Datasets:

Haxirus

/

Fine-Tuning_Dataset

like 0

Does Bupropion and Temazepam interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Temazepam is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Temozolomide interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Temozolomide may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Teniposide interact?

The subject drug is known to be an inhibitor of CYP2C9 while the affected drug is reported to be metabolized by CYP2C9. Concomitant administration of these agents can cause an increase in the serum concentration of the affected drug due to decreased metabolism by CYP2C9, which may result in increased incidence and/or severity of adverse effects related to the affected drug. In short, The metabolism of Bupropion can be decreased when combined with Teniposide, and the severity of the interaction is moderate.

Does Bupropion and Tenofovir alafenamide interact?

Because tenofovir is primarily excreted by the kidneys by a combination of glomerular filtration and active tubular secretion, coadministration of VEMLIDY with drugs that reduce renal function or compete for active tubular secretion may increase concentrations of tenofovir and other renally eliminated drugs and this may increase the risk of adverse reactions. In short, The serum concentration of Tenofovir alafenamide can be increased when it is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Tenofovir disoproxil interact?

The subject drug is a nephrotoxic agent that may potentially impair renal function and decrease the excretion of drugs that mainly undergo renal excretion as the principal mode of clearance, such as the affected drug. Attenuated renal excretion of the affected drug may increase drug concentrations, leading to an elevated risk for drug-related adverse effects. In short, Tenofovir disoproxil may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tenoxicam interact?

The subject drug is a nephrotoxic agent that may potentially impair renal function and decrease the excretion of drugs that mainly undergo renal excretion as the principal mode of clearance, such as the affected drug. Attenuated renal excretion of the affected drug may increase drug concentrations, leading to an elevated risk for drug-related adverse effects. In short, Tenoxicam may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tepotinib interact?

The subject drug is a strong inhibitor of CYP2C9 while the affected drug is metabolized by CYP2C9. Concomitant administration will lead to an increase in serum concentrations of the affected drug, leading to accumulation of the drug and an increase in the risk and severity of adverse effects. In short, The metabolism of Bupropion can be decreased when combined with Tepotinib, and the severity of the interaction is major.

Does Bupropion and Terbinafine interact?

Both of these agents are reported to be metabolized by CYP2C9. Concomitant administration of multiple CYP2C9 substrates can result in competition for the CYP2C9 binding sites and consequently reduced metabolism and increased plasma levels of one or both of the affected drugs. Elevated plasma levels may result in a higher incidence and/or severity of adverse effects. In short, The metabolism of Bupropion can be decreased when combined with Terbinafine, and the severity of the interaction is minor.

Does Bupropion and Terbutaline interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Terbutaline may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Terfenadine interact?

The subject drug is a strong CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, which could increase serum concentrations as well as the risk and severity of adverse effects. In short, The metabolism of Terfenadine can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Testosterone cypionate interact?

When a CYP2B6 substrate is coadministered with another CYP2B6 substrate, both substrates will invariably compete with each other to be metabolized by the limited quantities of CYP2B6 isoenzymes present in the body. When one substrate is subsequently capable of 'out-competing' the other, this other substrate will have its CYP2B6 facilitated metabolism stalled or otherwise decreased for a time, resulting in increased serum concentrations of this substrate and/or an increased risk, incidence, or severity of adverse effects associated with exposure to this substrate. In short, The metabolism of Testosterone cypionate can be decreased when combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Testosterone enanthate interact?

When a CYP2B6 substrate is coadministered with another CYP2B6 substrate, both substrates will invariably compete with each other to be metabolized by the limited quantities of CYP2B6 isoenzymes present in the body. When one substrate is subsequently capable of 'out-competing' the other, this other substrate will have its CYP2B6 facilitated metabolism stalled or otherwise decreased for a time, resulting in increased serum concentrations of this substrate and/or an increased risk, incidence, or severity of adverse effects associated with exposure to this substrate. In short, The metabolism of Testosterone enanthate can be decreased when combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Testosterone propionate interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Testosterone propionate which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Testosterone undecanoate interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Testosterone undecanoate which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Testosterone interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Testosterone may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tetrabenazine interact?

