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What is the interaction between Duloxetine and Cetirizine? | Concurrent use of cetirizine or levocetirizine with alcohol or other agents that exhibit central nervous system (CNS) depressant effects may result in additive impairment of mental alertness and performance.
abdominal pain abscess Acidosis Amnesia animal bite Anorexia anosmia aortic aneurysm Apnea appendicitis More | 468,467 |
How should the interaction between Budesonide and Osilodrostat be managed? Describe the necessary steps. | The possibility of increased systemic adverse effects of budesonide should be considered during coadministration with CYP450 3A4 inhibitors. If concomitant use cannot be avoided, the dosing times between budesonide and the CYP450 3A4 inhibitor should be separated by as much as possible. In addition, the lowest effective dosage of budesonide should be prescribed, and further adjustments made as necessary according to therapeutic response and tolerance. | 902,778 |
What is the severity level of interaction between Doxacurium and Methylprednisolone? | Moderate | 793,154 |
How should the interaction between Cladribine and Leflunomide be managed? Describe the necessary steps. | Concomitant use of oral cladribine with immunosuppressive or myelosuppressive agents should be avoided if possible. Acute short-term therapy with corticosteroids can be administered. Caution is advised if IV cladribine must be used in patients who have recently received or are receiving treatment with other immunosuppressive or myelosuppressive drugs, and vice versa. Close clinical and laboratory monitoring for the development of severe hematologic adverse effects is recommended both during and after discontinuation of therapy. In patients who have previously been treated with immunomodulatory or immunosuppressive drugs, consider potential additive effect, mode of action, and duration of effect of the other drugs prior to initiation of cladribine. Patients should be advised to contact their physician if they develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. | 1,089,854 |
What is the severity level of interaction between Imipramine and Brompheniramine? | Moderate | 193,469 |
Explain the mechanism of interaction between Brentuximab vedotin and Cytarabine. | Synergy | 132,262 |
Explain the mechanism of interaction between Interferon beta-1b and Stavudine. | Synergy | 78,666 |
What is the severity level of interaction between Coral snake (micrurus fulvius) immune globulin antivenin (equine) and Metipranolol (ophthalmic)? | Moderate | 70,867 |
How should the interaction between Bexarotene and Porfimer sodium be managed? Describe the necessary steps. | Concomitant use of photosensitizing agents with porfimer should be avoided for at least 30 days and maybe up to 90 days or longer depending on patient's hepatic and/or renal function. | 1,003,244 |
What is the severity level of interaction between Liraglutide and Alimemazine? | Moderate | 935,343 |
Explain the mechanism of interaction between Moexipril and Trabectedin. | Synergy | 309,751 |
What is the interaction between Ulipristal and Butalbital? | The concomitant use of CYP450 3A4 inducers may decrease the plasma concentrations and efficacy of ulipristal, which is primarily metabolized by the isoenzyme. Induction of CYP450 3A4 may last for up to 4 weeks after discontinuation of the enzyme inducer. | 660,223 |
What is the interaction between Ivabradine and Phenobarbital? | Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of ivabradine and its active N-desmethylated metabolite, both of which are primarily metabolized by the isoenzyme. | 526,399 |
What is the interaction between Vinorelbine and Carmustine? | The concomitant or sequential administration of multiple antineoplastic agents may result in additive toxicities, particularly in the bone marrow and gastrointestinal tract. | 1,101,231 |
Explain the mechanism of interaction between Sotalol and Voriconazole. | Synergy | 413,920 |
What is the severity level of interaction between Ivacaftor and Secobarbital? | Moderate | 1,106,437 |
How should the interaction between Promazine and Quinidine be managed? Describe the necessary steps. | Coadministration of class IA or class III antiarrhythmic agents with other drugs that can prolong the QT interval should preferably be avoided unless benefits are anticipated to outweigh the risks. Caution and clinical monitoring are recommended if concomitant use is required. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. | 1,294,247 |
Explain the mechanism of interaction between Bosentan and Megestrol acetate. | Metabolism | 711,863 |
What is the interaction between Galantamine and Clidinium? | Acetylcholinesterase inhibitors (e.g., donepezil, galantamine, physostigmine, rivastigmine, tacrine) may antagonize the effects of anticholinergic agents and other agents that rely partially on their anticholinergic activity for therapeutic effects (e.g., some antiparkinsonian and antiemetic/antivertigo agents; class IA antiarrhythmics). By inhibiting the metabolism of acetylcholine, more of the neurotransmitter may be available to compete at muscarinic receptors, the site of action of anticholinergic agents. Conversely, anticholinergic agents may negate the already small pharmacologic benefits of acetylcholinesterase inhibitors in the treatment of dementia. These agents may also adversely affect elderly patients in general. Clinically significant mental status changes associated with anticholinergic agents can range from mild cognitive impairment to delirium, and patients with Alzheimer's disease and other dementia are especially sensitive. | 422,066 |
