Datasets:

clinicalnlplab

/

chemprot_dev

like 0

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$, phorbol esters, and @GENE$ each decreased alpha-AR mRNA levels by 70-80%.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: NE, @CHEMICAL$, and bradykinin each decreased @GENE$ mRNA levels by 70-80%.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: NE, @CHEMICAL$, and @GENE$ each decreased alpha-AR mRNA levels by 70-80%.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ inhibitor @GENE$ (H-7) abolished the effects of phorbol esters and NE and decreased basal mRNA levels by 52 +/- 3%.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ inhibitor (+)-1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (@GENE$) abolished the effects of phorbol esters and NE and decreased basal mRNA levels by 52 +/- 3%.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ inhibitor (+)-1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) abolished the effects of @GENE$ and NE and decreased basal mRNA levels by 52 +/- 3%.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ inhibitor (+)-1-(5-isoquinolinesulfonyl)-2-methylpiperazine dihydrochloride (H-7) abolished the effects of phorbol esters and @GENE$ and decreased basal mRNA levels by 52 +/- 3%.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Neither ryanodine nor @CHEMICAL$ inhibited down-regulation of @GENE$ mRNA by NE.

CPR:3

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Neither ryanodine nor EGTA inhibited down-regulation of @CHEMICAL$ mRNA by @GENE$.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Neither @CHEMICAL$ nor EGTA inhibited down-regulation of @GENE$ mRNA by NE.

