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Safety of union home care aides in Washington State. A rate-based understanding of home care aides' adverse occupational outcomes related to their work location and care tasks is lacking. Within a 30-month, dynamic cohort of 43 394 home care aides in Washington State, injury rates were calculated by aides' demographic and work characteristics. Injury narratives and focus groups provided contextual detail. Injury rates were higher for home care aides categorized as female, white, 50 to <65 years old, less experienced, with a primary language of English, and working through an agency (versus individual providers). In addition to direct occupational hazards, variability in workload, income, and supervisory/social support is of concern. Policies should address the roles and training of home care aides, consumers, and managers/supervisors. Home care aides' improved access to often-existing resources to identify, manage, and eliminate occupational hazards is called for to prevent injuries and address concerns related to the vulnerability of this needed workforce.

The present invention is directed generally to telephony devices, and more particular, to telephony devices having integrated messaging capabilities. As the telecommunications industry has grown, the number and different types of telephony devices has also dramatically increased. The use of telephony devices in mobile and cordless environments has also increased accordingly. There has also been an increased need and interest in providing reliable and easy to use peripheral devices such as answering machines, caller ID boxes, and the like. Digital answering machines have gained wide spread use by the telecommunications consumers. A typical digital answering machine is formed as a stand alone device which is coupled between a telephone and the subscriber line of the telephone in order to intercept and answer an incoming call under predefined conditions. The answering machine also provides the capability of storing messages from the calling party for later retrieval. Various approaches have been taken to integrate the functionality of an answering machine within a telephone. For example, the basic components of the digital answering machine have been incorporated into a telephone. Such systems typically include a digital voice memory for storing messages, including broadcast messages and received messages, and a digital signal processor (DSP) dedicated to answering machine functions such as compression of the messages, storage and retrieval. Another approach for integrating answering machine functions within an existing telephone is to provide an answering service remote from the telephone. This type of service routes unanswered calls to the remote answering service where messages are stored for access over the subscriber line. As the telecommunications industry continues to grow, there remains an interest in providing increased accessibility to the various telephony functions including answering functions. It is also desirable, however, to reduce the overall costs of the various telephony devices. Thus, there is generally a tension between a desire to provide added functionality while meeting the demands of lower costs. Generally, the present invention relates to communication devices having integrated messaging capabilities. In one particular embodiment, a communication device is provided which operates in a communication mode and a message mode. The communication device includes a speaker, a receiver provided to receive signals of a call received from a calling party and a memory arrangement for storing messages. A processor is coupled to the memory arrangement and is configured to code and decode signals in accordance with a cordless communication compression scheme used for cordless communication when in the communication mode. The processor is further configured to code signals received from the calling party, using the wireless communication compression scheme, for storage in the memory arrangement as a message when in the message mode. In accordance with another embodiment of the invention, a cordless telephone system having message recording capabilities is provided. The cordless phone includes a base station coupled to a switched telephone network. The base station includes a base station processing unit configured to receive signals from the switched telephone network and to code and decode the signals in accordance with a wireless transmission compression scheme. The base station further includes a transmitter/receiver coupled to the processing unit to transmit/receive coded signals. The cordless phone further includes a handset having a transmitter/receiver configured to transmit/receive coded signals for wireless communication with the base station, and a handset processing unit, coupled to the transmitter/receiver, configured to code and decode signals transmitted to and received from the base station. A memory arrangement is provided within the base station or the handset and is coupled respectively to either the base station processing unit or the handset processing unit. The memory arrangement is used to store messages which are coded by the respective one of the base station processing unit and the handset processing unit using the wireless transmission compression scheme. One embodiment of the invention provides messaging functions within a cordless phone system. In operation, the base station receives a call from a calling party. The cordless phone retrieves a broadcast message from a memory arrangement of the cordless phone in response to initiation of a message mode. The broadcast message is transmitted from the base station to the calling party. A message from the calling party is received at the base station and coded using a cordless transmission compression scheme used for cordless communication between the base station and the handset. The coded message from the calling party is stored in the memory arrangement of the cordless phone. In one particular embodiment, data transmitted between the base station and the handset are coded using adaptive differential pulse code modulation (ADPCM). In a further embodiment, the messages stored in the memory arrangement are also coded using ADPCM. The above summary of the present invention is not intended to describe each illustrated embodiment or every implementation of the present invention. The figures and the detailed description which follow more particularly exemplify these embodiments.

It is generally known that a semiconductor having few crystal defects and good crystallinity is grown on a substrate by using a substrate lattice-matched with the semiconductor to be grown. There is, however, no substrate that is lattice-matched with a nitride semiconductor, has excellent crystallinity, and allows a nitride semiconductor crystal-to be stably grown. For this reason, there is no choice but to grow a nitride semiconductor on a substrate, e.g., a sapphire, spinnel, or silicon carbide substrate, that is not lattice-matched with nitride semiconductors. Various research institutes have made attempts to manufacture GaN bulk crystals that are lattice-matched with nitride semiconductors. However, it has only been reported that GaN bulk crystals having sizes of several millimeters are obtained. That is, any practical GaN bulk crystal like the one from which many wafers are cut to be actually used as substrates for the growth of nitride semiconductor layers has not been obtained. As a technique of manufacturing GaN substrates, for example, Jpn. Pat. Appln. KOKAI Publication Nos. 7-202265 and 7-165498 disclose a technique of forming a ZnO buffer layer on a sapphire substrate, growing a nitride semiconductor on the ZnO buffer layer, and dissolving and removing the ZnO buffer layer. However, since the ZnO buffer layer grown on the sapphire substrate has poor crystallinity, it is difficult to obtain a nitride semiconductor crystal having good quality by growing a nitride semiconductor on the buffer layer. In addition, it is difficult to continuously grow a nitride semiconductor thick enough to be used as a substrate on the thin ZnO buffer layer. When a nitride semiconductor electronic element used for various electronic devices such as a light-emitting diode (LED) device, a laser diode (LD) device, and a light-receiving device is to be manufactured, if a substrate made of a nitride semiconductor having few crystal defects can be manufactured, a new nitride semiconductor having few lattice defects and forming a device structure can be grown on the substrate. Therefore, the obtained device acquires greatly improved performance. That is, a high-performance device that has not been realized in the past can be realized. It is, therefore, an object of the present invention to provide a method of growing a nitride semiconductor crystal having excellent crystallinity. More specifically, it is an object of the present invention to provide a method of growing a nitride semiconductor crystal that can provide a nitride semiconductor substrate, a nitride semiconductor substrate, and a nitride semiconductor device formed on the nitride semiconductor substrate.

Establishment of a mass screening method of sand fly vectors for Leishmania infection by molecular biological methods. Surveillance of the prevalence of Leishmania and its vector, sand fly species, in endemic and surrounding areas is important for prediction of the risk and expansion of leishmaniasis. In this study, a method for the mass screening of sand flies for Leishmania infection was established. This method was applied to 319 field-captured specimens, and 5 positive sand flies were detected. Sand fly species were identified by polymerase chain reaction (PCR)-restriction fragment length polymorphism (RFLP) of the18S rRNA gene, and all the positive flies were Lu. hartmanni. Furthermore, cytochrome b (Cyt b) gene sequence analyses identified all the parasites as Endotrypanum species including a probable novel species. Because the method requires minimum effort and can process a large number of samples at once, it will be a powerful tool for studying the epidemiology of leishmaniasis.

1. Field of the Invention: The present invention relates to an apparatus and method, for use with the satellite-based communications network, for improving the reliability and speed at which communication between a user terminal and the network is established. More particularly, the present invention relates to an apparatus and method for arranging data of a channel request message transmitted from a user terminal to a gateway station via a satellite in the satellite-based network to insure that critical data for establishing communication between the user terminal and the satellite-based network is received at the satellite during the appropriate receiving time frame window. 2. Description of the Related Art: A satellite communications network, such as a geosynchronous earth orbit mobile communications network, comprises at least one geosynchronous earth orbit satellite, a ground-based advanced operations center (AOC) and spacecraft operations center (SOC) associated with the satellite, at least one ground-based gateway station (GS), and at least one user terminal (UT), which is typically a hand-held or vehicle mounted mobile telephone. The satellite enables the user terminal to communicate with other user terminals, or with other telephones in the terrestrial public switched telephone network (PSIN), via the gateway stations under the control of the gateway stations. The AOC provides system-wide resource management and control functions for its respective satellite, and the SOC controls on-orbit satellite operations for its respective satellite. When a user terminal is operated to establish a radio resource connection, it generates and transmits a channel request message to the network on a random access channel (RACH) at a frequency assigned by the gateway station to a spot beam covering an area in which the user terminal is located. Typically, a channel request message includes data used to represent the mobile user terminal, as well as contention resolution and timing synchronization information. To increase the likelihood that the channel request message is received at the satellite during a receiving time frame, the transmitter of the user terminal takes into account an estimated time which will elapse between the point in time when the channel request message is transmitted and the point in time when the channel request message is received at the satellite, which is known as the propagation delay. Typically, a user terminal will calculate, based on information broadcast by the network, the propagation delay for a distance measured from a location on the earth'ss surface at the center of the spot beam in which the user terminal is located to the satellite, which is orbiting at about 22,000 miles above the earth's surface. Because the distance from the surface of the earth at the equator to the satellite is less than the distance from the surface of the earth in the extreme northern and southern hemispheres to the satellite, the propagation delay for a message sent from a user terminal close to the equator is less than that for a message sent from a user terminal in, for example, northern Europe. Also, if the user terminal is at a distance from the center of the spot beam, the propagation delay is different than at the center of the spot beam, because the distance from the user terminal to the satellite is different. However, some user terminals are equipped with global positioning system (GPS) equipment and could thus better estimate their location with respect to the center of their respective spot beam. Also, some user terminals can estimate their location with respect to the center of their respective spot beam based on the power level at which the user terminal receives the spot beam. In either instance, these type of user terminals can better estimate the propagation delay for the channel request message, and therefore increase the likelihood that the channel request message will be received at the satellite during a receiving time frame. Moreover, because the duration of a conventional channel request message is a fraction of the duration of a receiving time frame at the satellite, the entire channel request message can generally be received within the desired time frame. To decrease call set up time, it is desirable to include in the channel request message information pertaining to the position of the user terminal making the call, the called party number, the cause for establishing the call, the service provider identification, and so on, in addition to the contention resolution and synchronization information. However, this additional information increases the overall length of the channel request message, and thus increases the likelihood that a complete channel request message will not be received by the satellite during a receiving time frame window. That is, if the instant at which the channel request message is transmitted is not accurately synchronized with the receiving time frame window, some of the information in the channel request message will not reach the satellite during the receiving time frame window, and will thus be lost. Consequently, if information necessary for call set up, such as contention resolution and timing synchronization information, is not received by the satellite, the call cannot be set up. Furthermore, even if the user terminal resends the channel request message, unless the timing difference between transmission of the channel request message and the appearance of the receiving time frames at the satellite is resolved, the network still cannot set up a call. Accordingly, a need exists for an apparatus and method which enables a user terminal to transmit additional call set-up information in a channel request message to accelerate call set-up time between the user terminal and satellite-based communications network, while also assuring that the information necessary for call set-up is received intact by the satellite in the network.