How should the interaction between Nebivolol and Terazosin be managed? Describe the necessary steps. | Caution is advised during coadministration of these agents, particularly when initiating an alpha-blocker in the presence of a beta-blocker, including ophthalmic formulations. Small initial dosages of the alpha-blocker should be considered and gradually titrated to desired effect, while the systemic beta-blocker dosage may also need to be reduced. Hemodynamic responses should be monitored, especially during the first few weeks of therapy. Taking the alpha-blocker at bedtime may minimize the occurrence of orthostatic effects. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. | 1,265,387 |
Explain the mechanism of interaction between Treprostinil and Dalteparin. | Synergy | 59,443 |
What is the severity level of interaction between Pexidartinib and Felbamate? | Major | 730,660 |
What is the severity level of interaction between Hydrocodone and Butabarbital? | Major | 703,136 |
What is the interaction between Voriconazole and Carbamazepine? | Coadministration with carbamazepine or long-acting barbiturates may significantly reduce the plasma concentrations of voriconazole. Although specific data are lacking, these agents are potent inducers of CYP450 isoenzymes that are responsible for the metabolic clearance of voriconazole and are expected to decrease the systemic exposure to voriconazole.
abdominal pain aphasia asthenia Ataxia Clotting coma diarrhea drowsiness drug toxicity NOS endometriosis More | 473,178 |
Explain the mechanism of interaction between Lurasidone and Fentanyl. | Synergy | 806,680 |
What is the interaction between Lapatinib and Orciprenaline? | Beta-2 adrenergic agonists can cause dose-related prolongation of the QT interval and potassium loss. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. Clinically significant prolongation of QT interval and hypokalemia occur infrequently when beta-2 agonists are inhaled at normally recommended dosages. However, these effects may be more common when the drugs are administered systemically or when recommended dosages are exceeded. | 262,600 |
What is the severity level of interaction between Afatinib and Calaspargase pegol? | Moderate | 590,605 |
Explain the mechanism of interaction between Entecavir and Acyclovir. | Excretion | 279,812 |
Explain the mechanism of interaction between Modafinil and Saxagliptin. | Metabolism | 706,248 |
What is the interaction between Bosutinib and Amlodipine? | Coadministration with inhibitors of CYP450 3A4 and/or P-glycoprotein (P-gp) may increase the plasma concentrations of bosutinib, which is a substrate of the isoenzyme and efflux transporter. | 286,647 |
What is the severity level of interaction between Thiethylperazine and Labetalol? | Moderate | 451,131 |
Explain the mechanism of interaction between Ixekizumab and Vitamin E. | Antagonism | 183,866 |
What is the interaction between Estazolam and Olopatadine (nasal)? | Concurrent use of olopatadine nasal spray with alcohol or other central nervous system (CNS) depressants may result in additive impairment of mental alertness and performance. Somnolence has been reported in some patients using olopatadine nasal spray in clinical trials. | 974,984 |
How should the interaction between Fostemsavir and Lesinurad be managed? Describe the necessary steps. | - | 25,347 |
What is the severity level of interaction between Paliperidone and Aldesleukin? | Moderate | 709,396 |
How should the interaction between Vilanterol and Lixisenatide be managed? Describe the necessary steps. | Close clinical monitoring of glycemic control is recommended following initiation or discontinuation of these drugs, and the dosages of concomitant antidiabetic agents adjusted as necessary. Patients should be advised to notify their physician if their blood glucose is consistently high or if they experience symptoms of severe hyperglycemia such as excessive thirst and increases in the volume or frequency of urination. | 1,000,346 |
How should the interaction between Tizanidine and Selpercatinib be managed? Describe the necessary steps. | Caution is recommended if selpercatinib is used in combination with other drugs that can prolong the QT interval. An electrocardiogram and serum electrolyte levels should be obtained prior to initiating selpercatinib therapy and periodically during treatment as appropriate based on individual risk factors including diarrhea. Correct hypokalemia, hypomagnesemia, and/or hypocalcemia before starting treatment and during treatment, as they may be risk factors for ventricular arrhythmias. | 227,603 |
What is the interaction between Hydrochlorothiazide and Lorazepam? | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis.