CPR:3

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ caused @GENE$ mRNA level to decrease with a half-life of 3.2 +/- 0.4 h and blocked the effect of H-7 to decrease basal alpha-AR mRNA level.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ caused alpha-AR mRNA level to decrease with a half-life of 3.2 +/- 0.4 h and blocked the effect of H-7 to decrease basal @GENE$ mRNA level.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Actinomycin D caused @CHEMICAL$ mRNA level to decrease with a half-life of 3.2 +/- 0.4 h and blocked the effect of @GENE$ to decrease basal alpha-AR mRNA level.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Actinomycin D caused alpha-AR mRNA level to decrease with a half-life of 3.2 +/- 0.4 h and blocked the effect of @CHEMICAL$ to decrease basal @GENE$ mRNA level.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Both @CHEMICAL$ and phorbol esters increased the rate of @GENE$ mRNA degradation.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Both NE and @CHEMICAL$ increased the rate of @GENE$ mRNA degradation.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In @CHEMICAL$-desensitized cells, phorbol esters and bradykinin each caused the expected down-regulation of @GENE$ mRNA.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In @CHEMICAL$-desensitized cells, phorbol esters and @GENE$ each caused the expected down-regulation of alpha-AR mRNA.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In NE-desensitized cells, @CHEMICAL$ and bradykinin each caused the expected down-regulation of @GENE$ mRNA.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: In NE-desensitized cells, @CHEMICAL$ and @GENE$ each caused the expected down-regulation of alpha-AR mRNA.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The protein phosphatase inhibitor @CHEMICAL$ prolonged the normally transient effect of NE for at least 24 h. We conclude that protein kinase C exerts two opposing effects on @GENE$ mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a protein kinase C substrate and 2) a permissive effect on alpha-AR gene transcription.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The protein phosphatase inhibitor @CHEMICAL$ prolonged the normally transient effect of NE for at least 24 h. We conclude that protein kinase C exerts two opposing effects on alpha-AR mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a @GENE$ substrate and 2) a permissive effect on alpha-AR gene transcription.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The protein phosphatase inhibitor @CHEMICAL$ prolonged the normally transient effect of NE for at least 24 h. We conclude that protein kinase C exerts two opposing effects on alpha-AR mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a protein kinase C substrate and 2) a permissive effect on @GENE$ gene transcription.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ inhibitor @GENE$ prolonged the normally transient effect of NE for at least 24 h. We conclude that protein kinase C exerts two opposing effects on alpha-AR mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a protein kinase C substrate and 2) a permissive effect on alpha-AR gene transcription.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The protein phosphatase inhibitor @CHEMICAL$ prolonged the normally transient effect of NE for at least 24 h. We conclude that @GENE$ exerts two opposing effects on alpha-AR mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a protein kinase C substrate and 2) a permissive effect on alpha-AR gene transcription.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The protein phosphatase inhibitor okadaic acid prolonged the normally transient effect of @CHEMICAL$ for at least 24 h. We conclude that protein kinase C exerts two opposing effects on @GENE$ mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a protein kinase C substrate and 2) a permissive effect on alpha-AR gene transcription.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The protein phosphatase inhibitor okadaic acid prolonged the normally transient effect of @CHEMICAL$ for at least 24 h. We conclude that protein kinase C exerts two opposing effects on alpha-AR mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a @GENE$ substrate and 2) a permissive effect on alpha-AR gene transcription.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The protein phosphatase inhibitor okadaic acid prolonged the normally transient effect of @CHEMICAL$ for at least 24 h. We conclude that protein kinase C exerts two opposing effects on alpha-AR mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a protein kinase C substrate and 2) a permissive effect on @GENE$ gene transcription.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The @CHEMICAL$ inhibitor okadaic acid prolonged the normally transient effect of @GENE$ for at least 24 h. We conclude that protein kinase C exerts two opposing effects on alpha-AR mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a protein kinase C substrate and 2) a permissive effect on alpha-AR gene transcription.