Datasets:

clinicalnlplab

/

chemprot_test

like 0

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and @CHEMICAL$ for DP, cicaprost, iloprost and isocabacyclin for @GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and @CHEMICAL$ for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @GENE$, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, @CHEMICAL$ and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @GENE$, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and @CHEMICAL$ showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @GENE$, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEM-GENE$, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, cicaprost, iloprost and isocabacyclin for @GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, @GENE$, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, @CHEMICAL$ and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, @GENE$, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and @CHEMICAL$ showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, @GENE$, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, @GENE$, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, @CHEMICAL$, iloprost and isocabacyclin for @GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, @CHEMICAL$, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, @GENE$ and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, @CHEMICAL$ and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, @GENE$ and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and @CHEMICAL$ showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, @GENE$ and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, cicaprost, @GENE$ and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, @CHEMICAL$ and isocabacyclin for @GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, @CHEMICAL$ and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and @GENE$ for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, @CHEMICAL$ and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and @GENE$ for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and @CHEMICAL$ showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and @GENE$ for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, cicaprost, iloprost and @GENE$ for IP, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and @CHEMICAL$ for @GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and @CHEMICAL$ for IP, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for @GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, @CHEMICAL$ and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for @GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and @CHEMICAL$ showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for @GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, cicaprost, iloprost and isocabacyclin for @GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for @CHEM-GENE$, and S-145, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for @CHEMICAL$, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and @GENE$, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, @CHEMICAL$ and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and @GENE$, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and @CHEMICAL$ showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and @GENE$, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, cicaprost, iloprost and isocabacyclin for IP, and @GENE$, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for @CHEMICAL$, and @GENE$, I-BOP and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and @CHEMICAL$, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, @GENE$ and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, @CHEMICAL$ and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, @GENE$ and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and @CHEMICAL$ showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, @GENE$ and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, cicaprost, iloprost and isocabacyclin for IP, and S-145, @GENE$ and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for @CHEMICAL$, and S-145, @GENE$ and GR 32191 for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, @CHEMICAL$ and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and @GENE$ for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, @CHEMICAL$ and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and @GENE$ for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and @CHEMICAL$ showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and @GENE$ for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and @GENE$ for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for @CHEMICAL$, and S-145, I-BOP and @GENE$ for TP. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and @CHEMICAL$ for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, @CHEMICAL$ and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and @CHEMICAL$ showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for @CHEMICAL$, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for @CHEMICAL$, and S-145, I-BOP and GR 32191 for @GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The DP, IP and TP receptors showed high ligand binding specificity and only bound their own putative ligands with high affinity such as PGD2, BW245C and BW868C for DP, cicaprost, iloprost and isocabacyclin for IP, and S-145, I-BOP and GR 32191 for @CHEM-GENE$. 3.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEM-GENE$ bound PGF2 alpha and fluprostenol with Ki values of 3-4 nM. In addition, PGD2, 17-phenyl-PGE2, STA2, I-BOP, PGE2 and M&B-28767 bound to this receptor with Ki values less than 100 nM. 4.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ bound @GENE$ alpha and fluprostenol with Ki values of 3-4 nM. In addition, PGD2, 17-phenyl-PGE2, STA2, I-BOP, PGE2 and M&B-28767 bound to this receptor with Ki values less than 100 nM. 4.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ bound PGF2 alpha and @GENE$ with Ki values of 3-4 nM. In addition, PGD2, 17-phenyl-PGE2, STA2, I-BOP, PGE2 and M&B-28767 bound to this receptor with Ki values less than 100 nM. 4.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ bound PGF2 alpha and fluprostenol with Ki values of 3-4 nM. In addition, @GENE$, 17-phenyl-PGE2, STA2, I-BOP, PGE2 and M&B-28767 bound to this receptor with Ki values less than 100 nM. 4.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ bound PGF2 alpha and fluprostenol with Ki values of 3-4 nM. In addition, PGD2, @GENE$, STA2, I-BOP, PGE2 and M&B-28767 bound to this receptor with Ki values less than 100 nM. 4.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ bound PGF2 alpha and fluprostenol with Ki values of 3-4 nM. In addition, PGD2, 17-phenyl-PGE2, @GENE$, I-BOP, PGE2 and M&B-28767 bound to this receptor with Ki values less than 100 nM. 4.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ bound PGF2 alpha and fluprostenol with Ki values of 3-4 nM. In addition, PGD2, 17-phenyl-PGE2, STA2, @GENE$, PGE2 and M&B-28767 bound to this receptor with Ki values less than 100 nM. 4.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ bound PGF2 alpha and fluprostenol with Ki values of 3-4 nM. In addition, PGD2, 17-phenyl-PGE2, STA2, I-BOP, @GENE$ and M&B-28767 bound to this receptor with Ki values less than 100 nM. 4.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ bound PGF2 alpha and fluprostenol with Ki values of 3-4 nM. In addition, PGD2, 17-phenyl-PGE2, STA2, I-BOP, PGE2 and @GENE$ bound to this receptor with Ki values less than 100 nM. 4.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ receptor bound @GENE$, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative EP1 antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The EP1 receptor bound @CHEMICAL$, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative @GENE$ antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ receptor bound 17-phenyl-PGE2, @GENE$ and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative EP1 antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The EP1 receptor bound 17-phenyl-PGE2, @CHEMICAL$ and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative @GENE$ antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ receptor bound 17-phenyl-PGE2, sulprostone and @GENE$ in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative EP1 antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The EP1 receptor bound 17-phenyl-PGE2, sulprostone and @CHEMICAL$ in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative @GENE$ antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to @GENE$ and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative EP1 antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The EP1 receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to @CHEMICAL$ and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative @GENE$ antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and @GENE$, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative EP1 antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The EP1 receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and @CHEMICAL$, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative @GENE$ antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. @GENE$ and two putative EP1 antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The EP1 receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. @CHEMICAL$ and two putative @GENE$ antagonists, AH6809 and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative EP1 antagonists, @GENE$ and SC-19220, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The EP1 receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative @CHEMICAL$ antagonists, @GENE$ and SC-19220, did not show any significant binding to this receptor.

