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In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Moreover , we were able to restore the peroxisomal beta - oxidation defect in the liver of ALDP - deficient mice by stimulation of ALDRP and PMP70 gene expression through a dietary treatment with the peroxisome proliferator fenofibrate .
### Output Text: | Moreover , we were able to restore the peroxisomal beta - oxidation defect in the liver of ALDP - deficient mice by stimulation of ALDRP and PMP70 gene expression through a dietary treatment with the peroxisome proliferator fenofibrate . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These results suggest that a correction of the biochemical defect in X - ALD could be possible by drug - induced overexpression or ectopic expression of ALDRP . .
### Output Text: | These results suggest that a correction of the biochemical defect in <span class="disease">X - ALD</span> could be possible by drug - induced overexpression or ectopic expression of ALDRP . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Centrosome amplification and a defective G2 - M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform - deficient cells .
### Output Text: | Centrosome amplification and a defective G2 - M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform - deficient cells . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Germline mutations of the Brca1 tumor suppressor gene predispose women to breast and ovarian cancers .
### Output Text: | Germline mutations of the Brca1 <span class="disease">tumor</span> suppressor gene predispose women to <span class="disease">breast and ovarian cancers</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: To study mechanisms underlying BRCA1 - related tumorigenesis , we derived mouse embryonic fibroblast cells carrying a targeted deletion of exon 11 of the Brca1 gene .
### Output Text: | To study mechanisms underlying BRCA1 - related tumorigenesis , we derived mouse embryonic fibroblast cells carrying a targeted deletion of exon 11 of the Brca1 gene . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We show that the mutant cells maintain an intact G1 - S cell cycle checkpoint and proliferate poorly .
### Output Text: | We show that the mutant cells maintain an intact G1 - S cell cycle checkpoint and proliferate poorly . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: However , a defective G2 - M checkpoint in these cells is accompanied by extensive chromosomal abnormalities .
### Output Text: | However , a defective G2 - M checkpoint in these cells is accompanied by extensive <span class="disease">chromosomal abnormalities</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Mutant fibroblasts contain multiple , functional centrosomes , which lead to unequal chromosome segregation , abnormal nuclear division , and aneuploidy .
### Output Text: | Mutant fibroblasts contain multiple , functional centrosomes , which lead to unequal chromosome segregation , abnormal nuclear division , and <span class="disease">aneuploidy</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These data uncover an essential role of BRCA1 in maintaining genetic stability through the regulation of centrosome duplication and the G2 - M checkpoint and provide a molecular basis for the role of BRCA1 in tumorigenesis . .
### Output Text: | These data uncover an essential role of BRCA1 in maintaining genetic stability through the regulation of centrosome duplication and the G2 - M checkpoint and provide a molecular basis for the role of BRCA1 in tumorigenesis . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Defective CD95 / APO - 1 / Fas signal complex formation in the human autoimmune lymphoproliferative syndrome , type Ia .
### Output Text: | Defective CD95 / APO - 1 / Fas signal complex formation in the human <span class="disease">autoimmune lymphoproliferative syndrome , type Ia</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Heterozygous mutations in the CD95 ( APO - 1 / Fas ) receptor occur in most individuals with autoimmune lymphoproliferative syndrome ( ALPS ) and dominantly interfere with apoptosis by an unknown mechanism .
### Output Text: | Heterozygous mutations in the CD95 ( APO - 1 / Fas ) receptor occur in most individuals with <span class="disease">autoimmune lymphoproliferative syndrome</span> ( <span class="disease">ALPS</span> ) and dominantly interfere with apoptosis by an unknown mechanism . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We show that local or global alterations in the structure of the cytoplasmic death domain from nine independent ALPS CD95 death - domain mutations result in a failure to bind the FADD / MORT1 signaling protein .
### Output Text: | We show that local or global alterations in the structure of the cytoplasmic death domain from nine independent <span class="disease">ALPS</span> CD95 death - domain mutations result in a failure to bind the FADD / MORT1 signaling protein . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Despite heterozygosity for the abnormal allele , lymphocytes from ALPS patients showed markedly decreased FADD association and a loss of caspase recruitment and activation after CD95 crosslinking .
