCCOP(=O)(O)O | Train |
JP_CHRIP:
Ethylenediamine
KR_NCIS:
1,2-Ethanediamine; Ethylenediamine
NZ_CCID:
Ethylenediamine | JP_CHRIP:
1,2-Diaminoehtane
1,2-Diaminoethane
1,2-Ethanediamine
1,2-Ethylenediamine
Dimethylenediamine
Ethane-1,2-diamine
Ethylene diamine
NZ_CCID:
1,2-Diaminoethane, 1,2-Ethanediamine, 1,2-Ethylenediamine, Dimethylenediamine, Ethylendiamine | 107-15-3 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-2020e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F417F0FB-94DF-4EFF-8B2B-07BA946DB39C | JP_CHRIP:
It is described that in a test in which undiluted this substance was applied to rabbits for 1 minute, there were severe inflammation and necrosis at the application site, and some animals had scars that reached the muscle (Initial Risk Assessment Report Ver.1.0, 55 (NITE, CERI, NEDO, 2007)), and in a test by 24-hour occlusive application of the undiluted this substance to rats, necrosis that reached the deep skin occurred and was still seen after 14 days (Initial Risk Assessment Report Ver.1.0, 55 (NITE, CERI, NEDO, 2007)). Therefore, it was classified in Category 1. Besides, pH was 11.8 (5 g/L aqueous solution) (SIDS (2001)).
NZ_CCID:
Skin Irritation
R-PHRASE: R 34. [N-CLASS]
UN CLASS 8, PG II.
Eye Irritation
SPECIES:
RESULT: Corrosive
REFERENCE SOURCE: Union Carbide Benelux Antwerpen (91) [IUCLID]
REMARK: EC Classification: Risk of serious damage to eyes.
R-PHRASE: R 34.[N-CLASS] | null | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | NCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.057F | J-GLOBAL | NCCN | Train |
JP_CHRIP:
N-(phosphonomethyl)glycine [glyphosate] | JP_CHRIP:
Glycine, N-(phosphonomethyl)-
Glyphosate
N-(Phosphonomethyl)glycine | 1071-83-6 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0095e.html | JP_CHRIP:
It is reported that in a test using rabbits (US EPA guidelines or OECD TG 404, GLP), slight irritation was observed and the score is 0.8. It is reported that in 4 other tests using rabbits (US EPA guidelines or OECD TG 404, GLP), no irritation was observed in any of these tests (EHC 159 (1994), JMPR (2004)).
Therefore, this substance was classified as "Not classified." | Provided | JP_CHRIP | 1 | OC(=O)CNCP(=O)(O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.359F | J-GLOBAL | O=C(O)CNCP(=O)(O)O | Train |
JP_CHRIP:
Hexanedioic acid, 1,6-dihydrazide | JP_CHRIP:
adipic dihydrazide
adipohydrazide
Hexanedioic acid, dihydrazide | 1071-93-8 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-meti-0019e.html | JP_CHRIP:
[Rationale for the Classification]
It was classified as "Not classified" from (1).
[Evidence Data]
(1) It is reported that in a skin irritation test with rabbits (n = 3) (OECD TG 404, GLP, semi-occlusive, 4-hour application, 72-hour observation), no skin irritation was seen (erythema/eschar score: 0/0/0, edema score: 0/0/0) (REACH registration dossier (Accessed Aug. 2020)). | Provided | JP_CHRIP | 1 | NNC(=O)CCCCC(=O)NN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.606D | J-GLOBAL | NNC(=O)CCCCC(=O)NN | Train |
JP_CHRIP:
2-Propyn-1-ol
KR_NCIS:
2-Propyn-1-ol
NZ_CCID:
2-Propyn-1-ol | JP_CHRIP:
prop-2-yn-1-ol (synonym:2-Propyn-1-ol)
KR_NCIS:
Propargyl alcohol; 1-propyne-3-ol; Propynyl alcohol; Ethynlcarbinol; 2-propynl alcohol; 2-propynol; 3-propynol
NZ_CCID:
1-Hydroxy-2-propyne, 1-Propyn-3-ol, 2-Propynyl alcohol, 3-Hydroxy-1-propyne, 3-Propynol, Ethynyl carbinol, Ethynylcarbinol, Propynyl alcohol | 107-19-7 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2005e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4FE7AA73-DB8C-45CA-AEB8-E9BA07C09AFF | JP_CHRIP:
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1B.
[Evidence Data]
(1) There are reports that in two skin irritation tests with rabbits, irritation and superficial necrosis after application of this substance itself and mild irritation after application of a 10% solution were observed (PATTY (6th, 2012), ACGIH (7th, 2001)).
(2) There is a report that in a skin irritation test (test method equivalent to OECD TG404) with rabbits, in the case of 1-minute application, slight necrosis was observed after 8 days and in the case of application for 5 or 15 minutes, severe necrosis was observed after 8 days (BUA 213 (1999), REACH registration dossier (Accessed Jul. 2018)).
[Reference Data, etc.]
(3) This substance was classified as "Skin Irrit. 1B" in EU CLP.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | Provided | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | OCC#C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J13B | J-GLOBAL | C#CCO | Train |
AU_HCIS:
chloroacetaldehyde
JP_CHRIP:
chloroacetaldehyde | AU_HCIS:
Acetaldehyde, chloro-
JP_CHRIP:
Chloroacetaldehyde
2-Chloro-1-ethanal
2-Chloroacetaldehyde
Monochloroacetaldehyde | 107-20-0 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=910
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-2006e.html | JP_CHRIP:
In the rabbit test, application of a 55% aqueous solution of the substance to the abdominal skin caused severe corrosion (DFGMAK-Doc.12 (1999)). In another rabbit test, application of a 30% aqueous solution of the substance caused severe damage to skin (ACGIH (2001)). Based on these documents, the substance was classified as Category 1. As relevant information, the substance was classified as "C; R34" in the EU classification (EU-Annex I (Access on Jun. 2009)). | null | AU_HCIS, JP_CHRIP | 2 | ClCC=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.060F | J-GLOBAL | O=CCCl | Train |
EU_REACH:
1,4-Dimethyl-1H-pyrazole | null | 1072-68-0 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18375/7/4/2/?documentUUID=7d543a91-d584-47a8-88a8-6e634e26088b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CN(N=C1)C | https://pubchem.ncbi.nlm.nih.gov/compound/136836 | PubChem | Cc1cnn(C)c1 | Train |
JP_CHRIP:
Chloromethyl methyl ether | JP_CHRIP:
Bis(chloromethyl)ether; chloromethyl methyl ether (technical-grade)
Chloromethoxymethane
Chloromethyl methyl ether (technical-grade)
CMME
Dimethylchloroether | 107-30-2 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-2023e.html | JP_CHRIP:
Based on reports that application to the skin of animals resulted in erythema and necrosis (EHC 201 (1998)) and that contact with the substance can induce a risk of chemical injury or necrosis in humans (ACGIH (2001)), the substance was classified into Category 1. | null | JP_CHRIP | 1 | COCCl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.063K | J-GLOBAL | COCCl | Train |
KR_NCIS:
Performic acid | null | 107-32-4 | 1Cat 1
| KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | null | null | KR_NCIS | 1 | C(=O)OO | https://pubchem.ncbi.nlm.nih.gov/compound/66051 | PubChem | O=COO | Train |
EU_REACH:
2,2,4,4,6,6-hexamethyl-3,5-dioxa-2,4,6-trisilaheptane | null | 107-51-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16055/7/4/2/?documentUUID=d6ba6aac-bc83-4063-96af-881fe340ad45 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/24705 | PubChem | C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C | Train |
EU_REACH:
2,2,4,4,6,6,8,8,10,10,12,12-dodecamethyl-3,5,7,9,11-pentaoxa-2,4,6,8,10,12-hexasilatridecane | null | 107-52-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20234/7/4/2/?documentUUID=55ac556e-5b08-4c40-90a7-603a32452e5b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/7875 | PubChem | C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C | Train |
AU_HCIS:
Phosphoric acid, dibutyl ester
JP_CHRIP:
Di-n-butyl phosphate | JP_CHRIP:
Di-n-butyl phosphate
Dibutyl acid o-phosphate
dibutyl phosphate
Phosphoric acid dibutyl ester
Phosphoric acid, dibutyl ester | 107-66-4 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6822
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2019e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1), it was classified in Category 1. Besides, the category was changed due to the new data obtained.
[Evidence Data]
(1) In an in vitro skin corrosion test using an artificial human epidermis model (EST-1000) in compliance with OECD TG 431, following 3 minutes and 60 minutes of exposure, cell viabilities were 64% and 2%, respectively (REACH registration dossier (Access on July 2019)).
[Reference Data, etc.]
(2) It was highly irritating in a skin irritation test in which 0.5 mL was administered semi-occlusively to the ears of rabbits for 8 hours (ACGIH (7th, 2009), SIDS (2004)).
