Datasets:

clinicalnlplab

/

chemprot_dev

like 0

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Thymidylate synthase and @CHEM-GENE$ are key enzymes involved in the de novo and salvage pathways for pyrimidine nucleotide synthesis, respectively.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEM-GENE$ is inhibited by 5-fluorodeoxyuridine monophosphate, forming an inactive ternary complex with intracellular folate.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ is inhibited by @GENE$, forming an inactive ternary complex with intracellular folate.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ is inhibited by 5-fluorodeoxyuridine monophosphate, forming an inactive ternary complex with intracellular @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Thirty-week administration of @CHEMICAL$ with or without leucovorin markedly suppressed both colorectal carcinogenesis and tumor growth, resulted in the increase of @GENE$ inhibition and the decrease of thymidine kinase activity in the tumor cells.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Thirty-week administration of @CHEMICAL$ with or without leucovorin markedly suppressed both colorectal carcinogenesis and tumor growth, resulted in the increase of thymidylate synthase inhibition and the decrease of @GENE$ activity in the tumor cells.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Thirty-week administration of UFT with or without @CHEMICAL$ markedly suppressed both colorectal carcinogenesis and tumor growth, resulted in the increase of @GENE$ inhibition and the decrease of thymidine kinase activity in the tumor cells.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Thirty-week administration of UFT with or without @CHEMICAL$ markedly suppressed both colorectal carcinogenesis and tumor growth, resulted in the increase of thymidylate synthase inhibition and the decrease of @GENE$ activity in the tumor cells.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Thirty-week administration of UFT with or without leucovorin markedly suppressed both colorectal carcinogenesis and tumor growth, resulted in the increase of @CHEM-GENE$ inhibition and the decrease of thymidine kinase activity in the tumor cells.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Thirty-week administration of UFT with or without leucovorin markedly suppressed both colorectal carcinogenesis and tumor growth, resulted in the increase of @CHEMICAL$ synthase inhibition and the decrease of @GENE$ activity in the tumor cells.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Thirty-week administration of UFT with or without leucovorin markedly suppressed both colorectal carcinogenesis and tumor growth, resulted in the increase of @CHEMICAL$ inhibition and the decrease of @GENE$ kinase activity in the tumor cells.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Thirty-week administration of UFT with or without leucovorin markedly suppressed both colorectal carcinogenesis and tumor growth, resulted in the increase of thymidylate synthase inhibition and the decrease of @CHEM-GENE$ activity in the tumor cells.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ is rapidly induced in growth-stimulated mouse fibroblasts and releases @GENE$ decarboxylase from antizyme suppression.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases @CHEMICAL$ decarboxylase from @GENE$ suppression.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases @CHEM-GENE$ from antizyme suppression.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ decarboxylase (@GENE$) catalyses the first step in the synthesis of the polyamines putrescine, spermidine and spermine.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEM-GENE$ (ODC) catalyses the first step in the synthesis of the polyamines putrescine, spermidine and spermine.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Ornithine decarboxylase (@CHEMICAL$) catalyses the first step in the synthesis of the polyamines putrescine, @GENE$ and spermine.

CPR:9

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ (ODC) catalyses the first step in the synthesis of the polyamines putrescine, @GENE$ and spermine.

CPR:9

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Ornithine decarboxylase (@CHEMICAL$) catalyses the first step in the synthesis of the polyamines putrescine, spermidine and @GENE$.

CPR:9

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ (ODC) catalyses the first step in the synthesis of the polyamines putrescine, spermidine and @GENE$.

CPR:9

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Ornithine decarboxylase (@CHEMICAL$) catalyses the first step in the synthesis of the polyamines @GENE$, spermidine and spermine.

CPR:9

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ (ODC) catalyses the first step in the synthesis of the polyamines @GENE$, spermidine and spermine.