### Output Text: | Despite heterozygosity for the abnormal allele , lymphocytes from <span class="disease">ALPS</span> patients showed markedly decreased FADD association and a loss of caspase recruitment and activation after CD95 crosslinking . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These data suggest that intracytoplasmic CD95 mutations in ALPS impair apoptosis chiefly by disrupting death - domain interactions with the signaling protein FADD / MORT1 . .
### Output Text: | These data suggest that intracytoplasmic CD95 mutations in <span class="disease">ALPS</span> impair apoptosis chiefly by disrupting death - domain interactions with the signaling protein FADD / MORT1 . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Analysis of alkaptonuria ( AKU ) mutations and polymorphisms reveals that the CCC sequence motif is a mutational hot spot in the homogentisate 1 , 2 dioxygenase gene ( HGO ) .
### Output Text: | Analysis of <span class="disease">alkaptonuria</span> ( <span class="disease">AKU</span> ) mutations and polymorphisms reveals that the CCC sequence motif is a mutational hot spot in the homogentisate 1 , 2 dioxygenase gene ( HGO ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: We recently showed that alkaptonuria ( AKU ) is caused by loss - of - function mutations in the homogentisate 1 , 2 dioxygenase gene ( HGO ) .
### Output Text: | We recently showed that <span class="disease">alkaptonuria</span> ( <span class="disease">AKU</span> ) is caused by loss - of - function mutations in the homogentisate 1 , 2 dioxygenase gene ( HGO ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Herein we describe haplotype and mutational analyses of HGO in seven new AKU pedigrees .
### Output Text: | Herein we describe haplotype and mutational analyses of HGO in seven new <span class="disease">AKU</span> pedigrees . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: These analyses identified two novel single - nucleotide polymorphisms ( INV4 + 31A - - > G and INV11 + 18A - - > G ) and six novel AKU mutations ( INV1 - 1G - - > A , W60G , Y62C , A122D , P230T , and D291E ) , which further illustrates the remarkable allelic heterogeneity found in AKU .
### Output Text: | These analyses identified two novel single - nucleotide polymorphisms ( INV4 + 31A - - > G and INV11 + 18A - - > G ) and six novel <span class="disease">AKU</span> mutations ( INV1 - 1G - - > A , W60G , Y62C , A122D , P230T , and D291E ) , which further illustrates the remarkable allelic heterogeneity found in <span class="disease">AKU</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Reexamination of all 29 mutations and polymorphisms thus far described in HGO shows that these nucleotide changes are not randomly distributed ; the CCC sequence motif and its inverted complement , GGG , are preferentially mutated .
### Output Text: | Reexamination of all 29 mutations and polymorphisms thus far described in HGO shows that these nucleotide changes are not randomly distributed ; the CCC sequence motif and its inverted complement , GGG , are preferentially mutated . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These analyses also demonstrated that the nucleotide substitutions in HGO do not involve CpG dinucleotides , which illustrates important differences between HGO and other genes for the occurrence of mutation at specific short - sequence motifs .
### Output Text: | These analyses also demonstrated that the nucleotide substitutions in HGO do not involve CpG dinucleotides , which illustrates important differences between HGO and other genes for the occurrence of mutation at specific short - sequence motifs . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Because the CCC sequence motifs comprise a significant proportion ( 34 . 5 % ) of all mutated bases that have been observed in HGO , we conclude that the CCC triplet is a mutational hot spot in HGO .
### Output Text: | Because the CCC sequence motifs comprise a significant proportion ( 34 . 5 % ) of all mutated bases that have been observed in HGO , we conclude that the CCC triplet is a mutational hot spot in HGO . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Fabry disease : identification of novel alpha - galactosidase A mutations and molecular carrier detection by use of fluorescent chemical cleavage of mismatches .
### Output Text: | <span class="disease">Fabry disease</span> : identification of novel alpha - galactosidase A mutations and molecular carrier detection by use of fluorescent chemical cleavage of mismatches . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Fabry disease ( FD ) ( angiokeratoma corporis diffusum ) is an X - linked inborn error of glycosphingolipid metabolism caused by defects in the lysosomal alpha - galactosidase A gene ( GLA ) .
