Datasets:

ravistech

/

clinical-trial-llm-v2

like 0

Follow

ravistech 6

Study Objectives The purpose of this pragmatic cluster randomized control trial is to test the effectiveness of cervical cancer screening follow-up completion using two implementation approaches for self-collected HPV testing in a rural, low-resource setting: 1) community health workers recruiting women door-to-door and 2) community health workers recruiting women at community health meetings. This study will also help to further understand how current patient referral systems are working between health facilities, patient and provider preferences for integrated care and health system related barriers to integrated cervical cancer screening. Hypothesis: More women will receive screening via the community health meeting but the engagement to care (i.e., visual inspection with acetic acid-our main outcome) will be greater in the door-to-door arm. Conditions: Human Papillomavirus 16, Human Papillomavirus 18, Papillomavirus Infections, Cervical Cancer, Pre-Cancerous Dysplasia Intervention / Treatment: BEHAVIORAL: Self-collected HPV testing for cervical cancer screening

Inclusion Criteria: * Women with no previous history of hysterectomy * aged 25-49 years old * no previous history of treatment for cervical cancer * provided written informed consent. Exclusion Criteria: * Women who are under 25 or over 49 years of age, * who have previously had a hysterectomy or been treated for cervical cancer * unable to provided informed consent.

Study Objectives l'ANI (Analgesia Nociception Index The main objective of the research is to estimate the Analgesia Nociception Index (ANI) as a parameter giving the possibility of measuring the pain in painful metastatic cancer. The parameter ANI is compared with visual analogical scale (VAS) score. Conditions: Pain, Cancer Intervention / Treatment: DEVICE: Non Invasive Monitoring Device (ANI)

Inclusion Criteria: * more than 18 years, -no legal protection, - * life expectancy is considered over 3-months * not receiving of béta-blocking, * Having a rhythm sinusal without extrasystole * benefiting from a coverage by a social security system Exclusion Criteria: * Pace-Maker * Diabetes mellitus

Study Objectives The goal of this clinical research study is to learn if lirilumab in combination with rituximab can help to control either CLL or Small lymphocytic lymphoma (SLL). The safety of the drug combination will also be studied. Conditions: Leukemia, Chronic Lymphocytic Leukemia, Lymphocytic Leukemia Intervention / Treatment: DRUG: Lirilumab, DRUG: Rituximab

Inclusion Criteria: * Patients will have a diagnosis of CLL or SLL who meet one or more criteria for active disease as defined by the International Working Group for CLL (IWCLL) and are: a. Cohort 1: refractory to and/or relapsed after at least one prior therapy OR b. Cohort 2: untreated patients with high-risk molecular features such as del(17p), mutated TP53, del(11q), unmutated IGHV gene, or are >65 years of age* Age 18 years or older* Eastern Cooperative Oncology Group (ECOG) Performance Status <=2* Patients must have adequate renal and hepatic function: Serum bilirubin <=1.5 x upper limit of normal (ULN). For patients with Gilbert's disease, serum bilirubin up to <=3 x ULN is allowed provided normal direct bilirubin; Serum creatinine ≤1.5 x ULN; alanine aminotransferase (ALT) and aspartate aminotransferase (AST) <=3 x ULN* Females of childbearing potential must have a negative serum or urine beta human chorionic gonadotrophin (Beta-hCG) pregnancy test result within 24 hours prior to the first dose of treatment and must agree to use an effective contraception method during the study and for 12 months following the last dose of the study drugs. Females of non- childbearing potential are those who are postmenopausal greater than 1 year or who have had a bilateral tubal ligation or hysterectomy. Males who have partners of childbearing potential must agree to use an effective contraceptive method during the study and for 31 weeks following the last dose of study drugs.* Patients or their legally authorized representative must provide written informed consent. Exclusion Criteria: * Prior malignancy active within the previous 2 years except for locally curable cancers that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer, carcinoma in situ of the cervix or breast, or localized prostate cancer. If patients have another malignancy that was treated within the last 2 years, such patients may be enrolled if the likelihood of requiring systemic therapy for this other malignancy within 2 years is less than 10%, as determined by an expert in that particular malignancy at MD Anderson Cancer Center and after consultation with the Principal Investigator.* Any major surgery, radiotherapy, chemotherapy, biologic therapy, immunotherapy, experimental therapy within 4 weeks prior to the first dose of the study drugs. For oral targeted therapies (such as ibrutinib, idelalisib, venetoclax), a washout of 3 days is allowed. Note: Prior treatment with anti CD20 monoclonal antibody, anti CD52 monoclonal antibody and lenalidomide are allowed. Prior treatment with anti-CTLA-4 and anti-PD1 therapies is allowed after a wash-out of 5 half-lives.* Significant cardiovascular disease such as uncontrolled or symptomatic arrhythmias, congestive heart failure, or myocardial infarction within 2 months of screening, or any Class 3 or 4 cardiac disease as defined by the New York Heart Association Functional Classification.* History of stroke or cerebral hemorrhage within 2 months.* Patients who have uncontrolled hypertension (defined as sustained systolic blood pressure >= 160 mmHg or diastolic >= 100 mmHg).* Known evidence of active cerebral/meningeal CLL. Patients may have history of central nervous system (CNS) leukemic involvement if definitively treated with prior therapy and no evidence of active disease at the time of registration.* Active, uncontrolled autoimmune hemolytic anemia or immune thrombocytopenia requiring steroid therapy.* Patients with autoimmune diseases are excluded: Patients with a history of Inflammatory Bowel Disease (including Crohn's disease and ulcerative colitis) are excluded from this study as are patients with a history of autoimmune disease (e.g., rheumatoid arthritis, systemic progressive sclerosis, systemic lupus erythematosus, Wegener's granulomatosis).* Patients with previous allogeneic stem cell transplant (SCT) within 6 months or with active acute or chronic graft-versus host disease are excluded. Patients must be off immunosuppression for graft versus host disease (GVHD) for at least 60 days before Cycle 1 Day 1.* Patients with organ allografts (such as renal transplant) are excluded.* History of any hepatitis (e.g., alcohol or non-alcohol steatohepatitis (NASH), auto immune, or grade 3-4 drug-related hepatitis).* Patients who are on high-dose steroids (doses >10mg/day of prednisone or equivalent) or immune suppression medications. Note: Patients on high-dose steroids (doses >10mg/day of prednisone or equivalent) or immune suppression medications are eligible provided these drugs are discontinued at least 3 days prior to starting on the study drugs.* Patients with uncontrolled active infection (viral, bacterial, and fungal) are not eligible.* Current or chronic hepatitis B or C infection, or known seropositivity for HIV.* Patient is pregnant or breast-feeding.* Concurrent use of investigational therapeutic agent* Patients may not receive other concurrent chemotherapy, radiotherapy, or immunotherapy. Localized radiotherapy to an area not compromising bone marrow function does not apply.* Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that in the opinion of the investigator may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and/or would make the patient inappropriate for enrollment into this study.

Study Objectives * To investigate the effect of catecholamine excess on brown fat. * To evaluate the effect of brown fat on energy expenditure and lipid and glucose metabolism Conditions: Pheochromocytoma, Adrenal Incidentaloma Intervention / Treatment: PROCEDURE: Removal of adrenal tumor

Inclusion Criteria: * 10 patients with pheochromocytoma * 5 patients with incidentaloma without hormone production * Age > 18 years Exclusion Criteria: * None

Study Objectives This trial intends to test the efficacy and safety of RAD001 in patients with advanced sarcoma who failed to conventional chemotherapy. Conditions: Soft Tissue Sarcomas, Bone Sarcomas Intervention / Treatment: DRUG: RAD001

Inclusion Criteria: * Patients with histologically confirmed metastatic, unresectable bone or soft tissue sarcomas who had past treatment with anthracycline and/or ifosfamide to which the disease was primarily refractory or progressed after initial response. * Any of above drugs is allowed to be used as adjuvant treatment. * Unidimensionally measurable disease * 3 or less than prior chemotherapies * Age 17 years old or older * ECOG performance status 2 or less, Life expectancy 6 month or less * Adequate bone marrow, liver, kidney, and cardiac function * Written informed consent Exclusion Criteria: * Pregnant or lactating patients * Patients with resectable metastasis * Patients with history of CNS metastasis * Gastrointestinal stromal tumors, chondrosarcoma, neuroblastoma * Hypersensitivity to the active substance, to other rapamycin derivatives, or to any of the excipients. * Any preexisting medical condition of sufficient severity to prevent full compliance with the study

Study Objectives This study designed to determine the Maximum Tolerated Dose (MTD) for patients with advanced Neuroendocrine Tumors (NETs) and to characterize the safety, tolerability, Pharmacokinetics and preliminary efficacy of pasireotide LAR administered i.m. once every 28 days. Conditions: Neuroendocrine Tumors Intervention / Treatment: DRUG: Pasireotide LAR

Inclusion Criteria: * ≥18 yrs old, histologically confirmed advanced well or moderately differentiated neuroendocrine tumor/carcinoma * unresectable metastatic NET tumor with measurable disease * life expectancy ≥ 12 weeks Exclusion Criteria: * Patients with CNS metastases who are neurologically unstable or requiring increasing doses of steroids to control their CNS disease * patients with known hypersensitivity to somatostatin analogs * patients with symptomatic cholelithiasis in the past 2 months * patients with history of another known primary malignancy with exception of non-melanoma skin cancer or carcinoma in situ of uterine cervix * patients with known history of hepatitis C or chronic active hepatitis B * patients with diagnosis of HIV. Other protocol-defined inclusion/exclusion criteria may apply

Study Objectives This phase II trial studies the side effects of palbociclib when given together with fulvestrant or tamoxifen citrate in treating patients with hormone receptor positive breast cancer that has spread from where it started to nearby tissue or lymph nodes (locally advanced) or has spread to other places in the body (metastatic). Palbociclib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Hormone therapy using fulvestrant or tamoxifen citrate may fight breast cancer by blocking the use of estrogen by the tumor cells. Giving palbociclib together with fulvestrant or tamoxifen citrate may work better in treating hormone receptor positive breast cancer. Conditions: Metastatic Breast Cancer, Hormone Receptor Positive Intervention / Treatment: DRUG: Palbociclib, DRUG: Tamoxifen, DRUG: Fulvestrant

Inclusion Criteria: * Histologically or cytologically proven diagnosis of breast cancer with evidence of metastatic or locally advanced disease, not amenable to resection or radiation therapy with curative intent. * Patients 18 years of age or older, Female patients should be either: * Postmenopausal, as defined by at least one of the following criteria: * Age >=60 years; * Age <60 years and cessation of regular menses for at least 12 consecutive months with no alternative pathological or physiological cause; * Documented bilateral oophorectomy; * Medically confirmed ovarian failure. OR * Pre/peri-menopausal, ie, not meeting the criteria for being postmenopausal who are also receiving ongoing treatment with Luteinizing hormone-releasing hormone (LHRH) agonists (goserelin or leuprolide). The first injection should occur at least two weeks before study start. * Documentation of ER-positive and/or PR-positive tumor (≥1% positive stained cells) based on most recent tumor biopsy (unless bone-only disease,discuss with study PI if results are discordant) utilizing an assay consistent with local standards. * Documented human epidermal growth factor receptor 2 negative (HER2-) tumor based on local testing on most recent tumor biopsy: HER2-negative tumor is determined as immunohistochemistry score 0/1+ or negative by in situ hybridization (FISH/CISH/SISH) defined as a HER2/CEP17 ratio <2 or for single probe assessment a HER2 copy number <4. * Must have received prior treatment with an Mechanistic target of rapamycin (mTOR) or phosphatidylinositol 3-kinase (PI3K) inhibitor * Up to 2 prior lines of chemotherapy are allowed in the metastatic setting. * Any number of lines of prior hormone therapy are allowed * Patients with clear progression on either tamoxifen or fulvestrant should receive the alternate agent. Patients with clear progression on both drugs are not eligible. * Ability to have a skin and tumor biopsy. Patients without accessible tumor for biopsy will be considered on a case by case basis. * Patients who cannot be biopsied will not be replaced (although up to 5 ineligible/inevaluable patients can be replaced) * A patient without biopsy amenable tumor must be cleared by the PI of the study; up to 10 patients without biopsy amenable tumor will be allowed in each arm of the study. * Patients without accessible tumor for biopsy must provide archived tumor from the most recent biopsy available * Bone marrow, hepatic, and renal function as follows: Adequate bone marrow function: * leukocytes > 2500/mL * absolute neutrophil count > 1,000/mL * platelets > 100,000/mL" Adequate hepatic function: * total bilirubin within normal institutional limits (unless Gilbert's disease with elevated indirect bilirubin only) * aspartate aminotransferase (AST) / (serum glutamic-oxaloacetic transaminase (SGOT) < 2.5 X institutional upper limit of normal * alanine aminotransferase (ALT) / (serum glutamic-pyruvic transaminase (SGPT) < 2.5 X institutional upper limit of normal * Adequate renal function: * creatinine within normal institutional limits * Measurable or evaluable disease as defined by RECIST version 1.1. Tumor lesions previously irradiated or subjected to other loco-regional therapy will only be deemed measurable if progression at the treated site after completion of therapy is clearly documented. * Eastern Cooperative Oncology Group (ECOG) performance status 0-1 * Resolution of acute toxic effects of prior therapy or surgical procedures to National Cancer Institute (NCI) CTCAE Grade <=1 (except alopecia) * Ability to understand a written informed consent document, and the willingness to sign it Exclusion Criteria: * Prior treatment with any cyclin-dependent kinase (CDK) inhibitor, and/or both fulvestrant and tamoxifen in the metastatic setting with clear progression. * Patients with advanced/metastatic, symptomatic, visceral spread, at risk of life-threatening complications in the short term by investigator assessment. * Known active uncontrolled or symptomatic central nervous system (CNS) metastases, carcinomatous meningitis, or leptomeningeal disease as indicated by clinical symptoms, cerebral edema, and/or progressive growth. Patients with a history of CNS metastases or cord compression are eligible if they have been definitively treated (eg, radiotherapy, stereotactic surgery) and are clinically stable off anticonvulsants and steroids for at least 4 weeks before randomization . * Current use of food or drugs known to be potent CYP3A4 inhibitors, drugs known to be potent CYP3A4 inducers (for examples, see the prohibited medications section), and drugs that are known to prolong the QT interval. See prohibited meds in appendix 5. * Major surgery, chemotherapy, radiotherapy, or other anti-cancer therapy within 2 weeks before randomization. * Any other malignancy within 3 years prior to randomization, except for adequately treated basal cell or squamous cell skin cancer, or carcinoma in situ of the cervix. * QTc interval >480 msec (based on the mean value of the triplicate ECGs), family or personal history of long or short QT syndrome, Brugada syndrome or known history of QTc prolongation or Torsade de Pointes. QTc (Bazett) = QT/√RR * Any of the following within 6 months prior to study enrollment: myocardial infarction, severe/unstable angina, ongoing cardiac dysrhythmias of NCI CTCAE Grade >=2, symptomatic congestive heart failure, or cerebrovascular accident excluding transient ischemic attack. * Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of palbociclib, such as history of GI surgery with may result in intestinal blind loops and patients with clinically significant gastroparesis, short bowel syndrome, unresolved nausea, vomiting, active inflammatory bowel disease or diarrhea of CTCAE v4.0 Grade >1. * Prior hematopoietic stem cell or bone marrow transplantation. * Abnormalities in coagulation such as bleeding diathesis, or treatment with anticoagulants (that cannot be safely held for biopsy) that would preclude tumor and skin biopsies. * For fulvestrant: Ongoing anticoagulation that would preclude an IM injection * For tamoxifen: Documented hypercoagulable state not receiving anticoagulation * Known or possible hypersensitivity to palbociclib (CTCAE v4.0). * Known human immunodeficiency virus infection. * Other severe acute or chronic medical or psychiatric condition, including recent or active suicidal ideation or behavior, or laboratory abnormality that may increase the risk associated with study participation or investigational product administration or may interfere with the interpretation of study results and, in the judgment of the investigator, would make the patient inappropriate for entry into this study. * Participation in other studies involving investigational drug(s) (Phases 1-4) within 2 weeks before randomization the current study. * Women should not become pregnant or breastfeed whilst on this study. Birth control methods are acceptable and will be discussed with study participants.

Study Objectives This is a pilot, simulated breast cancer screening study. The goal of the study is to explore these scanning modalities: 1) Combined digital breast tomosynthesis(DBT)/dual-sides 3 dimensional-automated ultrasound(AUS) 2. Explore the utility of photoacoustic imaging as an adjunct to digital breast tomosynthesis(DBT)/ultrasound(US)alone. Conditions: Breast Cysts, Breast Tumors Intervention / Treatment: PROCEDURE: X-ray and ultrasound imaging scanning, PROCEDURE: Photoacoustic imaging scans for breast cancer screening

Inclusion Criteria: * Women with possible masses * All women should have had mammograms at University of Michigan Health System within 1 year before this research study. Exclusion Criteria: * Women who are physically unable to tolerate the length of the scan. * Women who are less than 30 years of age or older than 80 years of age * Women who are pregnant or lactating * Women whose mass is in an area of the breast which makes it difficult to see in the research scans * Womens with a single diagnosis of mammographic calcifications * Women who have had a breast cancer with lumpectomy * Women who are prisoners * Women who are students or staff of investigators * Women who cannot give consent * Women with mammograms classified as probably benign because of follow-up of a recent benign biopsy. * Women with breast pain who have been categorized as BIRADS(Breast Imaging Reporting and Data System) category 0(incomplete) on their most recent mammograms. * Males, because their breast tissue is not easily imaged and numbers of potential cases are too few.

