Name
stringlengths 14
548
| Synonym
stringlengths 14
790
⌀ | CAS RN
stringlengths 7
12
| Y
class label 2
classes | Detailed Page
stringlengths 57
580
| Evidence
stringlengths 40
2.31k
⌀ | OECD TG 404
stringclasses 1
value | Data Source
stringclasses 34
values | Frequency
int64 1
6
| SMILES
stringlengths 2
255
| SMILES URL
stringlengths 45
101
| SMILES Source
stringclasses 4
values | Canonical SMILES
stringlengths 2
248
| Split
stringclasses 1
value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
JP_CHRIP:
1,2,4,5-Tetrachlorobenzene | JP_CHRIP:
Benzene tetrachloride
s-Tetrachlorobenzene | 95-94-3 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0066e.html | JP_CHRIP:
It was classified as "Not classified" because it is reported that no appreciable irritation was observed in a test by a repeated application of a 10% solution to the ear or abdominal skin of rabbits (BUA 86 (1991)), and it is described that this substance was concluded to be non-irritating in a skin irritation test (OECD TG 404) (BUA 86 (1991)). | Provided | JP_CHRIP | 1 | Clc1cc(Cl)c(Cl)cc1Cl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.573D | J-GLOBAL | Clc1cc(Cl)c(Cl)cc1Cl | Train |
EU_REACH:
2-[2-(4-methylcyclohex-3-en-1-yl)propyl]cyclopentan-1-one | null | 95962-14-4 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/30194/7/4/2/?documentUUID=7f54fd88-7be6-467a-87c0-fee4d0f64dab | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CCC(CC1)C(C)CC2CCCC2=O | https://pubchem.ncbi.nlm.nih.gov/compound/175661 | PubChem | CC1=CCC(C(C)CC2CCCC2=O)CC1 | Train |
EU_REACH:
methyl 1-(3-chloropyridin-2-yl)-3-(hydroxymethyl)-1H-pyrazole-5-carboxylate | null | 960316-73-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/16970/7/4/2/?documentUUID=c6359ae9-4890-4570-8bf7-f9e4831b0ff7 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | COC(=O)C1=CC(=NN1C2=C(C=CC=N2)Cl)CO | https://pubchem.ncbi.nlm.nih.gov/compound/53235501 | PubChem | COC(=O)c1cc(CO)nn1-c1ncccc1Cl | Train |
JP_CHRIP:
1,2,3-Trichloropropane | JP_CHRIP:
1,2,3-Trichloropropane
Allyl trichloride
Glycerol trichlorohydrin
Propane, 1,2,3-trichloro- | 96-18-4 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/16-mhlw-0117e.html | JP_CHRIP:
In a skin irritation test (in conformity to OECD TG 404), in which 0.5 mL of test substance was applied to rabbits for 4 hours, mild skin irritation was observed (SIDS (2004)). Therefore, it was classified as "Not classified" (corresponding to Category 3 in UN GHS classification). | Provided | JP_CHRIP | 1 | ClCC(Cl)CCl | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.962D | J-GLOBAL | ClCC(Cl)CCl | Train |
AU_HCIS:
1-Butanol, 2-amino-
NZ_CCID:
2-Amino-1-butanol | null | 96-20-8 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=5539
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/31824D2E-8478-4F6A-9AED-F1374214E4F6 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | AU_HCIS, NZ_CCID | 2 | CCC(CO)N | https://pubchem.ncbi.nlm.nih.gov/compound/22129 | PubChem | CCC(N)CO | Train |
EU_REACH:
3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl 2-chloroprop-2-enoate | null | 96383-55-0 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10080/7/4/2/?documentUUID=c618a845-7e18-4373-a433-f6800d8968a4 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C=C(C(=O)OCCC(C(C(C(C(C(F)(F)F)(F)F)(F)F)(F)F)(F)F)(F)F)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/59297287 | PubChem | C=C(Cl)C(=O)OCCC(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)C(F)(F)F | Train |
EU_REACH:
1,3-dioxolan-2-one | null | 96-49-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/14909/7/4/2/?documentUUID=d8a418a1-a143-4dbb-99f6-8549c99f4f82 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1COC(=O)O1 | https://pubchem.ncbi.nlm.nih.gov/compound/7303 | PubChem | O=C1OCCO1 | Train |
EU_REACH:
4-trans-ethyl-4'-trans-propyl-[1,1'-bicyclohexyl] | null | 96624-41-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27175/7/4/2/?documentUUID=03133f81-119c-437d-965b-e5b7cff42129 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCC1CCC(CC1)C2CCC(CC2)CC | https://pubchem.ncbi.nlm.nih.gov/compound/19850402 | PubChem | CCCC1CCC(C2CCC(CC)CC2)CC1 | Train |