(3) This substance may cause irritation of the skin in humans (HSDB (Access on June 2019)). | null | AU_HCIS, JP_CHRIP | 2 | CCCCOP(=O)(O)OCCCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J150.769I | J-GLOBAL | CCCCOP(=O)(O)OCCCC | Train |
KR_NCIS:
Bis(2,4,4-trimethylpentyl)phosphinodithioic acid | null | 107667-02-7 | 1Cat 1
| KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | null | null | KR_NCIS | 1 | CC(CC(C)(C)C)CP(=S)(CC(C)CC(C)(C)C)S | https://pubchem.ncbi.nlm.nih.gov/compound/163778 | PubChem | CC(CC(C)(C)C)CP(=S)(S)CC(C)CC(C)(C)C | Train |
NZ_CCID:
Isopentylamine | null | 107-85-7 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E42E4204-12D3-4C54-9191-3FC8D54CE4E2 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC(C)CCN | https://pubchem.ncbi.nlm.nih.gov/compound/7894 | PubChem | CC(C)CCN | Train |
JP_CHRIP:
3-Methyl-2-butenal | JP_CHRIP:
3,3-Dimethylacrolein
3-Methylcrotonaldehyde | 107-86-8 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0036e.html | JP_CHRIP:
In a test by an occlusive application of undiluted this substance to the rabbit skin for 3 minutes, 1 hour, or 4 hours, edema, erythema, and necrosis were observed from 1 hour after the application, necrosis that occurred hardened with time and became leather-like, and this persisted until day 8, the end of the observation period. As a result, it was judged as corrosive (SIDS (2003)), therefore it was classified in Category 1C. Besides, it is reported that necrosis in addition to erythema and edema were also found in another test by a 20-hour occlusive application of undiluted this substance to the rabbit skin, and it was assessed to be corrosive (SIDS (2003)). | null | JP_CHRIP | 1 | CC(=CC=O)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J9.338F | J-GLOBAL | CC(C)=CC=O | Train |
EU_REACH:
butyric acid
JP_CHRIP:
butyric acid
NZ_CCID:
Butyric acid | JP_CHRIP:
1-Propanecarboxylic acid
Butanic acid
Ethylacetic acid
n-Butanoic acid | 107-92-6 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13507/7/4/2/?documentUUID=93aea964-09a1-4fae-ad50-7b7cbac551aa
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0159e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B2AFBB3F-959A-4F22-A238-D2B061D4F1F1 | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
In List 1 data (PATTY (5th, 2001)), the substance is documented to be a severe irritant in rabbit tests, and in List 2 data (IUCLID (2000)), it is reported to be corrosive in rabbit tests (OECD Guidelines 404). In addition, it is rated as R34 in the EU classification.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | Provided | EU_REACH, JP_CHRIP, NZ_CCID | 3 | CCCC(=O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.068A | J-GLOBAL | CCCC(=O)O | Train |
JP_CHRIP:
3-Chloropropionic acid
NZ_CCID:
3-Chloropropionic acid | JP_CHRIP:
3-Chloropropionic acid
Propanoic acid, 3-chloro- | 107-94-8 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-2037e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B7EDFCF0-F122-4BE5-BAA3-19B92CC7E6C6 | JP_CHRIP:
[Rationale for the Classification]
It was classified in Category 1 from (1), (2).
[Evidence Data]
(1) The pH of this substance (200 g/L) was 0.9 (GESTIS (Access on May 2020)).
(2) This substance and its aqueous solutions were strong irritative/corrosive to the eye and skin (GESTIS (Access on May 2020)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | OC(=O)CCCl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.069J | J-GLOBAL | O=C(O)CCCl | Train |
EU_REACH:
β-alanine | null | 107-95-9 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/2084/7/4/2/?documentUUID=d7e37368-f9ac-430c-90cc-889f6f27ce53 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(CN)C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/239 | PubChem | NCCC(=O)O | Train |
JP_CHRIP:
beta-Mercaptopropionic acid
NZ_CCID:
3-Mercaptopropionic acid | null | 107-96-0 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0161e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/8C417E85-018E-4EAB-9F06-9D09571A24E0 | JP_CHRIP:
The substance was classified as Category 1 based on the documented case of "corrosive" (SIDS (2009)) resulted from the rabbit test in which necrosis and burns accompanied by erythema and edema were observed within 15 minutes of occlusive application of the test substance.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | OC(=O)CCS | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.166G | J-GLOBAL | O=C(O)CCS | Train |
NZ_CCID:
Chlorodiphenylphosphine | null | 1079-66-9 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7C22DC71-BBFE-4D3A-B969-4C56939405CC | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC=C(C=C1)P(C2=CC=CC=C2)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/66180 | PubChem | ClP(c1ccccc1)c1ccccc1 | Train |
NZ_CCID:
1,2-Ethanediamine, N,N-dimethyl- | NZ_CCID:
N,N-dimethylethylenediamine | 108-00-9 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/39607F72-2040-486E-B82E-2BCA0E277514 | NZ_CCID:
Skin Irritation
UN CLASS: PG II | null | NZ_CCID | 1 | CN(C)CCN | https://pubchem.ncbi.nlm.nih.gov/compound/66053 | PubChem | CN(C)CCN | Train |
AU_HCIS:
Ethanol, 2-(dimethylamino)-
JP_CHRIP:
2-dimethylaminoethanol; N,N-dimethylethanolamine
NZ_CCID:
Dimethylaminoethanol
US_HSDB:
2-DIMETHYLAMINOETHANOL | AU_HCIS:
2-dimethylaminoethanol
N,N-dimethylethanolamine
JP_CHRIP:
2-dimethylaminoethanol
Dimethylethanolamine
N,N-Dimethyl-2-hydroxyethylamine
N,N-dimethylethanolamine
NZ_CCID:
(2-Hydroxyethyl)dimethylamine, 2-(Dimethylamino) ethanol, 2-(Dimethylamino)-1-ethanol, 2-(Dimethylamino)ethanol, 2-(N,N-Dimethylamino)ethanol, 2-Dimethylaminoethanol, Bimanol, Deanol, Dimethyl(2-hydroxyethyl)amine, Dimethyl(hydroxyethyl)amine, Dimethylethanolamine, Dimethylmonoethanolamine, Ethanol, 2-(dimethylamino)-, N,N-Dimethyl-2-aminoethanol, N,N-Dimethyl-2-hydroxyethylamine, N,N-Dimethyl-N-(2-hydroxyethyl)amine, N,N-Dimethylaminoethanol, N,N-Dimethylethanolamine, N-(2-Hydroxyethyl)dimethylamine, Norcholine, Propamine A, Texacat DME | 108-01-0 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1879
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0034e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/11B13060-5626-4367-8D9D-F5F7DAA55F78
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1329 | JP_CHRIP:
Since GLP tests using rabbits concluded that the substance was corrosive (IUCLID, 2000), it was classified into Category 1.
NZ_CCID:
Skin Irritation
R-PHRASE: R 34. [N-CLASS]
Eye Irritation
R-PHRASE: R 34. [N-CLASS] | null | AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB | 4 | CN(C)CCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.068G | J-GLOBAL | CN(C)CCO | Train |
EU_REACH:
4-methylpentan-2-one
JP_CHRIP:
Methyl isobutyl ketone | JP_CHRIP:
4-Methyl-2-pentanone
4-Methyl-2-pentanone; Methyl isobutyl ketone
4-methylpentan-2-one
Hexone
Isopropylacetone
methylisobutyl ketone
methylisobutyl ketone(2-methyl-4-pentanone)
MIBK | 108-10-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14866/7/4/2/?documentUUID=61c2bbba-4873-420b-b530-05db459b7160
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0099e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
There is a report that in a skin irritation test with rabbits, as a result of an occlusive application with this substance for 10 hours, erythema was persistent until after 24 hours (SIDS (2011), EHC117 (1990), NTP TR 538 (2007)). In addition, there is a report that in a skin irritation test with guinea pigs, as a result of an application of this substance (5 or 10 mL), slight irritation was observed (DFGOT Vol. 13 (1999), PATTY (6th, 2012)). From the above, based on reports that recovery property was observed and slight irritation was observed, this substance was classified as "Not classified" (Category 3 in UN GHS classification). | Provided | EU_REACH, JP_CHRIP | 2 | CC(C)CC(=O)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.861D | J-GLOBAL | CC(=O)CC(C)C | Train |
NZ_CCID:
Isopentanoyl chloride | NZ_CCID:
isovaleryl chloride | 108-12-3 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/867E4D5E-34C4-417A-A200-391425F8F73A | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC(C)CC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/66054 | PubChem | CC(C)CC(=O)Cl | Train |
NZ_CCID:
1-(Dimethylamino)-2-propanol | null | 108-16-7 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/741C2CB9-124E-45D9-BCFF-B9F7FA9CCF1B | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC(CN(C)C)O | https://pubchem.ncbi.nlm.nih.gov/compound/37511 | PubChem | CC(O)CN(C)C | Train |
EU_REACH:
bis(propan-2-yl)amine
JP_CHRIP:
Diisopropylamine
NZ_CCID:
2-Propanamine, N-(1-methylethyl)- | JP_CHRIP:
Diisopropylamine
DIPA
N-(1-methylethyl)-2-propanamine
NZ_CCID:
Diisopropylamine, n-(1-Methylethyl)-2-propanamine | 108-18-9 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13145/7/4/2/?documentUUID=a6ad48e3-cf29-472e-b939-e9846a21f2ca
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2118e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0E0E3EE-5825-41B8-BEC5-AE9A27E04CEA | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
In a skin irritation test with rabbits (OECD TG 404 compliant), clear evidence of necrosis (discoloration to reddish brown and greenish brown at the application site) was observed within 24 hours after the 3-minute application of this substance. This was followed by drying and roughening, resulting in desquamation and open wounds, and becoming scarred. There is a description that the skin tissue showed irreversible damage in all its layers (ECHA registration information (Access on December 2017)). In addition, there is a description that alkylamines including this substance cause strong skin irritation and corrosivity (SIAP (2013)) and a description that the pH of this substance was 12.5 (HSDB (Access on August 2017)). Therefore, it was classified in Category 1A. Besides, in EU CLP classification, this substance is classified as "Skin Corr. 1B, H314" (ECHA CL Inventory (Access on August 2017)).
NZ_CCID:
Skin Irritation
R-PHRASE: R 34 Causes burns. [IUCLID 2000]
Eye Irritation
SPECIES: Rabbit
RESULT: Highly corrosive
REFERENCE SOURCE: Atochem Paris la Defense
(22) AMA-Arch-Ind-Hyg-Occup-med, vol 10, pg 61, (AMIHBC). [IUCLID 2000]
REMARK: EC Classification: Risk of serious damage to eyes. | Provided | EU_REACH, JP_CHRIP, NZ_CCID | 3 | CC(C)NC(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.496F | J-GLOBAL | CC(C)NC(C)C | Train |
JP_CHRIP:
Isopropyl ether | JP_CHRIP:
2,2'-Oxybispropane
2-Isopropoxypropane
diisopropyl ether
Isopropyl ether | 108-20-3 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2020e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1), it was classified as "Not classified."
[Evidence Data]
(1) In a ski irritation test in which 0.5 mL of this substance was applied semiocclusively to the skin of rabbits for 4 hours in accordance with OECD TG 404, the mean scores at 24/48/72 hours for erythema and edema were 1.77 and 0.87, respectively (REACH registration dossier (Access on July 2019)).
[Reference Data, etc.]