### Output Text: | <span class="disease">Fabry disease</span> ( <span class="disease">FD</span> ) ( <span class="disease">angiokeratoma corporis diffusum</span> ) is an <span class="disease">X - linked inborn error of glycosphingolipid metabolism</span> caused by defects in the lysosomal alpha - galactosidase A gene ( GLA ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The enzymatic defect leads to the systemic accumulation of neutral glycosphingolipids with terminal alpha - galactosyl moieties .
### Output Text: | The enzymatic defect leads to the systemic accumulation of neutral glycosphingolipids with terminal alpha - galactosyl moieties . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Clinically , affected hemizygous males have angiokeratoma , severe acroparesthesia , renal failure , and vasculopathy of the heart and brain .
### Output Text: | Clinically , affected hemizygous males have <span class="disease">angiokeratoma</span> , <span class="disease">severe acroparesthesia</span> , <span class="disease">renal failure</span> , and <span class="disease">vasculopathy of the heart and brain</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: While demonstration of alpha - galactosidase deficiency in leukocytes is diagnostic in affected males , enzymatic detection of female carriers is often inconclusive , due to random X - chromosomal inactivation , underlining the need of molecular investigations for accurate genetic counseling .
### Output Text: | While demonstration of <span class="disease">alpha - galactosidase deficiency</span> in leukocytes is diagnostic in affected males , enzymatic detection of female carriers is often inconclusive , due to random X - chromosomal inactivation , underlining the need of molecular investigations for accurate genetic counseling . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: By use of chemical cleavage of mismatches adapted to fluorescence - based detection systems , we have characterized the mutations underlying alpha - Gal A deficiency in 16 individuals from six unrelated families with FD .
### Output Text: | By use of chemical cleavage of mismatches adapted to fluorescence - based detection systems , we have characterized the mutations underlying <span class="disease">alpha - Gal A deficiency</span> in 16 individuals from six unrelated families with <span class="disease">FD</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The mutational spectrum included five missense mutations ( C202W , C223G , N224D , R301Q , and Q327K ) and one splice - site mutation [ IVS3 G ( - 1 ) - - > C ] .
### Output Text: | The mutational spectrum included five missense mutations ( C202W , C223G , N224D , R301Q , and Q327K ) and one splice - site mutation [ IVS3 G ( - 1 ) - - > C ] . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Studies at the mRNA level showed that the latter led to altered pre - mRNA splicing with consequent alteration of the mRNA translational reading frame and generation of a premature termination codon of translation .
### Output Text: | Studies at the mRNA level showed that the latter led to altered pre - mRNA splicing with consequent alteration of the mRNA translational reading frame and generation of a premature termination codon of translation . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: By use of this strategy , carrier status was accurately assessed in all seven at - risk females tested , whereas enzymatic dosages failed to diagnose or exclude heterozygosity . .
### Output Text: | By use of this strategy , carrier status was accurately assessed in all seven at - risk females tested , whereas enzymatic dosages failed to diagnose or exclude heterozygosity . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Prenatal diagnosis by FISH in a family with Pelizaeus - Merzbacher disease caused by duplication of PLP gene .
### Output Text: | Prenatal diagnosis by FISH in a family with <span class="disease">Pelizaeus - Merzbacher disease</span> caused by duplication of PLP gene . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: A diagnosis of Pelizaeus - Merzbacher disease ( MIM 312080 ) was made in a young boy .
### Output Text: | A diagnosis of <span class="disease">Pelizaeus - Merzbacher disease</span> ( MIM 312080 ) was made in a young boy . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: No mutation in the coding region of the proteolipid protein ( PLP ) gene had been found .
### Output Text: | No mutation in the coding region of the proteolipid protein ( PLP ) gene had been found . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The boys maternal aunt came for prenatal diagnosis when 16 + weeks pregnant and carrying a male fetus .
