instruction
stringlengths
33
156
input
float64
output
stringlengths
120
1.97k
Does Buspirone and Bacitracin interact?
null
The subject drug is a nephrotoxic agent that may potentially impair renal function and decrease the excretion of drugs that mainly undergo renal excretion as the principal mode of clearance, such as the affected drug. Attenuated renal excretion of the affected drug may increase drug concentrations, leading to an elevated risk for drug-related adverse effects. In short, Bacitracin may decrease the excretion rate of Buspirone which could result in a higher serum level, and the severity of the interaction is minor.
Does Buspirone and Baclofen interact?
null
Baclofen possesses CNS depressant effects and can cause drowsiness and sedation, which may be an additive when used concomitantly with other CNS depressants. In short, Baclofen may increase the central nervous system depressant (CNS depressant) activities of Buspirone, and the severity of the interaction is minor.
Does Buspirone and Balsalazide interact?
null
Concurrent use of drugs known to increase blood pressure is expected to result in an increased risk for supine hypertension. Closely monitor the patient for elevated blood pressure (including in supine and head-elevated positions) and for any evidence of toxicity. In short, The risk or severity of hypertension can be increased when Buspirone is combined with Balsalazide, and the severity of the interaction is minor.
Does Buspirone and Baricitinib interact?
null
The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Buspirone may decrease the excretion rate of Baricitinib which could result in a higher serum level, and the severity of the interaction is minor.
Does Buspirone and Beclomethasone dipropionate interact?
null
The subject is an inducer of the CYP3A5 enzyme, and the affected drug is a substrate of the CYP3A5 enzyme. When these drugs are administered concomitantly, the metabolism of the affected drug is increased, leading to decreased serum concentrations and lower efficacy. In short, The metabolism of Buspirone can be increased when combined with Beclomethasone dipropionate, and the severity of the interaction is moderate.
Does Buspirone and Benazepril interact?
null
The subject drug is known to produce hypertension, this effect can be achieved by different mechanisms. As a consequence, if this agent is used in combination with antihypertensive agents, there could be a decrease in the antihypertensive effects of the antihypertensive agents. In short, Buspirone may decrease the antihypertensive activities of Benazepril, and the severity of the interaction is minor.
Does Buspirone and Benperidol interact?
null
Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Buspirone is combined with Benperidol, and the severity of the interaction is moderate.
Does Buspirone and Benzatropine interact?
null
Reports have indicated that concomitant administration of benzatropine and inhibitors of dopamine activity can increase gastrointestinal adverse effects, fever, and heat intolerance. The effects could be caused by the reversal of dopamine antagonism or a neurotransmitter imbalance. In short, The risk or severity of adverse effects can be increased when Buspirone is combined with Benzatropine, and the severity of the interaction is moderate.
Does Buspirone and Benznidazole interact?
null
The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Buspirone may decrease the excretion rate of Benznidazole which could result in a higher serum level, and the severity of the interaction is minor.
Does Buspirone and Benzocaine interact?
null
Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Buspirone is combined with Benzocaine, and the severity of the interaction is moderate.
Does Buspirone and Benzphetamine interact?
null
Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Buspirone is combined with Benzphetamine, and the severity of the interaction is moderate.
Does Buspirone and Benzydamine interact?
null
Concurrent use of drugs known to increase blood pressure is expected to result in an increased risk for supine hypertension. Closely monitor the patient for elevated blood pressure (including in supine and head-elevated positions) and for any evidence of toxicity. In short, The risk or severity of hypertension can be increased when Buspirone is combined with Benzydamine, and the severity of the interaction is minor.
Does Buspirone and Benzyl alcohol interact?
null
Central nervous system (CNS) depressants can cause sedation, falls, respiratory depression, coma, and death.2,3 The potential interaction between a CNS depressant and another CNS depressant drug due to synergistic effects is well documented in the literature, although the risk and severity of CNS depression vary from each drug. The subject and affected drugs are both CNS depressants that, when co-administered, may result in a more profound CNS depression. As the risk and severity of CNS depression resulting from the combined use of CNS depressants vary from each agent, each interaction between CNS depressants should be considered individually. In short, The risk or severity of CNS depression can be increased when Buspirone is combined with Benzyl alcohol, and the severity of the interaction is moderate.
Does Buspirone and Bepotastine interact?
null
The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Buspirone may decrease the excretion rate of Bepotastine which could result in a higher serum level, and the severity of the interaction is minor.
