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We present a fatal case of subacute methanol toxicity with associated diffuse brain involvement, including bilateral putaminal necrosis and cerebral edema with ventricular compression.

The evaluation, causes, and differential diagnosis of alopecia in a black woman are discussed.

The development of safer and more effective means for VT control is progressing and is needed.

Blood, urine, and throat cultures were negative.

ECG and thallium-201 scintigram.

Lithium and maintenance ECT.

These results indicate that rEpo may benefit some patients with MDS and AA who are dependent on red cell transfusions while further studies will be necessary to elucidate the mechanism by which rEpo stimulates erythropoiesis and improves anemia in patients with these diseases.

Myasthenia-like syndrome induced by cardiovascular agents.

RESULTS: Scouting biopsies demonstrated multiple comedones and ruptured epidermoid cysts.

This toxic effect was attributed to lomustine and was not seen in patients treated with carmustine alone.

Massive pulmonary embolism due to late-onset heparin-induced thrombocytopenia following coronary artery bypass graft surgery: successful treatment with lepirudin.

CONCLUSIONS: The results of this self-selected case series must be interpreted with caution.

Pulmonary histopathology demonstrated a mononuclear interstitial infiltrate without evidence of malignant, infectious, granulomatous, or vascular causes.

To our knowledge, this is the first case of griseofulvin-exacerbated lupus in which nephrotic syndrome has been observed.

General aneurysmatosis due to cheese consumption: complications of an endocarditis caused by Lactococcus cremoris.

This panic anxiety was not relieved by taking etizolam and flunitrazepam again, but subsided rapidly by the re-administration of mianserin 30 mg/day, and because of that the depressive symptom also disappeared.

These findings suggest that clozapine-induced seizures can be successfully treated, that gradual dose titration can reduce the likelihood of further episodes of seizures and that concomitant use of a suitable mood stabilizer/anti-epileptic medication can improve the outcome of treatment-resistant schizophrenia.

Posterior circulation hyperperfusion syndrome after bilateral vertebral artery intracranial stenting.

Use of the Naranjo probability scale showed the relationship of itraconazole therapy and the occurrence of acute hepatitis as probable.

However, it is controversial whether progressive hepatic lesions develop in complete abstainers as a result of long-term cyanamide treatment.

It is very likely that the dexamethasone used in the antiemetic drug regimen contributed to the development of osteonecrosis in these patients.

Weight loss during therapy with olanzapine orally disintegrating tablets: two case reports.

We report a case of a patient with pulmonary hypertension and undifferentiated connective tissue disease who, after 2 months of treatment with epoprostenol, presented with rapidly progressive erythema, scaling, nausea and vomiting, and fever.

Cholesterol microembolization as a sequela of oral anticoagulant therapy has been reported to cause infarction of virtually any organ, often resulting in death.

The child, at present 15 months old, has had to undergo two operations for fronto-orbital advancement because of insufficient growth of the mid-face, nasal airway hypoplasia and increased intracranial pressure.

We report a patient with pulmonary adenocarcinoma complicated by the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) following systemic chemotherapy with cisplatin (CDDP) and vindesine (VDS).

Cholesterol crystal embolization-associated renal failure after therapy with recombinant tissue-type plasminogen activator.

We examined the correlations between the individual changes in serum creatinine (Scr), body weight (BW) and urine volume (UV) before and after the pulse therapy and other laboratory data such as Scr, total serum protein and albumin.

METHODS/RESULTS: This paper presents a new case of rifabutin uveitis and a review of the various published reports to date.

Disseminated Nocardia asteroides and coinfection with Trichophyton rubrum in a renal transplant recipient.

A 58-year old patient is reported who developed an ischaemic cerebrovascular accident 22 hours after successful thrombolysis with streptokinase for life-threatening pulmonary emboli.