### Output Text: | The boys maternal aunt came for prenatal diagnosis when 16 + weeks pregnant and carrying a male fetus . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Samples were tested for duplication of the PLP gene , by interphase FISH , in lymphocyte preparations from the proband , his aunt and an amniotic fluid cell preparation from the fetus .
### Output Text: | Samples were tested for duplication of the PLP gene , by interphase FISH , in lymphocyte preparations from the proband , his aunt and an amniotic fluid cell preparation from the fetus . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The proband was found to carry the duplication , thus confirming the diagnosis of Pelizaeus Merzbacher disease , but neither the aunt nor the fetus carried a duplication . .
### Output Text: | The proband was found to carry the duplication , thus confirming the diagnosis of <span class="disease">Pelizaeus Merzbacher disease</span> , but neither the aunt nor the fetus carried a duplication . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Dominant negative effect of the APC1309 mutation : a possible explanation for genotype - phenotype correlations in familial adenomatous polyposis .
### Output Text: | Dominant negative effect of the APC1309 mutation : a possible explanation for genotype - phenotype correlations in <span class="disease">familial adenomatous polyposis</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Inactivation of the adenomatous polyposis coli ( APC ) gene product initiates colorectal tumorigenesis .
### Output Text: | Inactivation of the <span class="disease">adenomatous polyposis coli</span> ( <span class="disease">APC</span> ) gene product initiates colorectal tumorigenesis . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Patients with familial APC ( FAP ) carry germ - line mutations in the APC gene and develop multiple colorectal adenomas and subsequent carcinomas early in life .
### Output Text: | Patients with <span class="disease">familial APC</span> ( <span class="disease">FAP</span> ) carry germ - line mutations in the <span class="disease">APC</span> gene and develop multiple <span class="disease">colorectal adenomas</span> and subsequent <span class="disease">carcinomas</span> early in life . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The severity of the disease correlates with the position of the inherited APC mutation ( genotype - phenotype correlation ) .
### Output Text: | The severity of the disease correlates with the position of the inherited <span class="disease">APC</span> mutation ( genotype - phenotype correlation ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Together with the fact that both germ - line and sporadic APC mutations cluster in the central region of the APC gene , this points to a dominant negative effect of certain APC mutants .
### Output Text: | Together with the fact that both germ - line and sporadic <span class="disease">APC</span> mutations cluster in the central region of the <span class="disease">APC</span> gene , this points to a dominant negative effect of certain <span class="disease">APC</span> mutants . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Loss of APC function was recently shown to result in enhanced beta - catenin - / Tcf - mediated transcription in colon epithelial cells .
### Output Text: | Loss of <span class="disease">APC</span> function was recently shown to result in enhanced beta - catenin - / Tcf - mediated transcription in colon epithelial cells . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Here , we provide experimental evidence for a dominant negative effect of APC gene products associated with severe polyposis .
### Output Text: | Here , we provide experimental evidence for a dominant negative effect of <span class="disease">APC</span> gene products associated with severe <span class="disease">polyposis</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Wild - type APC activity in beta - catenin - / Tcf - mediated transcription was strongly inhibited by a mutant APC that is truncated at codon 1309 .
### Output Text: | Wild - type <span class="disease">APC</span> activity in beta - catenin - / Tcf - mediated transcription was strongly inhibited by a mutant <span class="disease">APC</span> that is truncated at codon 1309 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In contrast , mutant APC gene products that are associated with attenuated polyposis ( codon 386 or 1465 ) interfered only weakly with wild - type APC activity .
### Output Text: | In contrast , mutant <span class="disease">APC</span> gene products that are associated with <span class="disease">attenuated polyposis</span> ( codon 386 or 1465 ) interfered only weakly with wild - type <span class="disease">APC</span> activity . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: These results suggest a molecular explanation for the genotype - phenotype correlation in FAP patients and support the idea that colorectal tumor growth might be , in part , driven by selection for a mutation in the mutation cluster region . .
### Output Text: | These results suggest a molecular explanation for the genotype - phenotype correlation in <span class="disease">FAP</span> patients and support the idea that <span class="disease">colorectal tumor</span> growth might be , in part , driven by selection for a mutation in the mutation cluster region . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: BRCA1 interacts with components of the histone deacetylase complex .