(2) This substance had a slight irritative effect on the skin and caused irritation to the eyes of rabbits (DFGOT vol.21 (2005)). | Provided | JP_CHRIP | 1 | CC(C)OC(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.069E | J-GLOBAL | CC(C)OC(C)C | Train |
EU_REACH:
isopropenyl acetate | null | 108-22-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17298/7/4/2/?documentUUID=37ceb158-2d81-44c8-ab37-dc1cdb5a3eb5 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(=C)OC(=O)C | https://pubchem.ncbi.nlm.nih.gov/compound/7916 | PubChem | C=C(C)OC(C)=O | Train |
JP_CHRIP:
Isopropyl chloroformate | JP_CHRIP:
Carbonochloridic acid 1-methylethyl ester
Chloroformic acid, isopropyl ester
isopropyl 1-chloromethanoate
Isopropyl chlorocarbonate
isopropyl chloroformate
Isopropyl chloromethanate | 108-23-6 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0067e.html | JP_CHRIP:
Based on a report that direct dropwise application to the skin causes deep necrosis and eschar formation in a guinea pig test (PATTY (5th, 2001)) and a report of "irritating and corrosive to the skin" (HSDB (2003)), the substance was classified into Category 1. | null | JP_CHRIP | 1 | CC(C)OC(=O)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.720E | J-GLOBAL | CC(C)OC(=O)Cl | Train |
JP_CHRIP:
Acetic anhydride
NZ_CCID:
Acetic anhydride
US_HSDB:
Acetic anhydride | JP_CHRIP:
Acetic acid, anhydride
Acetic oxide
Acetyl oxide
Ethanoic anhydride
NZ_CCID:
Acetanhydride, Acetic acid, anhydride, Acetic oxide, Acetyl acetate, Acetyl anhydride, Acetyl ether, Acetyl oxide, Ethanoic anhydride | 108-24-7 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2021e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/54C46A7E-73BC-4DB8-A03B-0BF27040E37C
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/233 | JP_CHRIP:
[Rationale for the Classification]
Based on (1)-(4), it was classified in Category 1.
[Evidence Data]
(1) This substance is a severe irritant to the eyes, mucous membranes and skin, and severe burns and vesiculation of the skin were reported from liquid splashes (ACGIH (7th, 2001)).
(2) In a skin irritation test with rabbits, under occluded conditions for 24 hours, it caused severe burns and blisters (ACGIH (7th, 2011)).
(3) This substance is corrosive to the skin, eyes and mucous membranes (SIDS (2002)).
(4) This substance is severely irritating to the skin and eyes, and direct contact with the liquid may result in burns (OEL Documentations (Japan Society For Occupational Health (JSOH), 1990), HSDB (Access on June 2019)).
[Reference Data, etc.]
(5) It was reported that it was mildly irritative in a skin irritation test in which 0.5 mL of this substance was applied to rabbits for 24 hours (DFGOT vol.13 (1999), SIDS (2002)).
(6) It was classified in Skin Irrit. 1B (H314) in the EU CLP Classification (EU CLP classification (Access on July 2019)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID, US_HSDB | 3 | CC(=O)OC(=O)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.417A | J-GLOBAL | CC(=O)OC(C)=O | Train |
AU_HCIS:
maleic anhydride
JP_CHRIP:
Maleic anhydride
NZ_CCID:
Maleic anhydride
US_HSDB:
MALEIC ANHYDRIDE | AU_HCIS:
2,5-Furandione
JP_CHRIP:
2,5-Furandione
cis-Butenedioic anhydride
Dihydro-2,5-dioxofuran
Maleic acid anhydride
Maleic anhydride
NZ_CCID:
2,5-Furandione, Dihydro-2,5-dioxofuran, Maleic acid anhydride, Toxilic anhydride, cis-Butenedioic anhydride | 108-31-6 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=2795
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2026e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9FAACCC4-8E62-4C8D-A7E6-A40199911812
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/183 | JP_CHRIP:
It is described in DFGOT vol. 4 (1992) that the application of the powder moistened with water caused necrosis in a skin irritation test with rabbits, although it is not a result of a 4-hour application. And it is described in SIDS (2007) that there was severe irritation in a skin irritation test with rabbits by a 4-hour application. Furthermore, this substance is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. SIDS (2007), EU DSD classification, and EU CLP classification were obtained in this investigation and added. The classification was changed to Category 1 because the information on sub-categorization could not be obtained (the information that irritation in a Draize test with rabbits or human findings is mild and disappear within seven days).
NZ_CCID:
Skin Irritation
R-PHRASE: R 34. [ECB]/ N-Class
Eye Irritation
R-PHRASE: R 34. [ECB]/ N-Class | null | AU_HCIS, JP_CHRIP, NZ_CCID, US_HSDB | 4 | O=C1OC(=O)C=C1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.419H | J-GLOBAL | O=C1C=CC(=O)O1 | Train |
JP_CHRIP:
propylene carbonate | JP_CHRIP:
2-oxo-4-methyl-1,3-dioxolane
propylene carbonate | 108-32-7 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0160e.html | JP_CHRIP:
The classification is based on descriptions that the substance was found to be a slight irritant in rabbit tests (PATTY (5th, 2001)) and it caused no irritation in other rabbit tests (OECD Guidelines 404) (IUCLID (2000)). | Provided | JP_CHRIP | 1 | CC1COC(=O)O1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.073C | J-GLOBAL | CC1COC(=O)O1 | Train |
AU_HCIS:
m-cresol [1]
JP_CHRIP:
m-Cresol
KR_NCIS:
m-Cresol
NZ_CCID:
3-Cresol
US_HSDB:
m-CRESOL | AU_HCIS:
o-cresol [2]
p-cresol [3]
mix-cresol [4]
Phenol, 3-methyl-
m-cresol
o-cresol
p-cresol
JP_CHRIP:
1-Hydroxy-3-methylbenzene
3-Cresol
3-Hydroxytoluene
3-Methylphenol
cresol
m-cresol
m-Cresol; 3-Methylphenol
Phenol, 3-methyl-
KR_NCIS:
1-Hydroxy-3-methylbenzene; 1-Hydroxy-3-methylbenzol; 1-Oxy-3-methylbenzol; 3-Cresol; 3-Hydroxytoluene; 3-Hydroxytoluol; 3-Kresol; 3-Methylphenol; m-Cresylic acid; m-Hydroxytoluene; M-Hydroxytoluol; M-Kresol; M-Kresylsaeure; m-Methylphenol; M-Oxytoluol; M-Tolylalkohol; Phenol, 3-Methyl; Phenol, 3-methyl-
NZ_CCID:
1-Hydroxy-3-methylbenzene, 3-Hydroxytoluene, 3-Methyl phenol, Metacresol, m-Cresol | 108-39-4 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1066
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2137e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/64AA8ADA-9DD7-4180-A4DD-37D14CC47600
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1815 | JP_CHRIP:
There is a report that when 0.5 mL of the undiluted liquid of this substance was applied to the skin of rabbits, severe erythema and edema occurred within 24 hours and this did not disappear within 72 hours (SIDS (2005)). In other tests with rabbits, there is a report that irreversible tissue destruction was observed 4 hours after application of this substance (EHC 168 (1995)), and that severe irritation and corrosion were observed (Initial Risk Assessment Report (NITE, CERI, NEDO, 2007)). From the above results, it was classified in Category 1. Besides, this substance was classified in "C; R34" in EU DSD classification and in "Skin Corr. 1B H314" in EU CLP classification.
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESULT: Dermal application of cresols (0.5 ml of o-, m- or p-cresol or a technical mixture of all three isomers) for 4 h caused visible and irreversible tissue destruction.
REFERENCE SOURCE: (Vernot et al., 1977). Cresols (EHC 168, 1995) [INCHEM]
Eye Irritation
R-PHRASE: R 34 Causes burns. [N-CLASS] | null | AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 5 | Cc1cccc(O)c1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.186J | J-GLOBAL | Cc1cccc(O)c1 | Train |
EU_REACH:
tert-butyl (2S)-2-[5-(4'-{2-[(2S)-1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl]pyrrolidine-1-carboxylate | null | 1085706-46-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/6021/7/4/2/?documentUUID=629fb0da-1cd8-4863-a858-26f103bc9944 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)(C)OC(=O)N1CCC[C@H]1C2=CC(=NN2)C3=CC=C(C=C3)C4=CC=C(C=C4)C5=CN=C(N5)[C@@H]6CCCN6C(=O)OC(C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/59345130 | PubChem | CC(C)(C)OC(=O)N1CCC[C@H]1c1cc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)OC(C)(C)C)[nH]4)cc3)cc2)n[nH]1 | Train |
EU_REACH:
2,4,6,8-tetramethyl-1,3,5,7-tetraoxocane
JP_CHRIP:
2,4,6,8-Tetramethyl-1,3,5,7-tetraoxacyclooctane | JP_CHRIP:
2,4,6,8-tetramethyl-1,3,5,7-tetraoxacyclooctane (synonym:metaldehyde)
metaldehyde | 108-62-3 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24890/7/4/2/?documentUUID=76e6ec4f-e828-4812-a5d5-db97444d7c48
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0185e.html | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
Based on a report of "not irritant" in a rabbit test (EPA RED (2006), A pesticide abstract and evaluation report (Food and Agricultural Materials Inspection Center) (2009)). | Provided | EU_REACH, JP_CHRIP | 2 | CC1OC(C)OC(C)OC(C)O1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.423F | J-GLOBAL | CC1OC(C)OC(C)OC(C)O1 | Train |
JP_CHRIP:
3,5-xylenol; 3,5-Dimethylphenol
KR_NCIS:
3,5-Dimethylphenol
NZ_CCID:
Phenol, 3,5-dimethyl- | JP_CHRIP:
3,5-Xylenol
Phenol, 3,5-dimethyl-
KR_NCIS:
1,3,5-Xylenol; 1-Hydroxy-3,5-dimethylbenzene; 3,5-Xylenol; Phenol, 3,5-dimethyl-; XYLENOL
NZ_CCID:
3,5-XYLENOL | 108-68-9 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2028e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/9D1BCFDA-2209-4D23-A4E5-DA83B7A37971 | JP_CHRIP:
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1.
[Evidence Data]
(1) Moderate burns to the skin were reported in rabbits after administration to the skin (concentration not specified) (NICNAS IMAP (Access on August 2019)).
(2) It was classified in "Skin Corr. 1B (H314)" in EU-CLP classification (EU CLP classification (Access on May 2019)).
[Reference Data, etc.]
(3) In a 24-hour occlusive skin irritation study with rabbits (Polyethylene glycol (PEG) 400 was used as vehicle), slight edema was observed in half of the animals at 24 hours after application and disappeared after 72 hours. PII was 0.25 (ACGIH (7th, 2019), (REACH registration dossier (Access on July 2019))).