CPR:9

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In untransfected CHL cells, @CHEMICAL$ had no effect at concentrations up to 100 microM. In @GENE$ transfected cells the rank order of agonist potency was A-54741 (mean pEC(50)=8.96)>dexmedetomidine (8.88)>UK-14304 (8.42)>B-HT 920 (7.05)>noradrenaline (6.92).

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In untransfected CHL cells, noradrenaline had no effect at concentrations up to 100 microM. In @CHEMICAL$ transfected cells the rank order of agonist potency was @GENE$ (mean pEC(50)=8.96)>dexmedetomidine (8.88)>UK-14304 (8.42)>B-HT 920 (7.05)>noradrenaline (6.92).

CPR:5

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In untransfected CHL cells, noradrenaline had no effect at concentrations up to 100 microM. In @CHEMICAL$ transfected cells the rank order of agonist potency was A-54741 (mean pEC(50)=8.96)>@GENE$ (8.88)>UK-14304 (8.42)>B-HT 920 (7.05)>noradrenaline (6.92).

CPR:5

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In untransfected CHL cells, noradrenaline had no effect at concentrations up to 100 microM. In @CHEMICAL$ transfected cells the rank order of agonist potency was A-54741 (mean pEC(50)=8.96)>dexmedetomidine (8.88)>@GENE$ (8.42)>B-HT 920 (7.05)>noradrenaline (6.92).

CPR:5

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In untransfected CHL cells, noradrenaline had no effect at concentrations up to 100 microM. In @CHEMICAL$ transfected cells the rank order of agonist potency was A-54741 (mean pEC(50)=8.96)>dexmedetomidine (8.88)>UK-14304 (8.42)>@GENE$ (7.05)>noradrenaline (6.92).

CPR:5

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In untransfected CHL cells, noradrenaline had no effect at concentrations up to 100 microM. In @CHEMICAL$ transfected cells the rank order of agonist potency was A-54741 (mean pEC(50)=8.96)>dexmedetomidine (8.88)>UK-14304 (8.42)>B-HT 920 (7.05)>@GENE$ (6.92).

CPR:5

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: 3. The selective @CHEMICAL$ ligand @GENE$ antagonized acidification rate changes with an affinity independent of the agonist used; the affinity (mean pK(B)) against noradrenaline was 8.43.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: 3. The selective @CHEMICAL$ ligand rauwolscine antagonized acidification rate changes with an affinity independent of the agonist used; the affinity (mean pK(B)) against @GENE$ was 8.43.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The selective @CHEMICAL$ ligands @GENE$ and doxazosin (each 3 microM) had no effect on noradrenaline responses.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The selective @CHEMICAL$ ligands prazosin and @GENE$ (each 3 microM) had no effect on noradrenaline responses.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The selective @CHEMICAL$ ligands prazosin and doxazosin (each 3 microM) had no effect on @GENE$ responses.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ were activated by @GENE$ as assessed using a glucocorticoid-responsive reporter plasmid, pTAT3-CAT.

CPR:3

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ antagonist @GENE$ (mifepristone) significantly counteracted the effect of dexamethasone on glucocorticoid receptor activation, indicating that the dexamethasone effect is specific and is mediated through the glucocorticoid receptor.

CPR:6

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The glucocorticoid receptor antagonist @CHEMICAL$ (mifepristone) significantly counteracted the effect of dexamethasone on @GENE$ activation, indicating that the dexamethasone effect is specific and is mediated through the glucocorticoid receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The glucocorticoid receptor antagonist @CHEMICAL$ (mifepristone) significantly counteracted the effect of dexamethasone on glucocorticoid receptor activation, indicating that the dexamethasone effect is specific and is mediated through the @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ antagonist RU-486 (@GENE$) significantly counteracted the effect of dexamethasone on glucocorticoid receptor activation, indicating that the dexamethasone effect is specific and is mediated through the glucocorticoid receptor.