Study Objectives The purpose of this study is to determine safety and feasibility of adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC) with mitomycin and cisplatin in patients with locally advanced gastric cancer undergoing standard surgical resection. Patients will be treated with HIPEC using a single dose of mitomycin 15mg/m2 and cisplatin 50mg/m2 at 41-42 C for 90 minutes, during the definitive surgical resection for gastric cancer. HIPEC will be performed after resection but before anastomosis. Conditions: Locally Advanced Malignant Neoplasm, Gastric Cancer Intervention / Treatment: DRUG: Hyperthermic Intraperitoneal Chemotherapy (HIPEC)

Inclusion Criteria: * Patients aged 18-75 with biopsy-proven gastric adenocarcinoma* Tumor clinically staged T3 or T4 and/or nodes staged clinically positive* ECOG performance status < 2 Exclusion Criteria: * Distant metastases* Peritoneal carcinomatosis* Synchronous malignancy* Tumors at the gastroesophageal junction* Recurrent gastric adenocarcinoma* Creatinine >= 1.5* Bilirubin >= 2* INR >= 2* Allergy to drugs included in the treatment plan* Pregnancy* Contraindication to major surgery

Study Objectives HPV is known to be the causal agent in the majority of cervical cancers. However, the role of the cervical bacterial microbiome in cervical cancer is not clear Conditions: Cervix Cancer Intervention / Treatment: DIAGNOSTIC_TEST: Cervical biopsy

Inclusion Criteria: * Women in fertile age Exclusion Criteria: * severe comorbidities

Study Objectives This study was aimed to evaluate efficacy and tolerability of thalidomide in improving prevention of chemotherapy-induced delayed nausea and vomiting in chemotherapy-naive patients after highly emetogenic chemotherapy. Conditions: Neoplasms Intervention / Treatment: DRUG: Thalidomide, DRUG: Placebo for thalidomide, DRUG: Palonosetron and Dexamethasone

Inclusion Criteria: * 18y ≤Age≤70y * Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2 * Histologically confirmed solid neoplasm * No prior chemotherapy * Laboratory test must meet the following criteria: hemoglobin (HGB) ≥90g/L, neutrophil count ≥1.5×109/L, platelet count ≥85×109/L, creatinine clearance rate (CCr) ≥60ml/min, total bilirubin (TBil) ≤1.5 upper normal limitation (UNL), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤2.5 UNL (For patients with liver metastasis, the AST/ALT must be ≤5.0 UNL), blood glucose ≤11.1 mmol/L * Life expectancy of at least 12 weeks * Signed informed consent * For women with child bearing potential, a negative serum or urine pregnancy test result should be obtained before enrollment * Cancer patients scheduled to receive HEC regimen. The HEC regimen was defined as chemotherapy containing a 50 mg/m2 or higher dose of cisplatin, or cyclophosphamide combination with doxorubicin/epirubicin Exclusion Criteria: * Diabetic patients * Pregnant or lactated women * Patient with history of thrombosis * Concomitant radiotherapy * Known hypersensitivity to thalidomide, palonosetron, or dexamethasone. * Concurrent administration of any other drug which affect antiemetic effect evaluation such as proton pump inhibitor, H2 blocker, amifostine, sedative drugs * CHOP regiment or taxanes-based regiment * Existing emesis within 24 hours before chemotherapy administration * Symptomatic brain metastasis or suspected clinical brain metastasis * Serious uncontrolled systemic illness or medical condition: congestive heart failure, unstable angina, history of documented myocardial infarction within 6 months, uncontrolled hypertension and high risk uncontrollable arrhythmias; Obvious neurological or mental abnormalities including mental disorder, epileptic dementia, which affect compliance; Uncontrolled acute infections; Uncontrolled peptic ulcer or other contraindication for corticosteroid therapy. * Inability to take or absorb oral medicine * Concurrent administration of any other investigational drug, or have been enrolled in other clinical trial with investigational drug treatment within the 30 days of start of study treatment * Unsuitable for the study or other chemotherapy determined by investigator

Study Objectives This study is to investigate safety and feasibility of a combination therapy of a tumor infiltrating lymphocytes (TIL) transfer with anti-programmed cell death protein (PD)-1 therapy in patients with metastatic melanoma that failed immunotherapy.Tumor-infiltrating lymphocytes will be expanded from resected melanoma samples from the patient and expanded TILs will be transferred to the patient after non-myeloablative chemotherapy with cyclophosphamide and fludarabine. TIL transfer will be combined with low dose Interleukin (IL)-2 and nivolumab anti-PD-1 treatment. The study uses a personalized Investigational Medicinal Product (IMP), i.e. TIL product and in combination with IL-2 treatment and nivolumab. Conditions: Advanced Melanoma Intervention / Treatment: DRUG: Combination of TIL Transfer with anti-PD-1 Therapy and low dose IL-2

Inclusion Criteria: * Histologically confirmed unresectable or metastatic melanoma * At least 1 PD-1 targeted immunotherapy and BRAF inhibition in case of BRAF mutated melanoma * Resectable tumor mass and measurable disease by CT or MRI per RECIST 1.1 criteria (in addition to the resected lesion) * World Health Organization (WHO) clinical performance Status (ECOG) 0-1 * Adequate organ function * Patients of both genders must be willing to practice a highly effective method of birth control during treatment and for five months after receiving the last dose of nivolumab for women and seven months for men * Patients must be able to understand and sign the Informed consent document * Hematology: Absolute neutrophil count greater than 1.5 x 109/L without support of filgrastim. Platelet count greater than 100 x 109/L. Hemoglobin greater than 5 mmol/L, or 80 g/L. * Chemistry: Serum alanine aminotransferase (ALAT)/ aspartate transaminase (ASAT) less than 3 times the upper limit of normal, unless patients have liver metastases (< 5 times ULN). Serum creatinine clearance 50 ml/min or higher. Total Bilirubin less than or equal to 20 micromol/L, except in patients with Gilbert's Syndrome who must have a total bilirubin less than 50 micromol/L. Lactate dehydrogenase (LDH) ≤ 2x ULN * Serology: Seronegative for HIV antibody. Seronegative for hepatitis B antigen, and hepatitis C antibody. Seronegative for syphilis. Exclusion Criteria: * Life expectancy of less than three months * Patients with metastatic ocular/ mucosal or other non-cutaneous melanoma. * Requirement for immunosuppressive doses of systemic corticosteroids (>10 mg/day prednisone or equivalent) or other immunosuppressive drugs within the last 3 weeks prior to randomization * Uncontrolled central nervous system (CNS) metastases. Controlled CNS metastases must be for at least 4 weeks stable. * Documented Forced expiratory volume at one second (FEV1) less than or equal to 50% predicted for patients with: * A prolonged history of cigarette smoking (greater than 20 pack/year within the past 2 years) * Symptoms of respiratory distress * All patients' toxicities due to prior non-systemic treatment must have recovered to a grade 1 or less. Patients may have undergone minor surgical procedures or focal palliative radiotherapy (to non-target lesions) within the past 4 weeks, as long as all toxicities have recovered to grade 1 or less. * Women who are pregnant or breastfeeding, because of the potentially dangerous effects of the preparative chemotherapy on the fetus or infant. * Any active systemic infections, coagulation disorders or other active major medical illnesses. * Contraindication for IL-2 or nivolumab (allergies etc.). * Any autoimmune disease: patients with a documented history of inflammatory bowel disease, including ulcerative colitis and Crohn's disease are excluded from this study as are patients with a history of symptomatic disease (e.g., rheumatoid arthritis, autoimmune thyroiditis (e.g. Hashimoto's disease), autoimmune hepatitis, systemic progressive sclerosis (scleroderma), Systemic Lupus Erythematosus, autoimmune vasculitis (e.g., Wegener's Granulomatosis). Subjects with motor neuropathy considered of autoimmune origin (e.g., Guillain-Barré Syndrome) are excluded from this study. Patients with vitiligo are eligible to enter the study

Study Objectives The objective of the study is to demonstrate the safety, tolerability, and activity of Rituximab-Bendamustine-Cytarabine(R-BAC) regimen in patients with mantle cell lymphoma (MCL) aged 65 years or more, as well as in younger patients who are not eligible for intensive regimens including/not including autologous transplantation. Conditions: Lymphoma, Mantle-Cell Intervention / Treatment: DRUG: Rituximab, Bendamustine, Cytarabine

Inclusion Criteria: * Previously untreated patients with MCL aged 65 years or more, or <65 years if not eligible for intensive treatments including/not including autologous transplantation. * MCL patients of any age who relapse/progress or are resistant after one line of chemotherapy. * CD20+ . * Karnofsky score of at least 70% * Adequate renal function (Creatinine clearance >40 mL/min), with preserved diuresis. * Adequate liver function: alanine aminotransferase (ALT)/aspartate aminotransferase (AST) <2.5 x upper limit of normal (ULN) value, total bilirubin <2 mg/dL, unless directly attributable to the patient's tumor. * Negative serum pregnancy test 1 week prior to treatment both for pre-menopausal women and for women who are <2 years after onset of menopause. * Hepatitis B core antibody (HBcAb) positive patients may be enrolled if correct antiviral prophylaxis is administered at least 2 weeks before initiating protocol treatment. * Written informed consent. Exclusion Criteria: * Prior treatment with Bendamustine. * Refractoriness to Rituximab, defined as progressive disease during a previous cycle including this drug, or relapse within 6 months to any previous cycle including Rituximab. * Previous Rituximab infusion-related severe reactions. * Human immunodeficiency virus (HIV) positive. * Medical conditions or organ injuries that could interfere with administration of therapy. * Active bacterial, viral, or fungal infection requiring systemic therapy. * Seizure disorders requiring anticonvulsant therapy. * Severe chronic obstructive pulmonary disease with hypoxaemia. * History of severe cardiac disease: New York Heart Association (NYHA) functional class III-IV, myocardial infarction within 6 months, ventricular tachyarrhythmias, dilatative cardiomyopathy, or unstable angina. * Uncontrolled diabetes mellitus. * Active secondary malignancy. * Known hypersensitivity or anaphylactic reactions to murine antibodies and proteins (for patients treated with Rituximab), to Bendamustine or mannitol. * Fertile men and women of childbearing potential unless surgically sterile or using adequate measures of contraception. * Major surgery within 4 weeks of study Day 1. * HBsAg+ and HCV+ patients * Any co-existing medical or psychological condition that would preclude participation in the study or compromise the patient's ability to give informed consent, or that may affect the interpretation of the results, or render the patient at high risk from treatment complications.

Study Objectives The purpose of this proposal is to develop and test the efficacy in a randomized, controlled clinical trial of an Oncology Nurse Care Management (ONCM) program to support cancer patients early in their course. The ONCM program will be compared with an Enhanced Usual Care (EUC) program that will provide education materials and treatment resources for patients. Efficacy will be measured by differences over time in participant-reported Quality of Life, Symptoms and Emotional Distress, and Quality of Care between patients receiving ONCM versus EUC. Conditions: Cancer Intervention / Treatment: OTHER: Oncology Nurse Care Management, OTHER: Patient-centered materials

Inclusion Criteria: * On the panel of an eligible and consenting primary care physician;* Diagnosed with a new occurrence of breast (females only) , colorectal, or lung cancer within the past three weeks;* Age 18 or older; and* Able to complete the baseline questionnaire. Exclusion Criteria: * They plan to disenroll from GH or be out of the area in the coming year; or* Primary care physician or specialty physician expects survival to be less than 12 months; or* Don't speak English; or* Have moderate cognitive impairment (a score of 3 or more on a six-item validated instrument, or psychosis as assessed by ICD-9 codes from GH medical record data.

Study Objectives The purpose of this study is to evaluate the tolerability of the study drug LY3039478 in Japanese participants with advanced solid tumors. Conditions: Advanced Solid Tumor Intervention / Treatment: DRUG: LY3039478

Inclusion Criteria: * Histological or cytological evidence of a diagnosis of solid tumor that is advanced and/or metastatic. * In the judgment of the investigator, participants must be appropriate candidates for experimental therapy after available standard therapies have failed or for whom standard therapy is not appropriate. * Performance status of ≤1 on the Eastern Cooperative Oncology Group (ECOG) scale. * Adequate organ function, including hematologic, hepatic, and renal. * Estimated life expectancy of ≥12 weeks. Exclusion Criteria: * Received previous therapy for cancer within 14 or 21 days of the initial dose of study drug for a nonmyelosuppressive or myelosuppressive agents, respectively. * Have serious preexisting medical conditions. * Have current or recent (within 3 months of study drug administration) gastrointestinal disease with chronic or intermittent diarrhea. * Have an active bacterial, fungal, and/or known viral infection. * Have known acute or chronic leukemia or current hematologic malignancies that may affect the interpretation of results.

Study Objectives To test the efficacy of two Traditional Chinese Medicine in preventing osteoporosis in patients receiving adjuvant endocrine therapy. Conditions: Breast Cancer, Osteoporosis Intervention / Treatment: DRUG: Letrozole, DRUG: Zhongyaofufang, DRUG: Xianlinggubao

Inclusion Criteria: * Histologically confirmed invasive breast cancer; * Post-surgery, primary lesion been removed; * Post-Menopausal patients or pre-menopausal patients who will receive ovarian function suppression; * Histologically confirmed ER and/or PR positive ; * Receiving adjuvant AIs therapy in the following one years; * Leukocyte ≥ 3\*10(9)/L; Platelets ≥ 75\*10(9)/L; * Serum glutamate oxaloacetate(AST/SGOT) or serum glutamic-pyruvic transaminase(ALT/SGPT) <2.5 times of upper limit of normal range; * Serum creatinine/blood urea nitrogen(BUN) ≤ upper limit of normal (UNL) range; * Written informed consent according to the local ethics committee equirements; Exclusion Criteria: * Metastatic Breast Cancer; * Received Neo-Adjuvant Endocrine Therapy; * History of pelvic fracture or bone metabolic disease; * Received drugs interfering bone metabolism in the last 12 months; * Baseline Bone Mineral Density: T < -2SD; * With other primary malignant disease; * With severe non-malignant co-morbidity that will influence long-term follow up; * Known severe hypersensitivity to any drugs in this study;

Study Objectives This phase 2 waitlist-controlled, randomized trial is designed to compare the difference in proliferative index (Ki67) between carbohydrate restricted diet and usual care over a 6 month period in men with prostate cancer who have been placed on Active Surveillance. Eligible patients include men over 18 years old, BMI \>25, with their most recently performed biopsy pathologically confirming prostate adenocarcinoma who have been placed on AS. Arms of the trial will be randomized 1:1 in a crossover approach, with Arm A receiving a carb restricted diet over 6 months then SOC and Arm B receiving the waitlist control arm (i.e. SOC then allowed to go on diet after 6 months). Ki67 will be performed on tissue from the most recent biopsy at the beginning of the study and again on tissue obtained in the 6 month SOC biopsy. Every patient will be on the study for 12 months, and the study will continue for approximately 3.5 years. Conditions: Prostate Cancer Intervention / Treatment: OTHER: Carbohydrate restricted diet, OTHER: Non-restricted diet, OTHER: Phone counseling with dietitian

Inclusion Criteria: * Pathologically confirmed prostate adenocarcinoma * Most recent biopsy positive for prostate cancer * Currently on or starting active surveillance * Ability to read, write, and understand English * BMI >24 kg/m2 * Written informed consent obtained from subject and ability for subject to comply with the requirements of the study. * Scheduled to undergo a prostate biopsy in 6 months as part of standard of care for their prostate cancer * Age > 18 years Exclusion Criteria: * Already consuming a severely carbohydrate-restricted (i.e. <20g total carbohydrates per day) or vegetarian diet * Medical comorbidities that in the opinion of the investigator limits the patient's ability to complete this study * Anticipate needing prostate cancer therapy within the next 12 months (i.e. surgery, radiation, or hormonal therapy) * Loss of >10% of body weight within the previous 6 months * Currently receiving any oral hormonal therapy for prostate cancer or BPH (finasteride, dutasteride, bicalutamide) * If prior oral hormonal therapy use for prostate cancer or BPH (as defined above), must not have been taking at time of prior biopsy and must be off for at least 3 months prior to study enrollment (oral medications) * Having ever received any injection hormonal therapy or investigational vaccine for prostate cancer (LHRH agonist, LHRH antagonists, ProstVax, Provenge) * Current use of weight loss medications including herbal weight loss supplements or enrolled in a diet/weight loss program

Study Objectives The purpose of the study is to compare the treatment of esomeprazole 40 mg once daily and lansoprazole 30 mg once daily in controlling intragastric pH in Barrett's Esophagus patients Conditions: Barrett's Esophagus Intervention / Treatment: DRUG: Esomeprazole, DRUG: Lansoprazole

Inclusion Criteria: * Documented history (within 2 yrs of histologically proven BE; * Aged 18-70 (inclusive); * Willing and able to comply with all study procedures Exclusion Criteria: * Signs of clinically significant GI bleeding within 3 days prior to randomization; * History of gastric or esophageal surgery; * Clinically significant illness within 2 weeks prior to first dose of study drug or during study

Study Objectives The primary objective of this study is the estimation of the human papillomavirus (HPV) 6, 11, 16, 18, 31, 33, 45, 52 and 58 seroconversion at 1 month post last dose (Month 7) following 3 doses and 2 doses of the 9vHPV vaccine. No hypothesis will be tested since this study is an estimation-only study. Conditions: Papillomavirus Infections Intervention / Treatment: BIOLOGICAL: 9vHPV vaccine

Inclusion Criteria: * Is Japanese male or female. * Is aged at the time of providing the documented informed consent (inclusive): (3-dose boy arm) male from 9 years to 15 years old, (2-dose boy arm) male from 9 years to 14 years old, or (2-dose girl arm) female from 9 years to 14 years old. * Has a legally acceptable representative who can read, understand and complete the vaccination report card (VRC). * Has not yet had coitarche and does not plan on becoming sexually active during the Day 1 through Month 7. Exclusion Criteria: * Has a fever (defined as oral temperature ≥37.5°C) within the 24-hour period prior to the Day 1 visit. * Has a history of severe allergic reaction that required medical intervention. * Is allergic to any vaccine component, including aluminum, yeast, or Benzonase™. * Has known thrombocytopenia or any coagulation disorder that would contraindicate intramuscular injections. * Is currently immunocompromised or has been diagnosed as having a congenital or acquired immunodeficiency, human immunodeficiency virus (HIV) infection, lymphoma, leukemia, systemic lupus erythematosus, rheumatoid arthritis, juvenile rheumatoid arthritis, inflammatory bowel disease, or other auto immune condition. * Has a history of splenectomy. * Has a history of genital warts or positive test for human papillomavirus (HPV). * Is, at the time of signing informed consent, a user of recreational or illicit drugs or has had a recent history (within 12 months) of drug or alcohol abuse or dependence at the discretion of the investigator. . * Has received within 12 months prior to enrollment, is receiving, or plans to receive during Day 1 through Month 7 of the study, any study-prohibited concomitant immunosuppressive therapy . * Has received within the 3 months prior to the Day 1 vaccination, is receiving, or plans to receive during Day 1 through Month 7 of the study, any immune globulin product or blood-derived product other than intravenous gamma globulin (IVIG). * Has received inactivated or recombinant vaccines within 14 days prior to Day 1 vaccination or receipt of live vaccines within 28 days prior to Day 1 vaccination. * Has previously received a marketed HPV vaccine or has participated in a clinical trial for any HPV vaccine (receiving either active agent or placebo). * Is concurrently enrolled in other clinical studies of investigational agents. * Is unlikely to adhere to the study procedures, keep appointments, or is planning to permanently relocate from the area prior to the completion of the study or to leave for an extended period when study visits would need to be scheduled. * Is or has an immediate family member (e.g., spouse, parent/legal guardian, sibling, or child) who is investigational site or Sponsor staff directly involved with this study.

Study Objectives While total hysterectomy without lymph node staging is standard for low- and intermediate-risk endometrial cancer, certain histopathologic factors can necessitate additional interventions. Our study assesses the influence of sentinel lymph node (SLN) biopsy on postoperative decision-making. Conditions: Endometrial Cancer, Endometrial Neoplasms, Endometrial Adenocarcinoma, Endometrial Cancer Stage I, Endometrial Cancer Stage II, Endometrial Endometrioid Adenocarcinoma, Sentinel Lymph Node, Hysterectomy, Laparoscopic Hysterectomy Intervention / Treatment: PROCEDURE: Laparoscopic total hysterectomy with bilateral salpingo-oophorectomy and sentinel lymph node biopsy

Inclusion Criteria: * Age ≥18 years * Histologically verified low-grade endometrioid adenocarcinoma of the endometrium (G1-G2) * FIGO stage IA * FIGO stage IB and II when LND is contraindicated * No contraindications for surgery * Signed informed consent Exclusion Criteria: * * Age <18 years * Presence of tumor spread outside the corpus uteri * Absence of tumor invasion into the myometrium * High-grade tumor (G3) * Bokhman type 2 tumor (e.g., clear cell adenocarcinoma, serous adenocarcinoma, carcinosarcoma, endometrial stromal sarcoma) * Preoperative treatment of endometrial cancer including radiotherapy, systemic chemotherapy, or hormone therapy * Prior pelvic or retroperitoneal LND * History of surgeries on the uterus and uterine appendages, with exceptions such as cesarean section, tubectomy, oophorectomy, ovarian resection, ovarian biopsy, and ovarian cauterization * Allergy to iodine-containing drugs * Contraindications to surgical treatment * Lack of signed informed consent

Study Objectives This study compared two doses of pembrolizumab (MK-3475) versus docetaxel in participants with non-small cell lung cancer (NSCLC) who had experienced disease progression after platinum-containing systemic therapy. Participants were assigned randomly to receive either pembrolizumab 2 mg/kg once every three weeks (Q3W), pembrolizumab 10 mg/kg Q3W or docetaxel 75 mg/m\^2 Q3W. The total number of participants randomized depended upon demonstration of sufficient objective responses at an interim analysis. Eligible participants who were allocated to the first course of pembrolizumab (2 mg/kg Q3W or 10 mg/kg Q3W) and experienced disease progression, to be permitted to receive a second course of pembrolizumab as long as Inclusion/Exclusion criteria were met. Protocol Amendment 12 (effective date: 09 Dec 2015) enabled eligible participants who were allocated to docetaxel and experienced disease progression, to be permitted to switch over to receive pembrolizumab 2 mg/kg Q3W as long as Inclusion/Exclusion criteria were met. With Protocol Amendment 15 (effective date: 03 Jan 2018), all second course and switch over participants will receive pembrolizumab 200 mg Q3W. Response or progression during the second and switch over pembrolizumab courses will not count towards efficacy outcome measures, and adverse events during the second and switch over pembrolizumab courses will not count towards safety outcome measures. Also with Amendment 15, once a participant has achieved the study objective or the study has ended, the participant will be discontinued from this study and enrolled in an extension study (Keynote 587; NCT03486873) to continue protocol-defined assessments and treatment. Switch over participants who have not transitioned to pembrolizumab will be considered for the extension study on a case-by-case basis. The primary study hypotheses are that pembolizumab prolongs Overall Survival (OS) and Progression-free Survival (PFS) per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST 1.1) by independent radiologists' review in previously-treated participants with NSCLC in the strongly positive programmed cell death ligand 1 (PD-L1) stratum compared to docetaxel and in participants whose tumors express PD-L1 compared to docetaxel. Conditions: Non Small Cell Lung Cancer (NSCLC) Intervention / Treatment: BIOLOGICAL: Pembrolizumab, DRUG: Docetaxel