During dose-finding studies for intravenous proton pump inhibitors omeprazole and pantoprazole, three of six young female volunteers receiving omeprazole and two young female volunteers receiving pantoprazole developed peripheral edema within 8 hr when high doses of the proton pump inhibitors were applied by continuous infusion together with large volumes of fluid.

The authors report a world class runner who sustained a rupture requiring surgical intervention.

Calcium administration should also be considered.

Apparent cyclophosphamide (cytoxan) embryopathy: a distinct phenotype?

Acute kidney injury caused by zonisamide-induced hypersensitivity syndrome.

Prominent eye movements during NREM sleep and REM sleep behavior disorder associated with fluoxetine treatment of depression and obsessive-compulsive disorder.

A case report.

Although this can be coincidental, it can also suggest that the basis of a thrombus may dissolve first with any, including oral, anticoagulation.

Intravenous cytarabine and methotrexate appear to act synergistically to enhance the potential for central nervous system toxicity.

To date, eight cases of TEN and one of SJS related to lamotrigine administration have been reported in the literature.

Classification included dry (7%), mild (48%), moderate (39%), and severe (6%).

A 69-year-old man developed pure red cell aplasia after taking fenoprofen for ten months.

The authors conclude that among patients taking high doses of oral niacin only those who experience visual symptoms need to be ophthalmologically evaluated.

Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered.

We report a patient in whom the anti-depressant trazodone hydrochloride (Molipaxin, Roussel), a serotonin antagonist, provoked generalized pustular psoriasis (GPP).

However, the use of lithium should be avoided with any patient who is purging, since it may exacerbate the loss of intracellular potassium, thereby increasing the risk of cardiac toxicity.

A postmortem liver biopsy revealed adenocarcinoma undergoing necrosis.

We report two patients with anhedonic ejaculation (ejaculation without orgasm) associated with initiation of treatment with desipramine.

The likelihood of an acute respiratory reaction during treatment may therefore depend on the bacillary load, the extent of lung disease present, and its severity may be related to the pre-treatment immune status of the patient.

Methemoglobinemia after axillary block with bupivacaine and additional injection of lidocaine in the operative field.

CONCLUSIONS: This case describes the clinically significant increase of INR in an elderly patient after adding a chemotherapy regimen of levamisole and 5-FU to a previous regimen of warfarin alone.

Diagnosis was assessed according to the international AIH scoring system, including liver biopsy and confirmed by positive response to steroid challenge.

The case illustrates the classic features of the syndrome and its dramatic response to corticosteroid treatment.

A dapsone hypersensitivity syndrome, consisting of fever, headache, nausea, vomiting, lymphadenopathy, hepatitis, hemolysis, leukopenia, and mononucleosis, has been described in patients treated with the drug for leprosy.

This case is the first report in which RLS augmentation is shown to be characterized by motor hyperkinesias paralleling levodopa plasma pharmacokinetic profile.

Six received intra-arterial alteplase and 1 underwent intracranial angioplasty; in a final patient, technical aspects prevented intra-arterial therapy.

Aseptic meningitis, hemolytic anemia, hepatitis, and orthostatic hypotension in a patient treated with trimethoprim-sulfamethoxazole.

Although major hazards of treatment of hypophosphatemic osteomalacia with phosphate and calcitriol are secondary hyperparathyroidism and vitamin D intoxication, potassium loss also should be kept in mind.

However, engraftment was not achieved.

Surgery and anaesthesia were uneventful and she gained good symptomatic relief.

Investigation confirmed the diagnosis of rhabdomyolysis, and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomylysis.

We conclude that these agents should be used with great care in patients in whom atherosclerotic vascular disease is likely.

We describe a patient with Wilson's disease who presented with neurologic disease, was treated with D-penicillamine, and suffered sudden neurologic deterioration coincident with therapy.

His recovery was uneventful.

Methylephedrine is generally harmless and is contained in many cough and cold preparations.

Sirolimus-associated pneumonitis has been described in renal transplant patients.