### Output Text: | BRCA1 interacts with components of the histone deacetylase complex . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Germ - line mutations in the BRCA1 tumor - suppressor gene are associated with an increased susceptibility to breast and ovarian cancer .
### Output Text: | Germ - line mutations in the BRCA1 tumor - suppressor gene are associated with an increased susceptibility to <span class="disease">breast and ovarian cancer</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: BRCA1 contains a carboxyl - terminal domain ( BRCT ) that is shared with several other proteins involved in maintaining genome integrity .
### Output Text: | BRCA1 contains a carboxyl - terminal domain ( BRCT ) that is shared with several other proteins involved in maintaining genome integrity . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: In an effort to understand the function of BRCA1 , we sought to isolate proteins that interact with the BRCT domain .
### Output Text: | In an effort to understand the function of BRCA1 , we sought to isolate proteins that interact with the BRCT domain . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Purified BRCT polypeptide was used as a probe to screen a human placenta cDNA expression library by Far Western analysis .
### Output Text: | Purified BRCT polypeptide was used as a probe to screen a human placenta cDNA expression library by Far Western analysis . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Here we report that BRCA1 interacts in vivo and in vitro with the Rb - binding proteins , RbAp46 and RbAp48 , as well as with Rb .
### Output Text: | Here we report that BRCA1 interacts in vivo and in vitro with the Rb - binding proteins , RbAp46 and RbAp48 , as well as with Rb . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Moreover , the BRCT domain associates with the histone deacetylases HDAC1 and HDAC2 .
### Output Text: | Moreover , the BRCT domain associates with the histone deacetylases HDAC1 and HDAC2 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: These results demonstrate that BRCA1 interacts with components of the histone deacetylase complex , and therefore may explain the involvement of BRCA1 in multiple processes such as transcription , DNA repair , and recombination . .
### Output Text: | These results demonstrate that BRCA1 interacts with components of the histone deacetylase complex , and therefore may explain the involvement of BRCA1 in multiple processes such as transcription , DNA repair , and recombination . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Combined genetic deficiency of C6 and C7 in man .
### Output Text: | <span class="disease">Combined genetic deficiency of C6 and C7</span> in man . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
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### Input Text: By routine screening of sera , a subject was discovered who showed a sub - total deficiency of C6 and C7 .
### Output Text: | By routine screening of sera , a subject was discovered who showed a <span class="disease">sub - total deficiency of C6 and C7</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: No clinical disease was associated with this deficiency which was transmitted through the subjects family as a single genetic characteristic , the C6 deficiency being associated with a silent allele at the structural locus .
### Output Text: | No clinical disease was associated with this deficiency which was transmitted through the subjects family as a single genetic characteristic , the <span class="disease">C6 deficiency</span> being associated with a silent allele at the structural locus . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: The propositus was found to have low quantities of an abnormal C6 which was both antigenically deficient and smaller in size than normal C6 ( 110 , 000 daltons compared with 140 , 000 daltons ) and small quantities of apparently normal C7 .
### Output Text: | The propositus was found to have low quantities of an abnormal C6 which was both antigenically deficient and smaller in size than normal C6 ( 110 , 000 daltons compared with 140 , 000 daltons ) and small quantities of apparently normal C7 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: It is concluded that the most likely explanation for this defect is that the subject has a structural mutation in his C6 gene which produces hyopsynthesis not only of C6 but also of the closely linked gene for C7 .
### Output Text: | It is concluded that the most likely explanation for this defect is that the subject has a structural mutation in his C6 gene which produces hyopsynthesis not only of C6 but also of the closely linked gene for C7 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
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### Input Text: These findings suggest the possibility that C6 and C7 may function as a single genetic unit and that the primary transcript copied from the genome includes information for both proteins . .
### Output Text: | These findings suggest the possibility that C6 and C7 may function as a single genetic unit and that the primary transcript copied from the genome includes information for both proteins . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Changes at P183 of emerin weaken its protein - protein interactions resulting in X - linked Emery - Dreifuss muscular dystrophy .