Inclusion Criteria: * Life expectancy of at least 3 months * Histologically- or cytologically-confirmed diagnosis of NSCLC that is anti-programmed cell death ligand 1 (PD-L1) positive per central laboratory review * At least one bi-dimensional measurable lesion * Radiographic progression after treatment with at least 2 cycles of a platinum-containing doublet * Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 Exclusion Criteria: * Prior therapy with docetaxel for NSCLC * Receiving systemic steroid therapy within 3 days prior to the first dose of study treatment or receiving any other form of immunosuppressive medication * Currently participating or has participated in a study using an investigational antineoplastic agent or device within 30 days of first dose * Expected to require any other form of systemic or localized antineoplastic therapy while on trial * History of allogeneic tissue/solid organ transplant * Prior systemic cytotoxic chemotherapy, antineoplastic biological therapy (e.g., cetuximab), major surgery within 3 weeks of the first dose of study drug; received thoracic radiation therapy of >30 Gy within 6 months of the first dose of study drug; received prior tyrosine kinase inhibitor therapy or completed palliative radiotherapy within 7 days of the first dose of study drug * Prior therapy with an anti-programmed cell death (PD)-1, anti-PD-L1, anti-PD-L2, anti-tumor necrosis factor CD137, or anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) antibody (including ipilimumab or any other antibody or drug specifically targeting T-cell co-stimulation or checkpoint pathways), or took part in another pembrolizumab trial * Known history of prior malignancy, with the exception of basal cell carcinoma of the skin, superficial bladder cancer, squamous cell carcinoma of the skin, or in situ cervical cancer, and has undergone potentially curative therapy with no evidence of that disease recurrence for 5 years since initiation of that therapy * Known active central nervous system (CNS) metastases and/or carcinomatous meningitis * Active autoimmune disease, or a documented history of autoimmune disease, or a syndrome that requires systemic steroids or immunosuppressive agents * Interstitial lung disease, or history of pneumonitis requiring systemic steroids for treatment * Known history or active human immunodeficiency virus (HIV), hepatitis B, or hepatitis C * Pregnant or breastfeeding, or expecting to conceive or father children within the projected duration of the trial through 120 days after last dose of pembrolizumab or 180 days after last dose of docetaxel

Study Objectives The study, investigates the current physical activity promotion practices among physicians and nurses, as well as social norms toward physical activity during treatment among cancer patients and among physicians and nurses who treat or counsel cancer patients. Conditions: Colorectal Cancer, Breast Cancer, Prostate Cancer, Physicians, Nurses Intervention / Treatment:

Inclusion Criteria: * HCP are eligible if they meet the following inclusion criteria: Working as an oncological nurse, general practitioner or physician specialized in oncology, radiology, surgery, gynecology, urology, gastroenterology or rehabilitation Signed informed consent * Patients are eligible if they meet the following inclusion criteria: Patients with a diagnosis of primary tumor or recurrence no longer than 2 years ago who are undergoing chemo- or radiotherapy currently or in the last 2 years Patients undergoing chemo- or radiotherapy currently or no longer than 2 years ago At least 18 years of age Sufficient German language skills Signed informed consent Exclusion Criteria: * HCP will be excluded from the trial if they meet the following exclusion criteria: No regular contact with cancer patients * Patients will be excluded from the trial if they meet the following exclusion criteria: Presence of comorbidities that preclude involvement in exercise programs (e.g. severe pain, advanced heart failure \[≥ NYHA III\]) Mentally retarded Reduced standing ability and no ability to walk

Study Objectives A Phase I, Open-Label, Two Parts Study to Assess the Safety, Tolerability,Pharmacokinetics and Preliminary Anti-tumour Activity of AZD9291 in Chinese Patients with Advanced Non-Small Cell Lung Cancer who have Progressed Following Prior Therapy with an Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Agent Study Objective: 1, Primary Objective To characterise the pharmacokinetics (PK) of AZD9291 and its metabolites (AZ5104 and AZ7550) after single then multiple doses of AZD9291 administered orally once daily in Chinese patients with locally advanced or metastatic non small cell lung Cancer (NSCLC) who have progressed following prior therapy with an approved Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor (EGFR TKI) agent. 2, Secondary objective(s) To investigate the safety and tolerability of AZD9291 when given orally to Chinese patients with locally advanced or metastatic NSCLC who have progressed following prior therapy with an approved EGFR TKI agent. To obtain a preliminary assessment of the anti-tumour activity of AZD9291 by evaluation of tumour response using Response Evaluation Criteria in Solid Tumours (RECIST) version 1.1. Conditions: Carcinoma, Non-Small-Cell Lung With EGFR Mutation Positive Intervention / Treatment: DRUG: AZD9291 40 mg, DRUG: AZD9291 80 mg

Inclusion Criteria: * Provision informed consent* Aged at least 18 years* Histological or cytological confirmation diagnosis of NSCLC* Locally advanced or metastatic NSCLC* Radiological documentation of disease progression while on a previous continuous treatment with an approved EGFR TKI. In addition other lines of therapy may have been given * Documented EGFR mutation (at any time since the initial diagnosis of NSCLC) known to be associated with EGFR TKI sensitivity (including G719X, exon 19 deletion, L858R, L861Q)* World Health Organisation (WHO) performance status 0-1* At least one lesion suitable for accurate repeated measurements* Females * Child bearing potential : should not be breast feeding, use adequate contraceptive measures for female patients with child-bearing potential, OR * Have evidence of non-child-bearing potential that meet one of the following criteria at screening: * Post-menopausal defined as aged more than 50 years and amenorrhoeic for at least 12 months following cessation of all exogenous hormonal treatments * Women below 50 years old would be consider postmenopausal if they have been amenorrheic for 12 months or more following cessation of exogenous hormonal treatments and with luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels in the post-menopausal range for the institution * Documentation of irreversible surgical sterilisation by hysterectomy, bilateral oophorectomy or bilateral salpingectomy but not tubal ligation* Male patients should be willing to use barrier contraception ie, condoms Exclusion Criteria: * Treatment with any of the following (prior to first dose of study treatment) * Treatment with an EGFR TKI within 8 days * Any investigational agents or other anticancer drugs from a previous treatment regimen or clinical study within 14 days * Previous treatment with AZD9291, or a Thr790Met (T790M) directed EGFR TKIs * Major surgery (excluding placement of vascular access) within 4 weeks * Radiotherapy : * Within 1 week if limited field of radiation for palliation of the first dose of study treatment * Within 4 weeks if receiving radiation to more than 30% of the bone marrow or with a wide field of radiation * Patients currently receiving (or unable to stop use at least 1 week) medications or herbal supplements known to be potent inhibitors or inducers of cytochrome P450 3A4 (CYP3A4) * Treatment with an investigational drug within five half-lives of the compound* Any unresolved toxicities from prior therapy greater than CTCAE grade 1 at the time of starting study treatment with the exception of alopecia and grade 2, prior platinum-therapy related neuropathy* Spinal cord compression or brain metastases unless asymptomatic, stable and not requiring steroids for at least 4 weeks prior to start of study treatment* Any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension and active bleeding diatheses, which in the investigator's opinion makes it undesirable for the patient to participate in the trial or which would jeopardise compliance with the protocol, or active infection including hepatitis B, hepatitis C and human immunodeficiency virus (HIV). Screening for chronic conditions is not required* Any of the following cardiac criteria: * Mean resting corrected QT interval (QTc) >470 msec obtained from 3 electrocardiograms (ECGs), using the screening clinic ECG machine derivedQTc value * Any clinically important abnormalities in rhythm, conduction or morphology of resting ECG eg, complete left bundle branch block, third degree heart block, second degree heart block, P wave to R wave (PR) interval >250 msec * Any factors that increase the risk of QTc prolongation or risk of arrhythmic events such as heart failure, hypokalaemia, congenital long (Q-T interval) QT syndrome, family history of long QT syndrome or unexplained sudden death under 40 years of age in first degree relatives or any concomitant medication known to prolong the QT interval* Past medical history of interstitial lung disease, drug-induced interstitial lung disease, radiation pneumonitis which required steroid treatment, or any evidence of clinically active interstitial lung disease 7, Inadequate bone marrow reserve or organs function as demonstrated by any of the following laboratory values: * Absolute neutrophil count <1.5x109/L * Platelet count <100x109/L * Hemoglobin <90 g/L * Alanine aminotransferase >2.5 times the upper limit of normal (ULN) if no demonstrable liver metastases or >5 times ULN in the presence of liver metastases * Aspartate aminotransferase >2.5 times ULN if no demonstrable liver metastases or >5 times ULN in the presence of liver metastases * Total bilirubin >1.5 times ULN if no liver metastases or >3 times ULN in the presence of documented Gilbert's Syndrome (unconjugated hyperbilirubinaemia) or liver metastases * Creatinine >1.5 times ULN concurrent with creatinine 8, Clearance <50 ml/min (measured or calculated by Cockcroft and Gault equation); confirmation of creatinine clearance is only required when creatinine is >1.5 times ULN Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of AZD9291 9, History of hypersensitivity to active or inactive excipients of AZD9291 or drugs with a similar chemical structure or class to AZD9291 10, Women who are breast feeding 11, Involvement in the planning and conduct of the study (applies to AstraZeneca staff or staff at the study site) 12, Judgement by the investigator that the patient should not participate in the study if the patient is unlikely to comply with study procedures, restrictions and requirements

Study Objectives Background: Psychological burden in cancer patients may worsen quality of life and even medical outcomes such as mortality. Nevertheless, many distressed patients are not recognized by the treating clinicians and left untreated even though effective psychosocial interventions exist. Existing screenings programs have multiple limitations such as the necessity of time consuming training and involvement of clincial staff, conventional screening instruments with limited diagnostic accuracy and the focusing on objective measures of distress, thereby neglecting subjective supportive care needs. Aims: To address some of the limitations outlined above, we developed an electronic psycho-oncological adaptive screening program (EPAS) which separately assesses distress and psychosocial care needs and provides immediate patient feedback with individualized recommendations about psychosocial care services. Design: Patients of the intervention are compared to a control condition. All participants are assessed at three measurement points (baseline, and at 3-months and 6-months follow-up). Outcomes: Outcomes assess aspects related to psychosocial care services, well-being and satisfaction. Recruitment: Patients are recruited within suitable health care facilities within the University Cancer Center Hamburg (UCCH) and other facilities in the competence network of the UCCH. Patients are checked for eligibility via review of the medical chart and consecutively recruited by research assistants. Duration of the study: From start of recruitment, 2 years are planned until data analysis. 1 year is planned for recruitment. Analyses: We conduct group comparisons in the study outcomes, both unconditional and condcitional (controlled for care relevant co-variates). Conditions: Cancer Intervention / Treatment: BEHAVIORAL: EPAS (electronic psycho-oncological adapative screening program)

Inclusion Criteria: * minimum age of 18 years * diagnosed with any malignancy according to ICD-10 (first diagnosis or relapse) Exclusion Criteria: * Patients with any impairments interfering with the ability to give informed consent

Study Objectives Radical cystectomy with urinary diversion is associated with substantial perioperative morbidity, including deep venous thrombosis, prolonged ileus, and postoperative functional decline. Post-operative morbidity after cystectomy prolongs the length of stay, increases the risk of readmission, and adds substantially to health care costs. Protocols that emphasize early and frequent ambulation after surgery decreases post-operative morbidity, but poor patient adherence diminishes the effectiveness of these protocols, which are currently implemented only during the hospital stay. Financial incentives overcome present bias and offer a novel and practical approach to increasing ambulation during the post-operative period in the hospital and also after discharge. This application proposes a pilot randomized, controlled trial to estimate the effect size of financial incentives on achieving a patient-specific daily step goal in the hospital and post-discharge for 1 month following radical cystectomy. Secondary outcomes include step count, composite morbidity, and functional decline. Forty-six adults with bladder cancer undergoing radical cystectomy at the Hospital of the University of Pennsylvania will be randomized to either control (education of step goal with monitoring and daily feedback) or a gain financial incentive combined with a lottery incentive if they achieve 75% of the daily goals during the study period. Fitbit Zips will be used to measure step counts for all participants. This proposal will provide the preliminary data needed to design future, larger trials that will test the effect of financial incentives to increase ambulation on post operative complications, readmissions, and functional decline. Conditions: Bladder Cancer Intervention / Treatment: OTHER: Financial Incentive to Increase Ambulation

Inclusion Criteria: * Planning to undergo radical cystectomy (either with ileal conduit, Indiana pouch, neobladder (e.g., Studer or Hautmann pouch) at the University of Pennsylvania * Patient has been diagnosed with bladder cancer * Patient is at least 21 years of age * Patient is ambulatory with baseline ECOG performance status less than or equal to 2 Exclusion Criteria: * Patient knows he or she will be unable or unwilling to use a mobile device and online tool to upload activity data * Poor preoperative performance status (ECOG 3 or greater) * Plan for cystectomy without cutaneous ureterostomies (without a bowel diversion) * Non-English speakers * Patient is non-ambulatory * Patient is incapable of consenting himself or herself prior to surgery (Because participating in this trial involves ongoing effort on the part of the subject, patients who are incapable of consenting for themselves at baseline are excluded) * Patients who do not have at least 24 hours of pre-operation ambulation data

Study Objectives This is a pilot study to evaluate the feasibility of, adherence to, and early efficacy of Band Together, a strength-training and walking program (intervention arm) vs. education on the benefits of exercise (control arm) in patients with aggressive gastrointestinal (GI) malignancies (gastric, gastroesophageal, and pancreatic cancer) undergoing neoadjuvant therapy. Conditions: Pancreatic Adenocarcinoma, Gastric Adenocarcinoma, Adenocarcinoma of the Gastroesophageal Junction Intervention / Treatment: BEHAVIORAL: Band Together, OTHER: Exercise Education

Inclusion Criteria: * Age 18 years or older* New diagnosis of potentially resectable or borderline resectable pancreatic adenocarcinoma, gastric adenocarcinoma, or adenocarcinoma of the gastroesophageal junction.* Patients must be evaluated at the Penn State Hershey Medical Center prior to receiving neoadjuvant chemotherapy or chemoradiation.* Patients must be deemed appropriate for neoadjuvant therapy by their treating health care providers.* The ability to speak and read English.* The ability to provide informed consent. Exclusion Criteria: * Angina (stable or unstable)* Paraplegia or quadriplegia* Joint or muscle conditions that prevent the patient from being able to grip and or lift resistance bands.* Patients who have already started neoadjuvant chemotherapy at other institutions.* Presence of metastatic disease.* Gastric or pancreatic histologies other than adenocarcinoma.* Pregnant women.* Prisoners* Patients screening positive on the Physical Activity Readiness Questionnaire (PAR-Q)

Study Objectives The Evaluating Cancer Survivorship Care Models project is an innovative 3-year study that is collecting data to help understand how to best deliver follow-up care to cancer survivors. Cancer is a complex disease requiring complex treatments that can cause lasting impacts after treatment ends. Some patients face physical, psychosocial, spiritual and/or practical challenges as they adjust to life after cancer. Fortunately, health care providers have begun to focus on the consequences of cancer and its treatment and are more actively working with cancer survivors to manage post-treatment needs and care. Led by the George Washington University and funded by the Patient-Centered Outcomes Research Institute, this project brings together representatives from the Commission on Cancer, the Cancer Support Community, LIVESTRONG and the American Cancer Society as well as cancer survivors and healthcare professionals to better understand how different strategies or models of care impact outcomes that are most important to cancer survivors. The project will focus on survivors of breast, prostate and colorectal cancers and will be relevant for understanding the needs and preferences of survivors of other cancers as well. The emphasis is on patient-centered outcomes, which are outcomes that are most significant to patients, such as patient satisfaction and quality of life. Conditions: Quality of Life, Cancer Intervention / Treatment: OTHER: Organizational Interview, OTHER: Organizational Survey, OTHER: Survivor Survey (1): Pre-Visit Baseline, OTHER: Survivor Survey (2): Post-Visit, OTHER: Survivor Survey (3): 3 Month Post-Visit, OTHER: Survivor Survey (4): 6 Month Post-Visit, OTHER: Clinician Survey

Inclusion criteria for the CER component: Survivorship program administrators oversee survivorship programs which: * See at least 60 new survivors of non-metastatic breast, prostate or colorectal cancer or survivors of any type of cancer yearly * Represent one of the clinical survivorship care models identified in our environmental scan * Indicate a high performance level on incorporating elements of survivorship care into clinical care delivery. Survivors: * English-speaking survivors of non-metastatic breast, prostate or colorectal cancers * Completed planned active treatment (chemotherapy, radiation, and/or surgery) with the exception of hormonal medication, aromatase inhibitors or other maintenance therapy * Diagnosed at 18 years old or older * First appointment with the survivorship program is planned but has not yet been completed Survivorship program clinicians: * Must be providing services for eligible survivors who have completed their first visit with the survivorship program and are participating in the study. Exclusion criteria for the CER component: Survivorship program administrators: * Programs with fewer than at least 60 new survivors yearly * Do not provide services to adult survivors of non-metastatic breast, prostate or colorectal cancer or survivors of any type of cancer * Do not represent one of the three models of clinical survivorship care as identified in our environmental scan * Do not indicate a high performance level on incorporating elements of survivorship care into clinical care delivery Survivors: * Received diagnosis for cancer that was not breast, prostate or colorectal cancer * Not English-speaking * Currently undergoing active treatment (defined as chemotherapy, radiation, and/or surgery) * Cancer has metastasized * Diagnosed at under 18 years old * Have completed first appointment with the survivorship program Men will be excluded from the breast cancer arm of the study. Women will be excluded from the prostate cancer arm of the study. Survivorship program clinicians: * Not providing services for eligible survivors.