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The protein phosphatase inhibitor okadaic acid prolonged the normally transient effect of @CHEMICAL$ for at least 24 h. We conclude that @GENE$ exerts two opposing effects on alpha-AR mRNA levels, 1) a decrease in the stability of the mRNA that requires the sustained phosphorylation of a protein kinase C substrate and 2) a permissive effect on alpha-AR gene transcription.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Molecular cloning and functional expression of @CHEMICAL$-like rat and human @GENE$ receptor genes.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Molecular cloning and functional expression of 5-HT1E-like @CHEM-GENE$ genes.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Sequential polymerase chain reaction experiments were performed to amplify a unique sequence representing a @CHEM-GENE$ from rat hypothalamic cDNA.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate @CHEMICAL$ corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [@GENE$, 5-HT1C, and 5-HT2; 5-HT is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate @CHEMICAL$ corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [5-HT1A, @GENE$, and 5-HT2; 5-HT is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate @CHEMICAL$ corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [5-HT1A, 5-HT1C, and @GENE$; 5-HT is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved @CHEMICAL$ from transmembrane domains III, V, and VI of known receptors [@GENE$, 5-HT1C, and 5-HT2; 5-HT is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved @CHEMICAL$ from transmembrane domains III, V, and VI of known receptors [5-HT1A, @GENE$, and 5-HT2; 5-HT is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved @CHEMICAL$ from transmembrane domains III, V, and VI of known receptors [5-HT1A, 5-HT1C, and @GENE$; 5-HT is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [@CHEMICAL$, 5-HT1C, and 5-HT2; @GENE$ is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [5-HT1A, @CHEMICAL$, and 5-HT2; @GENE$ is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [5-HT1A, 5-HT1C, and @CHEMICAL$; @GENE$ is serotonin (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [@CHEMICAL$, 5-HT1C, and 5-HT2; 5-HT is @GENE$ (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [5-HT1A, @CHEMICAL$, and 5-HT2; 5-HT is @GENE$ (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [5-HT1A, 5-HT1C, and @CHEMICAL$; 5-HT is @GENE$ (5-hydroxytryptamine)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [@CHEMICAL$, 5-HT1C, and 5-HT2; 5-HT is serotonin (@GENE$)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [5-HT1A, @CHEMICAL$, and 5-HT2; 5-HT is serotonin (@GENE$)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Degenerate oligonucleotides corresponding to conserved amino acids from transmembrane domains III, V, and VI of known receptors [5-HT1A, 5-HT1C, and @CHEMICAL$; 5-HT is serotonin (@GENE$)] were used as primers for the sequential reactions.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The resulting product was subcloned and used to screen a rat genomic library to identify a full-length clone (MR77) containing an @CHEMICAL$ encoding a 366-@GENE$ seven-transmembrane domain protein.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The resulting product was subcloned and used to screen a rat genomic library to identify a full-length clone (MR77) containing an intronless open reading frame encoding a @CHEM-GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The resulting product was subcloned and used to screen a rat genomic library to identify a full-length clone (@CHEMICAL$) containing an intronless open reading frame encoding a 366-@GENE$ seven-transmembrane domain protein.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Within the conserved transmembrane domains, the sequences exhibit approximately 52%, 59%, 65%, and 68% @CHEMICAL$ identity with the known @GENE$, rat 5-HT1B, rat 5-HT1D, and human 5-HT1E receptors, respectively.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Within the conserved transmembrane domains, the sequences exhibit approximately 52%, 59%, 65%, and 68% @CHEMICAL$ identity with the known rat 5-HT1A, @GENE$, rat 5-HT1D, and human 5-HT1E receptors, respectively.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Within the conserved transmembrane domains, the sequences exhibit approximately 52%, 59%, 65%, and 68% @CHEMICAL$ identity with the known rat 5-HT1A, rat 5-HT1B, @GENE$, and human 5-HT1E receptors, respectively.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Within the conserved transmembrane domains, the sequences exhibit approximately 52%, 59%, 65%, and 68% @CHEMICAL$ identity with the known rat 5-HT1A, rat 5-HT1B, rat 5-HT1D, and @GENE$ receptors, respectively.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The specific binding is displaced by the selective 5-HT1D agonist @CHEMICAL$ but not by the mixed @GENE$ agonist 5-carboxyamidotryptamine.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The specific binding is displaced by the selective @CHEMICAL$ agonist @GENE$ but not by the mixed 5-HT1A/1D agonist 5-carboxyamidotryptamine.