### Output Text: | Changes at P183 of emerin weaken its protein - protein interactions resulting in <span class="disease">X - linked Emery - Dreifuss muscular dystrophy</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Emery - Dreifuss muscular dystrophy ( EDMD ) is an X - linked recessive muscular dystrophy characterized by early contractures of the elbows , Achilles tendons and spine , slowly progressive muscle wasting and weakness , and cardiomyopathy associated with cardiac conduction defects .
### Output Text: | <span class="disease">Emery - Dreifuss muscular dystrophy</span> ( <span class="disease">EDMD</span> ) is an <span class="disease">X - linked recessive muscular dystrophy</span> characterized by early <span class="disease">contractures of the elbows , Achilles tendons and spine</span> , slowly progressive <span class="disease">muscle wasting</span> and <span class="disease">weakness</span> , and <span class="disease">cardiomyopathy</span> associated with <span class="disease">cardiac conduction defects</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: The emerin gene has been mapped to Xq28 and encodes a 34 - kDa serine - rich protein , emerin , which has been localized to the nuclear envelope in a wide variety of tissues , including skeletal and cardiac muscle .
### Output Text: | The emerin gene has been mapped to Xq28 and encodes a 34 - kDa serine - rich protein , emerin , which has been localized to the nuclear envelope in a wide variety of tissues , including skeletal and cardiac muscle . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Mutations spanning the emerin gene have been identified in patients with EDMD .
### Output Text: | Mutations spanning the emerin gene have been identified in patients with <span class="disease">EDMD</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: We present here the effect , on emerin protein expression , of two missense mutations identified in unrelated EDMD patients .
### Output Text: | We present here the effect , on emerin protein expression , of two missense mutations identified in unrelated <span class="disease">EDMD</span> patients . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: These alterations predict the replacement of a proline residue at position 183 with either a histidine or a threonine .
### Output Text: | These alterations predict the replacement of a proline residue at position 183 with either a histidine or a threonine . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Biochemical analysis has demonstrated that the mobility and expression levels of the mutant forms of emerin are indistinguishable from that of wild - type emerin , but that they have weakened interactions with nuclear lamina components .
### Output Text: | Biochemical analysis has demonstrated that the mobility and expression levels of the mutant forms of emerin are indistinguishable from that of wild - type emerin , but that they have weakened interactions with nuclear lamina components . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: In comparison with the usual EDMD phenotype , patients with P183 missense mutations have a later age at onset of first symptoms , elbow contractures , ankle contractures , upper limb weakness and lower limb weakness , but there is no difference for the age at onset of cardiac involvement .
### Output Text: | In comparison with the usual <span class="disease">EDMD</span> phenotype , patients with P183 missense mutations have a later age at onset of first symptoms , <span class="disease">elbow contractures</span> , <span class="disease">ankle contractures</span> , <span class="disease">upper limb weakness</span> and <span class="disease">lower limb weakness</span> , but there is no difference for the age at onset of <span class="disease">cardiac involvement</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: This is the first report of protein studies on patients with missense mutations resulting in the clinical features of EDMD .
### Output Text: | This is the first report of protein studies on patients with missense mutations resulting in the clinical features of <span class="disease">EDMD</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: These studies demonstrate the importance of proline 183 for the proper structure / function of emerin . .
### Output Text: | These studies demonstrate the importance of proline 183 for the proper structure / function of emerin . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Microdeletions at chromosome bands 1q32 - q41 as a cause of Van der Woude syndrome .
### Output Text: | Microdeletions at chromosome bands 1q32 - q41 as a cause of <span class="disease">Van der Woude syndrome</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Van der Woude syndrome ( VWS ) is an autosomal dominant disorder comprising cleft lip and / or cleft palate and lip pits .
### Output Text: | <span class="disease">Van der Woude syndrome</span> ( <span class="disease">VWS</span> ) is an <span class="disease">autosomal dominant disorder</span> comprising <span class="disease">cleft lip</span> and / or <span class="disease">cleft palate</span> and <span class="disease">lip pits</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: We reported previously a family whose underlying mutation is a 500 - 800 kb deletion localized to chromosome bands 1q32 - q41 [ Sander et al . , 1994 Hum Mol Genet 3 576 - 578 ] .