NZ_CCID:
Skin Irritation
SPECIES:
RESULT: Corrosive
REFERENCE SOURCE: [NTP]
Eye Irritation
SPECIES:
RESULT: Corrosive
REFERENCE SOURCE: [NTP] | null | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | Cc1cc(C)cc(O)c1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.425B | J-GLOBAL | Cc1cc(C)cc(O)c1 | Train |
JP_CHRIP:
Melamine | JP_CHRIP:
1,3,5-Triazine-2,4,6-triamine
2,4,6-Triamino-1,3,5-triazine
2,4,6-triamino-1,3,5-triazine (melamine)
Cyanurotriamide | 108-78-1 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/20-mhlw-0004e.html | JP_CHRIP:
[Rationale for the Classification]
It was classified as "Not classified" from (1) - (3).
[Evidence Data]
(1) No skin reactions were observed in a skin irritation test with rabbits according to OECD TG 404 (REACH registration dossier (Access on June 2020)).
(2) In a patch test in humans, no skin irritation or sensitization was found. And dermatitis was reported from the manufacture of melamine-formaldehyde resins or intermediate reaction products of formaldehyde and this substance, but not this substance itself (Environmental Risk Assessment for Chemical Substances vol. 8, Tentative Hazard Assessment Sheet (Ministry of the Environment, 2010)).
(3) This substance produced little or no irritation or sensitization when its 1% aqueous solution was applied to the guinea pig skin under occlusion. There was a similar result also in rabbits (Patty (6th, 2012), GESTIS (Access on April 2020)). | Provided | JP_CHRIP | 1 | Nc1nc(N)nc(N)n1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.428G | J-GLOBAL | Nc1nc(N)nc(N)n1 | Train |
JP_CHRIP:
2,6-Dimethylheptan-4-ol | null | 108-82-7 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0037e.html | JP_CHRIP:
The substance was classified as "Not classified" based on the rabbit test (OECD TG404) in which erythema and edema were not observed at 24, 48 and 72 hours after patch removal, and the PII was 0 (ECETOC TR66 (1995)). | Provided | JP_CHRIP | 1 | CC(C)CC(O)CC(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J58.121F | J-GLOBAL | CC(C)CC(O)CC(C)C | Train |
JP_CHRIP:
Diisobutyl ketone | JP_CHRIP:
2,6-Dimethyl-4-heptanone
2,6-dimethylheptan-4-one
Isovalerone | 108-83-8 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0095e.html | JP_CHRIP:
As for skin irritation tests (OECD TG404) with rabbits, both results of slight irritation and no irritation are reported as a result of a semi-occlusive application of this substance for 4 hours (SIDS (2004)). In addition, there is a report that in other skin irritation test with rabbits, as a result of a semi-occlusive application of 0.5 mL of this substance for 4 hours, erythema (average score 1.9) and edema (average score 0.4) were observed, but resolved within 14 days after the application (SIDS (2004)). From the above, it was classified as "Not classified" (Category 3 in UN GHS classification). | Provided | JP_CHRIP | 1 | CC(C)CC(=O)CC(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.081D | J-GLOBAL | CC(C)CC(=O)CC(C)C | Train |
AU_HCIS:
cyclohexylamine
JP_CHRIP:
Cyclohexylamine
KR_NCIS:
Cyclohexylamine
NZ_CCID:
Cyclohexanamine | AU_HCIS:
Cyclohexanamine
aminocyclohexane
aminohexahydrobenzene
hexahydroaniline
hexahydrobenzenamine
JP_CHRIP:
Aminocyclohexane
Aminohexahydrobenzene
Cyclohexanamine
Cyclohexylamine
Hexahydroaniline
KR_NCIS:
aminocyclohexane; hexahydroaniline
NZ_CCID:
1-Aminocyclohexane, 1-Cyclohexylamine, Aminocyclohexane, Aminohexahydrobenzene, Benzenamine, hexahydro-, Cyclohexylamine, Hexahydroaniline | 108-91-8 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=1117
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-2009e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/1D8BF38F-A57B-4567-A15D-34AFEB23507D | JP_CHRIP:
Open application to the rabbit skin resulted in a damage level of 7 on a scale of 1 to 10 within 24 hours, necrosis was seen (DFGMAK-Doc. 22 (2006)), and it is reported that this substance was found to be corrosive after 4-hour or 24-hour semi-occlusive application of 0.5 mL to the rabbit skin (DFGMAK-Doc. 22 (2006)). Furthermore, by 24-hour occlusive application of undiluted this substance to the guinea pig skin, edema, necrosis, and persistent eschars were observed, and severe irritation was shown (ACGIH (2001)). It was classified in Category 1 based on the above findings. Besides, pH is 11.5 (100 g/L).
NZ_CCID:
Skin Irritation
R-PHRASE: R 34. [N-CLASS]
UN CLASS: 8, PG II
Eye Irritation
SPECIES: Rabbit
RESULT: One drop of 50% AQ soln, applied to conjuntival sac of rabbit eye, caused complete destruction of eye.
REFERENCE SOURCE: [American Conference of Governmental Industrial Hygienists, Inc. Documentation of the Threshold Limit Values, 4th ed., 1980. Cincinnati, Ohio: American Conference ofGovernmmental Industrial Hygienists, Inc., 1980. 113]**QC REVIEWED**[HSDB]
R-PHRASE: R 34. [N-CLASS] | null | AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID | 4 | NC1CCCCC1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.870C | J-GLOBAL | NC1CCCCC1 | Train |
JP_CHRIP:
Phenol
KR_NCIS:
Phenol
NZ_CCID:
Phenol | JP_CHRIP:
Benzenol
Carbolic acid
Hydroxybenzene
Phenic acid
phenol, pure
KR_NCIS:
Hydroxybenzene
NZ_CCID:
(Mono)hydroxybenzene, Benzenol, Carbolic acid, Oxybenzene, Phenic acid, Phenyl alcohol, Phenyl hydrate, Phenyl hydroxide, Phenylic acid, Phenylic alcohol | 108-95-2 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2007.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/3817198F-CE0B-4133-87EE-5EE65B03E140 | JP_CHRIP:
【分類根拠】
（１）～（５）より区分1とした。
【根拠データ】
（１）本物質を含有する皮膚局所薬剤投与で刺激性皮膚炎の発生がみられ、皮膚への局所ばく露では、その部位に漂白作用又は紅疹が発生し、腐食や壊死に到る場合がある（CERI 有害性評価書 (2008)、MOE 初期評価 (2002)）。
（２）本物質はヒトが経口及び経皮ばく露すると、皮膚、眼及び粘膜に対して強い刺激性を示す（CERI 有害性評価書 (2008)）。
（３）本物質はウサギの皮膚に腐食性を示した（EPA Pesticides RED (2009)）。
（４）ウサギ、ラット、マウス、ブタの眼又は皮膚に本物質を適用した結果、発赤、炎症、変色、発疹、潰瘍、壊死、腐食性を認めたとする報告がみられ、眼や皮膚に対する強い刺激性ないし腐食性を示すと考える（CERI 有害性評価書 (2008)、CEPA PSAR (2000)、EHC (1994)）。
（５）In vitro 皮膚腐食性試験（OECD TG 431）において、皮膚腐食性がみられたとの報告がある（AICIS IMAP (2014)）。
【参考データ等】
（６）本物質は、平成8年労働省告示第33号（平成25年厚生労働省告示第316号により改正）において、労働基準法施行規則別表第一の二第四号1の厚生労働大臣が指定する単体たる化学物質及び化合物（合金を含む。）に「フェノール(別名石炭酸)」として指定されており、本物質にさらされる業務による、特定の症状又は障害を主たる症状又は障害とする疾病（頭痛、めまい、嘔吐等の自覚症状、皮膚障害、前眼部障害又は気道・肺障害）が、業務上の疾病として定められている。
NZ_CCID:
Skin Irritation
REMARK: C ? 10 % T; R23/24/25-48/20/21/22-34-68
3 % ? C < 10 % C ; Xn ; R20/21/22-34-68
1 % ? C < 3 % Xn ; R36/38-68
REFERENCE SOURCE: [ECB Annex]
NOTE: Classified as corrosive based on R34 risk phrase.
Eye Irritation
REMARK: C ? 10 % T; R23/24/25-48/20/21/22-34-68
3 % ? C < 10 % C ; Xn ; R20/21/22-34-68
1 % ? C < 3 % Xn ; R36/38-68
REFERENCE SOURCE: [ECB Annex]
NOTE: Classified as corrosive based on R34 risk phrase. | null | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | Oc1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.873H | J-GLOBAL | Oc1ccccc1 | Train |
NZ_CCID:
1-Methylpiperazine | null | 109-01-3 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6ED348DF-57B5-421A-9526-51D40A328D78 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data | null | NZ_CCID | 1 | CN1CCNCC1 | https://pubchem.ncbi.nlm.nih.gov/compound/53167 | PubChem | CN1CCNCC1 | Train |
NZ_CCID:
Morpholine, 4-methyl- | NZ_CCID:
4-methylmorpholine | 109-02-4 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/891B9007-ED91-4267-B18A-5FF4BCA0B94E | NZ_CCID:
Skin Irritation
UN CLASS: Sub Risk 8; PG II
R PHRASE: R 34 [MSDS, ABCR Gmbh and Co.]
[Chemfinder]
Eye Irritation
R-PHRASE: R 34. MSDS, ABCR Gmbh and Co.
[Chemfinder] | null | NZ_CCID | 1 | CN1CCOCC1 | https://pubchem.ncbi.nlm.nih.gov/compound/7972 | PubChem | CN1CCOCC1 | Train |
JP_CHRIP:
2-Methylpyridine (2-Picoline) | JP_CHRIP:
2-methylpyridine
2-Picoline
alpha-Picoline
o-Picoline
Pyridine, 2-methyl- | 109-06-8 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2021e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1) and (2), it was classified in Category 1. Besides, information for subcategorization was not obtained.
[Evidence Data]
(1) There is a report that in a skin irritation test (U.S. 49 CFR 173.240) with rabbits (n=6), after a 4-hour occlusive application of this substance, ulceration or necrosis was observed in all animals (REACH registration dossier (Accessed Sept. 2018)).