Study Objectives This is a Phase I, multi-centre, non-randomized, uncontrolled, open-label, dose escalating study of BI 836880 administered intravenously once a week. The eligible patient population will be patients with advanced solid tumors. The primary objective of this trial is to determine the maximum tolerated dose (MTD) and recommended Phase II doses for BI 836880 in patients with solid tumors. Preliminary safety data will be evaluated as secondary objectives. Subsequently, pharmacokinetic profile, pharmacodynamic changes in circulating biomarkers and Dynamic Contrast-Enhanced Magnetic Resonance Imaging ( DCE-MRI), anti-tumor activity and the immunogenicity of BI 836880 will be explored up to a total of 40 patients with advanced solid tumors. Dose escalation will be guided by a Bayesian logistic regression model with over dose control (EWOC) using at least 2 patients per dose cohorts. Safety criteria will be followed, including adverse events according to Common Terminology Criteria (CTCAE version 4.03), incidence of dose limiting toxicities, physical examination, vital signs, safety laboratory parameters and Eastern Cooperative Oncology Group (ECOG). Conditions: Neoplasms Intervention / Treatment: DRUG: BI 836880

Inclusion criteria: 1 Age >=18 years 2. Histologically confirmed malignancy which is locally advanced or metastatic solid tumor, and either refractory after standard therapy for the disease or for which standard therapy is not reliably effective e.g. patients do not tolerate or have contraindications to otherwise available standard therapy and tumour lesions evaluable for Dynamic contrast-enhanced (DCE)-MRI at MTD. * ECOG performance status <= 2 4. Adequate hepatic, renal and bone marrow functions as defined by the following criteria: * Total bilirubin within normal limits (<= 1.5x upper limit of normal (ULN) for patient with Gilberts syndrome)* Alanine amino transferase (ALT) and aspartate amino transferase (AST) <= 1.5x ULN (< 5x upper limit of normal (ULN) for patient known liver metastases)* Serum creatinine < 1.5x ULN* International normalized Ratio (INR) 0.8-1.2 or partial thromboplastin time (PTT) < 1.5x ULN* Absolute neutrophil count (ANC) > 1.5 109/L* Platelet count > 100x109/ L.* Haemoglobin > 10 g/dl (without transfusion within previous week) 5. Signed and dated written informed consent. 6. Life expectancy >= 3 months in the opinion of the investigator 7. Recovery from all reversible adverse events of previous anti-cancer therapies to baseline or CTCAE grade1, except for alopecia (any grade), sensory peripheral neuropathy CTCAE grade <= 2 or considered by the investigator as clinically not significant. 8. Male or female patients. Women of childbearing potential\* must be ready and able to use highly effective methods of birth control per International Conference on Harmonisation \[ICH M3(R2)\] in combination with male condom as "double barrier", during the trial and for at least 6 months after the end of treatment with BI 836880, that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria is provided in the patient information. Male patient must always use condoms when sexually active during the trial and for at least 6 months after the end of treatment with BI 836880. \*Women of childbearing potential are defined as: Any female who has experienced menarche and does not meet the criteria for "women not of childbearing potential" as described below. Women not of childbearing potential are defined as: Women who are postmenopausal (12 months with no menses without an alternative medical cause) or who are permanently sterilized (e.g., hysterectomy, bilateral oophorectomy or bilateral salpingectomy). Exclusion criteria: 1. Known hypersensitivity to the trial drugs or their excipients or risk of allergic of anaphylactic reaction to the study drug according to the investigator judgement (e.g. patient with history of anaphylactic reaction or autoimmune disease that is not controlled by nonsteroidal anti-inflammatory drugs (NSAIDS), inhaled corticosteroids, or the equivalent of < 10 mg/day prednisone) 2. Current or prior treatment with any systemic anti-cancer therapy either within 28 days or a minimum of 5 half-lives, whichever is shorter at the start of study treatment. 3. Serious concomitant disease (based on investigator judgement), especially those affecting compliance with trial requirements or which are considered relevant for the evaluation of the endpoints of the trial drug, such as neurologic, psychiatric, infectious disease or active ulcers (gastro-intestinal tract, skin) or laboratory abnormality that may increase the risk associated with trial participation or trial drug administration, and in the judgment of the investigator would make the patient inappropriate for entry into the trial. 4. Major injuries and/or surgery (as judged by the investigator) or bone fracture within 4 weeks of start of study treatment, or planned surgical procedures during the trial period. 5. Patients with personal or family history of QT prolongation and/or long QT syndrome, or prolonged QT interval corrected for heart rate according to Fridericia's formula (QTcF) at baseline (> 470 ms). QTcF will be calculated by Investigator as the mean of the 3 ECGs taken at screening. 6. Significant cardiovascular/ cerebrovascular disease (i.e uncontrolled hypertension, unstable angina, history of infarction within past 6 months, congestive heart failure > New York heart association ( NYHA II). Uncontrolled hypertension defined as: blood pressure in tested and relaxed condition >= 140 mmHg, systolic or > 90 mmHg diastolic (with or without medication), measured according to Section 5.3.2 and Appendix 10.2. 7. History of severe haemorrhagic or thromboembolic event in the past 12 months (excluding central venous catheter thrombosis and peripheral deep vein thrombosis). 8. Known inherited predisposition to bleeding or to thrombosis in the opinion of the investigator. 9. Patient with brain metastases that are symptomatic and/or require therapy. 10. Patients who require full-dose anticoagulation (according to local guidelines). No vitamin K antagonist and other anticoagulation allowed; low-molecular-weight heparin (LMWH) allowed only for prevention not for curative treatment. 11. Use of alcohol or drug incompatible with patient participation in the study in the investigator opinion 12. Patient unable or unwilling to comply with protocol 13. Women who are pregnant, nursing, or who plan to become pregnant while in the trial 14. Previous enrolment in this trial

Study Objectives CLGX818X2101 is a first-time in-human, phase I study to establish the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D) of daily administered LGX818 (daily, twice daily and/or every-other-day), a RAF kinase inhibitor. Patients with locally advanced or metastatic melanoma harboring the BRAF V600 mutation (during dose escalation phase and expansion phase) and patients with metastatic colorectal cancer harboring the BRAF V600 mutation (during the expansion phase) will be enrolled. The study consists of a dose escalation part were cohorts of patients will receive escalating oral doses of LGX818, followed by a safety dose expansion part were patients will be treated with oral dose of LGX818 given at the MTD or RP2D. Conditions: Melanoma and Metastatic Colorectal Cancer Intervention / Treatment: DRUG: LGX818

Inclusion Criteria: For the dose escalation phase: * Histologically confirmed diagnosis of locally advanced or metastatic melanoma (stage IIIB to IV per American Joint Committee on Cancer \[AJCC\]). For the dose expansion phase: (i) Histologically confirmed diagnosis of locally advanced or metastatic melanoma (stage IIIB to IV per American Joint Committee on Cancer \[AJCC\]), or (ii) confirmed diagnosis and non-resectable advanced metastatic colorectal cancer (mCRC) for which no further effective standard therapy exists.* Written documentation of BRAF V600E mutation, or any other BRAF V600 mutation.* Evidence of measurable disease Exclusion Criteria: * Previous therapy with a MEK inhibitor.* Symptomatic or untreated leptomeningeal disease.* Symptomatic or untreated brain metastasis.Patients previously treated for these conditions that are asymptomatic in the absence of corticosteroid therapy are allowed to enroll. Brain metastasis must be stable with verification by imaging.* Known acute or chronic pancreatitis.* Clinically significant cardiac disease* Impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of oral LGX818* Previous or concurrent malignancy. Exceptions to this exclusion criteria include: adequately treated basal cell or squamous cell skin cancer; in situ carcinoma of the cervix, treated curatively and without evidence of recurrence for at least 3 years prior to study entry; or other solid tumor treated curatively, and without evidence of recurrence for at least 3 years prior to study entry.* Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test (> 5 mIU/mL).* History of thromboembolic or cerebrovascular events within the last 6 months Other protocol-defined inclusion/exclusion criteria may apply

Study Objectives This is a phase 2 study of investigational drug, durvalumab given in combination with azacitidine (CC-486). The main purpose of this phase 2 study is to assess the antitumor activity of azacitidine in combination with durvalumab patients with microsatellite stable colorectal carcinoma (MSS-CRC), platinum resistant epithelial ovarian cancer type II (PR-OC), and estrogen receptor positive and HER2 negative breast cancer. Conditions: Microsatellite Stable Colorectal Carcinoma, Platinum Resistant Epithelial Ovarian Cancer Type II, Estrogen Receptor Positive and HER2 Negative Breast Cancer Intervention / Treatment: DRUG: Azacitidine, DRUG: Durvalumab

Inclusion Criteria: * Able to provide written informed consent. * Age ≥18 years or ≥20 years for Japanese participants. * Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1. * Life expectancy of ≥12 weeks * Have histologically or cytologically-documented, locally-advanced, or metastatic solid malignancy that is incurable and has either (a) failed prior standard therapy, (b) for which no standard therapy exists, or (c) standard therapy is not considered appropriate by the patient and treating physician. * Have one of the following advanced (unresectable and/or metastatic) solid tumor indications: * Microsatellite Stable Colorectal Carcinoma (MSS-CRC) * Platinum Resistant Epithelial Ovarian Cancer Type II (PR-OC) * Estrogen Receptor Positive and HER2 Negative Breast Cancer (ER+/HER2- BC): * The following considerations will be made regarding prior treatment regimens: * MSS-CRC: must have progressed or be intolerant of 5-FU, irinotecan, oxaliplatin and epidermal growth factor receptor (EGFR) mAb in patients with RAS wild type tumors, in recurrent/metastatic setting. * PR-OC: must have progressed on at least 1, maximum of 2 lines of cytotoxic agents in the platinum resistant disease setting * ER+/HER2- BC: must have progressed on at least 2, maximum of 5 lines of cytotoxic agents in recurrent/metastatic setting. * Adequate normal organ and marrow function * Willing and able to comply with the protocol for the duration of the study including undergoing treatment and scheduled visits and examinations including follow up. * At least one measurable lesion according to RECIST v1.1. * At least one lesion safely accessible for biopsy. * Be willing to provide tissue from a newly obtained core or excisional biopsy of a tumor lesion. * Consent to provide archival tumor tissue (initial and subsequent tumor biopsy samples, if possible) for correlative biomarker studies, if available. * Female subject of childbearing potential1 should have two negative pregnancy tests as verified by the investigator prior to starting any investigational product therapy * Females of childbearing potential who are sexually active with a non-sterilized male partner must agree to practice true abstinence or use at least two effective methods of contraception for the study defined period. * Non-sterilized males who are sexually active with a female partner of childbearing potential must agree to use at least two effective methods of contraception for the study defined period. Exclusion Criteria: * Involvement in the planning and/or conduct of the study or previous enrolment in the present study. * Participation in another clinical study with an investigational product during the last 28 days or 5 half-lives prior to study Day 1. Concurrent enrolment in an observational (noninterventional) clinical study or the follow-up period of an interventional study is allowed. * Any previous treatment with a PD1 or PD-L1 inhibitor, including durvalumab. Prior anti-CTLA4 agents are allowed. Prior therapy with T-cell co-stimulatory agents (e.g. anti-CD137 antibody, anti-OX40 antibody) are allowed. * Prior therapy with CC-486, azacitidine, decitabine or any other hypomethylating agent. * History of another primary malignancy with exceptions. * Receipt of the last dose of anti-cancer therapy (chemotherapy, immunotherapy, endocrine therapy, targeted therapy, biologic therapy, tumor embolization, monoclonal antibodies, other investigational agent) ≤ 28 days prior to the first dose of study drug (and within 6 weeks for nitrosourea or mitomycin C). * Mean QT interval corrected for heart rate (QTc) ≥470 ms. * Current or prior use of immunosuppressive medication within 28 days before the first dose of durvalumab with exceptions. * Any unresolved toxicity CTCAE grade 2 from previous anti-cancer therapy. * Any prior Grade ≥3 immune-related adverse event (irAE) while receiving any previous immunotherapy agent, or any unresolved irAE >Grade 1, with exception of chronic endocrinopathy that is stable on hormone replacement. * Active or prior documented autoimmune disease within the past 2 years. * Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis). * History of primary immunodeficiency * History of allogeneic organ transplant * History of hypersensitivity to study drug formulations, including azacitidine, mannitol, or durvalumab, its constituents, or to any other humanized monoclonal antibody * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, uncontrolled hypertension, unstable angina pectoris, cardiac arrhythmia, active peptic ulcer disease or gastritis, active bleeding diatheses including any patient known to have evidence of acute or chronic hepatitis B, hepatitis C or human immunodeficiency virus (HIV), or psychiatric illness/social situations that would limit compliance with study requirements or compromise the ability of the patient to give written informed consent * Known history of previous clinical diagnosis of tuberculosis * Receipt of live attenuated vaccination within 30 days prior to study entry or within 30 days of investigational products. * Female patients who are pregnant, breast-feeding or male or female patients of reproductive potential who are not employing an effective method of birth control. * Irritable bowel syndrome or other serious gastrointestinal chronic conditions associated with diarrhea within the past 3 years prior to the start of treatment, and/or history of prior gastrectomy or upper bowel removal, or any other gastrointestinal disorder or defect that would interfere with the absorption, distribution, metabolism or excretion of the investigational product and/or predispose the patient to an increased risk of gastrointestinal toxicity. * Untreated central nervous system (CNS) metastatic disease, leptomeningeal disease, or cord compression. * Patients with uncontrolled seizures. * Any concurrent chemotherapy, immunotherapy, or biologic or hormonal therapy for cancer treatment with the exception of patients on adjuvant endocrine therapy for a history of non-invasive breast cancer. * Major surgery within 28 days prior to Day 1 of the study or still recovering from prior surgery. * Any condition that, in the opinion of the investigator, would interfere with evaluation of study treatment or interpretation of patient safety or study results. * Patients who are involuntarily incarcerated or are unable to willingly provide consent or are unable to comply with the protocol procedures.

Study Objectives The investigational product (IP) HL-085 is an adenosine triphosphate-noncompetitive mitogen activated protein kinase (MEK) inhibitor with a strong selective anti-tumor activity, with a much lower dose than selumetinib. It has been shown strong anti-tumor activities in preclinical studies to treat solid tumors, e.g., melanoma, non-small cell lung cancer, colon cancer and other malignancies with RAF and RAS mutations. Kechow has completed phase I dose escalation study to test HL-085 in patients with advanced NRAS mutated melanoma in China. The tested doses were 0.5 mg, 1mg, 2mg, 3mg, 4mg, 6mg, 9mg, 12mg, 15mg and 18mg BID oral administration and there was no dose-limiting toxicity (DLT) identified. All patients tolerated the study drug reasonably well. This study is a Phase I, open-label, dose escalation study to evaluate tolerability, safety, pharmacokinetic (PK) and preliminary antitumor activities of HL-085 in US patients with advanced solid tumors. The objective of the dose escalation is to evaluate safety and tolerability of selected TID and BID dose regimens in US patient population with advanced solid tumor and establish the Recommended Phase 2 Dose (RP2D). The starting dose for this trial is 12 mg daily oral administration. Three selected daily doses - 12 mg (4mg TID, 6mg BID), 18 mg (6mg TID, 9 mg BID), and 24 mg (8 mg TID, 12 mg BID) will be tested in this study to assess safety and tolerability of HL-085 at the 3 selected dose levels in US patient population with advanced solid tumors. Conditions: Solid Tumor, Adult Intervention / Treatment: DRUG: HL-085

Inclusion Criteria: * Written informed consent must be obtained prior to any clinical trial procedures* Aged 18 years or over.* Must have a pathologically documented solid tumor(s) that has relapsed from, or is refractory to standard treatment, or unable to tolerate toxicities from the SOC/available treatments, or for which no standard treatment is available.* Must have at least one measurable lesion as defined by RECISTv1.1 criteria for solid tumors.* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2.* Life expectancy ≥3 months (as judged by the Investigator).* Must have adequate hematologic function (no blood transfusion and growth factor support for ≥14 days), adequate hepatic and renal function, and some key lab test results meeting the following laboratory values within 7 (+/-2) days before first dosing.* Must have the willingness and ability to comply with scheduled visits, treatment plans, laboratory tests and other study procedures. Exclusion Criteria: * Have biological, chemotherapy, immunotherapy or radiotherapy less than 4 weeks prior to starting the study treatment.* Have undergone or plan to have major surgery (except for tumor biopsy) or experienced severe trauma ≤28 days prior to starting the study treatment.* Have active central nervous system lesion (i.e., imaging instability and neurologically unstable). Note: patients who have received stereotactic radiotherapy or surgical treatment for brain tumor can be included after 3 months of procedure without symptoms.* Previous or history of second malignancy within 3 years prior to study treatment except for curatively treated.* Prior therapy with MEK-inhibitor with severe toxicity causing permanent damage from it, such as ocular, cardiac, pulmonary, etc. disorders and illness.* History of any of the following within 6 months prior to Screening: * Myocardial infarction. * Unstable angina. * Coronary artery bypass graft. * Coronary angioplasty or stenting. * Chronic heart failure (New York Heart Association Grade ≥2). * Ventricular arrhythmias requiring continuous therapy. * Supraventricular arrhythmias, including atrial fibrillation, which are uncontrolled. * Uncontrolled hypertension despite optimal medication management (per Investigator's assessment) * Cerebrovascular accidents including transient ischemic attack, or pulmonary embolism. * Creatine Phosphokinase (CPK) >2.5×ULN due to underlying cardiac disorders or myocardial infarction.* Mean resting QT calculated using Bazzetts formula (QTcB) ≥480 obtained from three electrocardiograms (ECGs); or family or personal history of long or short QT syndrome; Brugada syndrome or known history of QTc prolongation or Torsade de Pointes within 12 months of Screening.* Left ventricular ejection fraction (LVEF) <50%.* History or current evidence of retinal diseases (e.g., retinal vein occlusion \[RVO\] or retinal pigment epithelial detachment, macular degeneration, and retinal detachment).* Active/chronic infection with hepatitis C (note: patients positive for anti hepatitis C virus \[HCV\] antibody will be eligible if they are negative for HCV-ribonucleic acid \[HCV-RNA\]); or active hepatitis B, or active/chronic infection with human immunodeficiency virus (HIV).* Known active tuberculosis.* Infectious diseases requiring systemic treatment including patients tested positive for COVID-19 according to investigator site/institution's COVID-19 management policies and guidelines.* History of allogeneic bone marrow transplantation or organ transplantation.* Interstitial lung disease or interstitial pneumonitis, including clinically significant radiation pneumonitis (i.e., affecting activities of daily living or requiring therapeutic intervention). Patients with subclinical pneumonitis who have received immunotherapy previously can be included if his/her condition is stable without any medical intervention.* Known hypersensitivity to IP ingredients or their analogues.* Unable to swallow IP or has refractory nausea and vomiting, malabsorption, external biliary diversion, or any significant small bowel resection that may interfere with adequate absorption of IP.* Concomitant medication which are strong inducers or strong inhibitors of cytochrome P450 CYP2C9, CYP2C19, CYP 3A4.* Pregnant or breast-feeding females.* Female patients of child-bearing potential or male patients who will not use an effective form of contraception for the duration of the study (until at least 30 days after the last dose of study medication).

Study Objectives This study evaluates the ability of a prototype intraoperative handheld gamma camera (pIHGC) to image (detect) sentinel lymph nodes (SLNs) in melanoma and breast cancer during surgical excision, as compared to standard of care intraoperative gamma probes (GP). The unit of study in this trial was SNLs rather individual participants. Each device was assessed for relative node detection sensitivity (S) of those SLNs. Conditions: Multiple Myeloma, Breast Cancer Intervention / Treatment: DEVICE: Prototype intraoperative handheld gamma camera (pIHGC), DEVICE: Lymphoscintigraphy with intraoperative gamma probes (GP), RADIATION: radioactive Tc99M

INCLUSION CRITERIA * Malignancy for which sentinel node biopsy with lymphoscintigraphy are indicated as part of the standard of care for tumor staging * Age 18 or greater. * Healthy enough for surgery * Able to understand and willing to sign a written informed consent document. EXCLUSION CRITERIA * No exclusion requirements due to co-morbid disease or intercurrent illness. * Documented allergy to colloid. * Lymphoscintigraphy presents excessive high risk, eg, a consideration if pregnant or lactating

Study Objectives The study protocol is based on a multi-center semi-quantitative approach of EUS elastography data in combination with contrast-enhanced EUS, consisting of measuring SR and SH for focal pancreatic masses and lymph nodes, as well as several parameters of CE-EUS based on time-intensity-curve (TIC) analysis. A number of parameters must be taken into consideration, as the ROIs are still manually selected by the user. The aim of the study is to establish an EUS based diagnostic algorithm in patients with pancreatic masses and lymph nodes, with negative or inconclusive cytopathology after EUS-FNA, based on previously published results and cut-offs of elastography and contrast-enhancement. The proposed algorithm of sequential use of real-time elastography, followed by contrast-enhanced EUS could be a good clinical tool to help select the patients with possible pancreatic adenocarcinoma or malignant lymph nodes, in the setting of patients with negative EUS-FNA results. Conditions: Pancreatic Cancer, Secondary Malignant Neoplasm of Lymph Node, Benign Neoplasm of Lymph Nodes, Benign Pancreatic Tumors Intervention / Treatment: OTHER: Elastography, contrast enhancement

Inclusion Criteria: * Patients diagnosed with solid pancreatic tumor masses, with cytological / histo-logical confirmation * Patients with or without suspected lymph node involvement are eligible * Age 18 to 90 years old, men or women * Signed informed consent for EG-EUS, CE-EUS and FNA biopsy Exclusion Criteria: * Prior surgical treatment with curative intent or chemo-radiotherapy * Patients diagnosed with mucin producing tumors, pancreatic cystic tumors, etc.