The subject drug is a strong CYP2D6 inhibitor and tetrabenazine is metabolized by CYP2D6. Concomitant administration can reduce the metabolism of tetrabenazine, raising serum concentrations and increasing the risk and severity of adverse reactions like QTc prolongation. However, a single 50mg dose of tetrabenazine has not been shown to increase the QTc interval. In short, The metabolism of Tetrabenazine can be decreased when combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Tetracaine interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Bupropion is combined with Tetracaine, and the severity of the interaction is moderate.

Does Bupropion and Tetracycline interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Tetracycline may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tetradecyl hydrogen sulfate (ester) interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Tetradecyl hydrogen sulfate (ester) which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Thalidomide interact?

Coadministration of thalidomide with other CNS depressants, including alcohol, may cause an additive sedative effect, which can lead to serious respiratory depression and death. Thalidomide is a neurotoxic drug with effects that may be potentiated with CNS depressants. In short, Bupropion may increase the central nervous system depressant (CNS depressant) activities of Thalidomide, and the severity of the interaction is major.

Does Bupropion and Theophylline interact?

Bupropion carries a dose-dependent risk of seizure1 that may be further exacerbated when combined with other medications that can reduce the seizure threshold (i.e. increase the risk of seizure), such as the affected drug. This risk may be also compounded by patient-specific factors that may increase the risk of seizure such as metabolic disorders and illicit drug use. In short, The risk or severity of seizure can be increased when Bupropion is combined with Theophylline, and the severity of the interaction is moderate.

Does Bupropion and Thiethylperazine interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Thiethylperazine is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Thiopental interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Thiopental is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Thioridazine interact?

The subject drug is a strong CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, which could increase serum concentrations as well as the risk and severity of adverse effects. In short, The metabolism of Thioridazine can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Thiosulfuric acid interact?

When a CYP2B6 substrate is administered concurrently with a CYP2B6 inducer of unknown strength, the CYP2B6 mediated metabolism of the substrate will subsequently be enhanced - either slightly, moderately, or greatly. Such increases in metabolism consequently result in decreases in the substrate's serum concentration and/or therapeutic effect. In short, The metabolism of Bupropion can be increased when combined with Thiosulfuric acid, and the severity of the interaction is moderate.

Does Bupropion and Thiotepa interact?

Bupropion is extensively metabolized to hydroxybupropion by CYP2B6. In short, The serum concentration of Bupropion can be increased when it is combined with Thiotepa, and the severity of the interaction is minor.

Does Bupropion and Thiothixene interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Bupropion is combined with Thiothixene, and the severity of the interaction is moderate.

Does Bupropion and Tiagabine interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Tiagabine is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Tiaprofenic acid interact?

The subject drug is a nephrotoxic agent that may potentially impair renal function and decrease the excretion of drugs that mainly undergo renal excretion as the principal mode of clearance, such as the affected drug. Attenuated renal excretion of the affected drug may increase drug concentrations, leading to an elevated risk for drug-related adverse effects. In short, Tiaprofenic acid may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Ticagrelor interact?

The subject drug is known to be a weak inhibitor of CYP2C9 while the affected drug is reported to be metabolized by CYP2C9. Concomitant administration of these agents can cause an increase in the serum concentration of the affected drug due to decreased metabolism by CYP2C9, which may result in increased incidence and/or severity of adverse effects related to the affected drug. In short, The metabolism of Bupropion can be decreased when combined with Ticagrelor, and the severity of the interaction is minor.

Does Bupropion and Ticlopidine interact?

Prescribing information for extended-release bupropion (Wellbutrin® XL) states that its concomitant use with ticlopidine may cause an increase in bupropion exposure and a subsequent decrease in hydroxybupropion (an active bupropion metabolite) exposure. Ticlopidine is known to inhibit CYP2B6, which is the main enzyme involved in the hydroxylation of bupropion to hydroxybupropion - its coadministration with bupropion resulted in an 84% reduction in hydroxybupropion AUC, and an increase in parent drug AUC and Cmax of 73% and 39%, respectively. In short, The metabolism of Bupropion can be decreased when combined with Ticlopidine, and the severity of the interaction is moderate.

Does Bupropion and Timolol interact?

Timolol relies on CYP2D6 enzyme for metabolism. Inhibitors of this enzyme are likely to lead to decreased metabolism and increased exposure to timolol, leading to bradycardia and other adverse effects. In short, The metabolism of Timolol can be decreased when combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Tinidazole interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Tinidazole may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tiopronin interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Tiopronin which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tiotropium interact?