EU_REACH:
4-trans-Butyl-4'-trans-propyl-[1,1'-bicyclohexyl] | null | 96624-52-1 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/27171/7/4/2/?documentUUID=7db757dd-d416-4694-8516-85ff88745425 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCC1CCC(CC1)C2CCC(CC2)CCC | https://pubchem.ncbi.nlm.nih.gov/compound/11086663 | PubChem | CCCCC1CCC(C2CCC(CCC)CC2)CC1 | Train |
EU_REACH:
3-[benzyl({4-[2-(4-nitrophenyl)diazen-1-yl]phenyl})amino]propanenitrile | null | 96662-24-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/12107/7/4/2/?documentUUID=3df49d34-3273-4803-8110-a8b6d0fd9485 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC=C(C=C1)CN(CCC#N)C2=CC=C(C=C2)N=NC3=CC=C(C=C3)[N+](=O)[O-] | https://pubchem.ncbi.nlm.nih.gov/compound/15869329 | PubChem | N#CCCN(Cc1ccccc1)c1ccc(N=Nc2ccc([N+](=O)[O-])cc2)cc1 | Train |
EU_REACH:
4-methyl-3-nitrobenzoic acid | null | 96-98-0 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/5345/7/4/2/?documentUUID=2c363557-c8ce-4f99-9472-c39aa4748c9b | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=C(C=C(C=C1)C(=O)O)[N+](=O)[O-] | https://pubchem.ncbi.nlm.nih.gov/compound/7319 | PubChem | Cc1ccc(C(=O)O)cc1[N+](=O)[O-] | Train |
NZ_CCID:
Benzoic acid, 2-hydroxy-5-sulpho- | null | 97-05-2 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/002E9059-975E-4234-8FF5-7D6A59A6BBD8 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | C1=CC(=C(C=C1S(=O)(=O)O)C(=O)O)O | https://pubchem.ncbi.nlm.nih.gov/compound/7322 | PubChem | O=C(O)c1cc(S(=O)(=O)O)ccc1O | Train |
JP_CHRIP:
4-Nitro-o-anisidine | JP_CHRIP:
4-Nitro-o-anisidine | 97-52-9 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2017e.html | JP_CHRIP:
Based on a report that in a skin irritation test with rabbits, no irritation was observed in the application of 500 mg of this substance (NTP IMM98007 (2011) (Access on May 2017)), it was classified as "Not classified." Besides, there is a description in the information source in List 3 that no irritation tests with rabbits (according to OECD TG 404) (GESTIS (Access on May 2017)). | Provided | JP_CHRIP | 1 | COc1cc(ccc1N)[N+](=O)[O-] | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J96.207D | J-GLOBAL | COc1cc([N+](=O)[O-])ccc1N | Train |
EU_REACH:
1-(2,5-dioxoimidazolidin-4-yl)urea | null | 97-59-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13641/7/4/2/?documentUUID=dfbe1428-6ee4-4e73-bbdf-57019e1e6194 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1(C(=O)NC(=O)N1)NC(=O)N | https://pubchem.ncbi.nlm.nih.gov/compound/204 | PubChem | NC(=O)NC1NC(=O)NC1=O | Train |
NZ_CCID:
2-Methylpentanoic acid | null | 97-61-0 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/F02F6EDF-E0A6-46F0-AE49-69832589F52D | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCCC(C)C(=O)O | https://pubchem.ncbi.nlm.nih.gov/compound/7341 | PubChem | CCCC(C)C(=O)O | Train |
JP_CHRIP:
Isobutyric anhydride
NZ_CCID:
2-Methylpropionic anhydride | NZ_CCID:
iso-butyric anhydride | 97-72-3 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0158e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/166DD4DA-022D-40BA-B0F2-2B797880CE43 | JP_CHRIP:
The substance is rapidly hydrolyzed to isobutyric acid by contact with water (SIDS (J) (Access on Sep. 2010)). Thus, the substance was classified as Category 1 based on the document that open application of isobutyric acid to rabbit skin caused some necrosis within 24 hours (PATTY, 5th (2001)).
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | CC(C)C(=O)OC(=O)C(C)C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J38.161F | J-GLOBAL | CC(C)C(=O)OC(=O)C(C)C | Train |
JP_CHRIP:
Tetraethylthiuram disulfide (Disulfiram) | JP_CHRIP:
1,1'-Dithiobis(N,N-diethylthioformamide)
bis-(N,N-Diethylthiocarbamoyl)disulfide
Disulfiram
TETD
Tetraethylthiuramdisulfide | 97-77-8 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2003e.html | JP_CHRIP:
[Rationale for the Classification]
Based on evidence (1)-(4) that this substance is not skin irritating, it was classified as "Not classified."