At its core, the NFL combine is a fantastic opportunity for teams to test everything about draft prospects except their on-field performance. They see how fast and strong the players are, how they check out medically and how well they respond in an interview, even if some questions are borderline illegal. For draft analysts, the combine is an opportunity to stick irrelevant labels on players such as "high ceiling" and "freak athlete," sexy terms often given to players whose draft stock relies heavily on factors other than on-field performance. Those players have flown up post-combine draft boards this week while players with impressive college careers have started to fall. After a 4-12 season, the Lions aren't in the market for sexy. That's why they should pass on BYU defensive end Ezekial Ansah. He may be the next Jason Pierre-Paul, but he'll enter the league as a project. Instead, they should use the No. 5 pick on a polished pass rusher, with the top targets being LSU's Barkevious Mingo, Georgia's Jarvis Jones and Florida State's Bjoern Werner.

"This job is worth $10,000." "And I could go up for murder." "Janetti's brake lines were cut." "Give me Michael to drive the Flynn truck." "KlTT, I'm blind!" "Micro jam the brakes!" "(KITT) I can't." "I suggest you abandon." "We can pull this whole thing off with the produce delivery contract... that Joe set up." "I want those independents." "(KITT) Michael, there are two more vehicles moving toward the rear of the convoy." "[car tires screeching]" "(male narrator) Knight Rider, a shadowy flight into the dangerous world of a man... who does not exist." "[beeping]" "Michael Knight, a young loner... on a crusade to champion the cause of the innocent... the helpless, the powerless... in a world of criminals who operate above the law." "[beeping]" "[truck door shutting]" "[people chattering]" "[grunting]" "Come on, get up you creep." "You turned over on us." "You're worse than a traitor." "Calm down, Joe." "I'm trying to make a living." "We used to be friends." "Not anymore." "Come on." "[both grunting]" "(Dial) Take it easy, Joey." "Slow down." "This ain't life or death." "There's no war." "I'm still going to kill him." "You're dead, Janetti." "I know your route." "I know your schedule." "I'll find you and run you off the road." "Come on, Flynn." "Now come on, Phil." "Get out of here, you'll cool down." "I only left your lndependents 'cause I was about to lose everything." "I need the security of Shatner Trucking." "(Janetti) I have a family to support." "And Shatner's gonna put you all out of business." "Now we would have gone down together." "You're a traitor." "Yeah?" "Tell it to my grocer, Joe." "He deals in cash." "(Curtis) Now look here, Mr. Shatner." "I don't mind keeping my eyes on Independents, but... this is a little bit out of my line." "Nothing is out of line if I'm willing to pay the price... (Shatner) and you want to earn it." "This is a perfect chance to get rid of Flynn... and break the back of the whole independent operation." "But killing Janetti...." "I mean, I could go up for murder." "Not if you stage it correctly." "The one they'll grab will be Flynn." "I don't know, Mr. Shatner." "Don't you have other guys around to do this?" "This job is worth $10,000." "Maybe even an additional bonus when I control the area trucking." "(Shatner) Flynn is the energy and the brains... behind the whole Independent move." "If he gets arrested, he'll lose most of that support." "Then it'll work, Curtis." "Well, Janetti has a pick up and delivery in the hills." "That's the best place to do it." "Whatever you say." "[beeping]" "[screaming]" "(man on radio) This is Eugene Hansen with a KNX morning traffic report." "The good news is all of you... eastbound on the 607 freeway... are excused from being on time to work today." "The bad news is a three-car collision which has traffic...." "How did you let me get into this, anyway?" "(KITT) Sorry, but you were driving." "I know, I know, but why is this happening to me?" "Well, to tell you the truth this is called the morning traffic jam." "It's not an hour you're usually involved with." "You're usually going in the opposite direction." "However, we've only got 15 minutes to meet Devon." "KlTT." "Yes, Michael?" "Can you get me out of this traffic jam?" "May I drive?" "Well, it is against all Foundation regulations, but... I won't tell Devon, if you won't tell Devon." "I won't tell Devon." "Be my guest." "[laughing]" "Have I told you you're the greatest lately?" "Not lately, Michael." "(Devon) Michael, it's the simple matter... of a group of small operators... being swallowed up by a larger organization." "Shatner Trucking has done it very successfully before in the Midwest... with disastrous results." "Except in this case... the lndependents were being held together by Joe Flynn." "He's wanted for the murder of one of the Shatner drivers." "A man named Janetti." "(Bonnie) Yeah, Flynn threatened Janetti and four hours later..." "Janetti's brake lines were cut." "But with what's been going on over this past month... we're not sure that Flynn did it." "And although he's a brawler and a hothead... he's also the sole support of his family." "And he's the one man that Shatner has got to get rid of." "Excuse me, Devon." "You said the past few months?" "You've been involved in this situation that long?" "Well, we've been monitoring it rather than being involved in it." "Somebody's broken our code." "We've been getting messages on the computer." "No kidding." "Who's been sending them?" "We don't know." "Shatner is apparently planning to repeat his Midwest coup." "There's no federal or state authority investigating, and I believe that we should." "You both know that Joe Flynn could be guilty." "(Devon) Yes, I'm sure that is possible." "You find him, put him in a safe place, then prove the case." "Guilty or innocent." "Now, it sounds to me, you two are personally involved in this." "Isn't that a strict rule of The Foundation:" "No personal involvement?" "Michael, our code has been broken." "I got you." "Anything else?" "Yes, respect your equipment." "Be careful." "That too." "[engine starting]" "[birds chirping]" "(KITT) They had three rigs when the father was still alive." "Flynn is down to one, and operating out of his garage." "Michael, you're being scanned by an electronic beam." "A harmless but effective alarm system." "Gotta be a guard around here somewhere." "Damn right there is." "Now, freeze." "Take it easy. I just want to ask you a few questions." "is that so?" "Well, you better not be from the cops, or from Shatner Trucking... and we shoot burglars in this neighborhood." "I'm none of the three." "Now, can I have a little conversation... instead of looking at the barrel of that thing?" "[detector beeping] Take it easy, junior." "I'm not armed." "I'm no junior. I'm a girl." "He's got nothing on him, but some sort of wrist radio." "That's no regular metal detector, is it?" "She's no regular kid." "Now what do you want?" "I'm from The Foundation for Law and Government." "I'm here to investigate an incident involving Joe Flynn." "My son's innocent." "Your name Devon Miles?" "No." "No, it's Michael Knight." "How do you know Devon?" "I'm the one who's been sending him messages." "By computer?" "Once you break the code, all you gotta know how to do is type." "I do 80 words a minute." "You gonna help us out?" "I'm willing to try, but I gotta talk to Joe first." "You're going a little too fast." "Talk to Shatner." "I'm sorry, but Shatner's not the one wanted by the police." "You just became a burglar again." "Get off my property." "The longer Joe is on the run... the longer it's gonna take to get to the bottom of this." "Now, I'm telling you, I need to talk to your son." "Get out of here." "(KITT) That's an aggressively close-knit family, Michael." "That's why they know where Joe is." "Put a tap on their phone." "[beeping]" "So, what else does this car do besides look hot?" "Well, it's a lot more than a car." "(KITT) Thank you, Michael." "Voice modulator?" "That's great." "Will it give verbal response to major mathematical computations?" "Of course." "You gonna put my brother in jail?" "I said I was here to help." "You seem like an okay guy." "You know, you're a pretty bright girl." "(Michael) You got The Foundation's attention." "Cute, too." "You're teasing me." "That's what my brother always does." "I know I'm not pretty." "Yeah, you are." "(Mama Flynn) Flynn Trucking." "(Flynn) Hello, Mom." "It's Joe." "You're tapping our phone." "You're no friend." "You're a creep." "[car tires screeching]" "(Mama Flynn) Joey, you okay?" "(Flynn) I'm okay, Mom." "(Sally) Michael Knight had the phone tapped." "He's gonna know where Joey is." "Joey, get out of there." "A big guy in a black T-top is on his way to get you." "(Sally) Get going right now." "He's on his way." "(KITT) Sorry, Michael." "I know, partner, I know." "Look, backtrack that call and see if you can give me a location, will you?" "It's about a mile from here." "ETA, 40 seconds." "(KITT) Michael, there's Flynn's rig up ahead." "(Michael) Thanks, buddy." "[car tires screeching]" "We're going around him." "(KITT) You'll be cutting it close, Michael." "The road is too narrow." "We'll make it work for us." "[beeps] [car tires screeching]" "[exhales]" "Nice work, buddy." "Now just one more thing." "[car tires screeching]" "Michael, are you testing our courage, or my superstructure?" "[tires screeching]" "Would you like to know exactly... how close that truck is to us, Michael?" "Absolutely not." "Now, cool it." "If you wanted to kill me, you would've flattened me with the truck." "You from Shatner?" "No." "Not from Shatner or the police." "Now all I want is a little conversation." "(Flynn) Then why are you twisting my arm?" "'Cause I think you'd rather fight than talk." "All right, fair enough." "Let me go." "No more fighting." "I'm not gonna believe that." "Hey, I'm no liar and I'm no murderer." "All right. I'll deal with one thing at a time." "You'll have to deal with me first." "You just went from burglar to mugger." "Now, get your hands up and turn around." "Need a little diversion here, partner." "Of course, Michael." "[police siren wailing]" "This is the police." "You're surrounded." "All right." "I think we've had enough ambushes for one day, don't you?" "Oh, where are the police?" "(Sally) There are none, Mom." "It's that car of his." "It's something special." "It isn't special enough to take on three Flynns." "Enough!" "All you people do is fight?" "(Michael) So far all it's gotten you is a warrant for murder... and a license for Shatner to hunt you down." "Now, how about a little honest conversation for a change?" "Talk to me, Joe." "Look, I didn't cut Janetti's brakes. it's not my style." "Janetti pulled into the depot yard with full set of brakes." "When he pulled out, he was pumping air instead of brakes." "You were there at that depot when he was there." "I'm a trucker." "They have loads there." "You didn't have a load that day." "Come on, tell me the truth." "What were you doing there?" "I went to see Janetti." "I had to talk to him, had to apologize." "I shouldn't have hit him." "But I didn't kill him." "I'm innocent." "I don't know about that." "But I don't know you're guilty, either." "Who are you anyway?" "My name is Michael Knight." "I'm from The Foundation for Law and Government." "I've been sent here to make sure you're kept in a safe place... until I can get a handle on what's coming down here." ""Safe place." l think I know where that is." "All right, all I can say is you gotta trust me." "Doesn't look like I have much choice, does it?" "You do now." "Put this away." "All right, I'll go in with you." "Me, too." "No, stay here with Mom." "But I want to go." "I'll be all right." "(Sally) Pull over." "That's the car l'm looking for." "Thanks." "(KITT) Hold it, Sally." "The only thing you'll damage is your foot." "Shut up. I knew he was lying." "Nobody tells the truth." "You can't trust anything you don't program yourself." "Not true." "Who programmed you to argue?" "I don't argue, Sally, I merely correct improper calculations." "You can trust Michael Knight." "Yeah, says you." "He turned in my brother." "Now, listen, little girl." "I think I like you... but not if you won't keep an open mind when it comes to Michael." "He's a fair man." "What makes you so smart?" "I have computers that are pushed up to handle over two million K's." "What's your capabilities?" "Unlimited." "I now have over 50 million K's in storage... and can introduce one million more every day, if needed." "Tap into my equipment and we'll talk sometime." "Anytime, Sally." "But if you wait for Michael, I can arrange a guided tour... of my backup and design headquarters." "You expect me to be nice to him?" "Just be fair with him." "He'll help your brother if he can." "I don't know." "Sit down and relax, and we'll wait for Michael." "(Curtis) Relax, Mr. Shatner." "You'll just mess up your stomach again." "You're a rich man." "You've got nothing to worry about." "I didn't get rich by squandering my money or wasting my time... and I'm not about to let you do it for me." "And it doesn't cost me any more money... to get value for my dollar." "Like what?" "(Shatner) You are earning fat paychecks." "You got a $10,000 bonus for handling Janetti." "I want control of all trucking in this area." "I figured with Flynn out of the way there'd be nothing to stop us." "Don't figure, don't think, don't make decisions, and above all... don't tell me how to make a profit on my investments." "Now, you get out there... and make sure those independents... stay disorganized." "I don't want them even thinking they can pull together for the crop season." "I want that contract with Linden." "Finish Flynn's operation once and for all." "What are you waiting for?" "Car fare?" "Get back to your indie friends, so we know when and where to hit." "You're a Flynn, all right." "Now take it easy!" "You're a liar." "You turned in my brother." "I told him I'd keep him in a safe place... until I looked into this mess." "Now, he is safe." "In jail." "Don't con me." "You just wanted to see him arrested." "No, you're wrong." "Now, I'm not positive about anything yet... but if your brother is innocent and people are after these truckers... this could bring it out in the open." "I don't know anything about that stuff." "All I know is that you took Joe in and he was framed." "Sally, if your brother was framed, there are people who want to put him away real bad." "Now, if he's out there running loose like a wanted man... they have a license to kill him." "Joe is very safe in there." "Believe me." "Why don't you come with me?" "I want you to meet some other friends who want to help." "Come on." "(Michael) You might say that Bonnie is KlTT's mother." "She takes care of him... with all the maternal love and the ferocity of a tigress." "(Bonnie) Michael's kidding." "KlTT is his. I just put him back together again." "And Michael gives her a