abdominal distension abdominal pain birth defect abscess acute pancreatitis adenocarcinoma allergic rhinitis alopecia als anaemia More | 962,987 |
What is the interaction between Ethinylestradiol and Perampanel? | RECOMMENDED: Coadministration with certain anticonvulsants, such as rufinamide and perampanel, may reduce the efficacy of contraceptive hormones. The interaction stems from accelerated clearance of contraceptive hormones as well as decreased plasma concentrations of unbound (active) hormones due to induction of hepatic CYP450 enzymatic activity by the anticonvulsants. | 1,004,566 |
What is the interaction between Timolol (ophthalmic) and Lanreotide? | Somatostatin analogs (e.g., octreotide, lanreotide) can decrease heart rate and may potentiate the bradycardic effects of drugs like beta-blockers, calcium channel blockers, digitalis glycosides, and certain antiarrhythmic agents (e.g., class I antiarrhythmics, adenosine, amiodarone). | 319,591 |
What is the interaction between Durvalumab and Dimethyl fumarate? | The use of monomethyl fumarate (MMF) or its prodrugs, dimethyl fumarate and diroximel fumarate, with other immunosuppressive or myelosuppressive agents may increase the risk of infections. | 638,474 |
What is the severity level of interaction between Denosumab and Methotrexate? | Moderate | 435,320 |
What is the severity level of interaction between Ritonavir and Testosterone (topical)? | Moderate | 548,325 |
What is the severity level of interaction between Cefazolin and Torasemide? | Moderate | 132,327 |
How should the interaction between Ceritinib and Gatifloxacin be managed? Describe the necessary steps. | Caution is recommended if ceritinib is used in combination with other drugs that can prolong the QT interval. ECG and serum electrolytes, including potassium, magnesium and calcium, should be monitored before starting ceritinib therapy and periodically during treatment. | 634,655 |
Explain the mechanism of interaction between Brimonidine (ophthalmic) and Lofexidine. | Synergy | 504,482 |
What is the interaction between Itraconazole and Levobupivacaine? | Coadministration with inhibitors of CYP450 1A2 and/or 3A4 may increase the plasma concentrations of levobupivacaine, which is primarily metabolized by these isoenzymes. | 26,636 |
How should the interaction between Macimorelin and Daunorubicin (liposomal) be managed? Describe the necessary steps. | Coadministration of macimorelin with other drugs that can prolong the QT interval should generally be avoided. A sufficient washout period following discontinuation of these drugs is recommended prior to macimorelin administration. Patients treated with any medication that can cause QT prolongation should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. | 301,869 |
What is the severity level of interaction between Risperidone and Ioflupane I-123? | Moderate | 309,839 |
How should the interaction between Dichloralphenazone and Pindolol be managed? Describe the necessary steps. | Caution and close monitoring for development of hypotension is advised during coadministration of these agents. Avoid alcohol in patients receiving vasodilating antihypertensive drugs. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. | 1,068,890 |
How should the interaction between Dichloralphenazone and Carisoprodol be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 704,171 |
How should the interaction between Nitroprusside and Molindone be managed? Describe the necessary steps. | Close clinical monitoring for development of hypotension is recommended if phenothiazines or neuroleptic agents are used in patients receiving antihypertensive medications or vasodilators. A lower starting dosage and slower titration of the phenothiazine or neuroleptic may be appropriate, especially in the elderly. Patients should be advised to avoid rising abruptly from a sitting or recumbent position and to notify their physician if they experience dizziness, lightheadedness, syncope, orthostasis, or tachycardia. Patients should also avoid driving or operating hazardous machinery. | 860,827 |
What is the interaction between Glyburide and Hydrocortisone (topical)? | The efficacy of insulin and other antidiabetic agents may be diminished by topical corticosteroids, particularly during prolonged or indiscriminate use. Corticosteroids can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis. The duration of administration Close clinical monitoring of glycemic control is recommended if topical corticosteroids are administered chronically and/or to large areas in diabetic patients.