Study Objectives The purpose of this study is to learn fluid from sonohysterography can be used to diagnose endometrial cancer. Conditions: Endometrial Cancer Intervention / Treatment: PROCEDURE: Sonohysterography

Inclusion Criteria: * Newly diagnosed early-stage endometrial cancer Exclusion Criteria: * Recurrent or persistent endometrial cancer * Evidence of distant metastases

Study Objectives This 4 arm study will evaluate the efficacy and safety of 4 neoadjuvant treatment regimens in female patients with locally advanced, inflammatory or early stage HER2 positive breast cancer. Before surgery, patients will be randomized to one of 4 treatment arms, to receive 4 cycles of a)Herceptin + docetaxel b)Herceptin + docetaxel + pertuzumab c)Herceptin + pertuzumab or 4)pertuzumab + docetaxel. Pertuzumab will be administered at a loading dose of 840mg iv, then 420mg iv 3-weekly, Herceptin at a loading dose of 8mg/kg iv then 6mg/kg 3-weekly, and docetaxel at a dose of 75mg/m2 escalating to 100mg/m2 3-weekly. During the entire pre- and post-surgery period all patients will receive adequate chemotherapy as per standard of care, as well as any surgery and/or radiotherapy as required. The anticipated time on study treatment is 3-12 months, and the target sample size is 100-500 individuals. Conditions: Breast Cancer Intervention / Treatment: DRUG: Herceptin, DRUG: Docetaxel, DRUG: Pertuzumab

Inclusion Criteria: * female patients, >=18 years of age; * locally advanced, inflammatory or early stage invasive breast cancer; * HER2 positive (HER2+++ by IHC or FISH/CISH+). Exclusion Criteria: * metastatic disease (Stage IV) or bilateral breast cancer; * previous anticancer therapy or radiotherapy for any malignancy; * other malignancy, other than cancer in situ of the cervix, or basal cell cancer; * insulin-dependent diabetes; * clinically relevant cardiovascular disease.

Study Objectives The purpose of this study is to determine whether or not CTCs can be detected in blood samples taken from patients diagnosed with small cell lung cancer. The purpose is to compare CTC analysis to tumor samples to look for differences. Conditions: Small Cell Lung Cancer Intervention / Treatment:

Inclusion Criteria: * Histological proof of small cell lung cancer with extensive stage disease and have been untreated. * Must be willing to give and sign informed consent. * Must be 18 years of age Exclusion Criteria: * Less than 18 years of age.

Study Objectives This is a prospective randomised controlled trial to assess an intervention of inspection during both phases of colonoscopic examination ( insertion and withdrawal) improve adenoma detection rate when compared to inspection only during withdrawal. Conditions: Adenoma Colon, Serrated Adenoma Intervention / Treatment: OTHER: Colonic inspection

Inclusion Criteria: * Participants who are referred for a bowel scope screening procedure Exclusion Criteria: * Patients lacking capacity to give informed consent * Pregnant women * Age less than 55 years * Uncorrectable coagulopathy * Patients who are not fit for flexible sigmoidoscopy * Incomplete procedure

Study Objectives This study will evaluate the effect of cabozantinib compared to prednisone on overall survival in men with previously treated metastatic castration-resistant prostate cancer with bone-dominant disease who have experienced disease progression on docetaxel-containing chemotherapy and abiraterone or MDV3100. Conditions: Prostate Cancer, Castration Resistant Prostate Cancer, Pain, Prostatic Neoplasms Intervention / Treatment: DRUG: cabozantinib, DRUG: prednisone

Inclusion Criteria: * Histological or cytological diagnosis of castration resistant prostate cancer (serum testosterone less than 50 ng/dL). * Evidence of bone metastasis related to prostate cancer on bone scans. * Received prior docetaxel (minimum cumulative dose of 225 mg/m2) and either abiraterone or MDV3100 treatment and has evidence of prostate cancer progression on each agent independently. * Maintenance of LHRH agonist or antagonist unless treated with orchiectomy. * Recovered from toxicities related to any prior treatments, unless the toxicities are clinically non significant or easily manageable. * Adequate organ and marrow function. * Capable of understanding and complying with the protocol requirements and signed the informed consent form. * Sexually active fertile patients and their partners must agree to use medically accepted methods of contraception (eg, barrier methods, including male condom, female condom, or diaphragm with spermicidal gel) during the course of the study and for 4 months after the last dose of study treatment. Exclusion Criteria: * Prior treatment with cabozantinib. * Treatment with docetaxel, abiraterone, or MDV3100 in the last 2 weeks; or with any other type of cytotoxic or investigational anticancer agent in the last 2 weeks. * Radiation within 4 weeks (excluded if to mediastinum) or radionuclide treatment within 6 weeks of randomization. * Known brain metastases or cranial epidural disease. * Requires concomitant treatment, in therapeutic doses, with anticoagulants. * Requires chronic concomitant treatment of strong CYP3A4 inducers (eg, dexamethasone, phenytoin, carbamazepine, rifampin, rifabutin, rifapentin, phenobarbital, and St. John's Wort). * Uncontrolled, significant intercurrent illness including, but not limited to, cardiovascular disorders, gastrointestinal disorders, active infections, non-healing wounds, recent surgery. * Clinically significant hematemesis or hemoptysis, or other signs indicative of pulmonary hemorrhage in the last 3 months, or history of other significant bleeding in the past 6 months. * Cavitating pulmonary lesion(s) or a lesion invading or encasing a major blood vessel. * QTcF > 500 ms within 7 days of randomization. * Unable to swallow capsules or tablets. * Previously-identified allergy or hypersensitivity to components of the study treatment formulations. * Another diagnosis of malignancy requiring systemic treatment within 2 years of randomization.

Study Objectives This is an observational retrospective cohort study to determine metachronous peritoneal carcinomatosis in a specific subgroup of colon cancer patients, those with a final pathologic exam corresponding to pT4 tumors. Based on a sample size calculation of 1152 patients, a retrospective review of a three year period of every participant hospitals, 50 in total, of different characteristics, was stablished. Demographic, clinical, operative, histologic and oncologic follow-up variables were recorded. Conditions: Peritoneal Carcinomatosis, Colon Cancer Intervention / Treatment: OTHER: Follow-up

Inclusion Criteria: * Colon cancer above 15 cm from anal verge * Curative intent surgery * Pathologic confirmation of pT4 adenocarcinoma Exclusion Criteria: * R2 cancer resection * Inclusion in other randomized clinical trials * Pathologic diagnosis of colon cancer other than adenocarcinoma, such as GIST, leiomyosarcomas, neuroendocrine tumors, or other types even more unusual.

Study Objectives The goal of this psychosocial research study is to learn whether a website program called "Tendrils: Sexual Renewal for Women after Cancer " may help female cancer survivors improve their sex lives when used either as a self-help tool or in combination with brief sexual counseling by a health care professional. Objectives: Sexual dysfunction is the most common long-term consequence of cancer treatment, affecting half of survivors of breast and gynecological cancer and many women treated for other cancers. Yet, few women get the help they need for sexual problems. Our primary objective is to develop and evaluate a multimedia intervention program for women with cancer-related sexual dysfunction. Tendrils: A Sexual Renewal Program for Women Surviving Cancer will: 1) explain the causes of cancer-related sexual dysfunction; 2) offer self-help strategies to prevent or overcome problems; 3) advise women on seeking appropriate medical help; and 4) possibly serve as the core of a counseling program, along with a therapist manual. Tendrils is aimed at a wide audience, from newly diagnosed to long-term survivors, across cancer sites. Material will be presented with sensitivity to religious and cultural attitudes about sexuality. Animations will illustrate anatomy and physiology. The software will let women use Tendrils in a variety of formats: over the internet, on a CD-Rom, printed out, or as downloaded digital video or audio on a handheld computer or media player. Video vignettes will illustrate problems and strategies. Five female cancer survivors will host the program, sharing their experiences. Conditions: Sexual Dysfunction Intervention / Treatment: BEHAVIORAL: Focus Group, BEHAVIORAL: TENDRILS, BEHAVIORAL: Questionnaires, BEHAVIORAL: Sexual Counseling Sessions

Inclusion Criteria: * Phase I: Woman cancer survivor* Phase I: Speaks and reads English well enough to evaluate the website and participate in a focus group* Phase II: Had breast cancer or a gynecological cancer diagnosed 1 to 5 years previously* Phase II: Has a sexual partner in relationship of at least 6 months' duration.* Phase II: Has a score on the Female Sexual Function Inventory below the cut-off criterion indicating sexual dysfunction (i.e. less than 26.55 total score).* Phase II: Lives in commuting distance of MDACC so that can attend 3 counseling sessions if randomized to professional treatment group.* Phase II: Currently no evidence of active cancer.* Phase II: Not receiving any cancer treatment other than hormonal therapy. Exclusion Criteria: * Phase I: Under age 18* Phase II: Under age 18* Phase II: Currently in mental health care for a sexual problem.* Phase II: BSI-18 at study entry indicates high distress and a visit with project staff confirms that the participant is too distressed to benefit safely from the intervention.* Phase II: Cannot arrange for participant to have privacy when accessing internet at home, even if we offer loaner laptop and subsidized internet service.

Study Objectives The aim of the project is to clarify whether DLBCL exhibits mutational diversity among different lymph node tumors in one and the same patient. It is desired to find out whether a possible difference between lymph node tumors / tumors can explain why patients who initially (at diagnosis) have the same prognosis, sometimes have a completely different course, eg with rapid recurrence of the disease after treatment. A possible difference could also perhaps shed light on why disease in specific places spreads more frequently to the brain - and therefore have an impact on when one chooses to give preventive treatment against spread to the brain. Monitoring of circulating cell-free DNA (ctDNA) is a new, potential, non-invasive tool for measuring the full spectrum of genetic variations / mutations and is to be investigated in our study as a possible non-invasive assessment of diversity / heterogeneity. Conditions: Lymphoma, Large B-Cell, Diffuse Intervention / Treatment:

Inclusion Criteria: * Diagnosed with DLBCL* Immunochemotherapy (rituximab and CHOP-like chemotherapy) planned and not yet initiated (pretreatment with prednisolone is allowed)* Age ≥ 18 years* More than 1 lymphoma site accessible for biopsy* Patient must consent to permit genetic analysis of their tumor biopsies* Patient must consent to additional biopsies and blood samples* Tumor biopsy and/or bone-marrow biopsy used for diagnosis available* Patient must consent to access of their medical records to monitor the clinical process* Written informed consent* Baseline 18FDG-PET/CT available Exclusion Criteria: * History of previous or current malignancies* Other previous/current hematological malignancies or inflammatory disease* HIV* Concurrent diagnosis of follicular lymphoma or other indolent lymphomas (composite histology)* If the patient is deemed to have an acute treatment need, the patient cannot be included in the project.* Patients on blood thinners, which must be paused before an additional biopsy, causing too much delay in initiating treatment will be excluded -

Study Objectives This is a post-authorization, retrospective multicentre observational nationwide study (PAS-OD). It will be conducted by reviewing medical records and database of patients who participated in the validation of the psychometric properties of the GAH study (CEL-GAH-2011-01). In all cases, only data prior to the start date of the study will be collected to ensure its retrospective nature, thereby reflecting routine clinical practice and non-interference in the physician's clinical practice Conditions: Myelodysplastic Syndromes, Leukemia Myeloid Acute, Multiple Myeloma, Leukemia, Lymphocytic, Chronic, B-Cell Intervention / Treatment:

Inclusion Criteria: * Patients who were participating in the GAH study (CEL-GAH-2011-01). * Patients who have been scheduled to start treatment at a date less than three months after completion of the GAH (CEL-GAH-2011-01) scale in one of these visits: baseline, test-retest or sensitivity to change. * Patients who give informed consent to participate in the study as long as such consent is possible. Exclusion Criteria: * Not applicable

Study Objectives This trial combines trastuzumab and bevacizumab monoclonal antibodies, with ABI-007 and carboplatin, as neoadjuvant therapy in previously untreated locally advanced breast cancers demonstrating HER2 gene amplification. It is hoped that this novel combination will result in increased pathologic response rates that will translate into long term outcome improvements in HER2 positive patients with locally advanced breast cancer. Conditions: Breast Cancer Intervention / Treatment: DRUG: nab-paclitaxel, DRUG: Bevacizumab, DRUG: Trastuzumab

Inclusion Criteria: * Female patients with histologically confirmed adenocarcinoma of the breast or inflammatory breast cancer * Clinical stage T 1-4, N 0-3, M0 * FISH+ HER2 gene amplified breast cancer * 18 years or older * Normal cardiac function * Performance status 0-2 * Cannot have received any prior chemotherapy for this disease or cannot have received chemotherapy for any other cancer in the past 5 years. * Previous diagnosis of noninvasive breast cancer is OK. * Must have adequate bone marrow, renal and liver function. * Pregnant or lactating females not allowed. * Preexisting peripheral neuropathy must be equal to or less than grade 1 * Must have archived tumor tissue for tissue testing. Exclusion Criteria: You cannot be in this study if you any of the following: * History of cardiac disease, with New York Heart Association Class II or greater with congestive heart failure * Any heart attack, stroke or TIAs within the last 6 months or serious arrhythmias needing medication; no bleeding diathesis or coagulopathy. * No prior investigational drug within the last 30 days * No prior trastuzumab or bevacizumab therapy There are additional inclusion/exclusion criteria. The study center will determine if you meet all of the criteria. If you do not qualify for the trial, study personnel will explain the reasons.

Study Objectives Radiotherapy is the primary treatment modality or an important adjunct treatment for many patients with H\&N carcinoma. Local control is directly related to dose and to the technical accuracy with which the dose is delivered to the target volume. Traditional radiotherapy techniques result in significant doses being delivered to normal tissues adjacent to the target, including the spinal cord and salivary glands. This leaves the patient with significant acute and late normal tissue toxicity that impacts on both the ability to tolerate the actual treatment and on the patient's long-term quality of life. Recently, the investigators have used static conformal multisegmental intensity modulated radiotherapy (IMRT) for a comprehensive irradiation of head and neck cancer with dose sparing of uninvolved tissues. This has resulted in substantial preservation of major salivary gland function in many patients with primary sites in the oral pharynx, oral cavity, nasopharynx, and pyriform sinus. While the investigators' results to date have shown promising preservation of salivary flow, they do not know whether patients treated with IMRT have similar local control rates as those treated with standard radiotherapy. Some investigators have raised the concern that by giving a low radiation dose to areas adjacent to the target volume there is a risk of undertreating the disease. On the other hand, the IMRT delivered with this protocol (called "simultaneous integrated boost", or SIB) may improve local control rates by delivering the same biologically effective dose in a shorter overall time period. This is a phase I/II trial which seeks to establish the efficacy of IMRT for H\&N cancer treatment, and to further investigate the relationship between radiation dose to the parotid glands, salivary flow, and quality of life. Conditions: Head and Neck Cancer Intervention / Treatment: PROCEDURE: Intensity-Modulated Radiation Therapy

Inclusion Criteria: * Squamous cell cancer of head and neck for radical/postoperative radiation therapy * American Joint Committee on Cancer (AJCC) stage I-IV with M0 and N0-2 disease * Karnofsky performance status (KPS) >= 70% Exclusion Criteria: * M1 or N3 disease * Ineligibility for radiotherapy * Recent malignancy * Previous cancer or head and neck radiotherapy * Salivary gland dysfunction * Unwilling to provide informed consent

Study Objectives This is a prospective observational study aiming: 1) To quantify lung function using perfusion dual energy computed tomography (DECT) and use this information at the time of treatment planning with preferential sparing of functional lung parenchymal 2) to validate results of lung function obtained using DECT with lung perfusion scintigraphy results, the current standard method; 4) to compare dosimetry of whole lungs vs. functional lungs in patients treated with either stereotactic body radiotherapy (SBRT) for early stage lung cancer or conventional radiotherapy for locally advanced lung cancer and 5) to evaluate lung function 6, 12 and 24 months post-radiotherapy with both perfusion DECT and pulmonary function tests and compare radiation dose-map to functional lung-map. Conditions: Lung Cancer, Lung Function Decreased, Radiation Pneumonitis Intervention / Treatment: RADIATION: Thoracic radiotherapy

Inclusion Criteria: * ≥ 18 years * ECOG 0-2 * Pulmonary neoplasia, confirmed histopathologically or by imaging * Prognosis evaluated ≥ 1 year by attending MD * Clinically acceptable lung capacity to undergo radiotherapy * Initial assessment including history, physical examination, biochemistry, PFT, chest radiograph, chest and abdominal-pelvic scan, PET * Written consent * The patient must be available for treatment and monitoring. Patients registered in the study should be treated in our center. Exclusion criteria * Previous radiotherapy in the radiation field * Presence of any major medical condition that, in the opinion of the investigator, would prevent follow-up at 6, 12 and 24 months post-radiotherapy. * Iodine allergy * Pregnancy and lactation

Study Objectives This community-based randomized trial tested the effects of a social support intervention to increase Chamorro, Samoan, and Tongan women's Pap test behavior and social support among their male spouses or significant others in Southern California. Conditions: Cervical Cancer Intervention / Treatment: BEHAVIORAL: Intervention

Inclusion Criteria: * Women ages 21 to 65 * Of Chamorro, Samoan, and/or Tongan ethnicity * Has a significant other (married or in a long-term relationship for more than 5 years). Exclusion Criteria: * Not a member of one of the churches or clans visited for recruitment

Study Objectives The association between radiation exposure and cardiac disease is well recognized, it is not fully understood if there exists an optimal or "safe" radiation dose-volume relationship. Conditions: Node Positive Breast Cancer Intervention / Treatment: RADIATION: Radiation therapy groups

Inclusion Criteria: * Women with node positive breast cancer treated with surgery, anthracycline-based or similar cardiotoxic chemotherapy, and regional nodal irradiation between 2000-2007. Exclusion Criteria: * Women who have not received anthracycline-based or similar cardiotoxic chemotherapy, and regional nodal irradiation between 2000-2007.

Study Objectives The purpose of the study is to understand the effect of Metformin on patients with PCOS. Conditions: PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries Intervention / Treatment: DRUG: Metformin intervention for 12 weeks

Inclusion Criteria: * Individuals who are 20 to 40 years old, planning to become pregnant or infertile women.* Individuals who are diagnosed as PCOS according to the revised 2003 Rotterdam diagnostic criteria: if 2 out of 3 criteria are met: 1) Oligo- and/or anovulation; 2) Clinical and/or biochemical signs of hyperandrogenism; 3) Polycystic ovaries, and exclusion of other aetiologies (congenital adrenal hyperplasia, androgen-secreting tumors, Cushing's syndrome).* Individuals who can insist on continuous monitoring in the outpatient clinic. Individuals who are not participating in other research projects currently or 3 months before the intervention. Exclusion Criteria: * Individuals who suffering from other diseases that may cause hyperandrogenism and ovulation abnormalities.* Individuals who are during pregnant, lactation or menopause.* Individuals who currently receiving weight-loss drugs or surgery or within the past 2 months.* Individuals who take niacin, nicotinamide, or other vitamin B3-related supplementation currently or within the past 2 months.* Individuals who need regular medication to treat chronic diseases such as diabetes, hypertension, gout, hyperuricemia, etc.* Use of medications that affect hormone levels, appetite, carbohydrate absorption, and metabolism within the past 2 months.* Individuals with severe liver diseases or kidney disease that are ineligible to participate in the study.* A medical history of severe cardiovascular and cerebrovascular diseases.* Individuals who currently suffer from severe gastrointestinal diseases or undergo gastrointestinal resection that may affect nutrient absorption.* Individuals who drink more than 15g of alcohol per day or have a smoking habit.* Individuals who need drug treatment for any mental illness such as epilepsy and depression.* Cancer patients.* Individuals who suffer from infectious diseases such as hepatitis B, active tuberculosis, AIDS, etc.