[Evidence Data]
(1) There is a report that a drunken-like effect was seen due to exposure with workers at a manufacturing plant, but it is also known that skin irritation is generally seen at the time of perspiration, and minimal skin irritation was observed in only 9% of the overall. In addition, exposure concentrations were not determined (ACGIH (7th, 2001)).
(2) There is a report that in a skin irritation test (corresponds to OECD TG 404, n=6) with rabbits, when this substance was applied for 4 hours, PII (skin primary irritation index) was 0.13 (maximum 8) (NICNAS IMAP (Accessed Jun. 2018), REACH registration dossier (Accessed Jun. 2018))
(3) There is a report that in a skin irritation test (corresponds to OECD TG 404, GLP-compliant) with rabbits, when this substance was applied for 24 hours, the erythema score was 0.25, but recovery was complete in 3 days, and the edema score was 0 (NICNAS IMAP (Accessed Jun. 2018), REACH registration dossier (Accessed Jun. 2018)).
(4) There is a report that in a skin irritation test (corresponds to OECD TG 404, GLP-compliant) with rabbits, when this substance was applied for 24 hours, the erythema score was 0.96, but recovery was complete in 7 days, and the edema score was 0 (NICNAS IMAP (Accessed Jun. 2018), REACH registration dossier (Accessed Jun. 2018)). | Provided | JP_CHRIP | 1 | CCN(CC)C(=S)SSC(=S)N(CC)CC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.980B | J-GLOBAL | CCN(CC)C(=S)SSC(=S)N(CC)CC | Train |
EU_REACH:
methyl 2-[[4-ethoxy-6-(methylamino)-1,3,5-triazin-2-yl]carbamoylsulfamoyl]benzoate | null | 97780-06-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20802/7/4/2/?documentUUID=bb417d49-fab8-41e6-a350-6bd3c59c9602 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC1=NC(=NC(=N1)NC(=O)NS(=O)(=O)C2=CC=CC=C2C(=O)OC)NC | https://pubchem.ncbi.nlm.nih.gov/compound/91756 | PubChem | CCOc1nc(NC)nc(NC(=O)NS(=O)(=O)c2ccccc2C(=O)OC)n1 | Train |
JP_CHRIP:
Triethylborane
NZ_CCID:
Borane, triethyl- | NZ_CCID:
Triethylborane, Triethylboron | 97-94-9 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/10-mhlw-0199e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/DA2A3A18-B3F5-4666-AD2A-6C944F6126B4 | JP_CHRIP:
The substance was classified as Category 1 based on the documents that the substance caused strong irritation to human skin, eye and respiratory system (HSDB (2010)) and the substance was classified as "C; R34 (Skin Corr. 1B)" as trialkyboranes in the EU classification (EC-JRC (ESIS) (Access on Dec. 2010)).
NZ_CCID:
Skin Irritation
R-PHRASE: R 34 Causes burns. [N-CLASS]
Eye Irritation
R-PHRASE: R 34 Causes burns. [N-CLASS] | null | JP_CHRIP, NZ_CCID | 2 | CCB(CC)CC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J55.478B | J-GLOBAL | CCB(CC)CC | Train |
EU_REACH:
2-chloro-1,1-dimethoxyethane | null | 97-97-2 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/17184/7/4/2/?documentUUID=a82e2414-69a9-4b74-8509-a41746bfe512 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | COC(CCl)OC | https://pubchem.ncbi.nlm.nih.gov/compound/60986 | PubChem | COC(CCl)OC | Train |
EU_REACH:
2,9-dimethyl-5,7,12,14-tetrahydro-5,12-diazapentacene-7,14-dione | null | 980-26-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15097/7/4/2/?documentUUID=aabf1b39-4487-4c50-b208-f10146622530 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC1=CC2=C(C=C1)NC3=CC4=C(C=C3C2=O)NC5=C(C4=O)C=C(C=C5)C | https://pubchem.ncbi.nlm.nih.gov/compound/70423 | PubChem | Cc1ccc2[nH]c3cc4c(=O)c5cc(C)ccc5[nH]c4cc3c(=O)c2c1 | Train |
JP_CHRIP:
Benzenesulfonyl chloride
NZ_CCID:
Benzenesulphonyl chloride | null | 98-09-9 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/09-mhlw-0094e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/15891980-7B2F-49FA-9776-0F56221A1F4B | JP_CHRIP:
Based on a result of "corrosive" in a rabbit test (IUCLID (2000)), the substance was classified into Category 1.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | JP_CHRIP, NZ_CCID | 2 | ClS(=O)(=O)c1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.983G | J-GLOBAL | O=S(=O)(Cl)c1ccccc1 | Train |
JP_CHRIP:
Benzenesulfonic acid
NZ_CCID:
Benzenesulphonic acid | JP_CHRIP:
Benzenemonosulfonic acid
Phenylsulfonic acid | 98-11-3 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0071e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/E6F359F2-D929-4675-A78E-45582CC9C70B | JP_CHRIP:
It was classified in Category 1 because there is a description of severe skin irritation in guinea pigs (HSDB (2002)), and the saturated solution of this substance has pH 2.