CPR:5

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The specific binding is displaced by the selective 5-HT1D agonist sumatriptan but not by the mixed @CHEMICAL$ agonist @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The specific binding is displaced by the selective @CHEMICAL$ agonist sumatriptan but not by the mixed 5-HT1A/1D agonist @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: HeLa cells transfected with the MR77 gene exhibited inhibition of @CHEM-GENE$ in response to serotonin.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: HeLa cells transfected with the @CHEMICAL$ gene exhibited inhibition of @GENE$ cyclase in response to serotonin.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: HeLa cells transfected with the MR77 gene exhibited inhibition of @CHEMICAL$ in response to @GENE$.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: HeLa cells transfected with the @CHEMICAL$ gene exhibited inhibition of adenylate cyclase in response to @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: MR77 thus represents a @CHEM-GENE$ of the 5-HT1 class, and we propose that, based on the pharmacological characterization, MR77 represents an additional 5-HT1E-like receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: MR77 thus represents a @CHEMICAL$ receptor of the @GENE$ class, and we propose that, based on the pharmacological characterization, MR77 represents an additional 5-HT1E-like receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ thus represents a @GENE$ receptor of the 5-HT1 class, and we propose that, based on the pharmacological characterization, MR77 represents an additional 5-HT1E-like receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: MR77 thus represents a @CHEMICAL$ receptor of the 5-HT1 class, and we propose that, based on the pharmacological characterization, @GENE$ represents an additional 5-HT1E-like receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: MR77 thus represents a @CHEMICAL$ receptor of the 5-HT1 class, and we propose that, based on the pharmacological characterization, MR77 represents an additional @GENE$-like receptor.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The antiarrhythmic effects of exogenous @CHEMICAL$ and Valsalva on this form of VT may be due to receptor-mediated inhibition of @GENE$ or to noncardiac receptor-mediated effects, i.e., exogenous adenosine may modulate VT through alterations in autonomic tone by activation of arterial chemoreceptors, and Valsalva has been shown to decrease venous return, resulting in a reduction in cardiac dimensions and myocardial stretch.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The antiarrhythmic effects of exogenous @CHEMICAL$ and Valsalva on this form of VT may be due to receptor-mediated inhibition of adenylate cyclase or to noncardiac receptor-mediated effects, i.e., exogenous adenosine may modulate VT through alterations in autonomic tone by activation of arterial @GENE$, and Valsalva has been shown to decrease venous return, resulting in a reduction in cardiac dimensions and myocardial stretch.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The antiarrhythmic effects of exogenous adenosine and Valsalva on this form of VT may be due to receptor-mediated inhibition of @CHEM-GENE$ or to noncardiac receptor-mediated effects, i.e., exogenous adenosine may modulate VT through alterations in autonomic tone by activation of arterial chemoreceptors, and Valsalva has been shown to decrease venous return, resulting in a reduction in cardiac dimensions and myocardial stretch.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The antiarrhythmic effects of exogenous adenosine and Valsalva on this form of VT may be due to receptor-mediated inhibition of @CHEMICAL$ cyclase or to noncardiac receptor-mediated effects, i.e., exogenous adenosine may modulate VT through alterations in autonomic tone by activation of arterial @GENE$, and Valsalva has been shown to decrease venous return, resulting in a reduction in cardiac dimensions and myocardial stretch.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The antiarrhythmic effects of exogenous adenosine and Valsalva on this form of VT may be due to receptor-mediated inhibition of @CHEMICAL$ or to noncardiac receptor-mediated effects, i.e., exogenous @GENE$ may modulate VT through alterations in autonomic tone by activation of arterial chemoreceptors, and Valsalva has been shown to decrease venous return, resulting in a reduction in cardiac dimensions and myocardial stretch.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: The antiarrhythmic effects of exogenous adenosine and Valsalva on this form of VT may be due to receptor-mediated inhibition of adenylate cyclase or to noncardiac receptor-mediated effects, i.e., exogenous @CHEMICAL$ may modulate VT through alterations in autonomic tone by activation of arterial @GENE$, and Valsalva has been shown to decrease venous return, resulting in a reduction in cardiac dimensions and myocardial stretch.

CPR:3

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: VT recurred with the addition of aminophylline, a @CHEMICAL$ @GENE$ antagonist.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: VT recurred with the addition of @CHEMICAL$, a competitive @GENE$ antagonist.

CPR:6

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: VT recurred with the addition of aminophylline, a competitive @CHEM-GENE$ antagonist.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ (10 mg i.v.), a cholinesterase inhibitor that potentiates the effects of acetylcholine at the @GENE$, terminated VT in four of four patients, an effect that was reversed by atropine.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ (10 mg i.v.), a @GENE$ inhibitor that potentiates the effects of acetylcholine at the muscarinic cholinergic receptor, terminated VT in four of four patients, an effect that was reversed by atropine.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Edrophonium (10 mg i.v.), a cholinesterase inhibitor that potentiates the effects of @CHEMICAL$ at the @GENE$, terminated VT in four of four patients, an effect that was reversed by atropine.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Edrophonium (10 mg i.v.), a @CHEMICAL$ inhibitor that potentiates the effects of @GENE$ at the muscarinic cholinergic receptor, terminated VT in four of four patients, an effect that was reversed by atropine.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Edrophonium (10 mg i.v.), a cholinesterase inhibitor that potentiates the effects of acetylcholine at the @CHEMICAL$, terminated VT in four of four patients, an effect that was reversed by @GENE$.