Study Objectives The purpose of this research study is to learn about the effectiveness of using lower-intensity radiation and chemotherapy to treat human papillomavirus (HPV) associated low-risk oropharyngeal and/or unknown primary squamous cell carcinomas of the head and neck. The cure rate for this type of cancer is estimated to be high, \> 90%. The standard treatment for this cancer is 7 weeks of radiation with 3 high doses of cisplatin. Sometimes surgery is performed afterwards. This standard regimen causes a lot of side effects and long term complications. This study is evaluating whether a lower dose of radiation and chemotherapy may provide a similar cure rate as the longer, more intensive standard regimen. Patients in this study will receive 1 less week of radiation and a lower weekly dose of chemotherapy followed by a limited surgical evaluation. Conditions: Carcinoma, Squamous Cell, Head and Neck Neoplasms, Oropharyngeal Neoplasms Intervention / Treatment: RADIATION: Intensity Modulated Radiotherapy (IMRT), DRUG: Cisplatin, PROCEDURE: Limited surgical evaluation

Inclusion Criteria: * ≥ 18 years of age* T0-3, N0 to N2c, M0 squamous cell carcinoma of the oropharynx* Biopsy proven squamous cell carcinoma that is HPV and/or p16 positive* ≤ 10 pack-years smoking history or > 5 years of abstinence from smoking* History/physical examination within 8 weeks prior to registration* Radiologic confirmation of the absence of hematogenous metastasis within 12 weeks prior to registration.* The Eastern Cooperative Oncology Group (ECOG) Performance Status 0-1* Complete Blood Count (CBC)/differential obtained within 4 weeks prior to registration, with adequate bone marrow function defined as follows: Absolute neutrophil count (ANC) ≥ 1,800 cells/mm3; Platelets ≥ 100,000 cells/mm3; Hemoglobin ≥ 8.0 g/dl.* Adequate renal and hepatic function within 4 weeks prior to registration, defined as follows: Serum creatinine < 2.0 mg/dl; Total bilirubin < 2 x the institutional upper limit of normal (ULN); aspartate aminotransferase (AST) or alanine aminotransferase (ALT) < 3 x the institutional ULN.* Negative serum pregnancy test within 2 weeks prior to registration for women of childbearing potential.* Women of childbearing potential and male participants who are sexually active must practice adequate contraception during treatment and for 6 weeks following treatment.* Patients must be deemed able to comply with the treatment plan and follow-up schedule.* Patients must provide study specific informed consent prior to study entry. Exclusion Criteria: * Prior history of radiation therapy to the head and neck* Prior history of head and neck cancer.* Severe, active co-morbidity, defined as follows: Unstable angina and/or congestive heart failure requiring hospitalization within the last 6 months; Transmural myocardial infarction within the last 6 months; Acute bacterial or fungal infection requiring intravenous antibiotics at the time of registration; Chronic Obstructive Pulmonary Disease exacerbation or other respiratory illness requiring hospitalization or precluding study therapy at the time of registration; Hepatic insufficiency resulting in clinical jaundice and/or coagulation defects; Note, however, coagulation parameters are not required for entry into this protocol; Pre-existing ≥ grade 2 neuropathy; Prior organ transplant.* Known HIV positive* Significant pre-existing hearing loss, as defined by the patient or treating physician.

Study Objectives The purpose of this study is to evaluate the efficacy and safety of amolimogene, in the treatment of patients with high-grade cervical intraepithelial lesions of the uterine cervix. Conditions: Uterine Cervical Dysplasia Intervention / Treatment: DRUG: Amolimogene, DRUG: Amolimogene, OTHER: Placebo

Inclusion Criteria: To be considered for enrollment, patients must: * Have an abnormal Pap smear (atypical squamous cells of undetermined significance \[ASCUS\], atypical squamous cells, cannot exclude high grade \[ASC-H\], low grade squamous intraepithelial lesion \[LSIL\], high grade squamous intraepithelial lesion \[HSIL\]) result within 6 months of screening visit.* Have a colposcopically visible lesion suspected to be high-grade that does not involve more than 75% of the cervix.* Have a CIN 2/3 consensus pathology diagnosis on tissue taken from a colposcopically-directed punch biopsy.* Not have evidence of cervical carcinoma on Pap smear or biopsy and not have a positive endocervical curettage.* Not have atypical endometrial cells or glandular-cell atypia on Pap smear or biopsy.* Have colposcopic visualization of entire squamocolumnar junction and of the entire lesion (i.e. cannot extend into canal).* Not have concomitant cancer, history of malignancies, including carcinoma of the cervix, except for non-melanoma skin cancer.* Be willing to sign an Institutional Review Board (IRB) approved informed consent. Minors must have the consent of a parent or legal guardian as required by local laws and regulations.* Agree to use 2 acceptable forms of contraception (e.g., double-method including at least one barrier and one hormonal method).* Be capable of complying with the protocol.* Not have other illnesses that would put the patient at undue risk for participation in the trial or would interfere with the required clinical observations.* Not have abnormalities of hematological, renal, or hepatic function as determined by clinical laboratory testing.* Not have immunologic disorder such as immunodeficiency, lupus, or other chronic auto-immune disease.* Not have an active systemic infection requiring treatment.* Not have ongoing systemic chronic steroid therapy or immunosuppressive medication (inhalers used for treating asthma and topical steroids are permitted).* Not be positive for HIV antibody.* Not be pregnant or lactating.* Not plan to use a cervical cap or diaphragm during the study.* Not have been treated with any investigational agent within 30 days prior to randomization in this trial.* Not have had prior gene therapy.* Not have had an excisional or ablative procedure performed on the cervix within one year of enrollment.* Be willing to consent to an excisional procedure, such as LEEP or cold-knife cone procedure, if indicated. Please note: There may be additional inclusion/exclusion criteria. The study center will determine if patients meet all of the criteria. If patients do not qualify for the trial, study personnel will explain the reasons. If patients do qualify, study personnel will explain the trial in detail using an IRB-approved informed consent, and answer any questions. Patients can then decide if they wish to participate.

Study Objectives Currently, there is a lack of patient education materials regarding cytotoxic chemotherapy side effects, research supported treatments, and the utilization of CAM by cancer patients at Penn State Cancer Institute. The investigators aim to develop an educational brochure, which educates patients about the chemotherapy side effects they may experience, and provide them with the tools to address the problem themselves, know when to contact their medical oncologist, and understand when it is appropriate to go to the Emergency Department. By educating patients regarding these problems, patient anxiety may decrease, the number of calls into the oncologist office may decrease, and Emergency Department visits may decrease, which would decrease costs for the patient, the hospital, and the health system. If this intervention is found to be useful and impactful, it can be further utilized within the Cancer Institute by other disease teams, by other Penn State institutions, or by other institutions across the country. Conditions: Chemotherapeutic Toxicity, Chemotherapeutic Agent Toxicity, Chemotherapy Effect Intervention / Treatment: OTHER: Educational Brochure

Inclusion Criteria: * Adults with a diagnosis of breast or gastrointestinal cancer, at any stage or progression, who are cytotoxic chemotherapy treatment naïve and initiating treatment or have newly begun cytotoxic chemotherapy within the last 6 weeks. Patients receiving multiple therapy forms, such as immune or humoral, can be included if they are also receiving cytotoxic chemotherapy as a part of their regimen. All patients will receive the brochure, therefore, there will not be a control arm in this study. 1. Adult >20 year of age 2. Ability to understand and read written English without any functional difficulty 3. ECOG performance status 0-3 4. May be involved with other cancer trials being offered at the Penn State Cancer Institute Exclusion Criteria * Inability to give informed consent* Pregnant females* Inability to understand or read written English* Patients who have previously undergone cytotoxic chemotherapy at any point in their lifetime or began chemotherapy for their breast or gastrointestinal cancer greater than 6 weeks from the initiation of the study

Study Objectives Soft tissue sarcoma STS is a group of malignant tumors derived from connective tissue other than bone and cartilage. It can occur in any part of the body at any age, and there is no significant gender difference.According to pathological classification, STS has 19 tissue types and more than 50 disease subtypes.Currently, surgical resection, radiotherapy and drug therapy are the main treatment methods.But about 50% of the patients with distant metastasis happened not the surgical removal of, quite a number of in patients with distant metastasis after died of disease progression 8-12 months in drug treatment of soft tissue sarcoma, the current widely used chemotherapy regimens for ADM/IFO single-agent or joint IFO ADM is a line of chemotherapy, in addition, paclitaxel, gemcitabine, dorsey race, it was also used for soft tissue sarcomas of second-line chemotherapy scheme, however, for some special subtypes of sarcoma,Such as myxoid liposarcoma, pleomorphic rhabdomyosarcoma, leiomyosarcoma, glandular soft tissue sarcoma and superficial malignant fibrous histiocytoma, are not sensitive to chemotherapy or low sensitivity.Therefore, how to improve the survival rate of these patients is an urgent problem to be solved. Anlootinib hydrochloride is a multi-target tyrosine kinase inhibitor that has shown good efficacy in solid tumors such as NSCLC, ovarian cancer, soft tissue tumors, and medullary thyroid cancer.Especially in the field of soft tissue sarcomas, the results of phase IIb clinical data were satisfactory.Therefore, Investigator plan to conduct the study of anrotenil hydrochloride capsule for the treatment of soft tissue sarcomas with first-line chemotherapy failure (anthracycline) Conditions: Soft Tissue Sarcomas Intervention / Treatment: DRUG: Anlotinib Hydrochloride

Inclusion Criteria: * The patients volunteered to participate in this study and signed the informed consent;* Pathologically confirmed advanced soft tissue sarcomas with at least one measurable lesionMainly including Synovial sarcoma (Synovial sarcoma), Leiomyosarcoma (Leiomyosarcoma), gland Alveolar soft tissue sarcoma (Alveolar soft part sarcoma), Undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma (Undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma), liposarcoma (AdipocyticEpithelial sarcoma, Fibrosarcoma, Clear cell sarcoma, Epithelioid sarcoma, and other Tumors.Except for:Malignant peripheral nerve sheath tumor, Undifferentiated sarcoma, Rhabdomyosarcoma, chondrosarcoma, Osteosarcoma, dermato-fibrosarcomaProtuberans, gastrointestinal stromal tumor, Primitive neuroectodermal tumor, Inflammatory myofibroblastic tumor, Malignant mesothelioma.* Patients who have failed treatment with at least one or two line chemotherapy regimen (doxorubicin + ifosfamide, gemcitabine + docetaxel) within the last 6 months (except for acinar soft tissue sarcoma);\[note: treatment failure refers to the occurrence of disease progression or intolerance during treatment or within 3 months of the last treatment\]* 18 \~ 70 years old;ECOG PS score is 0\~1;Expected survival beyond 3 months;* Patients who are effective with other targeted drugs, but have drug resistance and disease progression, and stop taking drugs for more than 4 weeks;* Major organ functions meet the following criteria within 7 days before treatment: 1. blood routine examination standard (in the condition of no blood transfusion within 14 days) : * hemoglobin (HB) ≥90g/L; * absolute value of neutrophils (ANC)≥1.5×109/L; * platelet (PLT) ≥80×109/L 2. biochemical examination shall meet the following standards: * total bilirubin (TBIL) ≤1.5 times the upper limit of normal value (ULN); * alanine aminotransferase (ALT) and aspartate aminotransferase AST≤ 2.5×ULN, if accompanied by liver metastasis, ALT and AST≤5×ULN; * serum creatinine (Cr)≤1.5×ULN or creatinine clearance rate CCr≥60ml/min; 3. doppler ultrasound evaluation: left ventricular ejection fraction (LVEF) ≥ normal low limit (50%).* Women of childbearing age should agree that they must obtain a certain amount during the study period and within 6 months after the study Use contraceptives (such as intrauterine devices, birth control pills or condoms);Negative serum or urine pregnancy test within 7 days before study enrollment and must be non-lactating;Men should agree to patients who must use contraception during the study period and within 6 months of the end of the study period. Exclusion Criteria: * Patients who have previously used anlotinib hydrochloride capsules;* With pleural effusion or ascites, cause respiratory syndrome (≥CTC AE grade 2 dyspnea);* Patients who have received targeted therapy of vascular endothelial growth inhibitors, such as sunitinib, sorafenib, imatinib, bevacizumab, famitinib, apatinib, reagfenib and other drugs, have failed to respond to treatment.Other malignancies were present or present at the same time within 4.5 years, except cured carcinoma in situ of the cervix, non-melanoma skin cancer and superficial bladder tumor \[Ta (non-invasive tumor), Tis (carcinoma in situ) and T1 (tumor infiltrating basement membrane)\];* Systemic antitumor therapy, including cytotoxic therapy, immunotherapy, or mitomycin C, was planned for the first 4 weeks of the group or in this study.Radiotherapy was performed in the first 4 weeks or in the second 2 weeks before the grouping.* Unrelieved toxic reactions above CTC AE(4.0) level 1 due to any previous treatment, excluding hair loss;* Having multiple factors affecting oral medications (such as inability to swallow, chronic diarrhea and intestinal obstruction);* Patients with brain metastasis with symptoms or symptom control time less than 2 months;* Patients with any serious and/or uncontrolled illness, including: 1. Patients with unsatisfactory blood pressure control (systolic blood pressure ≥ 150 mmHg, diastolic blood pressure ≥ 100 mmHg); 2. Patients with grade I or above myocardial ischemia or myocardial infarction, arrhythmia (including QTc≥480ms) and grade ii or above congestive heart failure (New York heart association grade (NYHA)); 3. Active or uncontrolled severe infection (≥ grade CTC AE 2 infection); * Patients with cirrhosis, decompensated liver disease, active hepatitis or chronic hepatitis should receive antiviral treatment; * Renal failure requires hemodialysis or peritoneal dialysis;* Patients with any serious and/or uncontrolled illness, including: 1. a history of immunodeficiency, including HIV positive or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation; 2. poor diabetes control (FBG > 10mmol/L); 3. the urine routine indicated that urine protein ≥++, and confirmed the 24-hour urine protein quantitative > 1.0g. 4. patients with seizures requiring treatment;* Significant surgical treatment, open biopsy or significant traumatic injury received within 28 days prior to grouping;* Any physical signs or history of bleeding, regardless of severity;Unhealed wounds, ulcers or fractures were found in patients with any bleeding or bleeding event ≥CTCAE level 3 within 4 weeks before grouping;* 6 months in the event of overactive/venous thrombosis, such as cerebrovascular accident (including temporary ischemic attack), deep venous thrombosis and pulmonary embolism;* Having a history of abuse of psychotropic substances and being unable to quit or having mental disorders;* Participated in clinical trials of other anti-tumor drugs within four weeks; According to the researchers' judgment, there are concomitant diseases that seriously endanger patients' safety or prevent patients from completing the study.

Study Objectives The purpose of this study is to determine the safety and effectiveness of a multi-drug regimen (which includes prednisone, vincristine, cytarabine, doxorubicin, 6 mercaptopurine, and methotrexate) which is considered standard treatment for children and young adults with acute lymphoblastic leukemia (ALL), in combination with PEG-asparaginase and clofarabine to treat older adults with ALL. PEG-asparaginase has been used in chemotherapy treatment regimens for both children and adults with ALL. Clofarabine has been used in chemotherapy treatment regimens for children with ALL and has been shown to decrease the number of leukemia cells. Participants with leukemia that has an abnormal chromosome, called the Philadelphia chromosome, will also be given imatinib. Conditions: Acute Lymphoblastic Leukemia Intervention / Treatment: DRUG: Prednisone, DRUG: Vincristine, DRUG: Doxorubicin, DRUG: PEG-asparaginase, DRUG: Cytarabine, DRUG: Methotrexate, DRUG: Imatinib, DRUG: Clofarabine, DRUG: 6 Mercaptopurine

Inclusion Criteria: * Acute lymphoblastic leukemia, excluding known mature B-cell ALL by the presence of any of the following: surface immunoglobulin, L3 morphology, t(8;14)(q24;q32), t(8;22), or t(2;8). * Patients with mature B-cell ALL will be removed from the protocol as soon as the diagnosis is made and should be treated on a B-cell leukemia protocol. * Patients with lymphoblastic lymphoma are also eligible * No prior anti-leukemic therapy except <1 week of steroids, and/or emergent radiation therapy to the mediastinum, or hydroxyurea or emergent leukopheresis. Longer steroid use for diseases other than leukemia is permitted. * Age 51-75 years * Ejection fraction > 45% * Creatinine < 2.0 mg/dl * Total bilirubin < 3.0 mg/dl * ECOG (Eastern Cooperative Oncology Group) Performance Status of 0, 1, 2 * Non-pregnant and non lactating Exclusion Criteria: * Known HIV positive * Comorbid medical condition, in the investigator's opinion, would make participation in this trial and adherence to the protocol guidelines difficult * Active psychiatric or mental illness making informed consent or careful clinical follow-up unlikely

Study Objectives The aim of this study is the synergistic effect of cancer ablation and life information rehabilitation therapy on unresectable lung cancer. Conditions: Small-cell Lung Cancer Intervention / Treatment: DEVICE: Cancer ablation, DRUG: Life information rehabilitation therapy

Inclusion Criteria: * All standard therapies have failed according to NCCN guidelines or the patient refuses standard therapies * Body tumor 1-6, with at least one tumor length > 2 cm * KPS ≥ 70, lifespan > 6 months * Platelet count ≥ 80×109/L，white blood cell count ≥ 3×109/L, neutrophil count ≥ 2×109/L, hemoglobin ≥ 80 g/L Exclusion Criteria: * Patients with cardiac pacemaker * Patients with brain metastasis * Patients with grade 3 hypertension or diabetic complication, severe cardiac and pulmonary dysfunction

Study Objectives Fruquintinib with PD-1 inhibitors (FP) and TAS-102 with bevacizumab (TB) are two common therapies for patients with previous-treated metastatic colorectal cancer (mCRC). However, it's still not clear that which therapy can bring better prognosis. Our study sought to investigate the efficacy and safety of fruquintinib with PD-1 Inhibitors versus TAS-102 with bevacizumab in Late-Line mCRC between July 2019 to October 2022July 2019 and June 2021 at the Hunan Cancer Hospital. Conditions: Metastatic Colorectal Adenocarcinoma Intervention / Treatment: DRUG: Fruquintinib, DRUG: PD-1 inhibitors, DRUG: Trifluridine/Tipiracil, DRUG: Bevacizumab

Inclusion Criteria: * Has histologically confirmed unresectable adenocarcinoma of the colon or rectum (all other histological types are excluded).* Have progressed from at least 2 lines of standard treatment,including fluoropyrimidines, irinotecan, oxaliplatin, with or without targeted drugs, like bevacizumab and cetuximab (only for RAS wild-type). Regorafenib was permitted but not required for inclusion.* Has measurable or non-measurable disease as defined by RECIST version 1.1* Is able to swallow oral tablets.* Estimated life expectancy ≥12 weeks.* Eastern Cooperative Oncology Group performance status (ECOG PS) less than 2* Has adequate organ function. Exclusion Criteria: * Pregnancy, lactating female or possibility of becoming pregnant during the study.* Has not recovered from clinically relevant non-hematologic CTCAE grade ≥ 3 toxicity of previous anticancer therapy (excluding alopecia, and skin pigmentation).* Has symptomatic central nervous system metastases that are neurologically unstable or requiring increasing doses of steroids to control CNS disease.* Has severe or uncontrolled active acute or chronic infection.* Known carriers of HIV antibodies.* Confirmed uncontrolled arterial hypertension or uncontrolled or symptomatic arrhythmia.

Study Objectives The Prometra Pump is approved by the FDA for use in the United States. The purpose of this study is to collect long-term safety data on the Prometra Pump. Conditions: Chronic Pain, Cancer Pain, Intractable Pain, Back Pain Intervention / Treatment: DEVICE: Prometra Programmable Intrathecal Infusion Pump

Inclusion Criteria: * Patient meets at least one of the following: * is suffering from malignant pain (i.e., cancer pain) * has chronic, non-malignant pain * subject was enrolled in PUMP I or PUMP II study and chooses to participate in this Post-Approval study * Patient with an existing implantable pump for pain therapy that requires replacement* Patient is at least 22 years of age.* Investigator considers the patient to be able and willing to fulfill all study requirements.* Patient has provided written informed consent to participate in the study. Exclusion Criteria: * Patient meets any of the contraindications for use of the Prometra System* Patient has a prior history of granuloma formation, or is receiving treatment for a suspected granuloma.* Patient is pregnant or breast-feeding or is of child-bearing potential and not employing effective birth control.