CPR:6

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The glucocorticoid receptor antagonist RU-486 (@CHEMICAL$) significantly counteracted the effect of dexamethasone on @GENE$ activation, indicating that the dexamethasone effect is specific and is mediated through the glucocorticoid receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The glucocorticoid receptor antagonist RU-486 (@CHEMICAL$) significantly counteracted the effect of dexamethasone on glucocorticoid receptor activation, indicating that the dexamethasone effect is specific and is mediated through the @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ antagonist RU-486 (mifepristone) significantly counteracted the effect of @GENE$ on glucocorticoid receptor activation, indicating that the dexamethasone effect is specific and is mediated through the glucocorticoid receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The glucocorticoid receptor antagonist RU-486 (mifepristone) significantly counteracted the effect of @CHEMICAL$ on @GENE$ activation, indicating that the dexamethasone effect is specific and is mediated through the glucocorticoid receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The glucocorticoid receptor antagonist RU-486 (mifepristone) significantly counteracted the effect of @CHEMICAL$ on glucocorticoid receptor activation, indicating that the dexamethasone effect is specific and is mediated through the @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ antagonist RU-486 (mifepristone) significantly counteracted the effect of dexamethasone on glucocorticoid receptor activation, indicating that the @GENE$ effect is specific and is mediated through the glucocorticoid receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The glucocorticoid receptor antagonist RU-486 (mifepristone) significantly counteracted the effect of dexamethasone on @CHEMICAL$ activation, indicating that the @GENE$ effect is specific and is mediated through the glucocorticoid receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The glucocorticoid receptor antagonist RU-486 (mifepristone) significantly counteracted the effect of dexamethasone on glucocorticoid receptor activation, indicating that the @CHEMICAL$ effect is specific and is mediated through the @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The presence of @CHEMICAL$ confers their responsiveness to glucocorticoids and indicates that the airway epithelium may be a target for the anti-inflammatory effects of inhaled @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Although many of the receptors we have examined are expressed at reduced levels on apoptotic neutrophils, we found that there was differential loss of certain receptors (e.g. @CHEMICAL$, CD15 and CD120b) and increased expression of aminopeptidase-@GENE$ (CD13).

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Although many of the receptors we have examined are expressed at reduced levels on apoptotic neutrophils, we found that there was differential loss of certain receptors (e.g. CD16, @CHEMICAL$ and CD120b) and increased expression of aminopeptidase-@GENE$ (CD13).

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Although many of the receptors we have examined are expressed at reduced levels on apoptotic neutrophils, we found that there was differential loss of certain receptors (e.g. CD16, CD15 and @CHEMICAL$) and increased expression of aminopeptidase-@GENE$ (CD13).

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Although many of the receptors we have examined are expressed at reduced levels on apoptotic neutrophils, we found that there was differential loss of certain receptors (e.g. CD16, CD15 and CD120b) and increased expression of @CHEM-GENE$ (CD13).

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Although many of the receptors we have examined are expressed at reduced levels on apoptotic neutrophils, we found that there was differential loss of certain receptors (e.g. CD16, CD15 and CD120b) and increased expression of aminopeptidase-@CHEMICAL$ (@GENE$).

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: A positron emission tomography study of quetiapine in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high @CHEM-GENE$ occupancy.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: A positron emission tomography study of @CHEMICAL$ in schizophrenia: a preliminary finding of an antipsychotic effect with only transiently high @GENE$ occupancy.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: As such, relatively little has been published regarding its in vivo effects at the @CHEM-GENE$ (D2) and serotonin type 2a (5-HT2a) receptor systems.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: As such, relatively little has been published regarding its in vivo effects at the @CHEMICAL$ type 2 (@GENE$) and serotonin type 2a (5-HT2a) receptor systems.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: As such, relatively little has been published regarding its in vivo effects at the @CHEMICAL$ type 2 (D2) and @GENE$ systems.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: As such, relatively little has been published regarding its in vivo effects at the @CHEMICAL$ (D2) and @GENE$ type 2a (5-HT2a) receptor systems.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: As such, relatively little has been published regarding its in vivo effects at the dopamine type 2 (@CHEMICAL$) and @GENE$ type 2a (5-HT2a) receptor systems.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: As such, relatively little has been published regarding its in vivo effects at the dopamine type 2 (D2) and @CHEM-GENE$ systems.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: RESULTS: @CHEMICAL$ was an effective antipsychotic and improved the extrapyramidal symptoms and @GENE$ level elevation noted at baseline.