The subject drug is a strong CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, which could increase serum concentrations as well as the risk and severity of adverse effects. In short, The metabolism of Tiotropium can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Tipranavir interact?

The subject drug is a strong CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, which could increase serum concentrations as well as the risk and severity of adverse effects. In short, The metabolism of Tipranavir can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Tirofiban interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Tirofiban may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tixocortol interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Tixocortol which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tizanidine interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Tizanidine is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Tobramycin interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. The affected drug is a narrow therapeutic index drug that undergoes renal excretion as its main elimination pathway: a change in serum concentration may significantly elevate the risk of developing drug-related adverse effects. In short, Bupropion may decrease the excretion rate of Tobramycin which could result in a higher serum level, and the severity of the interaction is moderate.

Does Bupropion and Tocilizumab interact?

The formation of CYP450 enzymes is inhibited by the presence of increased levels of cytokines during chronic inflammation. Agents that reduce cytokine levels can normalize CYP450 formation and increase the metabolism of drugs. This interaction may significantly alter the therapeutic efficacy of CYP2B6 substrates. In short, The metabolism of Bupropion can be increased when combined with Tocilizumab, and the severity of the interaction is moderate.

Does Bupropion and Tocopherol interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Tocopherol which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tolazamide interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Tolazamide may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tolbutamide interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Tolbutamide may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tolcapone interact?

Despite the fact that these drugs are sometimes used in combination to treat depression in Parkinson's disease3, the administration of bupropion with anti-Parkinson drugs may lead to central nervous system toxicity. Bupropion is considered a norepinephrine-dopamine reuptake inhibitor, is found to occupy the DAT dopamine transporter, and acts as a dopamine agonist. Additive effects of these dopaminergic drugs may produce excess dopaminergic activity. Agitation, restlessness, tremor, ataxia, gait disturbance, and dizziness are some examples of effects that may occur from concurrent administration. In short, The risk or severity of adverse effects can be increased when Bupropion is combined with Tolcapone, and the severity of the interaction is moderate.

Does Bupropion and Tolfenamic acid interact?

The subject drug is a nephrotoxic agent that may potentially impair renal function and decrease the excretion of drugs that mainly undergo renal excretion as the principal mode of clearance, such as the affected drug. Attenuated renal excretion of the affected drug may increase drug concentrations, leading to an elevated risk for drug-related adverse effects. In short, Tolfenamic acid may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tolmetin interact?

The subject drug is a nephrotoxic agent that may potentially impair renal function and decrease the excretion of drugs that mainly undergo renal excretion as the principal mode of clearance, such as the affected drug. Attenuated renal excretion of the affected drug may increase drug concentrations, leading to an elevated risk for drug-related adverse effects. In short, Tolmetin may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tolterodine interact?

The subject drug is a strong CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, which could increase serum concentrations as well as the risk and severity of adverse effects. In short, The metabolism of Tolterodine can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Tolvaptan interact?

The subject drug induces diuresis1,2, which can theoretically increase the excretion rate of the affected drug, which is eliminated by the kidneys. Additionally, it could affect renal tubular reabsorption of certain drugs. Exposure to the affected drug can be markedly reduced, leading to subtherapeutic drug levels that are unlikely to elicit an adequate clinical response. In short, Tolvaptan may increase the excretion rate of Bupropion which could result in a lower serum level and potentially a reduction in efficacy, and the severity of the interaction is moderate.

Does Bupropion and Topiramate interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Topiramate is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Topotecan interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Topotecan may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Torasemide interact?

The subject drug induces diuresis1,2, which can theoretically increase the excretion rate of the affected drug, which is eliminated by the kidneys. Additionally, it could affect renal tubular reabsorption of certain drugs. Exposure to the affected drug can be markedly reduced, leading to subtherapeutic drug levels that are unlikely to elicit an adequate clinical response. In short, Torasemide may increase the excretion rate of Bupropion which could result in a lower serum level and potentially a reduction in efficacy, and the severity of the interaction is moderate.

Does Bupropion and Trabectedin interact?