CPR:4

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Edrophonium (10 mg i.v.), a @CHEMICAL$ inhibitor that potentiates the effects of acetylcholine at the muscarinic cholinergic receptor, terminated VT in four of four patients, an effect that was reversed by @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: It can be identified by termination of the tachycardia in response to activation of the @CHEMICAL$ A1 or @GENE$, which results in inhibition of adenylate cyclase.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: It can be identified by termination of the tachycardia in response to activation of the @CHEMICAL$ A1 or muscarinic cholinergic receptor, which results in inhibition of @GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: It can be identified by termination of the tachycardia in response to activation of the @CHEM-GENE$ or muscarinic cholinergic receptor, which results in inhibition of adenylate cyclase.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: It can be identified by termination of the tachycardia in response to activation of the adenosine A1 or @CHEMICAL$, which results in inhibition of @GENE$ cyclase.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: It can be identified by termination of the tachycardia in response to activation of the adenosine A1 or muscarinic cholinergic receptor, which results in inhibition of @CHEM-GENE$.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: It can be identified by termination of the tachycardia in response to activation of the @CHEMICAL$ or muscarinic cholinergic receptor, which results in inhibition of @GENE$ cyclase.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ induces c-fos in rat striatum: reversal with dopamine D1 and @GENE$ antagonists.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ induces @GENE$ in rat striatum: reversal with dopamine D1 and NMDA receptor antagonists.

CPR:3

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ induces c-fos in rat striatum: reversal with @GENE$ and NMDA receptor antagonists.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Amantadine induces c-fos in rat striatum: reversal with @CHEMICAL$ D1 and @GENE$ antagonists.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Amantadine induces @CHEMICAL$ in rat striatum: reversal with @GENE$ D1 and NMDA receptor antagonists.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Amantadine induces c-fos in rat striatum: reversal with @CHEM-GENE$ and NMDA receptor antagonists.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Amantadine induces c-fos in rat striatum: reversal with dopamine D1 and @CHEM-GENE$ antagonists.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Amantadine induces @CHEMICAL$ in rat striatum: reversal with dopamine D1 and @GENE$ receptor antagonists.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Amantadine induces c-fos in rat striatum: reversal with @CHEMICAL$ and @GENE$ receptor antagonists.

false

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: @CHEMICAL$ (1-aminoadamantane) induced @GENE$ expression in the central, dorsal-medial and ventral-medial part of the striatum.

CPR:3

TASK: the task is to classify relations between a chemical and a gene for a sentence. INPUT: the input is a sentence where the chemical is labeled as @CHEMICAL$ and the gene is labeled as @GENE$ accordingly in a sentence. OUTPUT: your task is to select one out of the six types of relations ('CPR:3', 'CPR:4', 'CPR:5', 'CPR:6', 'CPR:9', and 'false') for the gene and chemical without any explanation or other characters: CPR:3, which includes UPREGULATOR, ACTIVATOR, and INDIRECT UPREGULATOR CPR:4, which includes DOWNREGULATOR, INHIBITOR ,and INDIRECT DOWNREGULATOR CPR:5, which includes AGONIST, AGONIST ACTIVATOR, and AGONIST INHIBITOR CPR:6, which includes ANTAGONIST CPR:9, which includes SUBSTRATE, PRODUCT OF and SUBSTRATE PRODUCT OF false, which indicates no relations The following examples are provided: Example-1 Q: Three lines of evidence suggest that calmodulin inhibition is not responsible for the inhibition of binding and endocytosis: 1) Promethazine, a phenothiazine that is a poor inhibitor of calmodulin, is nearly as effective as TFP at inhibiting endocytosis; calmidazolium, a potent inhibitor of several calmodulin functions, did not cause a loss of binding; 2) the microinjection of calmodulin into cells did not reverse the effects of @CHEMICAL$; using pressure microinjection, we introduced up to a 100-fold excess of @GENE$ over native levels into individual gerbil fibroma cells; using rhodamine-labeled alpha 2-macroglobulin, we saw that the W-7 induced inhibition of receptor-mediated endocytosis was the same in injected and uninjected cells; 3) we injected calcineurin, a calmodulin-binding protein, into cells (1-3 pg/cell) and observed no effect on the receptor-mediated endocytosis of rhodamine-labeled alpha 2-macroglobulin. Example-1 A: false Q: Amantadine (@CHEMICAL$) induced @GENE$ expression in the central, dorsal-medial and ventral-medial part of the striatum.

CPR:3