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | JP_CHRIP, NZ_CCID | 2 | OS(=O)(=O)c1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J62.182J | J-GLOBAL | O=S(=O)(O)c1ccccc1 | Train |
JP_CHRIP:
Trichlorophenylsilane | null | 98-13-5 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0011e.html | JP_CHRIP:
It was classified in Category 1 base on a result as "highly corrosive" in a rabbit test (IUCLID (2000)) and a result indicating "corrosion" in another rabbit test (HSDB (2000)). | null | JP_CHRIP | 1 | Cl[Si](Cl)(Cl)c1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J54.322E | J-GLOBAL | Cl[Si](Cl)(Cl)c1ccccc1 | Train |
EU_REACH:
1-chloro-3-(trifluoromethyl)benzene | null | 98-15-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19799/7/4/2/?documentUUID=da93ee4f-47e1-45f8-8309-595e50d30ad6 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC(=CC(=C1)Cl)C(F)(F)F | https://pubchem.ncbi.nlm.nih.gov/compound/7374 | PubChem | FC(F)(F)c1cccc(Cl)c1 | Train |
AU_HCIS:
1,2-Benzenediol, 4-(1,1-dimethylethyl)-
NZ_CCID:
4-t-Butylpyrocatechol | NZ_CCID:
4-tert-butylcatechol | 98-29-3 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=6586
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/779E6331-F4AE-4B13-9B1B-352BDCAA6AB2 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | AU_HCIS, NZ_CCID | 2 | CC(C)(C)C1=CC(=C(C=C1)O)O | https://pubchem.ncbi.nlm.nih.gov/compound/7381 | PubChem | CC(C)(C)c1ccc(O)c(O)c1 | Train |
EU_REACH:
ethyl 1-cyclopropyl-6,7-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate | null | 98349-25-8 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/10623/7/4/2/?documentUUID=2291aa59-18ef-485e-a4f1-205ef78b096e | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCOC(=O)C1=CN(C2=CC(=C(C=C2C1=O)F)F)C3CC3 | https://pubchem.ncbi.nlm.nih.gov/compound/9817544 | PubChem | CCOC(=O)c1cn(C2CC2)c2cc(F)c(F)cc2c1=O | Train |
EU_REACH:
trans-1,4-bis(isocyanatomethyl)cyclohexane | null | 98458-83-4 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26702/7/4/2/?documentUUID=fecb723c-8202-4de1-bb82-06bf9427fb51 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1CC(CCC1CN=C=O)CN=C=O | https://pubchem.ncbi.nlm.nih.gov/compound/61504 | PubChem | O=C=NCC1CCC(CN=C=O)CC1 | Train |
NZ_CCID:
4-Bromobenzenesulphonyl chloride | null | 98-58-8 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/2893EFAD-9CC9-4251-834A-0027964E8BE9 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC(=CC=C1S(=O)(=O)Cl)Br | https://pubchem.ncbi.nlm.nih.gov/compound/7396 | PubChem | O=S(=O)(Cl)c1ccc(Br)cc1 | Train |
NZ_CCID:
4-Toluenesulphonyl chloride | NZ_CCID:
4-Methylbenzenesulfonyl chloride, 4-Toluenesulfonyl chloride, Benzenesulfonyl chloride, 4-methyl-, Tosyl chloride, p-Methylbenzenesulfonyl chloride, p-Toluenesulfochloride, p-Toluenesulfonic acid chloride, p-Toluenesulphonyl chloride, p-Tolylsulfonyl chloride, p-Tosyl chloride, para-Toluenesulfonyl chloride | 98-59-9 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/38C8068C-2B7E-4CA4-AB65-012C913832B8 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CC1=CC=C(C=C1)S(=O)(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/7397 | PubChem | Cc1ccc(S(=O)(=O)Cl)cc1 | Train |
NZ_CCID:
4-Chlorobenzenesulphonyl chloride | null | 98-60-2 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/4168693B-5296-46E1-89C3-386A788C54E0 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC(=CC=C1S(=O)(=O)Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/7398 | PubChem | O=S(=O)(Cl)c1ccc(Cl)cc1 | Train |
NZ_CCID:
4-Methoxybenzenesulphonyl chloride | null | 98-68-0 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/B4755BD2-F16B-4465-92A1-033F6D04568A | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [CHEMWATCH]
Eye Irritation
R PHRASE: R 41 [CHEMWATCH] | null | NZ_CCID | 1 | COC1=CC=C(C=C1)S(=O)(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/7401 | PubChem | COc1ccc(S(=O)(=O)Cl)cc1 | Train |
NZ_CCID:
4-Nitrobenzenesulphonyl chloride | null | 98-74-8 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D222C6C1-5B24-4F4F-90EF-213D01E3C7BF | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC(=CC=C1[N+](=O)[O-])S(=O)(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/7404 | PubChem | O=[N+]([O-])c1ccc(S(=O)(=O)Cl)cc1 | Train |
JP_CHRIP:
Cumene | JP_CHRIP:
(1-Methylethyl)benzene
1-Methylethylbenzene
2-Phenylpropane
isopropylbenzene
isopropylbenzene [synonym:cumene] | 98-82-8 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/ghs/21-mhlw-2011.html | JP_CHRIP:
【分類根拠】
（１）より、区分に該当しない。
【根拠データ】
（１）ウサギ（n= 6）を用いた皮膚刺激性試験（OECD TG404相当、無傷／有傷皮膚、72時間観察）では、24及び72時間後の観察で浮腫はみられなかったが、軽度で回復性のある紅斑が全例にみられた。6例の個体別平均スコア（フルスコア：8）は各々2、1.5、2、2、2及び1.5で無傷皮膚と有傷皮膚には差はなかった（AICIS IMAP (2016)、EU RAR (2001)、ACGIH (7th, 2001)、厚労省 リスク評価書 (2015)、産衛学会 許容濃度暫定値の提案理由書 (2019)、REACH登録情報 (Accessed Dec. 2021)）。
【参考データ等】
（２）本物質は皮膚刺激性物質である（AICIS IMAP (2016)、NTP(2009)）。
（３）厚労省 リスク評価書 (2015)では、皮膚刺激性/腐食性：軽度の刺激性とされた。
（４）ウサギを用いた皮膚刺激性試験（原液0.5 mL、24時間適用）では、皮膚剥離を伴う軽微な脱脂作用がみられ、軽微な皮膚刺激性と判定された（ACGIH (7th, 2001)、厚労省 リスク評価書 (2015)、産衛学会 許容濃度暫定値の提案理由書 (2019)）。 | Provided | JP_CHRIP | 1 | CC(C)c1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.581E | J-GLOBAL | CC(C)c1ccccc1 | Train |
AU_HCIS:
benzoyl chloride
JP_CHRIP:
Benzoyl chloride
KR_NCIS:
Benzoyl chloride
NZ_CCID:
Benzoyl chloride
US_HSDB:
Benzoyl chloride | JP_CHRIP:
alpha-Chlorinated toluenes (benzal chloride, benzotrichloride, benzyl chloride) and benzoyl chloride (combined exposures)
alpha-Chlorobenzaldehyde
Benzenecarbonyl chloride
Benzoic acid chloride
KR_NCIS:
Benzenecarbonyl chloride; Benzoic acid chloride
NZ_CCID:
Benzenecarbonyl chloride, Benzoic acid, chloride | 98-88-4 | 1Cat 1
| AU_HCIS: http://hcis.safeworkaustralia.gov.au/HazardousChemical/Details?chemicalID=457
JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/18-mhlw-2015e.html
KR_NCIS: https://ncis.nier.go.kr/en/main.do, button "Hazardous chemical substances"
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/BDEC200B-FA30-411E-A0FD-F2252AD43C67
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/383 | JP_CHRIP:
[Rationale for the Classification]
Based on (1)-(3), it was judged that this substance is corrosive to the skin, and it was classified in Category 1.
[Evidence Data]
(1) It is described that this substance is corrosive to humans in multiple articles in literature (NICNAS IMAP (Accessed Aug. 2018), Vincoli (1996), Bruze et al. (2000)).
(2) In a skin irritation test (n=6) with rabbits, after a 4-hour application followed by 72-hour observation, an irritation score of 3.8 is reported (REACH registration dossier (Accessed Aug. 2018)).
(3) There is also a report that this substance is very strongly irritating to rabbit skins (Risk Assessment Report (Ministry of Health, Labour and Welfare, 2008), ACGIH (7th, 2001)).
[Reference Data, etc.]
(4) This substance was classified as "Skin Corr. 1B" in the EU CLP.
NZ_CCID:
Skin Irritation
R-PHRASE: R 34
UN CLASS: 8 PG II [ICSC 2000]
Eye Irritation
EU Classification
Symbol: C
R: 34
S: (1/2-)26-45
EFFECTS OF SHORT-TERM EXPOSURE:
Tear drawing. The substance is corrosive to the eyes, the skin and the respiratory tract. Corrosive on ingestion. Inhalation of the vapour or aerosol may cause lung oedema (see Notes).