The subject drug is known to be a strong inhibitor of CYP2D6 while the affected drug is reported to be metabolized by CYP2D6. Co-administration of these agents can produce an increase in the serum concentration of the affected drug as a result of a strong inhibition of CYP2D6 activity. This interaction may be significant as the affected drug has a narrow therapeutic index, therefore any increase in the serum concentration of this drug may lead to drastic effects on the tolerability of the medication and a significant increase in incidence or severity of adverse effects. In short, The metabolism of Trabectedin can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Tramadol interact?

Bupropion carries a dose-dependent risk of seizure1 that may be further exacerbated when combined with other medications that can reduce the seizure threshold (i.e. increase the risk of seizure), such as the affected drug. This risk may be also compounded by patient-specific factors that may increase the risk of seizure such as metabolic disorders and illicit drug use. In short, The risk or severity of seizure can be increased when Bupropion is combined with Tramadol, and the severity of the interaction is moderate.

Does Bupropion and Trametinib interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Trametinib which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Tranylcypromine interact?

Bupropion is a dopaminergic agent that is used in the treatment of Parkinson's disease, depression, and smoking cessation. Based on the findings from animal studies, co-administration of bupropion with monoamine oxidase inhibitors may enhance the acute toxicity effects of bupropion, as indicated by an increase in mortality and a decrease in time to death . This interaction applies to both immediate release and sustained release forms of bupropion. In short, The risk or severity of adverse effects can be increased when Tranylcypromine is combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Trazodone interact?

Bupropion carries a dose-dependent risk of seizure1 that may be further exacerbated when combined with other medications that can reduce the seizure threshold (i.e. increase the risk of seizure), such as the affected drug. This risk may be also compounded by patient-specific factors that may increase the risk of seizure such as metabolic disorders and illicit drug use. In short, The risk or severity of seizure can be increased when Bupropion is combined with Trazodone, and the severity of the interaction is moderate.

Does Bupropion and Treprostinil interact?

Both of these agents are reported to be metabolized by CYP2C9. Concomitant administration of multiple CYP2C9 substrates can result in competition for the CYP2C9 binding sites and consequently reduced metabolism and increased plasma levels of one or both of the affected drugs. Elevated plasma levels may result in a higher incidence and/or severity of adverse effects. In short, The metabolism of Bupropion can be decreased when combined with Treprostinil, and the severity of the interaction is minor.

Does Bupropion and Triamterene interact?

The subject drug induces diuresis1,2, which can theoretically increase the excretion rate of the affected drug, which is eliminated by the kidneys. Additionally, it could affect renal tubular reabsorption of certain drugs. Exposure to the affected drug can be markedly reduced, leading to subtherapeutic drug levels that are unlikely to elicit an adequate clinical response. In short, Triamterene may increase the excretion rate of Bupropion which could result in a lower serum level and potentially a reduction in efficacy, and the severity of the interaction is moderate.

Does Bupropion and Triazolam interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Triazolam is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Triclabendazole interact?

Bupropion is extensively metabolized to hydroxybupropion by CYP2B6. In short, The serum concentration of Bupropion can be increased when it is combined with Triclabendazole, and the severity of the interaction is minor.

Does Bupropion and Triethylenetetramine interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Triethylenetetramine which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Trifluoperazine interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Trifluoperazine is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Trifluridine interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Trifluridine may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Trihexyphenidyl interact?

Despite the fact that these drugs are sometimes used in combination to treat depression in Parkinson's disease3, the administration of bupropion with anti-Parkinson drugs may lead to central nervous system toxicity. Bupropion is considered a norepinephrine-dopamine reuptake inhibitor, is found to occupy the DAT dopamine transporter, and acts as a dopamine agonist. Additive effects of these dopaminergic drugs may produce excess dopaminergic activity. Agitation, restlessness, tremor, ataxia, gait disturbance, and dizziness are some examples of effects that may occur from concurrent administration. In short, The risk or severity of adverse effects can be increased when Bupropion is combined with Trihexyphenidyl, and the severity of the interaction is moderate.

Does Bupropion and Trimebutine interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Trimebutine which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Trimethobenzamide interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Trimethobenzamide is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Trimethoprim interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Trimethoprim may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Trimetrexate interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Trimetrexate which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Trimipramine interact?

Bupropion carries a dose-dependent risk of seizure1 that may be further exacerbated when combined with other medications that can reduce the seizure threshold (i.e. increase the risk of seizure), such as the affected drug. This risk may be also compounded by patient-specific factors that may increase the risk of seizure such as metabolic disorders and illicit drug use. In short, The risk or severity of seizure can be increased when Bupropion is combined with Trimipramine, and the severity of the interaction is moderate.