The novel antipsychotics offer great potential for improving compliance.

Oral ketamine: a promising treatment for restless legs syndrome.

There was a clear relationship between restarting the Accutane and recurrence of the transient myopia.

However, 3 months later he developed increased intraocular pressure and a recurrence of the cystoid macular edema.

CONCLUSIONS: These findings suggest that, in patients who are susceptible, the periocular or systemic absorption of inhaled corticosteroids may be sufficient to produce CSC in humans, supporting previous hypotheses regarding the pathogenesis of the disorder.

Less common adverse events to dapsone include the idiosyncratic reactions of leukopenia and agranulocytosis, cutaneous eruptions, peripheral neuropathy, psychosis, toxic hepatitis, cholestatic jaundice, nephrotic syndrome, renal papillary necrosis, severe hypoalbuminemia without proteinuria, an infectious mononucleosis-like syndrome, and minor neurological and gastrointestinal complaints.

We describe two dark-skinned patients who developed hyperpigmented skin and tongue lesions during combination therapy with IFN and ribavirin.

Clonazepam was given as needed, and the patient was discharged on February 1 with myoclonus that soon subsided.

CT showed deep RIF extending from the vocal cords to the carina, with laryngotracheal compression but without cancer recurrence.

We consider asterixis to be an easily overlooked sign of neurotoxicity, which may occur even at low or moderate dosage levels, if certain drugs as lithium or clozapine are used in combination with CBZ.

We report a 43-year-old woman who developed sore throat, swelling of the lips and oral cavity and dysphagia, 2 weeks after the use of budesonide spray (Budefat) for treatment of bronchial asthma.

A 77-year-old man developed ankle, hand, and facial swelling 2 weeks after starting rosiglitazone.

Hyponatraemia developed after rechallenge with controlled release carbamazepine.

This report rules out other causes of toxic epidermal necrolysis and implicates ofloxacin in what appears to be an atypical presentation of drug-induced toxic epidermal necrolysis.

Adverse reactions, however, are relatively common as well.

Protease inhibitors (ritonavir and saquinavir) were added to the treatment and the patient developed progressive ataxia related to carbamazepine toxicity.

Ramipril-induced cutaneous vasculitis is particularly rare and our case was atypical because the patient had tolerated lisinopril before.

We report a patient who developed acute pancreatitis during amiodarone therapy.

Pemphigus vulgaris (PV) is a rare but potentially fatal autoimmune bullous disorder which frequently affects the oral mucosa.

The study was approved by the McGill University Health Centre Research Ethics Board.

Jaundice induced by streptokinase.

CONCLUSION: This is the first report of keratitis caused by Nocardia exalbida.

It has been described most recently in patients with solid tumors who receive taxane-based therapy.

Chlorambucil central nervous toxicity: a significant side effect of chlorambucil therapy in childhood nephrotic syndrome.

Gemcitabine therapy has been associated with radiation recall reactions when used in the treatment of carcinoma.

We report a case of reversible DKA and new-onset DM that developed in a demented patient who was treated with quetiapine for 14 days.

His diarrhea, consisting of 10 to 12 loose stools a day, had continued for approximately two weeks and was accompanied with abdominal cramping, fever, anorexia, and weight loss.

Pulmonary fibrosis subsequent to high doses of CCNU for chronic myeloid leukemia.

The authors report two cases of delayed elimination of methotrexate in patients receiving ciprofloxacin, with severe toxicity.

Systemic capillary leak syndrome after granulocyte colony-stimulating factor (G-CSF).

We believe that the infection was due to asymptomatic ethmoid sinusitis.

Although visual hallucinations have not been reported as an adverse effect of this agent, we describe three patients who experienced complex visual hallucinations and altered mental status after zonisamide treatment was begun or its dosage increased.

A typical regimen is cytarabine 3 g/m2 iv over one to three hours q 12h for a total of 8 to 12 doses.