CPR:6

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative EP1 antagonists, AH6809 and @GENE$, did not show any significant binding to this receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The EP1 receptor bound 17-phenyl-PGE2, sulprostone and iloprost in addition to PGE2 and PGE1, with Ki values of 14-36 nM. 16,16-dimethyl-PGE2 and two putative @CHEMICAL$ antagonists, AH6809 and @GENE$, did not show any significant binding to this receptor.

CPR:6

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$, a putative @GENE$ agonist, and misoprostol, a putative EP2/EP3 agonist, also bound to this receptor with Ki values of 120 nM. 5.

CPR:5

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$, a putative EP3 agonist, and misoprostol, a putative @GENE$/EP3 agonist, also bound to this receptor with Ki values of 120 nM. 5.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$, a putative EP3 agonist, and misoprostol, a putative EP2/@GENE$ agonist, also bound to this receptor with Ki values of 120 nM. 5.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: M&B-28767, a putative @CHEMICAL$ agonist, and @GENE$, a putative EP2/EP3 agonist, also bound to this receptor with Ki values of 120 nM. 5.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: M&B-28767, a putative EP3 agonist, and @CHEMICAL$, a putative @GENE$/EP3 agonist, also bound to this receptor with Ki values of 120 nM. 5.

CPR:5

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: M&B-28767, a putative EP3 agonist, and @CHEMICAL$, a putative EP2/@GENE$ agonist, also bound to this receptor with Ki values of 120 nM. 5.

CPR:5

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by @CHEMICAL$, AH-13205 and AH-6809 that bound to the @GENE$ receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the EP2 receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by @CHEMICAL$, AH-13205 and AH-6809 that bound to the EP2 receptor but not to the @GENE$ receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the EP2 receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by @CHEMICAL$, AH-13205 and AH-6809 that bound to the EP2 receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the @GENE$ but not to the EP2 receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by @CHEMICAL$, AH-13205 and AH-6809 that bound to the EP2 receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the @GENE$ receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by butaprost, @CHEMICAL$ and AH-6809 that bound to the @GENE$ receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the EP2 receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by butaprost, @CHEMICAL$ and AH-6809 that bound to the EP2 receptor but not to the @GENE$ receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the EP2 receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by butaprost, @CHEMICAL$ and AH-6809 that bound to the EP2 receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the @GENE$ but not to the EP2 receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by butaprost, @CHEMICAL$ and AH-6809 that bound to the EP2 receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the @GENE$ receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by butaprost, AH-13205 and @CHEMICAL$ that bound to the @GENE$ receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the EP2 receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by butaprost, AH-13205 and @CHEMICAL$ that bound to the EP2 receptor but not to the @GENE$ receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the EP2 receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by butaprost, AH-13205 and @CHEMICAL$ that bound to the EP2 receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the @GENE$ but not to the EP2 receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by butaprost, AH-13205 and @CHEMICAL$ that bound to the EP2 receptor but not to the EP4 receptor, and by 1-OH-PGE1 that bound to the EP4 but not to the @GENE$ receptor. 6.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The two receptors were discriminated by butaprost, AH-13205 and AH-6809 that bound to the @CHEMICAL$ receptor but not to the EP4 receptor, and by @GENE$ that bound to the EP4 but not to the EP2 receptor. 6.

false