anaphylactic reaction anaemia angina Aching joints AFIB Bacterial infection Blepharospasm bronchitis bursitis cellulitis More | 885,432 |
Explain the mechanism of interaction between Ivacaftor and Levamlodipine. | Metabolism | 717,528 |
What is the interaction between Acalabrutinib and Dipyridamole? | Coadministration of acalabrutinib and drugs that interfere with platelet function or coagulation may potentiate the risk of bleeding complications. | 1,310,769 |
What is the severity level of interaction between Somatotropin and Linagliptin? | Moderate | 527,222 |
Explain the mechanism of interaction between Carvedilol and Pazopanib. | Absorption | 1,300,063 |
What is the interaction between Flavoxate and Diphenhydramine? | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) may have additive effects when used in combination. Excessive parasympatholytic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures. Central nervous system-depressant effects may also be additively or synergistically increased when these agents are combined, especially in elderly or debilitated patients. | 693,035 |
What is the severity level of interaction between Rosiglitazone and Tipranavir? | Moderate | 524,092 |
Explain the mechanism of interaction between Calcium acetate and Liotrix. | Absorption | 459,560 |
What is the interaction between Levobunolol (ophthalmic) and Iothalamic acid? | Limited data suggest that patients receiving beta-blockers may have an increased risk of severe hypotensive and/or hypersensitivity reactions to parenteral iodinated contrast media. In addition, allergic/anaphylactoid reactions in these patients may be more difficult to treat. | 1,274,061 |
What is the interaction between Trihexyphenidyl and Flavoxate? | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) may have additive effects when used in combination. Excessive parasympatholytic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures. Central nervous system-depressant effects may also be additively or synergistically increased when these agents are combined, especially in elderly or debilitated patients. | 963,463 |
Explain the mechanism of interaction between Spironolactone and Duloxetine. | Synergy | 800,453 |
Explain the mechanism of interaction between Picosulfuric acid and Panobinostat. | Synergy | 266,981 |
Explain the mechanism of interaction between Edoxaban and Capsicum. | Synergy | 424,073 |
What is the interaction between Levorphanol and Methylphenobarbital? | Concomitant use of opioids with benzodiazepines or other central nervous system (CNS) depressants (e.g., nonbenzodiazepine sedatives/hypnotics, anxiolytics, muscle relaxants, general anesthetics, antipsychotics, other opioids, alcohol) may result in profound sedation, respiratory depression, coma, and death. The risk of hypotension may also be increased with some CNS depressants (e.g., alcohol, benzodiazepines, phenothiazines). | 734,205 |
Explain the mechanism of interaction between Fenoldopam and Amiloride. | Synergy | 702,961 |
What is the severity level of interaction between Prednisolone (ophthalmic) and Telaprevir? | Moderate | 948,348 |
What is the interaction between Benzatropine and Paliperidone? | Centrally-acting anticholinergic agents may antagonize the therapeutic effects of neuroleptic agents. Although these drugs have been used together clinically, the possibility of increased risk of adverse effects such as central nervous system depression and tardive dyskinesia should also be considered. In addition, excessive anticholinergic effects may occur in combination use, which can result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. | 55,139 |
How should the interaction between Mexiletine and Lumefantrine be managed? Describe the necessary steps. | Caution is advised if lumefantrine is used concurrently with medications that undergo metabolism by CYP450 2D6, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever lumefantrine is added to or withdrawn from therapy. | 257,778 |
What is the interaction between Silodosin and Secobarbital? | Many psychotherapeutic and CNS-active agents (e.g., anxiolytics, sedatives, hypnotics, antidepressants, antipsychotics, opioids, alcohol, muscle relaxants) exhibit hypotensive effects, especially during initiation of therapy and dose escalation. Coadministration with antihypertensives and other hypotensive agents, in particular vasodilators and alpha-blockers, may result in additive effects on blood pressure and orthostasis. | 448,602 |
What is the severity level of interaction between Duvelisib and Adalimumab? | Major | 1,150,856 |
Explain the mechanism of interaction between Isocarboxazid and Tetrabenazine. | Synergy | 536,994 |
Explain the mechanism of interaction between Magnesium hydroxide and Efavirenz. | Synergy | 1,274,610 |
Explain the mechanism of interaction between Trimethoprim and Efavirenz. | Synergy | 761,663 |
How should the interaction between Pentoxyverine and Metaxalone be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 247,322 |
What is the severity level of interaction between Canagliflozin and Ethinylestradiol? | Moderate | 1,225,447 |
Explain the mechanism of interaction between Valproic acid and Oxymorphone. | Synergy | 87,210 |