CPR:3

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Study of the additional subjects revealed that @CHEMICAL$ does give rise to transiently high (58%-64%) @GENE$ occupancy 2 to 3 hours after a single dose that then decreases to minimal levels in 12 hours.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: CONCLUSIONS: @CHEMICAL$ shows a transiently high @GENE$ occupancy, which decreases to very low levels by the end of the dosing interval.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the @CHEMICAL$ and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), insulin lispro (B28Lys,B29Pro human insulin), insulin glargine (A21Gly,B31Arg,B32Arg human insulin), insulin detemir (NN304) [B29Lys(@GENE$), desB30 human insulin], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and @CHEMICAL$ binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), insulin lispro (B28Lys,B29Pro human insulin), insulin glargine (A21Gly,B31Arg,B32Arg human insulin), insulin detemir (NN304) [B29Lys(@GENE$), desB30 human insulin], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of @CHEMICAL$ aspart (B28Asp human insulin), insulin lispro (B28Lys,B29Pro human insulin), insulin glargine (A21Gly,B31Arg,B32Arg human insulin), insulin detemir (NN304) [B29Lys(@GENE$), desB30 human insulin], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp @CHEMICAL$), insulin lispro (B28Lys,B29Pro human insulin), insulin glargine (A21Gly,B31Arg,B32Arg human insulin), insulin detemir (NN304) [B29Lys(@GENE$), desB30 human insulin], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), @CHEMICAL$ lispro (B28Lys,B29Pro human insulin), insulin glargine (A21Gly,B31Arg,B32Arg human insulin), insulin detemir (NN304) [B29Lys(@GENE$), desB30 human insulin], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), insulin lispro (B28Lys,B29Pro @CHEMICAL$), insulin glargine (A21Gly,B31Arg,B32Arg human insulin), insulin detemir (NN304) [B29Lys(@GENE$), desB30 human insulin], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), insulin lispro (B28Lys,B29Pro human insulin), @CHEMICAL$ glargine (A21Gly,B31Arg,B32Arg human insulin), insulin detemir (NN304) [B29Lys(@GENE$), desB30 human insulin], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), insulin lispro (B28Lys,B29Pro human insulin), insulin glargine (A21Gly,B31Arg,B32Arg @CHEMICAL$), insulin detemir (NN304) [B29Lys(@GENE$), desB30 human insulin], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), insulin lispro (B28Lys,B29Pro human insulin), insulin glargine (A21Gly,B31Arg,B32Arg human insulin), @CHEMICAL$ detemir (NN304) [B29Lys(@GENE$), desB30 human insulin], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), insulin lispro (B28Lys,B29Pro human insulin), insulin glargine (A21Gly,B31Arg,B32Arg human insulin), insulin detemir (NN304) [B29Lys(@CHEMICAL$), desB30 human @GENE$], and reference insulin analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In this study, we compared the insulin and IGF-I receptor binding properties and metabolic and mitogenic potencies of insulin aspart (B28Asp human insulin), insulin lispro (B28Lys,B29Pro human insulin), insulin glargine (A21Gly,B31Arg,B32Arg human insulin), insulin detemir (NN304) [B29Lys(@CHEMICAL$), desB30 human insulin], and reference @GENE$ analogs.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The attachment of a @CHEMICAL$ chain to LysB29 provided @GENE$ detemir with reduced receptor affinities and metabolic and mitogenic potencies but did not change the balance between mitogenic and metabolic potencies.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$, an inactivating 2P domain @GENE$ channel.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: TWIK-2, an inactivating @CHEM-GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: We cloned human and rat @CHEMICAL$ and expressed this novel 2P domain @GENE$ channel in transiently transfected COS cells.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: We cloned human and rat TWIK-2 and expressed this novel @CHEM-GENE$ in transiently transfected COS cells.