(2) Although the animal species is unknown, this substance is moderately to severely irritating, and signs of necrosis, ulceration and regeneration are reported (PATTY (6th, 2012)). | null | JP_CHRIP | 1 | Cc1ccccn1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.087C | J-GLOBAL | Cc1ccccn1 | Train |
EU_REACH:
2-(chloromethyl)-4-methylquinazoline | null | 109113-72-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5361/7/4/2/?documentUUID=da6ee861-4d6c-48d7-8dbb-ae69aff4d045 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=NC(=NC2=CC=CC=C12)CCl | https://pubchem.ncbi.nlm.nih.gov/compound/241518 | PubChem | Cc1nc(CCl)nc2ccccc12 | Train |
EU_REACH:
tert-butyl 2-methylpropaneperoxoate | null | 109-13-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11987/7/4/2/?documentUUID=3211c910-debc-4194-acf9-fb39a6a268b8 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)C(=O)OOC(C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/61023 | PubChem | CC(C)C(=O)OOC(C)(C)C | Train |
EU_REACH:
docosyl 4-hydroxybenzoate | null | 109236-76-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17137/7/4/2/?documentUUID=80544fc4-ffef-4ee8-859c-e3003de26978 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCCCCCCCCCCCCCCCCCCCOC(=O)C1=CC=C(C=C1)O | https://pubchem.ncbi.nlm.nih.gov/compound/13923401 | PubChem | CCCCCCCCCCCCCCCCCCCCCCOC(=O)c1ccc(O)cc1 | Train |
AU_HCIS:
9-Octadecenamide, N-[3-(dimethylamino)propyl]-, (Z)- | null | 109-28-4 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6760 | null | null | AU_HCIS | 1 | CCCCCCCC/C=C\CCCCCCCC(=O)NCCCN(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/6436063 | PubChem | CCCCCCCC/C=C\CCCCCCCC(=O)NCCCN(C)C | Train |
EU_REACH:
oxacycloheptadecan-2-one | null | 109-29-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24078/7/4/2/?documentUUID=6c9e667b-e071-43c6-9639-68604402dd91 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1CCCCCCCC(=O)OCCCCCCC1 | https://pubchem.ncbi.nlm.nih.gov/compound/7984 | PubChem | O=C1CCCCCCCCCCCCCCCO1 | Train |
EU_REACH:
1,3-dibutyl-2-thiourea | null | 109-46-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26084/7/4/2/?documentUUID=06e11ce9-90d4-4319-9d3e-083179e35202 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCNC(=S)NCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/2723622 | PubChem | CCCCNC(=S)NCCCC | Train |
JP_CHRIP:
valeric acid
NZ_CCID:
Pentanoic acid | JP_CHRIP:
1-Butanecarboxylic acid
n-Pentanoic acid
Propylacetic acid
Valeric acid
NZ_CCID:
valeric acid | 109-52-4 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0092e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DF30F573-B567-4F11-8DF4-D2F4F6318CCD | JP_CHRIP:
Since there is a description that, valeric acid is a strong skin irritant in undiluted form (PATTY (5th, 2001)), and valeric acid is rated iC; R34 by EU (EU-AnnexI (accessed August 2008)), the substance was classified into Category 1. As relevant information, it is reported that using mixed isomers of valeric acid demonstrated some tissue necrosis in a 24h rabbit skin irritation assay (PATTY (5th, 2001)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | CCCCC(=O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.504K | J-GLOBAL | CCCCC(=O)O | Train |
AU_HCIS:
3-aminopropyldimethylamine
JP_CHRIP:
3-aminopropyldimethylamine; N,N-dimethyl-1,3-diaminopropane
NZ_CCID:
3-Dimethylaminopropylamine | AU_HCIS:
N,N-dimethyl-1,3-diaminopropane
1,3-Propanediamine, N,N-dimethyl-
JP_CHRIP:
1,3-Propanediamine, N,N-dimethyl-
1-Amino-3-dimethylaminopropane
3-aminopropyldimethylamine
N,N,-Dimethyl-1,3-propanediamine
N,N-Dimethyl-1,3-diaminopropane
NZ_CCID:
N,N-Dimethyltrimethylenediamine | 109-55-7 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=219
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0037e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6DBCCA85-778B-4CE8-9459-D51F291EE5FA | JP_CHRIP:
There are several reports characterizing the substance as strongly irritating to corrosive in rabbit tests (IUCLID (2000), BUA report No. 197 (1996)). In addition, the substance was documented to cause necrosis as its dermal symptom (BUA report No. 197 (1996)). As such, the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | CN(C)CCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J50.732F | J-GLOBAL | CN(C)CCCN | Train |
JP_CHRIP:
Propyl chloroformate
KR_NCIS:
n-Propyl chloroformate | JP_CHRIP:
Carbonochloridic acid, propyl ester
Formic acid, chloro-, propyl ester
Propyl chlorocarbonate
KR_NCIS:
Carbonochloridic acid, propyl ester; CHLOROFORMATE, PROPYL; Formic acid, chloro-, propyl ester; n-Propyl chloroformate; Propyl chlorocarbonate; Propyl chloroformate | 109-61-5 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2023e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | JP_CHRIP:
[Rationale for the Classification]
Based on (1), it was classified in Category 1B.
[Evidence Data]
(1) In a skin corrosion test in which 0.5 mL of this substance was applied to two rabbits, it was corrosive, and persistent erythema, edema and necrosis were observed after 15-minute and 20-hour exposure (SIDS (2012), REACH registration dossier (Access on July 2019)).
[Reference Data, etc.]
(2) In a skin irritation test in which 0.5 mL of this substance was applied to rabbits under occlusive application for 24 hours, the mean scores of intact skins were 7.8 at 24 hours and 8.0 at 72 hours, and the mean scores of abraded skins were 8.0 both at 24 hours and 72 hours (SIDS Dossier (2012)).
(3) It was classified as "Skin Corr. 1B (H314)" in the EU CLP classification (EU CLP classification (Access on July 2019)). | null | JP_CHRIP, KR_NCIS | 2 | CCCOC(=O)Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.719A | J-GLOBAL | CCCOC(=O)Cl | Train |
JP_CHRIP:
n-Pentane | JP_CHRIP:
Amyl hydride
n-Pentane | 109-66-0 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2096e.html | JP_CHRIP:
Based on a primary irritation index of 0.67 in a skin irritation test with rabbits (OECD TG 404, GLP-compliant), it was judged not to be irritating (SIDS (2010), EU-RAR (2003)). In addition, it is described that this substance is not irritating as a result of 24-hour semi-occlusive application to humans (GLP-compliant) (EU-RAR (2003)). On the other hand, it is described that by skin contact with this substance, degreasing and irritation occurred (OEL Documentations (Japan Society for Occupational Health (JSOH), 1987)), and that after skin application to volunteers, there was irritation such as pain, burning sensations and blisters, but no information on the test conditions and the degree of irritation were provided. Based on the above, the test result from the study according to the test guideline was adopted, and it was classified as "Not classified." | Provided | JP_CHRIP | 1 | CCCCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J15I | J-GLOBAL | CCCCC | Train |
JP_CHRIP:
n-Butylamine
KR_NCIS:
n-Butylamine
NZ_CCID:
1-Butanamine | JP_CHRIP:
1-Aminobutane
Monobutylamine
n-Butylamine
KR_NCIS:
1-Butanamine; 1-aminobutane; Monobutylamine;Butan-1-amine
NZ_CCID:
1-Aminobutane, Mono-n-butylamine, Monobutylamine, Norvalamine, n-Butylamine | 109-73-9 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2119e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/04BD6D13-E553-4012-8A6A-1E85A90D7E82 | JP_CHRIP:
There is a description that in a skin irritation test with guinea pigs, necrosis occurred after application (OEL Documentations (Japan Society For Occupational Health, 1994)). There is a description that in a skin irritation test (equivalent to OECD TG 404) with rabbits, in exposure time of 1 minute, immediate necrosis occurred, eschar was produced, and it showed corrosivity (SIDS(2016)). Therefore, this substance was classified in Category 1. Besides, this substance was classified as "Skin Corr.1A, H314" in the EU CLP classification (ECHA CL Inventory (Access on August 2017)).
NZ_CCID:
Skin Irritation
SPECIES: Guinea pig
RESULT: N-Butylamine causes skin necrosis when applied at 0.5 ml/kg.
REFERENCE SOURCE: [Peer Reviewed] Clayton, G.D., F.E. Clayton (eds.) Pattys Industrial Hygiene and Toxicology. Volumes 2A, 2B, 2C, 2D, 2E, 2F: Toxicology. 4th ed. New York, NY: John Wiley & Sons Inc., 1993-1994. 1105. [HSDB]
R-PHRASE: R 35 Causes severe burns [IUCLID 2000]
Eye Irritation
SPECIES:
RESULT: 10 and 50% v/v aqueous solutions and undiluted base produce severe eye burns in animals. The immediate eyen reaction is not appreciable altered by prolonged washing or attemps at neutralization when these are commenced within 15 sec after application
REFERENCE SOURCE: BASF AG Ludwigshafen
(81) Fasett D.W.: unpublished data; cited in: Pattys Industrial hyiene and Toxicology, Vol. IIB, 3155, (1982). [IUCLID 2000]
R-PHRASE: R 35 Causes severe burns [IUCLID 2000] | Provided | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | CCCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.436H | J-GLOBAL | CCCCN | Train |
NZ_CCID:
1,3-Diaminopropane | NZ_CCID:
1,3-propylenediamine | 109-76-2 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6FA76FE5-2F11-461E-AB95-6CB542DBF178 | NZ_CCID:
Skin Irritation
UN #2734 UN CLASS: 8 PG II
Eye Irritation
R PHRASE: R 35 [Company Data]
UN #2734 UN CLASS: 8 PG II | null | NZ_CCID | 1 | C(CN)CN | https://pubchem.ncbi.nlm.nih.gov/compound/428 | PubChem | NCCCN | Train |
JP_CHRIP:
2-methylaminoethanol
NZ_CCID:
2-(Methylamino) ethanol
US_HSDB:
2-Methylaminoethanol | JP_CHRIP:
(2-Hydroxyethyl)methylamine
2-(methylamino)ethanol
2-methylaminoethanol
Methylethylolamine
Monomethylethanolamine
NZ_CCID:
2-methylaminoethanol | 109-83-1 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0093e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C06F2FAD-F992-4DF1-992C-0526C97B09E2
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/1128 | JP_CHRIP:
The classification is based on the results of "being corrosive" after application to skin of rabbits for 1 - 4 hours (IUCLID (2000)). As relevant notes, its pH is 13.4 (100 mL/L) (IUCLID (2000)), and it is rated C;R34 in EU classification (EU-Annex 1 (accessed August 2008)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID, US_HSDB | 3 | CNCCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.187H | J-GLOBAL | CNCCO | Train |
NZ_CCID:
2-Methoxyethylamine | null | 109-85-3 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/0C11A983-26C0-468A-B6A0-04611D6017CE | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | COCCN | https://pubchem.ncbi.nlm.nih.gov/compound/8018 | PubChem | COCCN | Train |
EU_REACH:
Isooctadecanoic acid, 1,1'-(2,2-dimethyl-1,3-propanediyl) ester | null | 109884-54-0 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17513/7/4/2/?documentUUID=5003d932-d1e9-490c-96ee-8adab9b79cf7 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCCCCCCCC(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/10282874 | PubChem | CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCCCCCCCC(C)C | Train |
JP_CHRIP:
Diethylamine
NZ_CCID:
Ethanamine, N-ethyl-
US_HSDB:
DIETHYLAMINE | JP_CHRIP:
Diethamine
N,N-Diethylamine
N-Ethylethanamine
NZ_CCID:
Diethylamine, N,N-Diethylamine, n-Ethylethanamine | 109-89-7 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/14-mhlw-2042e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/5819CBE2-8F54-4733-8F2D-4C4262A0407E
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/524 | JP_CHRIP:
There are multiple reports that it was corrosive in tests with rabbits (ACGIH (7th, 2013), IUCLID (2000)). Additionally, there is a description that this substance was severely irritating, and the skin of the contact site was damaged (OEL Documentations (Japan Society For Occupational Health (JSOH), 1989)). From the above, it was classified in Category 1. Besides, this substance was classified as "Skin" by ACGIH, as "C:R35" in the EU DSD classification, and as "H314 Skin Corr. 1A" in the EU CLP classification.