What is the interaction between Asparaginase Escherichia coli and Cannabidiol? | Coadministration of cannabidiol with other agents known to induce hepatotoxicity may potentiate the risk of liver injury. Cannabidiol causes dose-related elevations of liver transaminases, both alanine aminotransferase (ALT) and aspartate aminotransferase (AST). | 1,169,805 |
What is the interaction between Rasagiline and Triamterene? | Monoamine oxidase inhibitors (MAOIs) may potentiate the hypotensive effect of some medications. MAOIs alone quite commonly produce orthostatic hypotension. This effect may stem from a gradual MAOI-induced accumulation of false neurotransmitters in peripheral adrenergic neurons that have minimal activity at alpha- and beta-adrenergic receptors, resulting in a functional block of sympathetic neurotransmission. The interaction has been reported with the concomitant use of beta-blockers. | 236,892 |
How should the interaction between Levetiracetam and Pimozide be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 958,942 |
Explain the mechanism of interaction between Dalteparin and Ginkgo biloba. | Synergy | 236,699 |
What is the severity level of interaction between Fluoxetine and Nebivolol? | Moderate | 786,274 |
What is the interaction between Opium and Trimethadione? | Central nervous system- and/or respiratory-depressant effects may be additively or synergistically increased in patients taking multiple drugs that cause these effects, especially in elderly or debilitated patients. | 641,029 |
How should the interaction between Brivaracetam and Chloral hydrate be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 75,424 |
What is the interaction between Solifenacin and Griseofulvin? | Theoretically, coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of solifenacin, which has been shown to be a substrate of the isoenzyme in vitro. | 165,530 |
What is the severity level of interaction between Tretinoin and Methoxsalen? | Moderate | 967,138 |
What is the severity level of interaction between Nelarabine and Olaparib? | Moderate | 260,492 |
How should the interaction between Indapamide and Amlodipine be managed? Describe the necessary steps. | - | 727,581 |
What is the severity level of interaction between Dimethyl fumarate and Golimumab? | Major | 1,380,597 |
What is the interaction between Biperiden and Acrivastine? | Agents with anticholinergic properties (e.g., sedating antihistamines; antispasmodics; neuroleptics; phenothiazines; skeletal muscle relaxants; tricyclic antidepressants; disopyramide) may have additive effects when used in combination. Excessive parasympatholytic effects may result in paralytic ileus, hyperthermia, heat stroke, and the anticholinergic intoxication syndrome. Peripheral symptoms of intoxication commonly include mydriasis, blurred vision, flushed face, fever, dry skin and mucous membranes, tachycardia, urinary retention, and constipation. Central symptoms may include memory loss, disorientation, incoherence, hallucinations, psychosis, delirium, hyperactivity, twitching or jerking movements, stereotypy, and seizures. Central nervous system-depressant effects may also be additively or synergistically increased when these agents are combined, especially in elderly or debilitated patients. | 448,979 |
What is the interaction between Flurbiprofen and Acalabrutinib? | Coadministration of acalabrutinib and drugs that interfere with platelet function or coagulation may potentiate the risk of bleeding complications. | 214,070 |
What is the severity level of interaction between Halazepam and Nebivolol? | Moderate | 1,086,383 |
What is the severity level of interaction between Mepenzolate and Dextropropoxyphene? | Moderate | 45,394 |
Explain the mechanism of interaction between Magnesium hydroxide and Salsalate. | Excretion | 853,809 |
What is the severity level of interaction between Ponatinib and Fluvastatin? | Moderate | 363,712 |
How should the interaction between Trimipramine and Triclabendazole be managed? Describe the necessary steps. | Caution and clinical monitoring are recommended. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope. | 1,349,285 |
What is the interaction between Linezolid and Valganciclovir? | The use of ganciclovir with other potentially myelotoxic and/or nephrotoxic agents may increase the risk and severity of hematologic toxicity and/or nephrotoxicity due to both additive pharmacodynamic effects and additive effects on the kidney. Ganciclovir alone may cause severe leucopenia, neutropenia, anemia, thrombocytopenia, pancytopenia, bone marrow depression, aplastic anemia, increased serum creatinine levels, and acute renal failure, and the risk may theoretically increase when coadministered with other myelotoxic or nephrotoxic therapy. | 274,589 |
How should the interaction between Dextromethorphan and Felbamate be managed? Describe the necessary steps. | During concomitant use of these drugs, patients should be monitored for potentially excessive or prolonged CNS and respiratory depression. Cautious dosage titration may be required, particularly at treatment initiation. Ambulatory patients should be counseled to avoid hazardous activities requiring mental alertness and motor coordination. | 132,575 |
What is the severity level of interaction between Pramipexole and Aripiprazole? | Moderate | 1,364,341 |