[ICSC 2000] | null | AU_HCIS, JP_CHRIP, KR_NCIS, NZ_CCID, US_HSDB | 5 | ClC(=O)c1ccccc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.987J | J-GLOBAL | O=C(Cl)c1ccccc1 | Train |
JP_CHRIP:
N,N-Dimethylcyclohexylamine
NZ_CCID:
Cyclohexyldimethylamine | JP_CHRIP:
N,N-Dimethyl-cyclohexylamine
Cyclohexanamine, N,N-dimethyl-
Cyclohexylamine, N,N-dimethyl-
Cyclohexyldimethylamine
N,N-Dimethylaminocyclohexane
N-Cyclohexyldimethylamine
NZ_CCID:
(Dimethylamino)Cyclohexane, N, N-Dimethylcyclohexanamine, N,N-Dimethylcyclohexylamine | 98-94-2 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/17-mhlw-2015e.html
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/D1F03E47-69FF-4B3D-BF20-ABA7BDE1E357 | JP_CHRIP:
Based on a report that it was corrosive in a skin irritation test with rabbits, and a description that the 5 g/L aqueous solution of this substance was pH 12 (GESTIS (Access on May 2017)), and that the corrosive properties were attributable to the alkaline properties of the aqueous solution of this substance (SIAP (2012)), it was classified in Category 1.
NZ_CCID:
Skin Irritation
N,N-Dimethyl-cyclohexylamine has a specific UN number 2264 Class 8 Sub risk 3 packing group II, with risk phrases R10,R20/21/22,R34.
Class 8 packing group II is equivalent to an HSNO 8.2B classification.
Eye Irritation
N,N-Dimethyl-cyclohexylamine has a specific UN number 2264 Class 8 Sub risk 3 packing group II, with risk phrases R10,R20/21/22,R34. | null | JP_CHRIP, NZ_CCID | 2 | CN(C)C1CCCCC1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J4.960C | J-GLOBAL | CN(C)C1CCCCC1 | Train |
EU_REACH:
(2R)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran; (2R)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran; (2S)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran; (2S)-6-fluoro-2-[(2S)-oxiran-2-yl]-3,4-dihydro-2H-1-benzopyran | null | 99199-90-3 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7989/7/4/2/?documentUUID=c0d62c61-66f0-4edb-9563-92c0f06152b6 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1CC2=C(C=CC(=C2)F)OC1C3CO3 | https://pubchem.ncbi.nlm.nih.gov/compound/11658439 | PubChem | Fc1ccc2c(c1)CCC(C1CO1)O2 | Train |
EU_REACH:
trehalose | null | 99-20-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/26864/7/4/2/?documentUUID=77f7f2d0-73f4-429d-b101-7c237782ac02 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O)O)O | https://pubchem.ncbi.nlm.nih.gov/compound/7427 | PubChem | OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O | Train |
EU_REACH:
4,4'-Methylenebis(N-butoxycarbonylcyclohexanamine) | null | 99305-42-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/20249/7/4/2/?documentUUID=e113222c-646e-45bf-b87e-8df97c8f14f8 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CCCCOC(=O)NC1CCC(CC1)CC2CCC(CC2)NC(=O)OCCCC | https://pubchem.ncbi.nlm.nih.gov/compound/11742316 | PubChem | CCCCOC(=O)NC1CCC(CC2CCC(NC(=O)OCCCC)CC2)CC1 | Train |
EU_REACH:
trimethylsilane | null | 993-07-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19701/7/4/2/?documentUUID=b97fb748-c412-4f1e-8725-5e76728b4248 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C[SiH](C)C | https://pubchem.ncbi.nlm.nih.gov/compound/70435 | PubChem | C[SiH](C)C | Train |
NZ_CCID:
3,5-Dinitrobenzoyl chloride | null | 99-33-2 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/42A7A118-D942-47EB-9B2E-063759012F7E | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=C(C=C(C=C1[N+](=O)[O-])[N+](=O)[O-])C(=O)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/7432 | PubChem | O=C(Cl)c1cc([N+](=O)[O-])cc([N+](=O)[O-])c1 | Train |
JP_CHRIP:
tert-Amyl methyl ether [TAME or 2-methoxy-2-methylbentane] | JP_CHRIP:
1,1-Dimethyl propylmethyl ether
2-Methyl-2-methoxybutane
Butane, 2-methoxy-2-methyl-
Methyl-tert-pentyl ether
TAME
tert-Pentyl methyl ether | 994-05-8 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0020e.html | JP_CHRIP:
In a skin irritation test using rabbits (OECD TG 404, GLP compliance), 4-hour application with 500 micro L this substance (98.4%) resulted in the irritation score of 0, and it was judged to be not irritating (EU-RAR (2006)). From the above result, it was judged to be "Not classified." | Provided | JP_CHRIP | 1 | CCC(C)(C)OC | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J125.007H | J-GLOBAL | CCC(C)(C)OC | Train |
EU_REACH:
chlorotriethylsilane
NZ_CCID:
Chlorotriethylsilane | null | 994-30-9 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/19870/7/4/2/?documentUUID=0376eda7-1481-43e3-a105-965f183d3948
NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/12EB044C-011B-450A-B037-2351BF6AA3D1 | EU_REACH:
Experimental study (OECD TG 404, GLP)
NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | Provided | EU_REACH, NZ_CCID | 2 | CC[Si](CC)(CC)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/13819 | PubChem | CC[Si](Cl)(CC)CC | Train |
JP_CHRIP:
1,2-Dichloro-4-nitrobenzene | JP_CHRIP:
1,2-Dichloro-4-nitrobenzene
3,4-Dichloronitrobenzene
Benzene, 1,2-dichloro-4-nitro-
DCNB | 99-54-7 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/08-meti-0017e.html | JP_CHRIP:
Since the 24 hour skin irritation/corrosion test with rabbits (OECD TG 404, GLP) did not identify skin irritation (average scored values for erythema/crust and edema:0.2, 0.0) (SIDS (2003)), it was classified into "Not classified". | Provided | JP_CHRIP | 1 | [O-][N+](=O)c1ccc(Cl)c(Cl)c1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J3.584J | J-GLOBAL | O=[N+]([O-])c1ccc(Cl)c(Cl)c1 | Train |
EU_REACH:
1,5,2,4-dioxadithiane 2,2,4,4-tetraoxide | null | 99591-74-9 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/7762/7/4/2/?documentUUID=e8145276-df84-424d-8ad0-bc3ae18b5e65 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1OS(=O)(=O)CS(=O)(=O)O1 | https://pubchem.ncbi.nlm.nih.gov/compound/11600810 | PubChem | O=S1(=O)CS(=O)(=O)OCO1 | Train |
EU_REACH:
3,4,5-trifluorophenol | null | 99627-05-1 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/4466/7/4/2/?documentUUID=738c89d3-4675-48a2-aa3a-8b1832b39883 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=C(C=C(C(=C1F)F)F)O | https://pubchem.ncbi.nlm.nih.gov/compound/2777943 | PubChem | Oc1cc(F)c(F)c(F)c1 | Train |
EU_REACH:
dimethyl(propan-2-yl)amine | null | 996-35-0 | 1Cat 1
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/13880/7/4/2/?documentUUID=7425a16d-9690-43c5-990d-bb20be72b921 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | CC(C)N(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/70452 | PubChem | CC(C)N(C)C | Train |
JP_CHRIP:
m-Dinitrobenzene | JP_CHRIP:
1,3-Dinitrobenzene
1,3-Dinitrobenzol
1,3-DNB
Benzene, 1,3-dinitro-
dinitrobenzene
m-Dinitrobenzene | 99-65-0 | 0NC
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/19-mhlw-2049e.html | JP_CHRIP:
[Rationale for the Classification]
Based on (1) and (2), it was classified as "Not classified."
[Evidence Data]
(1) In a skin irritation test with rabbits according to OECD TG 404, it revealed no irritation (GESTIS (Access on July 2019)).
(2) Although details were unknown, there is a report that no irritation was observed in a skin irritation test with rabbits (ATSDR (1995)).
[Reference Data, etc.]
(3) In a skin irritation test with guinea pigs applied with a formulation containing 0.5% of this substance, no irritation was observed (ATSDR (1995)). | Provided | JP_CHRIP | 1 | [O-][N+](=O)c1cccc(c1)[N+](=O)[O-] | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J1.177K | J-GLOBAL | O=[N+]([O-])c1cccc([N+](=O)[O-])c1 | Train |
NZ_CCID:
Diethylaminotrimethylsilane | NZ_CCID:
N,N-diethyltrimethylsilylamine | 996-50-9 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/FF37B5D2-C349-4EE7-B15B-2363FF81881A | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | CCN(CC)[Si](C)(C)C | https://pubchem.ncbi.nlm.nih.gov/compound/70454 | PubChem | CCN(CC)[Si](C)(C)C | Train |
EU_REACH:
1,2,3-trichloro-12,24-dihydro-5H-naphtho[2,3-h]naphtho[2'',3'':6',7']indolo[2',3':6,7]anthra[2,1,9-mna]acridine-5,10,13,18,25-pentone | null | 99688-45-6 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/24668/7/4/2/?documentUUID=e9988da8-b9fa-423f-a563-dcb52766b31c | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC=C2C(=C1)C(=O)C3=C(C2=O)C4=C(C=C3)C5=CC6=C(C=C5N4)C(=O)C7=C8C6=C(C(=C9C8=C(C=C7)C1=C(N9Cl)C2=C(C=C1)C(=O)C1=CC=CC=C1C2=O)Cl)Cl | https://pubchem.ncbi.nlm.nih.gov/compound/44147486 | PubChem | O=C1c2ccccc2C(=O)c2c1ccc1c2[nH]c2cc3c(=O)c4ccc5c6ccc7c(c6n(Cl)c6c(Cl)c(Cl)c(c3cc21)c4c56)C(=O)c1ccccc1C7=O | Train |
JP_CHRIP:
p-sec-Butylphenol | JP_CHRIP:
4-(1-methylpropyl)phenol
p-sec-butylphenol | 99-71-8 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/12-mhlw-0072e.html | JP_CHRIP:
In a test by a 4-hour semi-occlusive application of 0.5 mL of the undiluted solution of this substance liquefied by heating to the rabbit skin (GLP-compliant), all six animals showed necrosis, PII (primary irritation index) was 7.25, and it was concluded to be corrosive (HPVIS (2009)). Therefore, it was classified in Category 1. | null | JP_CHRIP | 1 | CCC(C)c1ccc(O)cc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J362J | J-GLOBAL | CCC(C)c1ccc(O)cc1 | Train |
NZ_CCID:
2,4'-Dibromoacetophenone | null | 99-73-0 | 1Cat 1
| NZ_CCID: https://www.epa.govt.nz/database-search/chemical-classification-and-information-database-ccid/view/EF35CDD3-C8B4-41E2-9F8F-F6B499D9D2D1 | NZ_CCID:
Skin Irritation
R PHRASE: R 34 [Company Data]
Eye Irritation
R PHRASE: R 34 [Company Data] | null | NZ_CCID | 1 | C1=CC(=CC=C1C(=O)CBr)Br | https://pubchem.ncbi.nlm.nih.gov/compound/7454 | PubChem | O=C(CBr)c1ccc(Br)cc1 | Train |
JP_CHRIP:
4-Isopropylaniline | JP_CHRIP:
4-isopropylaniline | 99-88-7 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/11-mhlw-0013e.html | JP_CHRIP:
On the basis of a result as "corrosive" in a test using rabbits (OECD TG 404: GLP) (IUCLID (2000), it was classified in Category 1. | Provided | JP_CHRIP | 1 | CC(C)c1ccc(N)cc1 | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J11.624F | J-GLOBAL | CC(C)c1ccc(N)cc1 | Train |
JP_CHRIP:
2-Hydroxypropyl acrylate
US_HSDB:
2-Hydroxypropyl acrylate | JP_CHRIP:
2-Propenoic acid, 2-hydroxypropyl ester
Acrylic acid, 2-hydroxypropyl ester
beta-Hydroxypropyl acrylate
Propylene glycol monoacrylate | 999-61-1 | 1Cat 1
| JP_CHRIP: https://www.nite.go.jp/chem/english/ghs/15-mhlw-0067e.html
US_HSDB: https://pubchem.ncbi.nlm.nih.gov/source/hsdb/7913 | JP_CHRIP:
It is reported that in a skin irritation test using rabbits, moderate edema and moderate to severe necrosis were observed after this substance (170 to 250 mg/kg) was locally applied, and moderate chemical burns were found after application of a 10% aqueous solution (ACGIH (7th, 2001)). Moreover, it is reported that moderate irritation was found after open application of an isomer mixture containing 75% this substance (25% 1-hydroxy-2-propyl acrylate) to rabbit skin (DFGOT vol. 16 (2001)). Furthermore, it is reported that severe deep-seated necrosis was observed after 15-minute or 4-hour occlusive application of an isomer mixture containing 66% this substance (33% 1-hydroxy-2-propyl acrylate, 1% free acrylic acid or 1-hydroxy-3-propyl acrylate) (animal species: unknown) (DFGOT vol. 16 (2001)). From the above reports, the substance was classified in Category 1. Besides, it is classified in "Skin. Corr. 1B H314" in EU CLP classification (ECHA CL Inventory (Access on September 2015)). | null | JP_CHRIP, US_HSDB | 2 | CC(O)COC(=O)C=C | https://jglobal.jst.go.jp/en/redirect?Nikkaji_No=J33.773K | J-GLOBAL | C=CC(=O)OCC(C)O | Train |
EU_REACH:
4-hydroxybenzoic acid | null | 99-96-7 | 0NC
| EU_REACH: https://echa.europa.eu/registration-dossier/-/registered-dossier/15944/7/4/2/?documentUUID=500bdcb0-2581-4d12-8cfb-3faea4b487c7 | EU_REACH:
Experimental study (OECD TG 404, GLP) | Provided | EU_REACH | 1 | C1=CC(=CC=C1C(=O)O)O | https://pubchem.ncbi.nlm.nih.gov/compound/135 | PubChem | O=C(O)c1ccc(O)cc1 | Train |