NZ_CCID:
Skin Irritation
R-PHRASE: R 35 Causes severe burns. [IUCLID 2000]
[N-Class]
Eye Irritation
SPECIES:
RESULT: Contact with liquid can damage eyes, possibly permanently.
REFERENCE SOURCE: [Lewis, R.J. Saxs Dangerous Properties of Industrial Materials. 9th ed. Volumes 1-3. New York, NY: Van Nostrand Reinhold, 1996. 1147]**PEER REVIEWED** [HSDB] | null | JP_CHRIP, NZ_CCID, US_HSDB | 3 | CCNCC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J807I | J-GLOBAL | CCNCC | Train |
JP_CHRIP:
Ethyl vinyl ether | JP_CHRIP:
ethyl vinyl ether | 109-92-2 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0048e.html | JP_CHRIP:
Based on reports of grade 1 (maximum grade 10) irritation after open application to the skin of rabbits (PATTY (5th, 2001)), and not irritating in another rabbit test (OECD TG404), the substance was classified as "Not classified". | Provided | JP_CHRIP | 1 | CCOC=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.440F | J-GLOBAL | C=COCC | Train |
EU_REACH:
2-({3-[bis(cyanomethyl)amino]propyl}(cyanomethyl)amino)acetonitrile | null | 110057-45-9 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4332/7/4/2/?documentUUID=8313cf05-f1e8-4098-8ad7-0ce8f2f0a05f | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(CN(CC#N)CC#N)CN(CC#N)CC#N | https://pubchem.ncbi.nlm.nih.gov/compound/314171 | PubChem | N#CCN(CC#N)CCCN(CC#N)CC#N | Train |
EU_REACH:
succinic acid | null | 110-15-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15265/7/4/2/?documentUUID=42f74ea6-278b-4aac-bcbc-20d60bbcf2da | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C(CC(=O)O)C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/1110 | PubChem | O=C(O)CCC(=O)O | Train |
JP_CHRIP:
N,N,N',N'-tetramethylethylenediamine
NZ_CCID:
1,2-Ethanediamine, N,N,N',N'-tetramethyl- | JP_CHRIP:
N,N,N',N'-Tetramethyl-1,2-ethanediamine
NZ_CCID:
Propamine D, Temed, Tetrameen, Tetramethyl ethylene diamine, Tetramethyldiaminoethane | 110-18-9 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0167e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/22193BD3-92A5-4F59-817B-BD1499249582 | JP_CHRIP:
In skin irritation tests using rabbits (HSDB (2002)), 1-hour and 4-hour applications resulted in full-thickness necrosis or ulceration and ecchymoses; and the necrosis persisted for 14 days. Based on this information, the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESULT: Substance appears to be a corrosive with irreversible effects at day 14
REFERENCE SOURCE: Union Carbide Corp; Catalyst C-271: Acute Toxicity and Irritancy Testing Using the Rat (Peroral & Inhalation Toxicity) and the Rabbit (Cutaneous & Eye Tests); 08/24/93; EPA Document No. 89-930000176; Fiche No. OTS0538306] **UNREVIEWED** [HSDB]
Eye Irritation
SPECIES: Rabbit
RESULT: Slight to moderate corneal opacity and iritis, and severe conjunctival irritation were common to all treated eyes, the corneal injury with hemorrhaging of the nictitating membrane developing by the 24th hour observation. A purulent ocular discharge was noted in 3/4 rabbits by 72 hours post-instillation. By Day 14, 2/4 treated rabbit eyes were free of all irritative signs. The remaining minor corneal vascularization and conjunctival irritation in 1 and 2 rabbits, respectively, persisted to Day 21
REFERENCE SOURCE: Union Carbide Corp; Catalyst C-271: Acute Toxicity and Irritancy Testing Using the Rat (Peroral & Inhalation Toxicity) and the Rabbit (Cutaneous & Eye Tests); 08/24/93; EPA Document No. 89-930000176; Fiche No. OTS0538306] **UNREVIEWED** [HSDB]
EXPERT JUDGEMENT: Appears to be a eye corrosive as standard test uses 0.1 ml not the 0.01 ml used in this test. Therefore the effects are expected to be enhanced so classified as an eye corrosive rather than an eye irritant | null | JP_CHRIP, NZ_CCID | 2 | CN(C)CCN(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J34.745K | J-GLOBAL | CN(C)CCN(C)C | Train |
ChemSkin:
Isopropyl myristate
EU_REACH:
isopropyl myristate | null | 110-27-0 | 0NC
| ChemSkin: https://doi.org/10.3390/toxics9110314
EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16077/7/4/2/?documentUUID=ced703af-f120-4c1f-bea9-59e0b6a33326 | ChemSkin:
Experimental study (OECD TG 404)
EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | ChemSkin, EU_REACH | 2 | CCCCCCCCCCCCCC(=O)OC(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/8042 | PubChem | CCCCCCCCCCCCCC(=O)OC(C)C | Train |
EU_REACH:
2,6-difluoro-3-(propane-1-sulfonamido)benzoic acid | null | 1103234-56-5 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/8013/7/4/2/?documentUUID=8cf76091-2c73-4919-b6a9-59a7249d0760 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)O)F | https://pubchem.ncbi.nlm.nih.gov/compound/46192923 | PubChem | CCCS(=O)(=O)Nc1ccc(F)c(C(=O)O)c1F | Train |
EU_REACH:
2-methyl-4,6-bis[(octylsulfanyl)methyl]phenol | null | 110553-27-0 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13350/7/4/2/?documentUUID=c5664c74-61e4-4751-a365-e08a272f853b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCCCCCSCC1=CC(=C(C(=C1)C)O)CSCCCCCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/113646 | PubChem | CCCCCCCCSCc1cc(C)c(O)c(CSCCCCCCCC)c1 | Train |
NZ_CCID:
Amylamine | NZ_CCID:
N-Pentylamine | 110-58-7 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/CCE3EABA-1E70-4D06-A6C1-73A681F66700 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCCN | https://pubchem.ncbi.nlm.nih.gov/compound/8060 | PubChem | CCCCCN | Train |
NZ_CCID:
1,4-Diaminobutane | NZ_CCID:
putrescine | 110-60-1 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/6FB495BD-EFEE-4F4A-82C5-8BDAD63297AB | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C(CCN)CN | https://pubchem.ncbi.nlm.nih.gov/compound/1045 | PubChem | NCCCCN | Train |
JP_CHRIP:
2-Butyne-1,4-diol
KR_NCIS:
2-Butyne-1,4-diol
NZ_CCID:
2-Butyne-1,4-diol | JP_CHRIP:
1,4-Butynediol
1,4-Dihydroxy-2-butyne
2-Butynediol
But-2-yne-1,4-diol
KR_NCIS:
Butynediol; But-2-yne-1,4-diol
NZ_CCID:
2-BUTYNEDIOL, BIS(HYDROXYMETHYL)ACETYLENE, BUTYNEDIOL | 110-65-6 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0026e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B3754F63-18D5-46D6-8120-81E735B4679C | JP_CHRIP:
In the rabbit test (OECD TG 404) treated 6 animals with 0.5 g for 4 hours, severe erythema and severe edema within 24 hours, and necrosis within 6 days were noted in all animals. Based on the information, the substance was classified as Category 1. The substance was classified as "R34" in the EU classification (EU-Annex I (Access on May 2010))
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESULT: Irritating
REFERENCE SOURCE: BASF AG Ludwigshafen 73)BASF AG, Abteilung Toxikologie, unveroeffentlichte Untersuchung (XXIII/126), 31.12.1973. [ICULID 2000]
R-PHRASE: R 34 Causes burns. [ECB]
Eye Irritation
SPECIES: Rabbit
RESULT: Moderate
REFERENCE SOURCE: Journal of Applied Toxicology, Vol. 12, No. 2, pages 113-115, 7 references, 1992. [toxnet] | Provided | JP_CHRIP, KR_NCIS, NZ_CCID | 3 | OCC#CCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.098I | J-GLOBAL | OCC#CCO | Train |
AU_HCIS:
Phenol, isononyl-
KR_NCIS:
Isononylphenol | null | 11066-49-2 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5792
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances" | null | null | AU_HCIS, KR_NCIS | 2 | CC(C)CCCCCCC1=CC=CC=C1O | https://pubchem.ncbi.nlm.nih.gov/compound/119757 | PubChem | CC(C)CCCCCCc1ccccc1O | Train |
NZ_CCID:
Butylmethylamine | NZ_CCID:
N-Methylbutylamine, N-butylmethylamine | 110-68-9 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/C445C8AD-F04B-4CB8-948C-F49B51562D96 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCCNC | https://pubchem.ncbi.nlm.nih.gov/compound/8068 | PubChem | CCCCNC | Train |
NZ_CCID:
2-(Ethylamino) ethanol | null | 110-73-6 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D4C3AAF5-BE47-48D2-90B9-62EEFF41DECA | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCNCCO | https://pubchem.ncbi.nlm.nih.gov/compound/8072 | PubChem | CCNCCO | Train |
AU_HCIS:
piperazine
JP_CHRIP:
Piperazine
NZ_CCID:
Piperazine | AU_HCIS:
[liquid]
JP_CHRIP:
1,4-Diazacyclohexane
1,4-Diethylenediamine
Antiren
Diethyleneimine
Hexahydropirazine | 110-85-0 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3552
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-meti-0015e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7CAEF84F-55E5-4F70-833F-89CA4277EB87 | JP_CHRIP:
There is a report that in a skin irritation test (OECD TG404) with rabbits, as a result of a semi-occlusive application of this substance (50% aqueous solution) for 4 hours, severe erythema and necrosis were observed (EU-RAR (2005)). In addition, there is a report that in another skin irritation test with rats or mice, necrosis on the application site was observed after a 4 hour-application of this substance (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), DFGOT Vol. 9 (1998)). From the above, it was classified in Category 1. Besides, this substance was classified as "Skin. Corr. 1B H314" in EU CLP classification (ECHA CL Inventory (Access on September 2015)).