Does Buspirone and Berotralstat interact?
null
The subject drug is a moderate CYP2D6 inhibitor and the affected drug is metabolized by CYP2D6. Concomitant administration may decrease the metabolism of the affected drug, leading to increased serum concentrations as well as increased risk and severity of adverse effects. In short, The metabolism of Buspirone can be decreased when combined with Berotralstat, and the severity of the interaction is moderate.
Does Buspirone and Betamethasone interact?
null
The subject is a weak inducer of the CYP3A5 enzyme, and the affected drug is a substrate of the CYP3A5 enzyme. When these drugs are administered concomitantly, the metabolism of the affected drug is increased, leading to decreased serum concentrations and lower efficacy. In short, The metabolism of Buspirone can be increased when combined with Betamethasone, and the severity of the interaction is minor.
Does Buspirone and Betaxolol interact?
null
The subject drug is known to produce hypertension, this effect can be achieved by different mechanisms. As a consequence, if this agent is used in combination with antihypertensive agents, there could be a decrease in the antihypertensive effects of the antihypertensive agents. In short, Buspirone may decrease the antihypertensive activities of Betaxolol, and the severity of the interaction is minor.
Does Buspirone and Bicisate interact?
null
The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Buspirone may decrease the excretion rate of Bicisate which could result in a higher serum level, and the severity of the interaction is minor.
Does Buspirone and Bimekizumab interact?
null
The formation of CYP450 enzymes is inhibited by the presence of increased levels of cytokines during chronic inflammation. Agents that reduce cytokine levels can normalize CYP450 formation and increase the metabolism of drugs. This interaction may significantly alter the therapeutic efficacy of CYP2D6 substrates. In short, The metabolism of Buspirone can be increased when combined with Bimekizumab, and the severity of the interaction is moderate.
Does Buspirone and Biperiden interact?
null
The subject drug is known to be an inhibitor of CYP2D6 while the affected drug is reported to be metabolized by CYP2D6. Concomitant administration of these agents can cause an increase in the serum concentration of the affected drug due to a decrease in metabolism by CYP2D6, which may result in increased incidence and/or severity of adverse effects related to the affected drug. In short, The metabolism of Buspirone can be decreased when combined with Biperiden, and the severity of the interaction is moderate.
Does Buspirone and Bismuth subgallate interact?
null
The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Buspirone may decrease the excretion rate of Bismuth subgallate which could result in a higher serum level, and the severity of the interaction is minor.
Does Buspirone and Bisoprolol interact?
null
The subject drug is known to produce hypertension, this effect can be achieved by different mechanisms. As a consequence, if this agent is used in combination with antihypertensive agents, there could be a decrease in the antihypertensive effects of the antihypertensive agents. In short, Buspirone may decrease the antihypertensive activities of Bisoprolol, and the severity of the interaction is minor.
Does Buspirone and Bleomycin interact?
null
The renal excretion of drugs is the overall result of a combination of kidney processes that include glomerular filtration, passive diffusion, tubular secretion, and tubular reabsorption. Since two of these mechanisms - tubular secretion and reabsorption - are saturable processes , they are consequently susceptible to competition between multiple substrates excreted by the kidneys. If two or more medications that are mainly renally excreted are co-administered, they may compete for renal elimination; there is a large likelihood that one agent may "out-compete" or saturate the renal excretion mechanisms before the other concomitantly administered agent(s) are excreted. As a result, the elimination of these other concurrently administered agents may be inhibited or otherwise delayed, which could lead to increases in their serum concentrations and the risk, incidence, and/or severity of adverse effects associated with the exposure to such drugs. In short, Bleomycin may decrease the excretion rate of Buspirone which could result in a higher serum level, and the severity of the interaction is minor.
Does Buspirone and Bortezomib interact?
null
Both of these drugs are metabolized by CYP2D6. Concomitant administration of these agents may produce a decrease in the metabolic rate of one or both drugs as they compete for metabolism by CYP2D6 enzymes. This may result in elevated serum concentrations of one or both medications and may, therefore, increase the incidence or severity of associated adverse effects. In short, The metabolism of Buspirone can be decreased when combined with Bortezomib, and the severity of the interaction is minor.
Does Buspirone and Bosentan interact?
null
The subject drug is known to produce hypertension, this effect can be achieved by different mechanisms. As a consequence, if this agent is used in combination with antihypertensive agents, there could be a decrease in the antihypertensive effects of the antihypertensive agents. In short, Buspirone may decrease the antihypertensive activities of Bosentan, and the severity of the interaction is minor.