great many opportunities to do so." "Joey would love to see all of this." "He still doesn't have a lot of faith in computers or any of that technology... in spite of the fact that I.... in spite of what?" "Oh, nothing." "Excuse us." "Step into my office here." "You set everything up, right?" "Me?" "What?" "I checked the schedules and loading capacities... of the lndependent deliveries." "They were to the minute, and they were to the ounce." "You did that." "My brother Joe runs the family business." "Sure he does." "You can't tell anyone." "You have to promise not to." "I think it's something you should be proud of." "Yeah, right." "Try and convince a bunch of truckers... that a 15-year-old girl is running their schedule." "(Sally) Those guys listen to Joe, and they really look up to him." "Besides, he's the best." "I'm sure he is." "But, you know, you're not so bad yourself." "And you got him in jail." "We're going to lose everything we worked for." "We were counting on Joe to keep things going... until after we made the crop season." "Then we'd be home free." "Well, we're willing to do everything we can to help you." "You too?" "Of course." "Then give me Michael to drive the Flynn truck." "Wait a minute, I already got a job." "Hey, I'm talking to your boss." "I think it can be arranged." "Great." "All right, listen up." "You'll get union wages, profit participation, and supplemental health benefits." "(Sally) But you better be clear about one thing." "I think I know." "You're the boss." "You got it." "(Sally) Then you pick up at the train yards... for an intermediate drop at Armorbuilt." "Got it?" "Over." "I got it, Boss." "Say, does a lunch break enter into any of our schedules?" "Eat it on the move." "Out." "Out." "Hey, you hungry back there, partner?" "(KITT) Perhaps a little lonely, Michael... but rather enjoying my independence." "And if I may say so, that schedule that Sally laid out... is well planned and fiscally sound." "In fact, it's excellent." "Easy for you to say, you're not driving." "Yes, I am, Michael, and without union benefits." "Don't worry, you'll be on a coffee break in just a couple of minutes." "I'm stopping by the truck stop to see Mama Flynn." "What about your schedule?" "We'll work overtime." "Easy for you to say." "If you were on our side, you wouldn't have had Joey put in jail." "(Michael) He's gotta face that charge... or he's gonna end up running from the cops for the rest of his life." "We would've covered for him, kept the association going." "Now he didn't kill Janetti." "Then why don't you do something about both of those problems?" "That's just so much talk, man." "We're through as independents." "We might as well save our breath." "(men) Oh, yeah, yeah." "Come on, come on." "Come on, guys." "At least listen to him." "(man) What for?" "I've got more to lose than any of you... and I don't see anybody else rushing forward to do us any favors." "(Curtis) Oh, yeah?" "We're done, and so we might as well just forget it." "You're not done unless you're just looking for excuses to give up." "(Michael) The way I figure it, there's still a chance... of keeping this whole group together." "That is, if you guys really want to." "I'd be real careful with your words now, mister." "You're about one sentence away from insulting me." "It's about time I got you guys to listen." "We can pull this whole thing off with the produce delivery contract that Joe set up." "(Michael) We got enough people in this room... to meet the original date... and the full season delivery." "(Burgers) We've only got 24 hours." "Without Joe. lt's not worth it without him." "I'd just as soon repaint my rig with Shatner's colors." "He's right, big guy." "We could all end up like Joey." "Well, I think Joey is innocent." "Well, we all do." "So what?" "I think I know who did it." "What?" "(Burgers) Who?" "Well, that's gonna take a couple days to prove." "In the meantime, don't you think it would be nice... to keep the lndependent truckers alive while I'm at it?" "Be a nice present for Joey, once he gets out of jail, huh?" "[crowd agreeing]" "Hold it there." "Now we're gonna make that produce delivery... but you got some delivering to do yourself." "I intend to." "[radio beeps]" "(KITT) Michael, I think you did very well in there." "Well, thank you." "But there are other possible problems... one of which is you've replaced Joe Flynn as a target." "Yeah, I know." "I believe Joe's innocent, partner." "Based on what?" "Him, his family, his friends..." "Shatner's history." "Most of all, my instincts." "What do you think?" "I deal in facts, but I also trust your instincts." "Thank you." "(KITT) Michael, what is it?" "I can't get a reading." "KlTT, I'm blind!" "Micro jam the brakes!" "I can't or you'll fishtail." "I suggest you abandon." "If I bail out, we'll lose the rig." "And live to fight another day." "Michael, please." "I got the message." "[engine revving]" "[beeping]" "Now, Michael." "All right, micro jam the brakes. it's worth the gamble now." "[beeping]" "[brakes screeching]" "We were very lucky, Michael." "Lucky to have you, partner." "(Sally) The whole brake system is shot." "Downtime is rated at 4% of total working days." "You are out one day and you lose a complete rig." "It's gonna take weeks just to get the parts." "As of now, your overall safety record is rated as poor to uninsurable." "You're fired." "I'm fired?" "Look, I'm sorry about the truck." "The truck won't make any difference now that we've lost." "We can't make the produce run, and there's no way the guys will hang in now." "[door opening] [door closing]" "They gotta hang in there." "They don't like to give up." "Did you do what I asked?" "I've known those men for years." "Any of those men could be the man who framed Joe." "Curtis was the only one who left the meeting early... and he had time to put the bomb in your rig." "Well, well, well." "I've managed to stir things up." "You've managed to make yourself a target." "Don't worry about me." "I wanna do this for you and Sally." "I don't want her to lose any more." "She lost her father when she was two." "Any chance of growing up in frilly dresses by the time she was five... and now her brother, and her business by 15." "You're important to her." "I don't want her to lose you, too." "I don't plan on that, either." "You mind if I talk to her?" "Thanks." "Hold it." "Hold it!" "Get in the car." "Now we are going to talk." "You know what you get for stealing kids?" "I only borrowed you... and I got your mother's permission." "Okay, so you got me." "What are you going to do?" "Put me in a safe place... like you did my brother?" "I'm going to try and explain things to you once more." "Forget it. I'm not listening." "(Sally) You're a loser." "Sally." "You're a loser." "You got any suggestions, KlTT?" "(KITT) Children should be treated with great patience... reasoned with and educated so that they can be... brought slowly into maturity and a solid relationship with society." "I don't have all that much time." "Then I suggest a firm, but kindly spanking." "Oh, so you're going to beat me up just 'cause some computer tells you to?" "You. I thought you were my friend." "Spanking?" "You know, buddy, that's not a bad idea." "Wait." "Come here." "You're not really going to do it, are you?" "Of course I'm not." "You know, nobody but Joey ever spanked me." "And he was like you." "He only threatened." "Well, if he's a little bit like me, then maybe, just maybe... I'm a little bit like him." "Yeah." "You're a lot like him." "It's just...." "I don't know." "What?" "Hey, it's okay to be scared." "We're gonna lose the house and the truck, and there's not gonna be anything left." "It's not right." "And even you and that fancy Foundation can't help us." "I am gonna help." "I am gonna help." "You know why?" "Because I care about you." "I care about you, and I care about your mama... and I care about your brother, Joe." "Now, I'm betting everything that I can deliver for you." "All you've got to do is one simple little thing." "Trust me." "That's it." "How about it, cutie?" "That's my girl, that's my girl." "(Shatner) There is no Joe Flynn... or an independent organization for you to deal with, Linden." "Well, I still have an arrangement." "I have been dealing with the Flynn family for years... and I gave my word." "And they gave theirs." "They said they'd deliver and they can't." "You've got over 100 tons of produce in... every day starting tomorrow." "You truck with me or it'll sit in here and rot." "Can you afford that?" "You know I can't, Shatner." "That would put me and lot of farmers out of business." "Then you should sign for the season's crop now." "'Course, doing business with a reputable firm... it is a little more expensive." "About 15%." "I can't manage that much." "Then don't pay it." "The Independents will deliver your crop at the quoted price." "Who are you?" "For the sake of conversation, why don't you call me Flynn." "Flynn is finished." "You must be looking to join him." "Now, you tried that and you couldn't pull it off." "I'm here to confirm, Mr. Linden." "Mama Flynn said that you could deal for her... and I'd like to help." "But I represent a lot of people and I'm responsible to them." "You got the message, big boy." "Bye-bye." "Sign both-- What if I guarantee it?" "Guarantee it?" "Just how would you go about that?" "How about a completion bond?" "If you can put up a $50,000 bond by midnight... then you get the contract." "I'll put up a hundred." "Fifty is sufficient, Shatner." "I did have a deal with Flynn first." "If he meets the bond, then he's got it." "You know where to get in touch with me." "Thank you, sir." "And when they can't make it, you're gonna come back to talk to me." "Only it's gonna cost you 30% this time." "You might as well make it 50%... because you're never gonna have a chance to collect it." "Did we arrive in time?" "Just in time." "Now for phase two." "[beeping]" "Hey, what do you think you're doing?" "I was checking for smoke damage." "What's that supposed to mean?" "Figure it out yourself." "Yeah, I'll just do that." "As a matter of fact, I'll be waiting for you." "[car door closing] [car engine starting]" "I don't care what you have to do. I want those independents stopped." "They'll be in convoys." "It's gonna take a lot of men." "Then get them." "It's not just money now." "That guy's got it in for me." "He's not going to stop till he gets me." "All the better." "When you wreck that convoy, make sure he doesn't live through it." "(Devon) A $50,000 bond?" "Michael, you've got to be round the bend." "You want the truckers to go down without a chance?" "Joe Flynn to stay in jail?" "Of course not." "Mama Flynn and Sally?" "No." "And The Foundation to look like fools?" "Naturally not." "Look, we're all in this together." "What is a $50,000 bond among friends?" "All right, Michael. I have a couple of calls to make." "(Devon) By the way, how are you going to replace Flynn's truck?" "I've got an idea." "[people chattering]" "Devon, it's going to be all right." "But The Foundation mobile unit to haul produce?" "Really, Michael." "I don't know how you talked me into it." "Don't blame me, Devon." "You always told me... you'd never do anything you don't really want to do." "Well, that's the way I always felt, till now." "You'll get used to it." "By the way, what kind of produce is it?" "Onions." "Onions?" "Really, Michael." "Barring any accidents, the smell could last for months." "Well, if you whistle or put a pin in your mouth... I won't have to watch a grown man cry. I gotta go, Devon." "Yes, just as well." "Good luck, Michael." "Thanks, Devon." "(KITT) Michael, I've come to understand your humor... but don't you think you're being a little rough on Devon?" "No." "Thank you for your prompt answer." "Ready?" "All set." "I think you guys know this is Shatner and his group's last shot at us." "Let them come." "I think they will." "Keep moving." "Sure." "Stick together." "[truck horn blaring]" "(Shatner) Get the cement truck in position... and let's take them out." "[car tires screeching]" "I don't like this, partner." "Everything's going too smooth." "[beeping]" "(KITT) Well, then you'll be happy to hear... that I'm picking up a signal... from the homing device on the Curtis truck." "Great." "What's the location?" "(KITT) Moving towards the rear of the convoy." "There are two vehicles with it." "[car tires screeching]" "[truck horn blaring]" "[banging] [truck tires screeching]" "[car horn blaring]" "[truck horn blaring]" "Mom, watch out on your blind side." "What are you doing here?" "Yell at me later, just drive." "[car tires screeching]" "That's our man, let's get him." "(KITT) Wait, Michael, there's something up ahead." "There's a vehicle blocking the road and it contains 10 tons of broken concrete." "All right, give me what I need." "[beeping]" "(KITT) Michael, I said it contains 10 tons of concrete." "You're not going to...." "Not without you, partner." "[beeps]" "Shatner, you there?" "(Curtis) It's over, Shatner." "We can't stop them." "Finish them off." "You can catch them." "You do it. I'm done." "Let's get out of here." "(KITT) Which one do we want, Michael?" "Curtis." "The cops can pick up Shatner anytime." "That's Curtis off to the right." "All right, how do you suggest we take him?" "Gently, Michael." "Gently." "I hate making excuses to Bonnie." "She worries." "(Michael) All right, all right." "I'll do my best." "Okay, micro jam his brakes." "My pleasure, Michael." "[beeping] [truck tires screeching]" "Turbo boost, now!" "[brakes screeching]" "Hey, what are you hassling me for, man?" "You could've killed me." "Like you tried to kill the people in the convoy, huh?" "I don't know what you're talking about. I'm on my way to pick up a load." "You wanna see some pictures?" "KlTT, punch up the pictures of our friend here and the convoy." "Take a look." "(Michael) Now, zoom in on that one." "Hold it right there." "You see that picture?" "That picture and the homing device I planted in the truck... tie you up on this one." "Now, would you also like to see the pictures of you cutting Janetti's brakes?" "Wait a minute, hold on." "Can we talk?" "I mean, I'm not the one making the big score here, you know." "KlTT, hit the record button." "Ready, Michael." "All right, start talking and give him to me." "[beeps]" "[all chattering]" "(crowd) All right, Michael." "Thanks, man." "You got it." "Take care." "(woman) Geez, I think you look great." "All right." "(KITT) It's nice to have a family and friends to come back to." "We've got a family." "We got Devon, we got Bonnie." "I got you." "Thank you, Michael." "You know, you really are a good guy." "You know, that really means a lot to me." "I mean, we won the whole thing." "The Independent Association, Joey out of jail... everything's going to be just great." "Take care, little girl." "Could you lean down a little?" "I gotta go." "You know, Michael, we're going to miss her." "Yeah, if she was just... ten years older... and two feet taller."