### Output Text: | We reported previously a family whose underlying mutation is a 500 - 800 kb deletion localized to chromosome bands 1q32 - q41 [ Sander et al . , 1994 Hum Mol Genet 3 576 - 578 ] . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Along with cleft lip / palate and lip pits , affected relatives exhibit developmental delays , suggesting that the function of a gene nearby may also be disrupted .
### Output Text: | Along with <span class="disease">cleft lip / palate</span> and <span class="disease">lip pits</span> , affected relatives exhibit <span class="disease">developmental delays</span> , suggesting that the function of a gene nearby may also be disrupted . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: To further localize the VWS gene we searched for other deletions that cause VWS .
### Output Text: | To further localize the <span class="disease">VWS</span> gene we searched for other deletions that cause <span class="disease">VWS</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: An allele loss assay was performed using a novel highly polymorphic marker , D1S3753 .
### Output Text: | An allele loss assay was performed using a novel highly polymorphic marker , D1S3753 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: From a panel of 37 unrelated individuals , we detected an allele loss in one family , indicating the presence of a deletion .
### Output Text: | From a panel of 37 unrelated individuals , we detected an allele loss in one family , indicating the presence of a deletion . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: In this family , the phenotype in three generations of affected individuals was confined to the cardinal signs of VWS .
### Output Text: | In this family , the phenotype in three generations of affected individuals was confined to the cardinal signs of <span class="disease">VWS</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Surprisingly , mapping of the new deletion showed that it extended 0 .
### Output Text: | Surprisingly , mapping of the new deletion showed that it extended 0 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: 2 - 1 Mb beyond the proximal breakpoint for the deletion described previously .
### Output Text: | 2 - 1 Mb beyond the proximal breakpoint for the deletion described previously . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: No deletions were detected in seven cases of popliteal pterygia syndrome , 76 cases of mixed syndromic forms of cleft lip and palate , and 178 cases of nonsyndromic cleft lip and palate .
### Output Text: | No deletions were detected in seven cases of <span class="disease">popliteal pterygia syndrome</span> , 76 cases of mixed <span class="disease">syndromic forms of cleft lip and palate</span> , and 178 cases of <span class="disease">nonsyndromic cleft lip and palate</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Splicing defects in the ataxia - telangiectasia gene , ATM : underlying mutations and consequences .
### Output Text: | Splicing defects in the <span class="disease">ataxia - telangiectasia</span> gene , ATM : underlying mutations and consequences . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Mutations resulting in defective splicing constitute a significant proportion ( 30 / 62 [ 48 % ] ) of a new series of mutations in the ATM gene in patients with ataxia - telangiectasia ( AT ) that were detected by the protein - truncation assay followed by sequence analysis of genomic DNA .
### Output Text: | Mutations resulting in defective splicing constitute a significant proportion ( 30 / 62 [ 48 % ] ) of a new series of mutations in the ATM gene in patients with <span class="disease">ataxia - telangiectasia</span> ( <span class="disease">AT</span> ) that were detected by the protein - truncation assay followed by sequence analysis of genomic DNA . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Fewer than half of the splicing mutations involved the canonical AG splice - acceptor site or GT splice - donor site .
### Output Text: | Fewer than half of the splicing mutations involved the canonical AG splice - acceptor site or GT splice - donor site . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: A higher percentage of mutations occurred at less stringently conserved sites , including silent mutations of the last nucleotide of exons , mutations in nucleotides other than the conserved AG and GT in the consensus splice sites , and creation of splice - acceptor or splice - donor sites in either introns or exons .
### Output Text: | A higher percentage of mutations occurred at less stringently conserved sites , including silent mutations of the last nucleotide of exons , mutations in nucleotides other than the conserved AG and GT in the consensus splice sites , and creation of splice - acceptor or splice - donor sites in either introns or exons . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: These splicing mutations led to a variety of consequences , including exon skipping and , to a lesser degree , intron retention , activation of cryptic splice sites , or creation of new splice sites .