Does Bupropion and Triprolidine interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Triprolidine is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Tropisetron interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Bupropion is combined with Tropisetron, and the severity of the interaction is moderate.

Does Bupropion and Tryptophan interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Tryptophan is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Umeclidinium interact?

The subject drug is a strong CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, which could increase serum concentrations as well as the risk and severity of adverse effects. In short, The metabolism of Umeclidinium can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Vadadustat interact?

Vadadustat is a mild inducer of CYP2B6. Therefore, the co-administration of vadadustat with sensitive substrates of CYP2B6 may alter their pharmacokinetics and decrease their concentration. In short, The serum concentration of Bupropion can be decreased when it is combined with Vadadustat, and the severity of the interaction is minor.

Does Bupropion and Valaciclovir interact?

The subject drug is a nephrotoxic agent that may potentially impair renal function and decrease the excretion of drugs that mainly undergo renal excretion as the principal mode of clearance, such as the affected drug. Attenuated renal excretion of the affected drug may increase drug concentrations, leading to an elevated risk for drug-related adverse effects. In short, Valaciclovir may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Valbenazine interact?

Since [+]-α-HTBZ, a valbenazine metabolite, is metabolized by CYP2D6, the co-administration of valbenazine with a strong CYP2D6 inhibitor can increase the exposure to valbenazine and thus increase the risk of exposure-related adverse reactions. In short, The serum concentration of Valbenazine can be increased when it is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Valdecoxib interact?

The subject drug is a nephrotoxic agent that may potentially impair renal function and decrease the excretion of drugs that mainly undergo renal excretion as the principal mode of clearance, such as the affected drug. Attenuated renal excretion of the affected drug may increase drug concentrations, leading to an elevated risk for drug-related adverse effects. In short, Valdecoxib may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Valganciclovir interact?

Bupropion carries a dose-dependent risk of seizure1 that may be further exacerbated when combined with other medications that can reduce the seizure threshold (i.e. increase the risk of seizure), such as the affected drug. This risk may be also compounded by patient-specific factors that may increase the risk of seizure such as metabolic disorders and illicit drug use. In short, The risk or severity of seizure can be increased when Bupropion is combined with Valganciclovir, and the severity of the interaction is moderate.

Does Bupropion and Valproic acid interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Valproic acid is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Valsartan interact?

The subject drug is known to be an inhibitor of CYP2C9 while the affected drug is reported to be metabolized by CYP2C9. Concomitant administration of these agents can cause an increase in the serum concentration of the affected drug due to decreased metabolism by CYP2C9, which may result in increased incidence and/or severity of adverse effects related to the affected drug. In short, The metabolism of Bupropion can be decreased when combined with Valsartan, and the severity of the interaction is moderate.

Does Bupropion and Vancomycin interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. The affected drug is a narrow therapeutic index drug that undergoes renal excretion as its main elimination pathway: a change in serum concentration may significantly elevate the risk of developing drug-related adverse effects. In short, Bupropion may decrease the excretion rate of Vancomycin which could result in a higher serum level, and the severity of the interaction is moderate.

Does Bupropion and Vardenafil interact?

Both of these agents are reported to be metabolized by CYP2C9. Concomitant administration of multiple CYP2C9 substrates can result in competition for the CYP2C9 binding sites and consequently reduced metabolism and increased plasma levels of one or both of the affected drugs. Elevated plasma levels may result in a higher incidence and/or severity of adverse effects. In short, The metabolism of Bupropion can be decreased when combined with Vardenafil, and the severity of the interaction is minor.

Does Bupropion and Varenicline interact?

Findings from in vitro studies showed that bupropion and its metabolites inhibit OCT2, suggesting that clinically relevant interaction through inhibition of OCT2 could occur at therapeutic bupropion doses. Co-administration of bupropion with OCT2 substrates may result in attenuated OCT2-mediated efflux of those drugs, thereby increasing drug serum concentrations. In short, The excretion of Varenicline can be decreased when combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Vecuronium interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Bupropion is combined with Vecuronium, and the severity of the interaction is moderate.

Does Bupropion and Vemurafenib interact?