In recent years, magnetic recording and reproducing devices have been requested to attain more capacity and achieve higher performance due to increasing amount of information for personal computers and expanding applications to image recording apparatus, car navigation apparatus, and the like. For higher recording density, a smaller unit of magnetization reversal in magnetic recording media and media noise reduction are required. Conventional magnetic recording media have adopted a configuration that the ferromagnetic crystal grains comprising magnetic recording layers are preliminarily separated by nonmagnetic materials contained in magnetic recording layers. To increase the magnetic recording density by active control of the separators, discrete track media in which recording tracks are separated, and further, bit patterned media in which recording bits are separated, have been researched and developed. The technique to form the separators has been a significant point for higher recording density in both of these media. For example, following techniques have been proposed to form the separators in discrete track media. One technique is the substrate processing type which preliminarily forms concentric lands and grooves on a substrate and forms a magnetic film thereon to form a patterned magnetic film. Another technique is the magnetic layer processing type which masks a magnetic film and etches the parts of a magnetic film to be grooves to form the pattern. These techniques, however, include a plurality of processes such as backfilling nonmagnetic materials into the grooves, planarizing the surface so as to have the same level as the magnetic film to be the islands, and forming a protection film on the planarized surface. Consequently, other problems arise such as increase in foreign substances produced on the surfaces of the magnetic film and the protection film and increase in roughness of the surfaces. They prevent the reduction in the spacing between a magnetic head and a magnetic disk (nano-spacing), which is another point for higher recording density. To overcome these problems, a method of forming separators by ion implantation has been attempted. For example, Japanese Patent Publication No. H5-205257 (“Patent Document 1”) discloses a method of forming separators between recording tracks of a discrete track medium by altering the magnetic property by means of nitrogen ion implantation into a magnetic layer, for example. According to Patent Document 1, this method can increase the track density without being significantly affected by the process accuracy to decrease the track width for a head. Japanese Patent Publication No. H9-167336 (“Patent Document 2”) attempted a method of forming servo patterns by ion implantation. According to Patent Document 2, the flatness of the surface can be much more improved. Methods for separating recording tracks in discrete track media or recording bits in bit patterned media are important issues. In use of the methods in the above-listed documents, to improve the track density while preventing side writings onto recording tracks, forming separators across the magnetic layer in the film thickness direction is required. The forming separators require ion implantation of a nonmagnetic element across the magnetic layer in the film thickness direction at a sufficiently high acceleration voltage. In the meanwhile, if the acceleration voltage is raised, the thickness of a mask layer formed on the magnetic layer should be increased to prevent the recording tracks on the magnetic layer from being doped with nonmagnetic element ions. In this regard, if the thickness of the mask layer is increased, a problem arises that pattern collapse occur when the pattern pitch of the mask layer is narrowed for higher recording density. Therefore, the film thickness of the mask layer should be thinned so as to match the pattern pitch. However, if the film thickness is thinned and the acceleration voltage is high, the mask layer may not be able to sufficiently block the radiated ions and the recording tracks of the magnetic layer are doped with the nonmagnetic element ions. As a result, the magnetic property of the recording tracks is changed so that the read/write performance is disadvantageously deteriorated. In this case, it is necessary to lower the acceleration voltage in the ion implantation to reduce the implantation energy. However, if the implantation energy is reduced, separators may not be formed across the magnetic layer in the film thickness direction. If the structure of the magnetic layer is not appropriate, a magnetic flux induced by the magnetic layer remained undoped under the separators strays to the surface of separators to cause noise. Then, when the implantation energy is reduced, it is necessary to optimize the structure of the magnetic layer so as to match the implantation energy.