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESULT: Corrosive
REFERENCE SOURCE: (BASF, 1984). Prepared by the National Chemicals Inspectorate, Sweden. Based on the EU Risk Assessment Report (RAR) on piperazine. [ECB]
R PHRASE: R 34 [N-Class)
Eye Irritation
R PHRASE: R 34 [N-Class) | Provided | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | C1CNCCN1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.981J | J-GLOBAL | C1CNCCN1 | Train |
AU_HCIS:
piperidine
JP_CHRIP:
piperidine
NZ_CCID:
Piperidine | JP_CHRIP:
Azacyclohexane
Hexahydropyridine
Pentamethyleneimine
NZ_CCID:
Azacyclohexane, Cyclopentimine, Cypentil, Hexahydropyridine, Hexazane, Pentamethyleneimine, Pentamethylenimine, Perhydropyridine, Pyridine, hexahydro- | 110-89-4 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3555
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0169e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/56281F0D-7408-4FB6-A95C-3022A12B8D5E | JP_CHRIP:
In the study using 6 rabbits, necrosis was observed in all test animals (PATTY (5th, 2001)). In other animal tests, the substance was reported to have a corrosive effect (HSDB (2008)). Furthermore, in human accident cases, severe epithelial damage and chemical burns were reported with the substance in contact with skin for no longer than 3 minutes (PATTY (5th, 2001)). Based on this information on animals and humans, the substance was classified into Category 1. Its pH = 12.6 (20degC, 100 g/L) (GESTIS (accessed in November 2008)) and it is rated as R34 in the EU classification.
NZ_CCID:
Skin Irritation
SPECIES: Human
RESULT: In an accidental case of skin exposure, third degree burns developed after only 3 min of skin contact.
REFERENCE SOURCE: [Peer Reviewed] [Snyder, R. (ed.). Ethyl Brownings Toxicity and Metabolism of Industrial Solvents. 2nd ed. Volume II: Nitrogen and Phosphorus Solvents. Amsterdam-New York-Oxford: Elsevier, 1990. 255] [HSDB]
UN CLASS: 8 PG I
Eye Irritation
SPECIES: Rabbit
RESULT: Severe damage with permanent corneal injury.
REFERENCE SOURCE: [Patty, F. (ed.). Industrial Hygiene and Toxicology: Volume II: Toxicology. 2nd ed. New York: Interscience Publishers, 1963. 2197]**PEER REVIEWED** [HSDB] | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | C1CCNCC1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.884C | J-GLOBAL | C1CCNCC1 | Train |
AU_HCIS:
morpholine
EU_REACH:
morpholine
JP_CHRIP:
Morpholine
NZ_CCID:
Morpholine | JP_CHRIP:
Diethylene oximide
Tetrahydro-1,4-oxazine
tetrahydro-1,4-oxazine [synonym:morpholine]
NZ_CCID:
1-Oxa-4-azacyclohexane, 2H-1,4-Oxazine, tetrahydro-, 4H-1,4-Oxazine, tetrahydro-, Diethylene imidoxide, Diethylene oximide, Diethyleneimide oxide, Diethylenimide oxide, Drewamine, Tetrahydro-1,4-oxazine, Tetrahydro-p-oxazine, p-Isoxazine, tetrahydro- | 110-91-8 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=3091
EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13364/7/4/2/?documentUUID=b5fbf61e-b34d-454d-90ce-c03f3e99c9d0
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2042e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E3D2089C-2B17-4F66-B6D3-AD8AA873BB6E | EU_REACH:
Experimental study (OECD TG 404, GLP)
JP_CHRIP:
Based on the description that this substance is corrosive to the human skin (SIDS (2015)), and multiple test reports that necrosis occurred due to the application of this substance in skin irritation tests with rabbits (EHC 179 (1996), IARC 47 (1989), ACGIH (7th, 2001), PATTY (6th, 2012), SIDS (2015)), it was classified in Category 1. Besides, in the EU CLP classification, this substance was classified as "Skin Corr. 1B" (ECHA CL Inventory (Access on June 2017)).
NZ_CCID:
Skin Irritation
UNCLASS: UN PG 1
R PHRASE: R 34 [iuclid 2000]
Eye Irritation
SPECIES: Rabbit
RESULT: Severe
REFERENCE SOURCE: American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1-1918- (29,1363,1946) [RTECS] | Provided | AU_HCIS, EU_REACH, JP_CHRIP, NZ_CCID | 4 | C1COCCN1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.453H | J-GLOBAL | C1COCCN1 | Train |
NZ_CCID:
1-Propanamine, 2-methyl-N-(2-methylpropyl)- | NZ_CCID:
Diisobutylamine | 110-96-3 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E0FADC70-DC8C-43B3-B549-0A727A41A55F | NZ_CCID:
Skin Irritation
REMARK: UN 2361 Class 3.0;Sub Risk 8; PG III
Eye Irritation
SPECIES:
RESULT: Irritating
REFERENCE SOURCE: Review by Thomas (1990) Ethyl Brownings Toxicity and Metabolism of Industrial Solvents.
REMARK: UN has classified as sub-risk 8 - corrosive.
EXPERT JUDGEMENT: This is probably a severe eye irritant, like many other secondary aliphatic amines. | null | NZ_CCID | 1 | CC(C)CNCC(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/8085 | PubChem | CC(C)CNCC(C)C | Train |
JP_CHRIP:
1,1'-iminodipropan-2-ol; di-isopropanolamine | JP_CHRIP:
1,1'-Iminodi-2-propanol
Bis(2-propanol) amine
diisopropanolamine
DIPA | 110-97-4 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0170e.html | JP_CHRIP:
There are several reports that the application of the substance to abraded or intact sites of rabbit skin caused moderate or slight hyperemia (IUCLID (2000); HSDB (2006)), or the application to abraded sites caused moderate denaturation (IUCLID (2000); HSDB (2006)). Furthermore, in Draize tests using rabbits, application of undiluted test substance to intact sites on the abdomens of rabbits caused irreversible, severe necrosis at several sites (HSDB (2006)). Thus the substance was classified into Category 1. | null | JP_CHRIP | 1 | CC(O)CNCC(C)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.102K | J-GLOBAL | CC(O)CNCC(C)O | Train |
JP_CHRIP:
heptanoic acid
NZ_CCID:
Heptanoic acid | JP_CHRIP:
Enanthic acid
n-Heptoic acid
n-Heptylic acid | 111-14-8 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0171e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/AB329A3C-A115-48A2-9A1B-217426CCA37F | JP_CHRIP:
Rabbits were exposed to the substance for 4 hours, and as a result, treated subjects, as a whole, were graded 5.6 on a scale of 1 to 8 of the primary irritation index, indicating that the substance is corrosive (Patty 5th, 2001). Based on these results, the substance was classified into Category 1. It is rated as R34 in the EU classification (equivalent to Category 1B or 1C) (EU-Annex 1, accessed in November 2008).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | CCCCCCC(=O)O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.985B | J-GLOBAL | CCCCCCC(=O)O | Train |
EU_REACH:
[6-(dimethylamino)hexyl]dimethylamine | null | 111-18-2 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/11920/7/4/2/?documentUUID=abaa9300-517a-409f-854a-5cf660535b57 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CN(C)CCCCCCN(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/8097 | PubChem | CN(C)CCCCCCN(C)C | Train |
NZ_CCID:
Sebacoyl dichloride | null | 111-19-3 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/667545F7-4B26-4C4C-9D45-F80090947A96 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C(CCCCC(=O)Cl)CCCC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/66072 | PubChem | O=C(Cl)CCCCCCCCC(=O)Cl | Train |
EU_REACH:
tetraethenylsilane | null | 1112-55-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24943/7/4/2/?documentUUID=5dd459b7-008e-4a43-a735-65d92c8bd0d5 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C=C[Si](C=C)(C=C)C=C | https://pubchem.ncbi.nlm.nih.gov/compound/66188 | PubChem | C=C[Si](C=C)(C=C)C=C | Train |
NZ_CCID:
Hexylamine
US_HSDB:
1-Hexylamine | null | 111-26-2 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D7A42524-7B09-4069-BC4C-81B932E204B0
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/8444 | NZ_CCID:
Skin Irritation
R PHRASE: R 35 [Company Data]
Eye Irritation
R PHRASE: R 35 [Company Data] | null | NZ_CCID, US_HSDB | 2 | CCCCCCN | https://pubchem.ncbi.nlm.nih.gov/compound/8102 | PubChem | CCCCCCN | Train |
JP_CHRIP:
Glutaraldehyde
KR_NCIS:
Glutaraldehyde
NZ_CCID:
Pentanedial, (glutaraldehyde)
US_HSDB:
Glutaraldehyde | JP_CHRIP:
Glutaraldehyde
1,5-pentanedial
1,5-Pentanedial (50% solution)
Glutaral
glutardialdehyde
Glutaric dialdehyde
Pentanedial
KR_NCIS:
1,5-pentanedial; 1,3-diformylpropane; Glutaral; Glutardialdehyde; Glutaric dialdehyde
NZ_CCID:
1,5-Pentanedial, Glutaral, Glutaraldehyde, Glutardialdehyde, Glutaric acid dialdehyde, Glutaric dialdehyde, Pentanedial | 111-30-8 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-meti-2008.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4DEED8F-54FD-4CBB-A0B9-656446DBE6FB
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/949 | JP_CHRIP:
【分類根拠】
（１）～（４）より、区分1Bとした。
【根拠データ】
（１）本物質は実験動物の皮膚に対して25％以上の水溶液で刺激性を示す。ヒトの皮膚に付着すると、発赤、水疱を生じるほか、のどや鼻粘膜への刺激症状がみられる。皮膚炎等の防止策として厚生労働省は作業環境気中濃度の最大値の目安を0.05 ppm に設定している（厚労省 リスク評価書 (2015)）。
（２）ウサギ（n=6）を用いた皮膚刺激性試験（OECD TG 404、GLP、4時間適用、10日観察）において、適用後24/48/72h後の紅斑スコアの平均は2.8、浮腫スコアの平均は2.6であり、10日後の観察でも壊死と剥離が認められ回復性はみられなかった。並行して実施した1時間ばく露群ではばく露後に生存した5例のうち2例で壊死、4例で皮膚剥離がみられ、3分ばく露群では1例で軽度の紅斑がみられたとの報告がある（ECHA RAC Opinion (2014)、CLH Report (2013)）。
（３）ウサギ（n=4）を用いた皮膚刺激性試験（4時間適用、8日観察）において、50％水溶液を適用した場合、8日後に壊死、紅斑及び浮腫が認められ、非可逆的な影響であった。また、ウサギ（n=2）を用いた皮膚刺激性試験（50％水溶液を1時間適用、8日観察）では8日後に紅斑及び浮腫を伴う重度の痂皮脱落が認められ、回復性はみられず、ウサギを用いた皮膚刺激性試験（50％水溶液を3分間適用、8日観察）では浮腫はみられず、8日後に痂皮がみられたとの報告がある（ECHA RAC Opinion (2014)、CLH Report (2013)）。
（４）ウサギ（n=5）を用いた皮膚刺激性試験（OECD TG 404相当、半閉塞）において、24％溶液適用群1例について、3分間適用し24時間観察したところ腐食性はみられなかったが、1時間または4時間適用し24時間観察したところ腐食性がみられた。15％溶液適用群1例について、3分間または1時間適用し72時間観察したところ腐食性はみられなかったが、4時間適用し72時間観察したところ腐食性がみられた。4％溶液適用群3例について、4時間適用し14日間観察したところ重度の浮腫がみられた（紅斑・痂皮スコア：3.3/2.7/2.7、浮腫スコア：4/2/3）との報告がある（REACH登録情報 （Accessed July 2021)）。
【参考データ等】
（５）本物質は、平成8年労働省告示第33号（平成25年厚生労働省告示第316号により改正）において、労働基準法施行規則別表第一の二第四号1の厚生労働大臣が指定する単体たる化学物質及び化合物（合金を含む。）に「グルタルアルデヒド」として指定されており、本物質にさらされる業務による、特定の症状又は障害を主たる症状又は障害とする疾病（皮膚障害、前眼部障害又は気道障害）が、業務上の疾病として定められている。
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [IUCLID 2000] [NCLASS]
Eye Irritation
SPECIES:
RESULT: A 0.1% solution of GA is not irritating to the eye; the threshold for conjunctival irritation is 0.2% and for corneal injury it is 1.0%. Eye injury is moderate at 2% and severe at > or =5%.