### Output Text: | These splicing mutations led to a variety of consequences , including exon skipping and , to a lesser degree , intron retention , activation of cryptic splice sites , or creation of new splice sites . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: In addition , 5 of 12 nonsense mutations and 1 missense mutation were associated with deletion in the cDNA of the exons in which the mutations occurred .
### Output Text: | In addition , 5 of 12 nonsense mutations and 1 missense mutation were associated with deletion in the cDNA of the exons in which the mutations occurred . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: No ATM protein was detected by western blotting in any AT cell line in which splicing mutations were identified .
### Output Text: | No ATM protein was detected by western blotting in any <span class="disease">AT</span> cell line in which splicing mutations were identified . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Several cases of exon skipping in both normal controls and patients for whom no underlying defect could be found in genomic DNA were also observed , suggesting caution in the interpretation of exon deletions observed in ATM cDNA when there is no accompanying identification of genomic mutations . .
### Output Text: | Several cases of exon skipping in both normal controls and patients for whom no underlying defect could be found in genomic DNA were also observed , suggesting caution in the interpretation of exon deletions observed in ATM cDNA when there is no accompanying identification of genomic mutations . . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Alpha - cardiac actin is a novel disease gene in familial hypertrophic cardiomyopathy .
### Output Text: | Alpha - cardiac actin is a novel disease gene in <span class="disease">familial hypertrophic cardiomyopathy</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: We identified the alpha - cardiac actin gene ( ACTC ) as a novel disease gene in a pedigree suffering from familial hypertrophic cardiomyopathy ( FHC ) .
### Output Text: | We identified the alpha - cardiac actin gene ( ACTC ) as a novel disease gene in a pedigree suffering from <span class="disease">familial hypertrophic cardiomyopathy</span> ( <span class="disease">FHC</span> ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Linkage analyses excluded all the previously reported FHC loci as possible disease loci in the family studied , with lod scores varying between - 2 .
### Output Text: | Linkage analyses excluded all the previously reported <span class="disease">FHC</span> loci as possible disease loci in the family studied , with lod scores varying between - 2 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: 5 and - 6 .
### Output Text: | 5 and - 6 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: 0 0 .
### Output Text: | 0 0 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Further linkage analyses of plausible candidate genes highly expressed in the adult human heart identified ACTC as the most likely disease gene , showing a maximal lod score of 3 .
### Output Text: | Further linkage analyses of plausible candidate genes highly expressed in the adult human heart identified ACTC as the most likely disease gene , showing a maximal lod score of 3 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: 6 6 .
### Output Text: | 6 6 . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: Mutation analysis of ACTC revealed an Ala295Ser mutation in exon 5 close to 2 missense mutations recently described to cause the inherited form of idiopathic dilated cardiomyopathy ( IDC ) .
### Output Text: | Mutation analysis of ACTC revealed an Ala295Ser mutation in exon 5 close to 2 missense mutations recently described to cause the inherited form of <span class="disease">idiopathic dilated cardiomyopathy</span> ( <span class="disease">IDC</span> ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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### Input Text: Overgrowth of oral mucosa and facial skin , a novel feature of aspartylglucosaminuria .
### Output Text: | <span class="disease">Overgrowth of oral mucosa and facial skin</span> , a novel feature of <span class="disease">aspartylglucosaminuria</span> . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
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Use <span class="disease"> to denote a disease.
### Input Text: Aspartylglucosaminuria ( AGU ) is a lysosomal storage disorder caused by deficiency of aspartylglucosaminidase ( AGA ) .
### Output Text: | <span class="disease">Aspartylglucosaminuria</span> ( <span class="disease">AGU</span> ) is a <span class="disease">lysosomal storage disorder</span> caused by <span class="disease">deficiency of aspartylglucosaminidase</span> ( AGA ) . |
In the sentence extracted from biomedical literature, identify all the disease entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="disease"> to denote a disease.
### Input Text: The main symptom is progressive mental retardation .
### Output Text: | The main symptom is progressive <span class="disease">mental retardation</span> . |