Use and abuse of systemic corticosteroid therapy. Steroid-responsive acute dermatoses should be treated with a single morning dose of prednisone for approximately 2 weeks. It is necessary to "taper" a short course of oral prednisone given by this method. Chronic dermatoses should be treated whenever possible with prednisone used in the morning and on alternate days. This method is effective, is free of most side effects, and suppresses the HPA axis minimally. There are few real advantages in using intramuscular corticosteroids. TAC is an unusually strong suppressor of the HPA axis. For chronic dermatoses, a less suppressive preparation might best be chosen if the physician feels that the intramuscular route is the most reasonable one. In any event TAC should never be used more often than every two months. Finally, the time-course of HPA recovery following short courses of steroids is presently unknown. Nonetheless, some astute critics of steroid metabolism have felt obliged to advise us that individuals who have received from 1 to 4 weeks of suppressive steroid treatment should be suspect as to the integrity of their HPA axis in stressful situations for up to one year. The withdrawal from, as well as the use of, systemic corticosteroids requires a creative and critical physician.

Leukocyte margination during hemorrhagic shock correlates to preshock margination and is reduced by fucoidin. Systemic and pulmonary circulation kinetics for 51Cr-erythrocytes and 111In-leukocytes were measured in rats during experimental hemorrhagic shock and normotension with or without pretreatment with the antirolling agent fucoidin. Leukocyte margination was expressed as transit factors (white blood cell transit time/red blood cell transit time) for polymorphonuclear and mononuclear cells. There was an increased pooling of leukocytes in the pulmonary and systemic vascular beds during shock with a maximum after 60 min when the transit factors had increased 2.90-3.72 times in the pulmonary vascular bed and 2.00-3.52 times in the systemic vascular bed for mononuclear and polymorphonuclear cells, respectively. High preshock pooling levels lead to a more pronounced increase in pooling during shock. Pretreatment with fucoidin significantly reduced the pooling increase in the systemic vascular bed. Granulocyte oxidative activity (nitro blue tetrazolium test) invariably increased during shock and was not affected by fucoidin.

Progressive Increase in Disinfection Byproducts and Mutagenicity from Source to Tap to Swimming Pool and Spa Water: Impact of Human Inputs. Pools and spas are enjoyed throughout the world for exercise and relaxation. However, there are no previous studies on mutagenicity of disinfected spa (hot tub) waters or comprehensive identification of disinfection byproducts (DBPs) formed in spas. Using 28 water samples from seven sites, we report the first integrated mutagenicity and comprehensive analytical chemistry of spas treated with chlorine, bromine, or ozone, along with pools treated with these same disinfectants. Gas chromatography (GC) with high-resolution mass spectrometry, membrane-introduction mass spectrometry, and GC-electron capture detection were used to comprehensively identify and quantify DBPs and other contaminants. Mutagenicity was assessed by the Salmonella mutagenicity assay. More than 100 DBPs were identified, including a new class of DBPs, bromoimidazoles. Organic extracts of brominated pool/spa waters were 1.8× more mutagenic than chlorinated ones; spa waters were 1.7× more mutagenic than pools. Pool and spa samples were 2.4 and 4.1× more mutagenic, respectively, than corresponding tap waters. The concentration of the sum of 21 DBPs measured quantitatively increased from finished to tap to pool to spa; and mutagenic potency increased from finished/tap to pools to spas. Mutagenic potencies of samples from a chlorinated site correlated best with brominated haloacetic acid concentrations (Br-HAAs) (r = 0.98) and nitrogen-containing DBPs (N-DBPs) (r = 0.97) and the least with Br-trihalomethanes (r = 0.29) and Br-N-DBPs (r = 0.04). The mutagenic potencies of samples from a brominated site correlated best (r = 0.82) with the concentrations of the nine HAAs, Br-HAAs, and Br-DBPs. Human use increased significantly the DBP concentrations and mutagenic potencies for most pools and spas. These data provide evidence that human precursors can increase mutagenic potencies of pools and spas and that this increase is associated with increased DBP concentrations.

Open-end spinning devices with such rotor bearing arrangements are known in various different embodiments, and have been extensively described, for example in German Patent Publications DE 195 43 745 A1, DE 196 01 034 A1, DE 197 05 607 A1 or DE 41 17 175 A1. For example, German Patent Publication DE 195 43 745 A1 describes an embodiment in which the spinning rotor is supported both radially and axially by means of a magnetic bearing arrangement. The magnetic bearing at the end of the rotor shaft described in German Patent Publication DE 195 43 745 A1 has a magnetic rotor ring as well as a magnetic stator ring. Here, the two magnetic rings are aligned magnetically in such a way that a bearing gap is created between them. To suppress the radial oscillations of the magnetically seated spinning rotor, which occur in particular during a starting phase, the stator magnet is furthermore seated with its movements limited in the radial direction. Here, the radial deflections of the magnetic stator ring are damped by a mechanical friction device. However, it is disadvantageous with this known installation that the static charge, which in particular occurs during the spinning of synthetic materials in the area of the spinning rotor, cannot be dissipated in a defined manner, since the spinning rotor is electrically insulated from the grounded components of the open-end spinning device. This electric charge has an interfering effect on the spinning process. In the open-end spinning device in accordance with German Patent Publication DE 197 05 607 A1, the spinning rotor is supported with its rotor shaft in the wedge gaps of a support ring bearing, and rests axially against an aerostatic bearing. The rotor shaft is made of carbide, at least in the area of the bearing surface which cooperates with the axial bearing. Because of the electrically insulated bearing of the spinning rotor, it is also possible with this known bearing arrangement for a static charge of the spinning rotor to appear during spinning of synthetic material in particular, leading to disadvantageous effects on the spinning process. Even temporary unintentional contact between the rotor shaft bearing surface and the bearing plate of the axial bearing, made of a carbon material, cannot produce a sufficient removal of the charge. An open end spinning device is furthermore known from German Patent Publication DE 196 01 034 A1, in which the spinning rotor is aerostatically seated both radially and axially. As with the above described bearing arrangements, the bearing arrangement in accordance with German Patent Publication DE 196 01 034 A1 also has the problem that a permanent electric insulation of the spinning rotor during the spinning operation is produced because of the air gap of the aerostatic bearing, and therefore no sufficient removal of the electrostatic charge created during spinning takes place. The problem of insufficient grounding of the spinning rotor, in particular in the course of processing synthetic feed materials, is also present in bearing arrangements of open-end spinning devices, such as those known from German Patent Publication DE 41 17 175 A1. With these bearing arrangements, which per se have proven themselves in actual use, the radial seating of the rotor shaft is customarily provided by plastic-coated support rings. Since the rotor shaft has a non-conducting, for example oxide-ceramic, insert in the area of its axial support, this also leads to an electric insulation and therefore to a static charge buildup of the spinning rotor.