The subject drug is known to be an inhibitor of CYP2C9 while the affected drug is reported to be metabolized by CYP2C9. Concomitant administration of these agents can cause an increase in the serum concentration of the affected drug due to decreased metabolism by CYP2C9, which may result in increased incidence and/or severity of adverse effects related to the affected drug. In short, The metabolism of Bupropion can be decreased when combined with Vemurafenib, and the severity of the interaction is moderate.

Does Bupropion and Venlafaxine interact?

Bupropion carries a dose-dependent risk of seizure1 that may be further exacerbated when combined with other medications that can reduce the seizure threshold (i.e. increase the risk of seizure), such as the affected drug. This risk may be also compounded by patient-specific factors that may increase the risk of seizure such as metabolic disorders and illicit drug use. In short, The risk or severity of seizure can be increased when Bupropion is combined with Venlafaxine, and the severity of the interaction is moderate.

Does Bupropion and Verapamil interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Verapamil may decrease the excretion rate of Bupropion which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Vernakalant interact?

The subject drug is a strong CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, which could increase serum concentrations as well as the risk and severity of adverse effects. In short, The metabolism of Vernakalant can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Vigabatrin interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Vigabatrin is combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Vilanterol interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bupropion may decrease the excretion rate of Vilanterol which could result in a higher serum level, and the severity of the interaction is minor.

Does Bupropion and Vilazodone interact?

The subject drug is a strong CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, which could increase serum concentrations as well as the risk and severity of adverse effects. In short, The metabolism of Vilazodone can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Viloxazine interact?

Bupropion is extensively metabolized to hydroxybupropion by CYP2B6. In short, The serum concentration of Bupropion can be increased when it is combined with Viloxazine, and the severity of the interaction is minor.

Does Bupropion and Voriconazole interact?

Bupropion is extensively metabolized to hydroxybupropion by CYP2B6. In short, The serum concentration of Bupropion can be increased when it is combined with Voriconazole, and the severity of the interaction is minor.

Does Bupropion and Vortioxetine interact?

Co-administration with strong CYP2D6 inhibitors, such as bupropion, may result in an increase in the concentration of vortioxetine.4 Bupropion has been associated with several cases of serotonin syndrome. There may be a potential risk for additive serotonergic effects during concomitant administration of bupropion and vortioxetine, which leads to fluctuations in heart rate, blood pressure, dilated pupils, agitation, confusion, sweating, diarrhea, and sometimes death. In short, The risk or severity of adverse effects can be increased when Bupropion is combined with Vortioxetine, and the severity of the interaction is moderate.

Does Bupropion and Voxelotor interact?

When a CYP2B6 substrate is coadministered with another CYP2B6 substrate, both substrates will invariably compete with each other to be metabolized by the limited quantities of CYP2B6 isoenzymes present in the body. When one substrate is subsequently capable of 'out-competing' the other, this other substrate will have its CYP2B6 facilitated metabolism stalled or otherwise decreased for a time, resulting in increased serum concentrations of this substrate and/or an increased risk, incidence, or severity of adverse effects associated with exposure to this substrate. In short, The metabolism of Voxelotor can be decreased when combined with Bupropion, and the severity of the interaction is moderate.

Does Bupropion and Warfarin interact?

The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. The affected drug is a narrow therapeutic index drug that undergoes renal excretion as its main elimination pathway: a change in serum concentration may significantly elevate the risk of developing drug-related adverse effects. In short, Bupropion may decrease the excretion rate of Warfarin which could result in a higher serum level, and the severity of the interaction is moderate.

Does Bupropion and Yohimbine interact?

The subject drug is a strong CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, which could increase serum concentrations as well as the risk and severity of adverse effects. In short, The metabolism of Yohimbine can be decreased when combined with Bupropion, and the severity of the interaction is major.

Does Bupropion and Zafirlukast interact?

The subject drug is known to be an inhibitor of CYP2C9 while the affected drug is reported to be metabolized by CYP2C9. Concomitant administration of these agents can cause an increase in the serum concentration of the affected drug due to decreased metabolism by CYP2C9, which may result in increased incidence and/or severity of adverse effects related to the affected drug. In short, The metabolism of Bupropion can be decreased when combined with Zafirlukast, and the severity of the interaction is moderate.

Does Bupropion and Zaleplon interact?

Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Zaleplon is combined with Bupropion, and the severity of the interaction is moderate.