REFERENCE SOURCE: Ballantyne B, Jordan SL. Applied Toxicology Group, Union Carbide Corporation, 39 Old Ridgebury Road, Danbury, CT 06817-0001, USA. J Appl Toxicol 2001 Mar-Apr;21(2):131-51 [MEDLINE]
SPECIES: Rabbit
RESULT: ...A 25% aq solution on rabbit eyes, caused severe injury, graded 9 on a scale of 10. A 1% solution quickly abolishes the b-wave of the rabbit retina in vitro.
REFERENCE SOURCE: Grant, W.M. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986. 462 **PEER REVIEWED** [HSDB] | Provided | JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 4 | O=CCCCC=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J2.454F | J-GLOBAL | O=CCCCC=O | Train |
JP_CHRIP:
1-Isocyanatobutane | JP_CHRIP:
1-Isocyanatobutane | 111-36-4 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0006e.html | JP_CHRIP:
After occlusive application of 0.5 mL of an undiluted test substance to rabbit ears for 15 or 30 minutes, effects became more serious and the skin was perforated in 1 to 2 days. Surface skin scaling was observed at the end of observation period of 7 days.
On the basis of the evaluation as "highly corrosive" (SIDS (2005)), it was classified in Category 1. | null | JP_CHRIP | 1 | CCCCN=C=O | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J36.974H | J-GLOBAL | CCCCN=C=O | Train |
AU_HCIS:
1,2-Ethanediamine, N-(2-aminoethyl)-
JP_CHRIP:
N-(2-Aminoethyl)-1,2-ethanediamine; Diethylenetriamine
NZ_CCID:
Diethylene triamine | AU_HCIS:
diethylenetriamine
DETA
ancamine DETA
3-azapentane-1.5-diamine
2,2'-iminobis(ethanamine)
JP_CHRIP:
3-Azapentane-1,5-diamine
Bis(2-aminoethyl)amine
DETA
N-(2-Aminoethyl)-1,2-ethanediamine
NZ_CCID:
1,2-Ethanediamine, N-(2-aminoethyl)-, 1,4,7-Triazaheptane, 1,5-Diamino-3-azapentane, 2-(2-Aminoethylamino)ethylamine, 3-Azapentane-1,5-diamine, Bis(2-aminoethyl)amine, Diethylenetriamine, N,N-Bis(2-aminoethyl)amine, N-(2-Aminoethyl)-1,2-ethanediamine | 111-40-0 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=7
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/13-mhlw-2028e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EB07CFC3-E1E7-4577-894F-87F4DD9E9498 | JP_CHRIP:
Strong corrosivity or corrosivity is described as health effects in humans (Environmental Risk Assessment for Chemical Substances vol. 11 (Ministry of the Environment, 2013), Initial Risk Assessment Report (NITE, CERI, NEDO, 2005)) and the results of skin irritation tests with rabbits (Initial Risk Assessment Report (NITE, CERI, NEDO, 2005), SIDS (2002)). Furthermore, this substance is classified in "C; R34" in EU DSD classification and "Skin Corr. 1B H314" in EU CLP classification. It was classified in Category 1 based on the above information.
NZ_CCID:
Skin Irritation
SPECIES: Rabbit
RESULT: Highly corrosive.
REFERENCE SOURCE: Dow Benelux N. V. Terneuzen (55)(55) Anonym.: Report of Union Carbide Corporation, 27.6.1983 [IUCLID 2000]
REMARK: EC Classification: Highly corrosive (causes severe burns)
Eye Irritation
SPECIES: Rabbit
RESULT: Highly corrosive
REFERENCE SOURCE: Dow Benelux N. V. Terneuzen (75)(75) Hollingworth, R.L. (1951). Report of The Dow Chemical Company, 13.8. 1951. [IUCLID 2000] | null | AU_HCIS, JP_CHRIP, NZ_CCID | 3 | NCCNCCN | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J5.108J | J-GLOBAL | NCCNCCN | Train |
JP_CHRIP:
N-(2-Aminoethyl)-2-aminoethanol
NZ_CCID:
2-(2-Aminoethylamino) ethanol | JP_CHRIP:
2-(2-aminoethylamino)ethanol
Ethanol, 2-[(2-aminoethyl)amino]-
N-(2-aminoethyl)-2-aminoethanol
NZ_CCID:
N-aminoethylethanolamine | 111-41-1 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0081e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4E713A4E-89DE-41C3-8C21-DDA1A6910DC0 | JP_CHRIP:
In a test by a semi-occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, necrosis occurred in 2/2 animals after a 4-hour application and 1/4 animals after a 1-hour application, and full-thickness skin necrosis was confirmed by pathological examination (SIDS (2008)). And full-thickness skin necrosis was also observed after a 4-hour or 1-hour application in another test by an occlusive application of 0.5 mL of undiluted this substance to the rabbit skin, and it was judged as corrosive (SIDS (2008)), but only minor irritation was noted after a 3-minute application. Therefore, it was classified in Category 1B. Besides, it was classified in C: R34 in EU classification (EC-JRC (ESIS) (Access on Aug. 2012)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | NCCNCCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.188F | J-GLOBAL | NCCNCCO | Train |
JP_CHRIP:
2,2'-thiodiethanol; thiodiglycol | JP_CHRIP:
2,2'-Thiodiethanol
Di(2-hydroxyethyl) sulfide
Diethanolsulfide
Thiodiethylene glycol
Thiodiglycol | 111-48-8 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-mhlw-0039e.html | JP_CHRIP:
Skin irritation tests using rabbits (complied with OECD guideline 404) concluded that the substance was not an irritant, based on the observation of slight erythema (score 1) in 1 of 3 treated rabbits (SIDS (2004)). From these results, the substance was classified into "Not classified" (also "Not classified" in the United Nations classification). | Provided | JP_CHRIP | 1 | OCCSCCO | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.988G | J-GLOBAL | OCCSCCO | Train |
JP_CHRIP:
Hexahydro-1H-azepin
NZ_CCID:
Hexamethyleneimine | JP_CHRIP:
Hexamethylenimine | 111-49-9 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0103e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/ED5CDB33-85DF-4F51-A46F-8D601369484F | JP_CHRIP:
Since the undiluted substance was dermally corrosive, producing an intact scab after 14 days by occluded application to the skin for 24-hour in an acute dermal toxicity test in rabbits (HSDB (2003)), the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | C1CCCNCC1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J22.113I | J-GLOBAL | C1CCCNCC1 | Train |
NZ_CCID:
Adipoyl dichloride | null | 111-50-2 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/7BEAA83C-BC76-4D17-9707-03DC183E614A | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C(CCC(=O)Cl)CC(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/61034 | PubChem | O=C(Cl)CCCCC(=O)Cl | Train |
EU_REACH:
1,4-diethyl 2-acetylbutanedioate | null | 1115-30-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/18399/7/4/2/?documentUUID=bd427c12-7b4b-4bf3-89ea-99a4ec6eea8d | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC(=O)CC(C(=O)C)C(=O)OCC | https://pubchem.ncbi.nlm.nih.gov/compound/66197 | PubChem | CCOC(=O)CC(C(C)=O)C(=O)OCC | Train |
NZ_CCID:
Triisobutylamine | NZ_CCID:
1-Propanamine, 2-methyl-N,N-bis(2-methylpropyl)- | 1116-40-1 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/A4406924-5585-431C-ABD5-5B23859590CD | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | CC(C)CN(CC(C)C)CC(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/14222 | PubChem | CC(C)CN(CC(C)C)CC(C)C | Train |