Acute adaptation in adrenergic control of lipolysis during physical exercise in humans. During prolonged exercise, the free fatty acids derived from adipocyte lipolysis are the principal fuel utilized by muscles. In humans, the lipid mobilization from adipose tissue is mainly regulated by insulin and catecholamines: the latter hormones have both beta-adrenergic stimulatory and alpha 2-adrenergic inhibitory effects on lipolysis. The aim of this study was to determine whether rapid alterations in the peripheral action of the regulatory hormones occur during physical work and whether they are of importance for the enhanced lipid mobilization. The acute effects of exercise on the regulation of lipolysis were investigated in isolated adipocytes removed from the gluteal region of 14 healthy volunteers before and immediately after the exercise period. Exercise induced a 20-35% significant increase in the lipolytic response to noradrenaline alone and in combination with the selective alpha 2-antagonist yohimbine and to the pure beta-agonist isoproterenol in isolated adipocytes. The antilipolytic effects of both the alpha 2-agonist clonidine and insulin were unaffected by exercise. Exercise did not influence the specific adipocyte receptor binding of 125I-cyanopindolol (beta-adrenergic receptor), [3H]yohimbine (alpha-adrenergic receptor), and mono-125I-[Tyr A14]insulin (insulin receptor). In conclusion, a single period of submaximal exercise increases adipocyte lipolytic responsiveness to catecholamines through an increased beta-adrenoceptor-mediated effect at steps distal to the receptor binding. Thus the increased peripheral action of catecholamines may be of importance for the observed enhanced lipid mobilization during physical work.

The end goal of the proposed program is to provide training through a truly multidisciplinary design course where engineering students and physical therapist students at the University of North Florida work together to design, fabricate, and test adaptive technology targeting postural control, mobility, social participation, and quality of lifefor children with developmental disabilities. As part of this program students will gain an increased appreciation of the diverse roles and contributions from different disciplines in the context of advanced rehabilitation technology development for pediatric applications. This program will enhance students training through a hands-on, interprofessional, and translational design experience focused on complete working prototypes that meet clinical and community needs. The specific program aims are: (1) To identify and describe various assistive technology solutions for functional limitations for a variety of developmental disabilities. (2) To develop sklls to function as a member of a multidisciplinary team including effective communication across disciplines and people first language, behavior and sensitivity during clinical observations with clients. (3) To identify, formulate, and solve engineering problems utilizing a family-centered functional approach to the assessment of assistive technology needs including cultural uniqueness as applied to ethnic and cultural minorities. (4) To understand the professional, legal, and ethical responsibility of interacting with a client in a professional capacity related t providing assistive technology devices and services. (5) To describe the process utilized to develop product concepts, specifications, prototyping, testing, and fabrication of an assistive technology finished product. (6) To compare and contrast the gaps between engineering and rehabilitation theory and reality.

The invention concerns a variable speed gear transmission comprising at least one gearwheel mounted through a rolling bearing on a transmission shaft, in which the gearwheel can be coupled to the transmission shaft through a coupling element, first cylindrical rolling elements being arranged in a cage in radial direction between an inner raceway formed on the transmission shaft and an outer raceway formed on a hub of the gearwheel, said cage comprising in pockets at least at three circumferential points, second cylindrical rolling elements having a slightly larger diameter than the first rolling elements. Gearwheels of the pre-cited type for variable speed gear transmissions, also called idler gears, are frequently arranged on the transmission shaft in split rolling bearing cages that expand under the effect of their inherent elasticity and come into play-free contact with the rolling elements. A cage of this type is known from DE 41 24 838 A1. In a no-load, unengaged condition, the bearing may not run kinematically under certain circumstances i.e., it may be subject to slippage. In the extreme case, the transmission shaft can come to a standstill and the idler gear may reach a speed of several hundred or several thousand rotations per minute. When the cage starts to rotate, the rolling elements are pressed against the outer raceway due to the centrifugal force so that the cage can reach approximately the same speed of rotation as the idler gear while, due to the operational clearance, the rolling elements can lose contact with the raceway of the transmission shaft. This results in a sliding movement of the rolling elements on the raceway of the transmission shaft that leads to increased wear and/or smearing in case of a sudden loading of the rolling elements. Efforts have been made to solve this problem by modifying the kinematics of the bearing during idling operation. One possibility of achieving this is to reduce the number of load-bearing rolling elements involved in idling operation. This results in a distribution of the weight of the idler gear among only a small number of rolling elements. Thus, for example, it is known from DE-OS 29 18 601 to mount shafts in a variable speed gear transmission through a bearing cage in which three circumferentially equally spaced pockets contain rolling elements having a larger diameter than the rest of the rolling elements. FIGS. 3 and 4 of this prior art document show a cage in which these larger diameter rolling elements are made in the form of hollow coiled wire cylinders. In DE 44 01 531 A1 an attempt is made to solve this problem, well known in the field of rolling bearings, by configuring needle rollers with an arcuate shape so that a radially elastically yielding arch is formed at their centers. It is also known from DE-OS 27 41 057 to configure a bearing so that it comprises a plurality of circumferentially spaced rolling elements whose enveloping circle diameter is smaller than the diameter of the shaft and that are deformable in radial direction. These rolling elements made of a plastic or of thin hollow steel bodies are arranged between the normal rolling elements and have a slightly larger diameter than these so that, in the installed state, they effect a pre-stressing of the bearing. A drawback of all the above solutions is that the rolling elements of larger diameter are of a different type from the remaining rolling elements and are very expensive to manufacture so that the total costs of the idler gear bearing are increased. It is an object of the invention to provide an idler gear bearing which possesses the property of elastic deformation of some of its rolling elements and still can be manufactured without extra fabrication costs. This and other objects and advantages of the invention will become obvious from the following detailed description. The invention achieves the above objects by the fact that the first and second rolling elements are of a same type, size ratios between the first and second rolling elements are defined so that, in an unloaded state, the larger diameter of the second rolling elements is such as to become equal to a diameter of the first rolling elements in an engaged state under radial loading, whereby a limit of elasticity of the second rolling elements having the larger diameter in the unloaded state is not exceeded. The provisions of the invention for the configuration of the idler gear bearing enable a simple but effective use of the law of elasticity for modifying the kinematics of the bearing. The invention utilizes the ability of the larger cylindrical rolling elements to reverse shape and volume variations brought about by outer forces or torques, in the present case by gear shifting, so that, in the engaged state under load, all the rolling elements have the same diameter while, in idling operation, the bearing comprises rolling elements of different diameters. It is quite obvious that the idler gear bearing of the invention having rolling elements of one and the same type is much simpler to manufacture than prior art bearings with different types of rolling elements. Moreover, the filling of rolling elements of the same type but with different diameters into the same bearing cage poses no problem from the fabrication point of view. According to further advantageous propositions of the invention, the diameter of the larger rolling elements is 2 to 5 xcexcm larger than the diameter of the rest of the rolling elements. The larger rolling elements and the rest of the rolling elements are arranged in alternating sequence with one another but it is also possible to arrange them in any other order. The invention will now be described with reference to one example of embodiment illustrated in the appended drawings.

This invention relates to an open wall storage assembly for use with unfinished walls and, in particular, a wall storage assembly for use in a wall region containing a plurality of vertical wall supports. In present day home construction, large areas of interior walls are left unfinished, typically in the basement and garage areas, although work rooms and laundry areas may be similarly unfinished. The homeowner desirous of utilizing this wall area typically provides shelving affixed to the exposed or internal surface of the vertical supports, thus providing storage which protrudes into the room area. A similar result obtains when closed wall storage assemblies such as cabinetry, are also affixed. Since these areas are frequently located in regions where space is at a premium, for example, the area adjacent customary automobile parking in garage facilities and areas adjacent the location of laundry equipment, the inability of the homeowner to effectively utilize the regions between vertical wall supports results in already crowded areas becoming further confined. While a variety of different shelving schemes and outwardly expandable cabinetry is available to promote storage in these areas, the homeowner is faced with a loss of room space especially where the cabinetry contains doors. Furthermore, the mounting of these storage assemblies on the relatively narrow face of the vertical support members utilized in house construction frequently requires the use of additional supporting structure underlying the assembly. This type of storage is characterized by the lack of utility of the region located within the wall between the vertical wall supports. In the construction of the typical house, it is common to find horizontal structural supports placed for fire break purposes and occasionally for structural rigidity between adjacent wall supports. If these members are present, the homeowner is reluctant to disturb them from both a structural and a fire retardant point of view. If these horizontal members are not present, the region between vertical supports and behind any such storage apparatus mounted on the narrow surfaces of the wall supports can act as a flue in the eventuality of fire along the base of the wall. Accordingly, it is a primary object of the present invention to provide an open wall storage assembly for use with unfinished walls which is readily installable by the homeowner and effectively utilizes the region between adjacent vertical wall supports heretofore ignored in the construction of storage means. Furthermore, the invention is characterized by a large area integral member which is utilized in surrounding engagement with adjacent vertical members and has flange members on the opposing vertical ends for affixation to the vertical wall supports. In the present invention, the individual installer can place the transverse shelving members at locations to fit his particular needs. Thus, the invention is located in heretofore unused areas in the support wall so as not to reduce the usable regions within the building.