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ currents are about 15 times larger than human TWIK-2 currents, but both exhibit outward rectification in a physiological @GENE$ gradient and mild inward rectification in symmetrical K(+) conditions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Rat TWIK-2 currents are about 15 times larger than @CHEMICAL$ currents, but both exhibit outward rectification in a physiological @GENE$ gradient and mild inward rectification in symmetrical K(+) conditions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ currents are about 15 times larger than human TWIK-2 currents, but both exhibit outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical @GENE$ conditions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Rat TWIK-2 currents are about 15 times larger than @CHEMICAL$ currents, but both exhibit outward rectification in a physiological K(+) gradient and mild inward rectification in symmetrical @GENE$ conditions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In a physiological @CHEMICAL$ gradient, @GENE$ is half inhibited by 0.1 mm Ba(2+), quinine, and quinidine.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In a physiological K(+) gradient, @CHEMICAL$ is half inhibited by 0.1 mm @GENE$, quinine, and quinidine.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In a physiological K(+) gradient, @CHEMICAL$ is half inhibited by 0.1 mm Ba(2+), @GENE$, and quinidine.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In a physiological K(+) gradient, @CHEMICAL$ is half inhibited by 0.1 mm Ba(2+), quinine, and @GENE$.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Finally, @CHEMICAL$ 53 in the @GENE$ is required for functional expression of TWIK-2 but is not critical for subunit self-assembly.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Finally, @CHEMICAL$ 53 in the M1P1 external loop is required for functional expression of @GENE$ but is not critical for subunit self-assembly.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: TWIK-2 is the first reported @CHEM-GENE$ that inactivates.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ is the first reported 2P domain @GENE$ channel that inactivates.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The base-line, transient, and delayed activities of @CHEMICAL$ suggest that this novel 2P domain @GENE$ channel may play an important functional role in cell electrogenesis.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The base-line, transient, and delayed activities of TWIK-2 suggest that this novel @CHEM-GENE$ may play an important functional role in cell electrogenesis.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Initial in vitro studies utilizing HEP-G2 liver cells revealed that addition of @CHEMICAL$ (EPA) blocked @GENE$ activity, the terminal enzymatic step in AA synthesis.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Initial in vitro studies utilizing HEP-G2 liver cells revealed that addition of eicosapentaenoic acid (@CHEMICAL$) blocked @GENE$ activity, the terminal enzymatic step in AA synthesis.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Initial in vitro studies utilizing HEP-G2 liver cells revealed that addition of eicosapentaenoic acid (EPA) blocked @CHEMICAL$ activity, the terminal enzymatic step in @GENE$ synthesis.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Effects of a @CHEM-GENE$ opener to reduce transmural dispersion of repolarization and prevent torsade de pointes in LQT1, LQT2, and LQT3 models of the long-QT syndrome.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: BACKGROUND: This study examines the effects of @CHEMICAL$, a @GENE$ opener, on transmural dispersion of repolarization (TDR) and induction of torsade de pointes (TdP) under conditions mimicking the LQT1, LQT2, and LQT3 forms of the congenital long-QT syndrome (LQTS).

CPR:3

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: BACKGROUND: This study examines the effects of nicorandil, a @CHEM-GENE$ opener, on transmural dispersion of repolarization (TDR) and induction of torsade de pointes (TdP) under conditions mimicking the LQT1, LQT2, and LQT3 forms of the congenital long-QT syndrome (LQTS).

false