Study Objectives The purpose of this study is to obtain an estimate of the objective response rate (ORR) of AMG 479 in patients with recurrent platinum-sensitive ovarian epithelial (including fallopian tube and primary peritoneal) carcinoma failing frontline chemotherapy. Conditions: Ovarian Neoplasms Intervention / Treatment: BIOLOGICAL: AMG 479

Inclusion Criteria: * Histologically-confirmed ovarian epithelial (including fallopian tube and primary peritoneal) carcinoma. Baseline paraffin embedded tissue from the patient's primary diagnosis is requested before study enrollment and should be forwarded to the designated central laboratory. In patients with measurable disease or sufficient ascites, fresh frozen tissue or ascites fluid should be obtained by needle biopsy and submitted to the designated central laboratory. * Prior treatment with at most 1 treatment regimen in the primary treatment setting. * Platinum-sensitive disease defined by recurrence or progression of disease > 6 months AND < 24 months after completion of prior platinum based chemotherapy. * Female > 18 years of age or legal age. * ECOG performance status ≤ 1. * Measurable disease as per Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Subjects with non-measurable disease with a biochemical recurrence are eligible provided the CA 125 is elevated by more than 2 times the upper limits of normal, confirmed in two successive samples, drawn at least one week apart. * Resolution of any toxic effects of prior therapy (except alopecia) to NCI CTCAE v.3.0 Grade ≤ 1 and to baseline laboratory values as defined in the inclusion criterion immediately below. * Adequate organ and bone marrow function * Nondiabetic patients or Type 1 or 2 Diabetic Patients controlled with HgbA1c < 8% and fasting blood glucose level <160 mg/dL * Adequate coagulation parameters (within 21 days prior to registration), International Normalized Ratio (INR) ≤1.5; Activated ProThrombin Time (APTT) ≤ 1.5 x ULN. Exclusion Criteria: * More than 1 prior chemotherapy regimen in the treatment of ovarian cancer. * Platinum-resistant disease as defined by a recurrence or progression less or equal to six months after completion of the frontline platinum based chemotherapy. * Anticipation of a need for a major surgical procedure (e.g., impending bowel obstruction, gastrointestinal perforation) or radiation therapy during the trial. * Diagnosis of any second malignancy within the last 5 years, except for adequately treated basal cell or squamous cell skin cancer, or for in situ carcinoma of the cervix uteri. * Prior treatment with investigational treatment targeted to IGF axis including, but not limited to, CP 751,871, IM-A12, RO4858696. * Previous exposure to AMG 479. * History of hypersensitivity to recombinant proteins. * Prior treatment with a humanized monoclonal antibody. * Treatment with chemotherapy, radiotherapy, surgery, blood products, or an investigational agent within 3 weeks of trial enrolment. * Any of the following within 6 months prior to trial registration: myocardial infarction, severe/unstable angina pectoris, coronary/peripheral artery bypass graft, NYHA class III or IV congestive heart failure, cerebrovascular accident or transient ischemic attack, pulmonary embolism, deep vein thrombosis, or other thromboembolic event. * History of brain metastases, spinal cord compression, or carcinomatous meningitis. * Patient of child-bearing potential is evidently pregnant (eg, positive human chorionic gonadotropin test) or is breast feeding. * Patient of child-bearing potential is not willing to use adequate contraceptive precautions. * Known active infection, or on antiretroviral therapy for HIV disease. * Known positive test for chronic hepatitis B or C infection. * Mental condition rendering the patient unable to understand the nature, scope, and possible consequences of the trial. * Refusal or inability to give informed consent to participate in the trial. * Other severe acute or chronic medical or psychiatric condition, or significant laboratory abnormality requiring further investigation that may cause undue risk for the patient's safety, inhibit protocol participation, or interfere with interpretation of trial results, and in the judgment of the investigator would make the patient inappropriate for entry into this trial.

Study Objectives This study is being done to compare standard radiation therapy with hypofractionated radiation therapy for patients with newly diagnosed glioblastoma Conditions: Glioblastoma Intervention / Treatment: RADIATION: Hypofractionated radiation therapy, RADIATION: Standard radiation therapy

Inclusion Criteria: * Newly-diagnosed, histologically proven, intracranial glioblastoma or gliosarcoma treated with maximal safe resection, which may be biopsy alone if resection is not possible.* History and physical examination, including neurological examination, within 14 days prior to randomization.* Age between 18 and 70 years, inclusive.* ECOG performance score 0-2.* Stable or decreasing dose of corticosteroids for at least 14 days prior to randomization (Stupp et al.).* Laboratory evaluation obtained within 7 days prior to randomization, with adequate function as defined below: (Stupp et al.) 1. ANC ≥ 1.5 x 10\^9/L 2. Platelets ≥ 100 x 10\^9/L 3. Serum creatinine ≤ 1.5 times ULN 4. Total serum bilirubin ≤ 1.5 times ULN 5. ALT < 3 times ULN 6. AST < 3 times ULN 7. Alkaline phosphatase < 3 times ULN* Patients must sign a study-specific informed consent prior to study registration and must be willing to comply with study treatment, questionnaire completion and follow-up. Exclusion Criteria: * Recurrent or multifocal malignant gliomas. Multicentric gliomas, defined as multiple, discrete areas of enhancement on T1 weighted MRI sequences with contrast all contained within one connected region of abnormality on T2 weighted/FLAIR MRI sequences, are allowed to enroll on this study.* Prior invasive malignancy (except for non-melanomatous skin cancer) unless expected survival from prior malignancy is ≥ 5 years.* Prior head or neck RT (except for T1 glottic cancer), or systemic therapy precluding delivery of concurrent and adjuvant temozolomide* Treatment with any other therapeutic clinical protocol within 30 days prior to study registration or during participation in the study.* Severe, active co-morbidity, defined as follows: 1. Unstable angina and/or congestive heart failure requiring hospitalization 2. Transmural myocardial infarction within the last 6 months 3. Acute bacterial or fungal infection requiring intravenous antibiotics at the time of study registration 4. Any severe, active co-morbidity precluding delivery of temozolomide.* Women of child-bearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception.* Pregnant or lactating women, due to possible adverse effects on the developing fetus or infant due to temozolomide.

Study Objectives The purpose of this study is to evaluate the safety and pharmacokinetics and assess the immunogenicity and effectiveness of AGS-16C3F in subjects with renal cell cancer (RCC). Conditions: Carcinoma, Renal Cell, Renal Cell Carcinoma of Papillary Histology, Renal Cell Carcinoma With Clear Cell Histology, Renal Cell Carcinoma With Non-Clear Cell Histology Intervention / Treatment: DRUG: AGS-16C3F

Inclusion Criteria: * Dose determination cohorts: Histologically confirmed diagnosis of metastatic RCC of either clear cell or non-clear histology. * Tumors with clear cell histology: subject must have progressed after at least one anti-vascular endothelial growth factor receptor (anti-VEGFR) therapy * Tumors with non-clear cell histology must be ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3) positive at pre-screening. This sub-group does not have any prior therapy requirement. * Dose expansion cohorts: Histologically confirmed diagnosis of metastatic RCC of either clear cell or papillary histology * Tumors with clear cell histology: subject must have progressed after at least one anti-VEGFR therapy * Tumors with papillary histology: includes unclassified histology with papillary features and must be ENPP3 positive at pre-screening. This sub-group does not have any prior therapy requirement. * Measurable disease according to Response Criteria for Solid Tumors (RECIST Version 1.1) * Eastern Cooperative Group (ECOG) performance status of 0-1 * Hematologic function, as follows: * Absolute neutrophil count (ANC) ≥ 1.5 x 109/L * Platelet count ≥ 100 x 109/L * Hemoglobin ≥ 9 g/dL (transfusions are allowed) * Renal function, as follows: * creatinine ≤ 1.5 x upper limit of normal (ULN), or calculated glomerular filtration rate (GFR) > 50 mL/min if creatinine > 1.5x ULN * Hepatic function, as follows: * Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) ≤ 2.5 x ULN or ≤ 5x ULN if known liver metastases * Total bilirubin ≤1.5 x ULN * International normalized ratio (INR) < 1.3 (or ≤ 3.0 if on therapeutic anticoagulation) * Women and men of childbearing potential must be advised and agree to practice effective methods of contraception during the course of the study and for 4 weeks after the last AGS-16C3F infusion administration Exclusion Criteria: * Current uncontrolled central nervous system (CNS) metastasis or malignant brain tumors * Use of any investigational drug (including marketed drugs not approved for this indication) within 4 weeks prior to screening. No time limit applies to the use of marketed drugs approved for this indication provided that the subject has progressed on the treatment and all toxicities attributable to the drug have resolved or returned to baseline * Known sensitivity to any of the ingredients of the investigational product AGS-16C3F * History of thromboembolic events and bleeding disorders ≤3 months (e.g., (deep vein thrombosis) DVT or pulmonary embolism (PE)) * Active angina or Class III or IV Congestive Heart Failure (CHF) (New York Heart Association CHF Functional Classification System) or clinically significant cardiac disease within 12 months of study enrollment, including myocardial infarction, unstable angina, grade 2 or greater peripheral vascular disease, congestive heart failure, uncontrolled hypertension, or arrhythmias not controlled by outpatient medication. * Major surgery within 4 weeks of study enrollment * Women who are pregnant (confirmed by positive pregnancy test) or lactating * Known positive test for human immunodeficiency virus (HIV), hepatitis C, or hepatitis B surface antigen. * Active infection requiring treatment with systemic (intravenous or oral) anti-infectives (antibiotic, antifungal, or antiviral agent) within 72 hours of screening. * History of eye surgery within 6 months, presence of cataracts or other ocular disorders significantly affecting vision

Study Objectives Basal cell carcinoma (BCC) is the most common malignant skin lesion in white adults. It is a slow-growing tumour which despite low metastatic potential may cause significant local tissue destruction and patient morbidity. Methyl aminolevulinate cream plus photodynamic therapy (MAL-PDT) for BCC is currently approved for a procedure using 2 treatment sessions 1 week apart. This procedure is considered quite time- and resource-consuming. Introducing a single treatment session, with a new PDT session for treatment failures after 3 months, might represent an attractive simplification. This randomised controlled single-blinded multi-centre study primarily aims to compare BCC lesion response rate of two treatment schedules: (a) 1 single treatment of Metvix-PDT with re-treatment of non-complete responders by 3 months, and (b) the usual schedule of 2 standard Metvix(R) PDT treatments 1 week apart. Secondary objectives are to investigate the treatment response in relation to clinical and histological tumour characteristics such as tumour thickness, subtype and immunohistochemical markers. Conditions: Skin Neoplasms, Carcinoma, Basal Cell Intervention / Treatment: DRUG: MAL-PDT re-treatment, DRUG: usual MAL-PDT

Inclusion Criteria: * male/female above 18 years of age * written informed consent * 1 or more primary histologically verified BCC, clinically assessed as of either superficial of nodular type Exclusion Criteria: * pregnancy * breastfeeding * Gorlin's syndrome * porphyria * xeroderma pigmentosum * history of arsenic exposure * known allergy to MAL * concomitant treatment with immunosuppressive medication * physical or mental conditions that most likely will prevent patients attending follow-up sessions

Study Objectives A prospective observational longitudinal study of 464 patients was performed between 2010 and 2015. Patients with invasive ductal carcinoma (IDC) and ductal carcinoma in situ associated to invasive ductal carcinoma (DCIS +IDC) were included and analyzed. Conditions: Outcome of Breast Cancer Intervention / Treatment: OTHER: None intervention

Inclusion Criteria: * Patients with invasive ductal carcinoma of the breast * Patients who received surgery for primary invasive breast cancer between 2010 and 2015 Exclusion Criteria: * Patients with metastasis at the diagnostic

Study Objectives This is the first study in which TAK-441 is administered to humans. The patient population will consist of adults aged 18 or older who have advanced nonhematologic malignancies and for whom standard treatment is no longer effective or does not offer curative or life-prolonging potential. Following completion of the dose escalation study, patients will be enrolled as part of 2 expansion cohorts. Conditions: Advanced Nonhematologic Malignancies, Carcinoma, Basal Cell Intervention / Treatment: DRUG: TAK-441

Inclusion Criteria: Each patient must meet all of the following inclusion criteria to be enrolled in the study: * Male or female 18 years or older * Eastern Cooperative Oncology Group (ECOG) performance status 0 to 2 * Diagnosis of a nonhematologic malignancy for which standard treatment is no longer effective or does not offer curative or life-prolonging potential * Meet other clinical, radiographic or laboratory inclusion criteria as specified in the protocol * Voluntary written consent Exclusion Criteria: Patients meeting any of the following exclusion criteria are not to be enrolled in the study: * Life-threatening illness unrelated to cancer * Receiving other treatment (radiotherapy, antineoplastics or investigational agents) within protocol specified windows of first dose of TAK-441 * Patients with brain metastases who do not meet criteria specified in study protocol * Known history of human immunodeficiency virus (HIV) infection, hepatitis B or hepatitis C * Major surgery within 14 days before the first dose of TAK-441 * Infection requiring systemic therapy, or other serious infection within 14 days of the first dose of TAK-441 * Do not meet other clinical, laboratory or radiographic criteria as specified in the protocol

Study Objectives The purpose of our study is to recruit and treat 96 men diagnosed with prostate cancer and scheduled for a prostatectomy with a capsule form of either purified isoflavones or placebo for a 3-6 week period to see if we can slow down the rate of prostate cancer growth. A placebo is a pill or something that looks like the medicine that is being studied but has no active medicine in it. We also want to see if taking purified isoflavones is safe and if it reduces lower urinary tract symptoms. In addition, we want to study if purified isoflavones are able to slow the progression of prostate cancer, and the mechanism of action of purified isoflavones. If the safety and the effects of purified isoflavones on slowing down the progression of prostate cancer is shown in our study, this will also be a safe way of treating men who are at high risk of prostate cancer, so that we can prevent prostate cancer in the future. Conditions: Prostate Cancer Intervention / Treatment: DRUG: Purified isoflavones, DRUG: Methyl cellulose blend

Inclusion Criteria: * Diagnosis of localized prostate cancer (PCa), based on pathological assessment from biopsy specimens * No prior or current therapy for PCa or history of cancer except non-melanoma skin cancer * Scheduled for prostatectomy between 3- 6 weeks (+/-3 days) after start of study agent * No known history of hepatic or renal disease (LFTs (SGOT/SGPT) > 5.0 x upper limit of normal as evidenced by impairment of baseline laboratory values, Actual creatinine clearance of >60 utilizing the Cockcroft-Gault formula (1976), which employs creatinine measurements and a patient's weight to predict the clearance. The constant is 1.23 for men. * Omnivorous diet * No evidence of prostatitis or urinary tract infection * Able and willing to give written informed consent * Currently not using or willing to discontinue any nutritional supplements that contain soy or soy isoflavones * Not allergic to study supplements * Not on antibiotics * Men who do not consume more than 3 - 4 oz. of soy or soy products per week * Not taking steroid hormones or medications which have known impact on prostatic specific antigen (PSA) * Health status cleared by primary MD or urologist * Eastern Cooperative Oncology Group (ECOG) performance status of 0-1 Exclusion Criteria: * Prior history of prostate cancer; Current or prior history of other malignancies (exceptions include nonmelanoma skin cancer or other cancer with no evidence of tumor recurrence five years after definitive treatment) * History of renal or hepatic disease, including history of hepatitis B, C or delta as evidenced by impairment of baseline laboratory values * Participation in any other investigational study or use of any other investigational agents within 30 days of study entry * History of allergic reactions attributed to soy isoflavones or other compounds of similar chemical or biologic composition to Novasoy 400® or the inactive components present in the purified isoflavone and placebo capsules * Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or any psychological, familial, sociological or other concomitant condition that would not allow adequate compliance with the study protocol * Only African American (a person having origins in any of the black racial groups of Africa) and Caucasian (a person having origins in any of the original people of Europe, Middle East, or North Africa) men, as defined by the NIH, will be included in this study. Since this is an investigation targeting men with PCa, women are not eligible for the study.

Study Objectives This 2-phase study will determine the safety of treating patients with prostate cancer with the genetically engineered HyperAcute-Prostate cancer vaccine. It will establish the proper vaccine dose and will examine side effects and potential benefits of the treatment. The vaccine contains killed prostate cancer cells containing a mouse gene that causes the production of a foreign pattern of protein-sugars on the cell surface. It is hoped that the immune response to the foreign substance will stimulate the immune system to attack the patient's own cancer cells that have similar proteins without this sugar pattern, causing the tumor to remain stable or shrink. Patients 19 years of age or older with hormone refractory prostate cancer that has recurred or no longer responds to standard treatment may be eligible for this study. Candidates will be screened with medical history and physical examination, blood tests, urinalysis, chest x-rays and CT scans. MRI, PET, and ultrasound scans may be obtained if needed. Participants will receive twelve vaccinations two weeks apart from each other. The vaccines will be injected under the skin, similar to the way a tuberculosis skin test is given. Phase I of the study will treat successive groups of patients with increasing numbers of the vaccine cells to evaluate side effects of the treatment and determine the optimum dose. Phase II will look for any beneficial effects of the vaccine given at the highest dose found to be safe in Phase I. Monthly blood samples will be drawn during the 6 months of vaccine treatment. In addition, patient follow-up visits will be scheduled every 2 months for the remaining first year (6 months) after vaccination and then every 3 months for the next 2 years for the following tests and procedures to evaluate treatment response and side effects: * Medical history and physical examination * Blood tests * X-rays and various scans (nuclear medicine/CT/MRI) * FACT-P Assessment questionnaire to measure the impact of treatment on the patient's general well-being. The questionnaire is administered before beginning treatment, monthly during treatment, and during follow-up visits after completing the treatment. It includes questions on the severity of prostate cancer symptoms and the ability to perform normal activities of daily life. Conditions: Prostate Cancer Intervention / Treatment: BIOLOGICAL: HyperAcute-Prostate Cancer Vaccine

Inclusion Criteria: * Phase I and Phase II Arm A: A histological diagnosis of prostate cancer with evidence of metastatic disease by CT scan or bone scan. Phase II, Arm B: Evidence of hormone refractive progressive disease by increasing PSA only. * For patients enrolling in Phase II, Arm B: refractory to hormone therapy defined by: two consecutive increases in PSA documented over a previous reference value, the first occurring a minimum of 1 week from the reference value, with one value of at least 4 ng/mL and the increase(s) must be by at least 1.0 ng/mL. * Castrate testosterone levels < 50 ng/dl (0.50 ng/mL) * AJCC Stage IV (any T, any N, M1), hormone refractory metastatic, progressive or recurrent prostate carcinoma. Patients must have failed one attempt at hormonal therapy and may have received 2 prior chemotherapy regimens. * ECOG performance status less than or equal to 2. * Serum albumin greater than or equal to 3.0 gm/dL. * Expected survival greater than or equal to 6 months. * Subjects must have a negative serology for Hep B, C, and HIV prior to entering study. * Adequate organ function including: Marrow: \*Hemoglobin greater than or equal to 10.0 mg/dL, \*absolute granulocyte count (AGC) greater than or equal to 1,500/mm(3), \*platelets greater than or equal to 100,000/mm(3), \*absolute lymphocyte count greater than or equal to 475/mm(3). Hepatic: \*serum total bilirubin less than or equal to 1.5 x upper limit of normal (ULN), \*ALT (SGPT) and AST (SGOT) less than or equal to 2.5 x ULN. Renal: \*serum creatinine less than or equal to 2.0 x ULN or creatinine clearance greater than or equal to 30 mL/min. * All on-study tests must be less than or equal to Grade I toxicity for patient to be eligible for study, excluding serum LDH levels. PT, PTT must be less than or equal to 1.5 x ULN except for patients who are on therapeutic anticoagulant therapy. * Measurable or bone metastases (Phase I, Phase II-Arm A) or non-measurable disease (Phase II-Arm B). * Patients must have been treated with hormonal therapy and may have been treated with surgery and/or radiation therapy and/or less than or equal to 2 different chemotherapy regimens (including neoadjuvant and adjuvant treatment). * Patients must be greater than or equal to 4 weeks since major surgery, radiotherapy, chemotherapy (6-weeks if they were treated with a nitrosourea or mitomycin) and recovered from the toxicity of prior treatment to less than or equal to Grade 1, exclusive of alopecia or fatigue. * Patients must have the ability to understand the study, its risks, side effects, potential benefits and is able to give written informed consent to participate. Patients may not be consented by a durable power of attorney (DPA). * Male subjects of child producing potential must agree to use contraception or avoidance of pregnancy measures while enrolled on study and receiving the experimental drug, and for one month after the last immunization. * Patients taking bisphosphonates at the time of registration into the trial are eligible, but bisphosphonates must be continued at a constant level throughout the trial period. Bisphosphonate use must be initiated at least 28 days prior to first treatment. Exclusion Criteria: * Age less than 19 years of age. * Active CNS metastases or carcinomatous meningitis. * Hypercalcemia greater than 2.9 mmol/L, unresponsive to standard therapy. * Other malignancy within last 5 years, unless the probability of recurrence of the prior malignancy is less than 5%. Patients curatively treated for squamous and basal cell carcinoma of the skin or patients with a history of malignant tumor in the past that have been disease free for at least 5 years are also eligible for this study. * History of organ transplant or active immunosuppressive therapy (such as cyclosporine, tacrolimus, etc.). * Subjects taking systemic corticosteroid therapy for any reason are not eligible. * Significant or uncontrolled congestive heart failure, myocardial infarction or significant ventricular arrhythmias within the last six months. * Active infection or antibiotics within 1-week prior to study, including unexplained fever (temp. greater than 38.1 degrees Celsius). * Autoimmune disease (e.g., systemic lupus erythematosis, active rheumatoid arthritis, etc). Patients with a remote history of asthma or mild active asthma are eligible. * Other serious medical conditions that may be expected to limit life expectancy to less than 2 years (e.g., liver cirrhosis). * Any condition, psychiatric or otherwise, that would preclude informed consent, consistent follow-up or compliance with any aspect of the study (e.g., untreated schizophrenia or other significant cognitive impairment, etc). * A known allergy to any component of the alpha (1,3) galactosyltransferase tumor vaccine or cell lines from which it is derived. * Concurrent therapy such as palliative radiation or opioid analgesics for tumor-associated pain. * Anti-androgen therapy within 42 days of first treatment. * Treatment with cimetidine within 30 days of first treatment. * Prior splenectomy.