Various techniques of etching resist-imaged photomasks, silicon wafers or other semiconductor materials have been used in semiconductor fabrication processes. A wet etching technique conducted in an immersion tank is a practical high-throughput, flexible fabrication process. By properly selecting etchant chemicals, etch reactions with the target film are thermodynamically favored over reactions with other films. Desirable etch-rate ratios can usually be obtained. A wet etching method is especially suitable for the blanket etching of polysilicon, oxide, nitride and metal. The method is capable of providing the necessary etch selectivity, a damage-free interface and particle-contamination-free wafers. In more recently developed wet etching technology, automated robotic handling systems and ultra-pure chemicals have been used to further improve particle control and process consistency. A well-controlled wet etching technique is therefore the choice of etching process in VLSI and ULSI fabrication processes. One of the key criteria in carrying out a wet etching process is that the etch products must be soluble in the etchant solution and therefore, no contaminating particles are generated. In an immersion etching process, the volume of the etching tank should be large enough to create enough pressure on the wafer surface in order to dislodge hydrogen gas bubbles evolved during etching reactions; to ensure an accurate balance of the etchant components; to keep the concentration of the etchant relatively constant; and to reduce the number of times the etchant tank must be changed in a production environment. An etchant bath change creates expensive down time, and furthermore, the handling of highly hazardous corrosive materials should be rinimized from a safety standpoint. Wet etching is a frequently used technique for stripping photoresist films from silicon wafers where a complete removal of the resist images without adversely affecting the wafer surface is desired. The resist layer or images should be completely removed without leaving any residues, including contaminant particles that may have been present in the resist. The underlying surface of the photoresist layer should not be adversely affected, for instance, undesirable etching of the metal or oxide surface should be avoided. Liquid etchant strippers should produce reasonable bath yield in order to prevent redeposition of dissolved resist on the wafers. The etchant should completely dissolve the photoresist layer in a chemical reaction, and not just lifting or peeling so as to prevent redeposition. It is also desirable that the etching or stripping time should be reasonably short in order to permit a high wafer throughput. Sulfuric acid (H.sub.2 SO.sub.4) and mixtures of H.sub.2 SO.sub.4 with other oxidizing agents such as hydrogen peroxide (H.sub.2 O.sub.2) are widely used in stripping photoresist or in cleaning a wafer surface after the photoresist has been stripped by other means. For instance, a frequently used mixture is seven parts H.sub.2 SO.sub.4 to three parts of 30% H.sub.2 O.sub.2, or a mixture of 88% sulfuric acid and 12% nitric acid. Wafers to be stripped can be immersed in the mixtures at a temperature between about 100.degree. C. and about 150.degree. C. for 5.about.10 minutes and then subjected to a thorough rinse by deionized water and dried by dry nitrogen. Inorganic chemical resist strippers, such as the sulfuric acid mixtures, are very effective in the residual-free removal of highly postbaked resist. They are more effective than organic strippers and the longer the immersion time, the cleaner and more residue-free wafer surface can be obtained. A typical wet chemical treatment system 10 is shown in FIG. 1. The system has a wet chemical holding tank 12 comprises an inner tank 14 and an outer tank 16. As shown in FIG. 1, the inner tank 14 is usually positioned inside the outer tank 16 and that the sidewall 18 of the inner tank is lower than the sidewall 20 of the outer tank. This allows an operating mode where the inner tank is usually filled first with an etchant chemical through inlets 24 and 26. Inlet 26 to the inner tank 14 also serves as a drain and is connected to drain control valve 28 such that liquid can be drained through outlet 32. Similarly, outlet 34 is connected to the bottom of the outer tank 16 to drain the liquid etchant contained in the outer tank through a drain control valve 36 and the outlet 32. The wet chemical treatment system 10 also includes a recirculating means 40 which has an inlet 42 for receiving a fluid from outlet 34 of the outer tank 16 through passageway 46, and an outlet 44 for feeding to filter means 50. A frequently used recirculating means suitable for the wet chemical treatment system is a mechanical pump that is specially outfitted for transporting corrosive fluids. In such a pump, any components that are in contact with the fluid being pumped is constructed of stainless steel, a corrosion-resistant polymeric material such as Teflon, or a metal coated with a corrosive-resistant polymeric material. The passage tubing 46, the drain control valves 28, 36, and the outlets 26, 34 are similarly constructed of corrosion-resistant materials. The wet chemical treatment system 10 further includes a filter means 50 and a heater means 60. The liquid being pumped by the recirculating means 40 through outlet 44 and passage tubing 52 into inlets 54 and 56 of the filter means 50. The filter means 50 is capable of filtering out particulate contaminants in the wet chemical, especially those of metal particles, such that any contamination of the wafer situated in process tank 14 can be avoided. The filtered wet chemical exits the filter means at outlets 48 and 58 to enter into the heater means 60. In most wet chemical treatment processes, either for cleaning or for etching, the wet chemical can be more efficient in its cleaning or etching function when the temperature of the chemical is raised to above ambient temperature. For instance, for most etching and cleaning processes, a temperature of between about 100.degree. C. and about 150.degree. C. is found to be most suitable. The wet chemical enters the heater through inlet 62 and exits at outlet 66 to return the wet chemical to the inner tank 14 through inlets 24 and 26. The inner tank 14 can be filled with fresh chemicals when needed through a filling means 72 controlled by a fill control valve 74. In the operation of a wet chemical treatment system such as that shown in FIG. 1, the system is normally mounted on a raised floor (or a removable floor) in a semiconductor fabrication facility. A typical mounting method for a wet chemical treatment system is shown in FIGS. 2A and 2B. After the treatment system 10 is positioned on a raised floor 30 with a bottom bracket 38 contacting the floor, the treatment system 10 is fastened to the raised floor 30 by a welded angle 64. The welded angle 64, frequently made of a corrosion-resistant metal, such as stainless steel, is attached to the side frame 68 of the treatment system 10 by bolts 70. Collars 76 are used to secure bolts 70 in their mounting position. The welded angle 64 is further attached to the raised floor 30 by bolts 78 through a horizontal flange 80 of the angle. The thickness of the welded angle or of any other anchoring metal plate should be at least 1 cm. The raised floor is normally fabricated of a grating of aluminum which has a smooth top surface and a corrugated back (not shown). The raised floor 30 may also be fabricated of any other suitable material that has the necessary rigidity and lightweight characteristics for easier removal and installation. The raised floor 30 is positioned on top of an I-beam 82 which is in turn positioned on top of a second I-beam 84. Normally, there is no fastening provided between the raised floor 30 and the top surface 86 of the I-beam 82. The I-beam 82 may be fastened to the second I-beam 84 by any suitable mechanical means such as by bolts, or by welding. The bottom flange 88 of the second I-beam 84 may be fastened to a concrete slab floor 90 by bolts 92. A side view of the welded angle 64 for the wet chemical treatment system 10 is shown in FIG. 2B. In the mounting method shown in FIGS. 2A and 2B, the wet chemical treatment system 10 is only secured to the raised floor 30 that is essentially supported by I-beams that are mounted to a slab floor. The conventional mounting method therefore does not meet the seismic prevention standard that is normally required in fabrication facilities which may be subjected to earthquake damages. The problem can be more serious when the wet chemical treatment system is mounted on a higher floor in a fabrication facility where the effect of an earthquake is more severe. For instance, one of such seismic prevention regulations requires that all equipment foot/frame anchoring mechanism and accessories must be designed to survive a force of 0.35 g.times.2.36, i.e., a force magnified for a 4.sup.th floor installation. It is therefore an object of the present invention to provide a method for mounting a process machine on a removable floor that does not have the drawbacks or shortcomings of the conventional mounting methods. It is another object of the present invention to provide a method for mounting a process machine on a removable floor that meets seismic prevention regulation for the containment of corrosive chemicals in a wet chemical treatment system. It is a further object of the present invention to provide a method for mounting a process machine on a removable floor in a semiconductor fabrication facility such that the process machine can survive earthquakes having a force of 0.35 g.times.2.36. It is another further object of the present invention to provide a method for mounting a semiconductor process machine on a removable floor in a fabrication facility by providing an I-beam equipped with an extended upper flange for supporting the removable floor. It is still another object of the present invention to provide a method for mounting a semiconductor process machine on a removable floor in a fabrication facility by providing an I-beam that is equipped with an extended upper flange for supporting the removable floor and for fastening by mechanical means to the process machine through the removable floor. It is yet another object of the present invention to provide a method for mounting a semiconductor process machine on a removable floor in a fabrication facility by utilizing a modified I-beam for supporting the removable floor and for mounting directly to the process machine. It is still another further object of the present invention to provide an earthquake-proof mounting fixture for mounting a process machine on a removable floor by utilizing an I-beam modified with an extended upper flange for supporting the removable floor and for attaching directly to the process machine through the floor. It is yet another further object of the present invention to provide an earthquake-proof mounting fixture for mounting a process machine on a removable floor by providing an I-beam modified with an extended upper flange for attaching to an L-shaped bracket mounted on the process machine through apertures provided in the removable floor.