Study Objectives To discover if the adding of a coxib increases the efficacy of the Aromasine. Conditions: Metastatic Breast Cancer Intervention / Treatment: DRUG: placebo, DRUG: Celecoxib, DRUG: Exemestane

Inclusion Criteria: * Femal patient aged > 18 years * Histologically proven breast cancer * Menopausal patient according to the following definition: * amenorrhoea > 1 year or menopause affirmed by a rate of oestradiol or hypophyseal gonadotrophin * surgical ovariectomy * treatment by LHRH analog * ovarian suppression by radiotherapy * amenorrhoea induced by chemotherapy > 1 year * Oestradiol and/or progesterone positive receptors * Presence of one or several metastatic lesion: * mesurable lesion * bone metastase were detected by bone scintigraphy * Patient who can have received: * Adjuvant chemotherapy and/or hormonotherapy (Tamoxifen) * Metastatic Treatment by chemotherapy * PS < 2 * Adequate biological values * Patient who has clearly given her consent by signing on informed consent form prior to participation Exclusion Criteria: * Patient previously treated with hormonotherapy in metastatic phase * Antecedent of treatment with aromatase inhibitors * local relapse (with the exception of cutaneous thoracic nodes) * Patient with only one metastatic lesion like: pleurisy , ascites, lung Lymphangitis carcinomatosa

Study Objectives Gastrointestinal stromal tumors (GISTs) are associated with a dismal prognosis in localized and advanced phase with a major resistance to conventional chemotherapy agents. Virtually all malignant GISTs actually harbor activating mutations of the KIT pathway in the tumor cells, leading to ligand-independent activation of KIT tyrosine kinase activity and tumor growth in vitro. Glivec® inhibits KIT and exerts a major antitumor efficacy in vivo in patients with advanced GIST. Glivec® is generally pursued until progression or intolerance. The optimal duration of treatment with Glivec® remains unknown. The objective of this study is to determine the feasibility of Glivec® treatment interruption with reintroduction at progression in GIST patients. Conditions: Sarcoma, Gastro-intestinal Stromal Tumors (GIST) Intervention / Treatment: DRUG: interruption of Glivec®

Inclusion Criteria: * Patients 18 years of age or over.* Histologically documented diagnosis of malignant GIST.* Immunohistochemical documentation of c-kit (CD117) expression either by the primary tumor or metastases using the DAKO assay.* Performance status 0,1, 2, 3 (ECOG)* Adequate end organ function, defined as the following: total bilirubin < 1.5 x ULN, SGOT and SGPT < 2.5 x UNL (or < 5 x ULN if hepatic metastases are present), creatinine < 1.5 x ULN, ANC > 1.0 x 109/L, platelets > 100 x 109/L.* Female patients of child-bearing potential must have negative pregnancy test within 7 days before initiation of study drug dosing. Post menopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential. Female patients of reproductive potential must agree to employ an effective barrier method of birth control throughout the study and for up to 2 weeks (according to updated Invest. Brochure) following discontinuation of study drug.* Written, voluntary, informed consent. Exclusion Criteria: * Patient has another malignant tumor in CR<3 years (except if the other primary malignancy is inactive and not requiring active intervention). Previous basal cell skin cancer or a cervical carcinoma in situ are allowed.* Patient with Grade III/IV cardiac problems as defined by the New York Heart Association Criteria. (i.e., congestive heart failure, myocardial infarction within 6 months of study)* Female patients who are pregnant or breast-feeding.* Patient has a known diagnosis of human immunodeficiency virus (HIV) infection.* Patients received chemotherapy within 2 weeks prior to study entry, unless the disease is rapidly progressing* Patients had a major surgery within 2 weeks prior to entry study* Patient with any significant history of non-compliance to medical regimens or with inability to grant reliable informed consent.* Previous treatment with Glivec®

Study Objectives Hysterectomy for benign indication is one of the most common surgical procedures in women. Numerous reviews and guidelines recommend the vaginal approach for benign hysterectomy, but the proportion of laparoscopic (and robotic) hysterectomies is increasing. This study will compare a range of clinical and subjective outcomes of vaginal vs. total laparoscopic hysterectomy. Outcomes include operating time, postoperative recovery, return to work as well as cosmesis, quality of life and sexual health. Conditions: Uterine Fibroids, Uterine Leiomyoma, Abnormal Uterine Bleeding, Unspecified Intervention / Treatment: PROCEDURE: Hysterectomy

Inclusion Criteria: * benign indication for vaginal hysterectomy (e.g., abnormal uterine bleeding, fibroids, atypical endometrial hyperplasia) * clinical exam indicates vaginal hysterectomy is feasible * no major concomitant surgery * able to complete questionnaires in German Exclusion Criteria: * uterine malignancy * major concomitant surgery (e.g., for incontinence or prolapse) * clinical exam indicating vaginal hysterectomy not feasible * contraindication for surgery or laparoscopy

Study Objectives Purpose: This randomized phase II trial evaluated whether the combination of cisplatin and paclitaxel plus All-trans retinoic acid (ATRA) increases Response rate (RR) and Progression-free survival (PFS) in patients with advanced Non-small cell lung cancer (NSCLC) with an acceptable toxicity profile and its association with the expression of Retinoic acid receptor beta 2 (RAR-beta2) as a response biomarker. Patients and Methods: Patients with stage IIIB and IV NSCLC were included to receive Paclitaxel and Cisplatin (PC). Patients were randomized to receive ATRA 20 mg/m2/day (RA/PC) or placebo (P/PC) 1 week prior to treatment until completing two cycles. RAR-beta2 expression was analyzed by Immunohistochemistry (IHC) and RT-PCR in tumor and adjacent lung tissue. Conditions: Non-Small-Cell Lung Carcinoma Intervention / Treatment: DRUG: ATRA, OTHER: PLACEBO

Inclusion Criteria: * Stage III B and IV NSCLC * Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 * No prior cytotoxic chemotherapy for NSCLC * Age ≥18 years, adequate laboratory measurements * Measurable disease according to Response Evaluation Criteria in Solid Tumors (RECIST) * Life expectancy of >12 weeks. Exclusion Criteria: * Patients who had received prior chemotherapy * Patients with other comorbid conditions

Study Objectives The objective of this study was to evaluate the safety profile of ELIGARD® in ethnic Asian prostate cancer patients. Conditions: Prostate Cancer Intervention / Treatment: DRUG: Leuprolide

Inclusion Criteria: * A patient for whom the physician has decided to initiate treatment with a Luteinizing Hormone Releasing Hormone (LHRH) agonist in standard clinical practice * Biopsy-proven prostate adenocarcinoma * Locally advanced prostate cancer with biochemical relapse radical prostatectomy and/or radiotherapy, OR hormonal treatment-naive advanced or metastatic prostate cancer patient who has not received chemotherapy and has no plans to undergo treatment with chemotherapy at study entry. * Patient who indicates that once the study is completed, he expects having access to androgen deprivation therapy (ADT), either medical or surgical, within the local healthcare system (either through public/ private health insurance or out of pocket payment). Exclusion Criteria: * Patient with castrate resistant prostate cancer * Patient who previously underwent bilateral orchiectomy * Patient who has received prior treatment with LHRH analogues * Prior or concomitant treatment with systemic chemotherapy. A patient where there is a likelihood to receive systemic chemotherapy should not be enrolled * Life expectancy of < 1 year due to comorbidities * Participation in another interventional clinical trial within one month prior to study entry or during the duration of the study * Patient who plans to receive intermittent ADT at the time of study entry * Patient receiving non-palliative radiotherapy within 3 months prior to study entry * Patient receiving adjuvant ADT in combination with definitive radiotherapy * Patient with metastatic hormonal treatment-naive prostate cancer, for whom chemo-hormonal treatment (combination of Docetaxel and ADT) is indicated. * Patient with hypersensitivity to gonadotropin releasing hormone (GnRH), GnRH agonist analogs or any of the components of ELIGARD® * Patient with any contraindication for ELIGARD® use based on local prescribing information

Study Objectives To measure arm function and quality of life of mastectomy patients. Conditions: Breast Cancer Intervention / Treatment: PROCEDURE: Arm exercises., PROCEDURE: Arm Exercises

Inclusion Criteria: * Patients who have been referred from UNMH to CRTC for further treatment following mastectomy/lumpectomy surgery. Exclusion Criteria: * Not specified

Study Objectives This is a Phase II, nonrandomized multicenter study designed to evaluate time to progression and response proportion of patients with advanced or metastatic transitional cell carcinoma of bladder receiving 6 cycles of gemcitabine, carboplatin and sorafenib and then maintenance sorafenib. Conditions: Bladder Cancer Intervention / Treatment: DRUG: Gemcitabine, DRUG: Carboplatin, DRUG: Sorafenib

Inclusion Criteria: * Histologic documentation of diagnosis of transitional cell carcinoma of the bladder, urethra, ureter, or renal pelvis * Unresectable, locally advanced or metastatic disease * CrCl ≥ 60 ml/min or serum creatinine < 1.5 * ≥ 4 weeks since prior RT * ECOG Performance Status of 0 or 1 (Appendix I) * Age ≥ 18 years of age * Women of childbearing potential and men must agree to use adequate contraception (barrier method of birth control) prior to study entry and for the duration of study participation. Men and women should use adequate birth control for at least 2 weeks after the last administration of sorafenib. * Women of childbearing potential must have a negative serum pregnancy test performed within 7 days prior to the start of treatment * Ability to understand and the willingness to sign a written informed consent. A signed informed consent must be obtained prior to any study specific procedures. * Adequate bone marrow, liver and renal function as assessed by the following: * Hemoglobin > 9.0 g/dl * Absolute neutrophil count (ANC) ≥ 1,500/mm3 * Platelet count ≥ 100,000/mm3 * Total bilirubin ≤ 1.5 times ULN * ALT and AST ≤ 2.5 times the ULN ( ≤ 5 x ULN for patients with liver involvement) * INR < 1.5 or a PT/PTT within normal limits. Patients receiving anti-coagulation treatment with an agent such as warfarin or heparin may be allowed to participate. For patients on warfarin, the INR should be measured prior to initiation of sorafenib and monitored at least weekly, or as defined by the local standard of care, until INR is stable. Exclusion Criteria: * Prior treatment with systemic chemotherapy (prior intravesical chemotherapy is permitted, and adjuvant therapy is permitted if > 12 months have lapsed) * Current, recent (within 4 weeks of the first infusion of this study), or planned participation in an experimental drug study * Cardiac disease: Congestive heart failure > class II NYHA. Patients must not have unstable angina (anginal symptoms at rest) or new onset angina (began within the last 3 months) or myocardial infarction within the past 6 months. * History of stroke within six months * Clinically significant peripheral vascular disease * Known brain metastasis. Patients with neurological symptoms must undergo a CT scan/MRI of the brain to exclude brain metastasis. * Cardiac ventricular arrhythmias requiring anti-arrhythmic therapy. * Uncontrolled hypertension defined as systolic blood pressure > 150 mmHg or diastolic pressure > 90 mmHg, despite optimal medical management. * Sorafenib is contraindicated in patients with known severe hypersensitivity to sorafenib or any of the excipients. * Known human immunodeficiency virus (HIV) infection or chronic Hepatitis B or C. * Active clinically serious infection > CTCAE Grade 2. * Thrombolytic or embolic events such as a cerebrovascular accident including transient ischemic attacks within the past 6 months * Pulmonary hemorrhage/bleeding event ≥ CTCAE Grade 2 within 4 weeks of first dose of study drug * Any other hemorrhage/bleeding event ≥ CTCAE Grade 3 within 4 weeks of first dose of study drug * Evidence or history of bleeding diathesis or coagulopathy * Major surgery, significant traumatic injury within 4 weeks of first study drug * Use of St. John's Wort or rifampin (rifampicin) * Known or suspected allergy to sorafenib or any agent given in the course of this trial * Any condition that impairs patient's ability to swallow whole pills * Any malabsorption problem * Anticipation of need for major surgical procedure during the course of the study * Pregnant (positive pregnancy test) or lactating * History of abdominal fistula, gastrointestinal perforation, or intra-abdominal abscess within 6 months prior to Day 0 * Serious, non-healing wound, ulcer, or bone fracture * Inability to comply with study and/or follow-up procedures * History of persistent gross hematuria

Study Objectives The aim of the study is a medico-economic evaluation to estimate a cost differential between three modalities of Intensity-Modulated Radiation Therapy for cancers of the prostate, cervix and anal canal with pelvic lymph node irradiation : treatment with helical Tomotherapy and dynamic arc therapy using two different technologies: RapidArc or VMAT. Conditions: Prostate Cancer, Cervical Cancer, Anal Canal Cancers Intervention / Treatment: RADIATION: Intensity-Modulated Radiation Therapy

Inclusion Criteria: * WHO performance index ≤ 2 * Age > 18 years * histologically proven carcinoma: Anal canal cancer locally advanced (> 4 cm and / or N1 to N3) under irradiation on pelvic and inguinal lymph nodes with concurrent chemotherapy. The boost with brachytherapy are accepted Prostate cancer with pelvic lymph nodes and radiation or hormone therapy Cervical Cancer under a purely medical treatment involving irradiation on pelvic lymph nodes and primary tumor with concurrent chemotherapy without surgery. The Boost by external radiotherapy or brachytherapy are accepted. * The investigator must ensure that the patient has not expressed its opposition to participate in this study. The signing of a consent form is optional; Exclusion Criteria: * History of invasive cancer other than basal cell carcinomas. * Indication of re-irradiation * para-aortic radiotherapy associated with pelvic irradiation. * post-operative radiotherapy. * geographical distance

Study Objectives This study aims to evaluate the prognostic value of circulating tumour cells (CTC) in patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy due to gastrointestinal cancers that have spread to the peritoneum. Conditions: Circulating Tumor Cell, Peritoneal Metastases, Hyperthermic Intraperitoneal Chemotherapy Intervention / Treatment: DIAGNOSTIC_TEST: iCellate

Inclusion Criteria: * Peritoneal metastases being treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy Exclusion Criteria: * None

Study Objectives To determine the safety and immunogenicity profile of two (2) different doses of the vaccine DPX-0907 to treat breast, ovarian and prostate cancer. Conditions: Ovarian Neoplasms, Breast Neoplasms, Prostatic Neoplasms Intervention / Treatment: BIOLOGICAL: DPX-0907 consists of 7 tumor-specific HLA-A2-restricted peptides, a universal T Helper peptide, a polynucleotide adjuvant, a liposome and Montanide ISA51 VG

Inclusion Criteria: * Patients with stage III or IV ovarian cancer who have completed a course of platinin-based cytotoxic therapy after debulking surgery with evidence of a complete or partial response by radiological imaging. Patients with metastatic ovarian cancer who have stable disease for greater than 3 months after completion of first-line therapy. * Patients with stage IV breast cancer who have received at least 1 course of hormonal or cytotoxic therapy for metastatic cancer. Patients must be off cytotoxic therapy with stable disease or better for 3 months or greater duration. Patients may have stable disease and still be on hormonal therapy. * Patients with prostate cancer who have failed at least 1 course of an accepted hormonal therapy. Specifically prostate cancer patients must have castrate testosterone levels (< 50 ng/dl) and 2 PSA values higher than the previously documented baseline at least 3 weeks apart or evidence of increases in measurable disease. These patients may have received previous courses of cytotoxic chemotherapy although chemotherapy naïve patients who are deemed not good candidates or who have refused cytotoxic therapy will be eligible. These patients may remain on anti-androgen therapy during the trial. Patients with evidence of progressive bone or other metastases are acceptable. * At least 8 weeks since previous courses of an investigational biologic therapy (i.e. cancer vaccine) including active or passive immunotherapy. * At least 30 days since localized surgery or radiotherapy. * At least 30 days since initiation of a biphosphonate treatment. * HLA A2 haplotype. Exclusion Criteria: * History of autoimmune disease, such as inflammatory bowel disease, systemic lupus erythematosus, ankylosing spondylitis, scleroderma, or multiple sclerosis. Patients with a remote history (greater than five years) of thyroiditis are not excluded. * Presence of an acute infection requiring antibiotics within 4 weeks of study entry or a chronic infection such as: urinary tract infection, HIV, or antigen positive viral hepatitis. * Previously resected brain metastases unless a CT or MRI scan of the brain shows no metastasis within 1 month of receiving DPX-0907. * Concurrent (within the last 5 years) second malignancy other than non-melanoma skin cancer, cervical carcinoma in situ, or controlled bladder cancer. * Acute or chronic skin disorders that will interfere with subcutaneous injection of the vaccine or subsequent assessment of potential skin reactions. * Serious intercurrent chronic or acute illness, such as cardiac disease (NYHA class III or IV) or hepatic disease. * Steroid therapy or other immunosuppressives, such as azathioprine or cyclosporin A, unless steroids are discontinued 6 weeks prior to study. * Allergies to any component of the vaccine. * Inability to gain venous access. * Previous splenectomy. * Previous lymphadenectomy in both inguinal regions. * Pregnant or nursing mothers. * Medical or psychological impediment or active drug or alcohol use that might preclude protocol compliance.

Study Objectives The EndoRotor® is intended for use (USA labeling) in endoscopic procedures by a trained gastroenterologist to resect and remove tissue, not intended for biopsy, of the gastrointestinal (GI) system including post-endoscopic mucosal resection (EMR) tissue persistence with a scarred base and residual tissue from the peripheral margins following EMR. In this trial investigators will conduct a post-market, prospective, non-randomized, multi-center study for the treatment of subjects with the need for resection of recurrent flat or sessile colorectal lesions where EndoRotor is the primary resection modality of persistent adenoma with a scarred base. Conditions: Polyp of Colon, Endoscopic Mucosal Resection, Recurrent Colon Adenoma Intervention / Treatment: DEVICE: EndoRotor Resection

Inclusion Criteria: * Subjects aged ≥18 to ≤85 years.* At least one recurrent flat or sessile colorectal lesion measuring up to 6 cm in diameter and/or length.* Presence of recurrent flat or sessile lesion where the EndoRotor may be used to resect recurrent neoplasia.* Favorable anatomy that allows the investigator to access the lesion.* Subject is able and willing to comply with site standard medical follow-up, including the 90-day follow-up visit.* Subject has been informed of the nature of the study, agrees to participate and has signed the consent form. Exclusion Criteria: * Inability to give informed consent.* Subject age is <18 years of age or >85 years of age.* Presence of a lesion that represents cancer or has a high chance of harboring submucosal invasive cancer.* Presence of synchronous lesions intended for resection that would require use of a concomitant resection modality* Medical reasons the procedure cannot be performed (i.e. labile blood pressure, anticoagulation laboratory levels that are too high and risk excessive bleeding, systemic infection, etc.)* Active antiplatelet therapy (Plavix , 325mg aspirin therapy) - patient off treatment for < 1 week.* Inability to undergo a procedure under propofol sedation or General Anesthesia.* Female patients who are known to be pregnant.* Co-morbid conditions that place the subject at an unacceptable surgical risk (e.g., severe chronic obstructive pulmonary disease, hepatic failure, cardiac disease, autoimmune disorders or conditions of severe immunosuppression).* Any clinical evidence that the investigator feels would place the subject at increased risk with the deployment of the device.* Subject is participating in another study of a device, medication, biologic, or other agent within 90 days and could, in the opinion of the investigator, impact the results of this study.* Subject has other medical, social or psychological problems that in the opinion of the investigator would preclude them from receiving this treatment and the procedures and participating in evaluations pre- and post-treatment.