Improved method for the determination of anatoxin-a and two of its metabolites in blue-green algae using liquid chromatography with fluorescence detection. Anatoxin-a, a neurotoxin produced by blue-green algae (BGA) species, can cause death to exposed organisms. In North America, BGA are harvested and sold as food supplements, some of which contain elevated levels of other algal toxins, such as microcystins. Concern that elevated levels of anatoxin-a also may be present in BGA food supplements has led to the development of a simple method to determine the presence of anatoxin-a in BGA. Some researchers have successfully analyzed this compound using liquid chromatography with fluorescence detection by forming a fluorescent derivative with 4-fluoro-7-nitrobenzofurazan (NBD-F) in water and phytoplankton extracts. With this method, the background noise is high in BGA extracts due to the presence of co-extractives. Addition of o-phthaldialdehyde (OPA) and mercaptoethanol to the extract before addition of the NBD-F resulted in the successful removal of primary amines from the background noise when the NBD-F derivatives were detected with fluorescence. Improved chromatograms were obtained when extracts were cleaned up in this manner, leading to a lower detection limit (approximately 50 microg/kg) for anatoxin-a. The detection limits obtained for the 2 degradation products dihydroanatoxin-a and epoxyanatoxin-a in BGA extracts were similarly low (55 and 65 microg/kg, respectively).

This invention relates to liquid compositions suitable as inks or toners for non-impact printing. The invention is particularly related to the manufacture of such liquid inks or toners. It has been recognised that certain properties of carrier fluids for inks or liquid developers are required for effective functioning in conventional electrostatic processes. Many of the physical requirements are mandatory, as known by those skilled in the art, but there are also other considerations, such as low toxicity, fire safety, low solvent power, low odour etc. For these reasons, isoparaffinic-hydrocarbons such as the Isopar(copyright) range manufactured by Exxon Corporation, the Shellsol(copyright) range manufactured by Shell Chemical and the Soltrol(copyright) range manufactured by Phillips Petroleum became the industry standards for liquid carriers. In more recent times, however, increased environmental concerns have placed these non-impact liquid processes under increasing pressure to further reduce or eliminate volatile emissions. Other carrier materials for inks or liquid developers have been investigated, and of these, silicone fluids are clearly liquids which combine all previously and currently desired properties for a modern ink and liquid toner carrier. In general, an electrostatic ink or liquid toner for developing electrostatic images is prepared by dispersing an inorganic or organic colorant such as iron oxide, carbon black, nigrosine, phthalocyanine blue, benzidine yellow, quinacridone pink and the like into a liquid vehicle which may contain dissolved or dispersed therein synthetic or naturally occurring polymers such as acrylics and their copolymers, alkyds, rosins, rosin esters, epoxies, polyvinyl acetate, styrene-butadiene, cyclised rubber, ethylene vinyl acetate copolymers, polyethylene, etc. Additionally, to impart or enhance an electrostatic charge on such dispersed particles, additives known as charge directors or charge control agents may be included. Such materials can be metallic soaps, fatty acids, lecithin, and the like. Silicone fluids have been used as a carrier for liquids for some time, for example, U.S. Pat. No. 3,105,821 to S. W. Johnson, and U.S. Pat. No. 3,053,688 to H. G. Greig. Both of these early patents recognised the virtues of silicone fluids, but the understanding of the functioning of liquid toners at that time was relatively empirical. More recently silicone fluids have again been recognised as desirable carrier fluids for liquid toners, as in for example U.S. Pat. No. 5,612,162 and U.S. Pat. No. 5,591,557, both to Lawson et al. More specifically, U.S. Pat. No. 5,612,162 to Lawson et al. discloses a composition and a method of forming a liquid developer or a constituent of a liquid developer for electrostatography comprising the steps of dispersing at least one monomer in silicone fluid and polymerizing the at least one monomer to form polymer particles in the silicone fluid. A homopolymer or a copolymer may be formed and a colorant, such as a pigment or dye, and a charge control agent may be added before or after the polymerisation. The disclosure further states that the liquid developer may further include a polymerisation stabiliser which is compatible with the silicone fluid. The stabiliser may be a silicone fluid such as dimethyl polysiloxane. It has been found that the high molecular weight, that is the 30,000 cSt and 60,000 cSt, dimethyl polysiloxane polymerisation stabilisers described in U.S. Pat. No. 5,612,162 that are compatible with silicone fluids, result in polymer dispersions that possess good suspension stability but poor fix strength, melt cohesion and adhesion properties. If the liquid carrier component of the polymer dispersions discussed in U.S. Pat. No. 5,612,162, which is removed by oven drying or centrifugation/filtration, the polymer spheres remaining can be analysed for fix performance. In this case, the non-volatile content of this formulation will upon heating/melting followed by cooling, produce a solid that possesses minimal adhesive and cohesive properties. The solidified polymer forms a xe2x80x9cchalky likexe2x80x9d resin that can be easily abraded or broken with minimal force. This property is obviously undesirable and when the polymer dispersion is formulated/incorporated into an ink jet ink for printing or liquid developer for electrostatography, the result is poor ink or liquid developer to substrate fix. It is the object of this invention to provide improved polymerisation stabilisers. It is a further objective of this invention to provide improved polymerisation stabilisers which result in the liquid ink or toner compositions exhibiting improved fix to a substrate.

Attitudes to animal-assisted therapy with farm animals among health staff and farmers. Green care is a concept that involves the use of farm animals, plants, gardens or the landscape in cooperation with health institutions for different target groups of clients. The present study aimed at examining psychiatric therapists' (n = 60) and farmers' (n = 15) knowledge, experience and attitudes to Green care and animal-assisted therapy (AAT) with farm animals for people with psychiatric disorders. Most respondents had some or large knowledge about Green care, but experience with Green care was generally low in both groups. Both farmers and therapists believed that AAT with farm animals could contribute positively to therapy to a large or very large extent, with farmers being significantly more positive. Most of the therapists thought that AAT with farm animals contributes to increased skills in interactions with other humans, with female therapists being more positive than males. Two-thirds of the therapists believed that AAT with farm animals to a large extent could contribute better to mental health than other types of occupational therapy. There were no differences in attitudes to AAT between psychiatrists/psychologists and psychiatric nurses. This study confirms the marked potential of offering AAT services with farm animals for psychiatric patients by documenting positive attitudes to it among psychiatric therapists.

Persistence of skin contamination and environmental shedding of Clostridium difficile during and after treatment of C. difficile infection. Current guidelines for control of Clostridium difficile infection (CDI) suggest that contact precautions be discontinued after diarrhea resolves. However, limited information is available regarding the frequency of skin contamination and environmental shedding of C. difficile during and after treatment. We conducted a 9-month prospective, observational study involving 52 patients receiving therapy for CDI. Stool samples, skin (chest and abdomen) samples, and samples from environmental sites were cultured for C. difficile before, during, and after treatment. Polymerase chain reaction ribotyping was performed to determine the relatedness of stool, skin, and environmental isolates. Fifty-two patients with CDI were studied. C. difficile was suppressed to undetectable levels in stool samples from most patients during treatment; however, 1-4 weeks after treatment, 56% of patients who had samples tested were asymptomatic carriers of C. difficile. The frequencies of skin contamination and environmental shedding remained high at the time of resolution of diarrhea (60% and 37%, respectively), were lower at the end of treatment (32% and 14%, respectively), and again increased 1-4 weeks after treatment (58% and 50%, respectively). Skin and environmental contamination after treatment was associated with use of antibiotics for non-CDI indications. Ninety-four percent of skin isolates and 82% of environmental isolates were genetically identical to concurrent stool isolates. Skin contamination and environmental shedding of C. difficile often persist at the time of resolution of diarrhea, and recurrent shedding is common 1-4 weeks after therapy. These results provide support for the recommendation that contact precautions be continued until hospital discharge if rates of CDI remain high despite implementation of standard infection-control measures.

The female contact of current commercial pin and sleeve electrical connectors, in one common form, has two opposing, semi-cylindrical fingers (or "beams" as they are sometimes called). Together, they form an elongated, cylindrical socket or female receptacle for a male connector pin, both fingers being integral with and extending from a common base in cantilever. Thus, each of the fingers extends from a common base, outwardly in a semi-cylinder to a distal end. Together they form a split cylinder--i.e., the socket. The semi-circular distal ends of the two fingers form an inlet opening to the socket through which the pin is placed in making a connection. A cylindrical sleeve is located around the outer edges of the fingers and it extends from the base of the fingers to a location short of the outermost or distal ends of the fingers. In other words, the outermost ends of the fingers, in the prior art, extend out of the sleeve at the location where they receive the connector pin in mating coupling. The cylindrical sleeve thus limits the outward flexing of the fingers at their base, but it leaves the inlet ends free, where damage can occur. Typically, connectors of this type have two through five or more poles, each pole being represented by a mating pin of a male connector and a corresponding socket of a female connector. All of the connector elements for both the male and the female connectors are held in place by a plastic body called an insert. An electric cable having a conductive wire for each pole is assembled to each male and female connector, with a wire attached to each connector element; and a covering or sheath of soft insulating plastic is molded to bridge the jacket of the cable to the insert, thereby enclosing and sealing the connections of the electrical wires to the connector elements. Thus, these connectors are frequently referred to in the industry as "molded" connectors. In connectors of this type, the primary mechanism for limiting the diameter of a pin being inserted is the opening formed in the plastic insert body just beyond the outer-most extension of the fingers. However, the insert body, being formed of a pliable, molded plastic, deforms under force, so that it is not uncommon for a person to attempt to assemble a male connector having oversized pins into a corresponding female connector. This may lead to damage. Experience has shown there are two problems with the female connector in the prior art structure. It must be realized that molded connectors are typically used in industrial or commercial applications and that they experience rugged conditions of use. The pins may be stepped on or otherwise mishandled so that one or more of the pins become misaligned (i.e., out of parallel) with the other pins of the male connector. During assembly to a female connector, a misaligned pin may cause damage to the socket. In assembling the male connector to a female connector, even if the pins are not misaligned, molded connectors are frequently subjected to rough handling so that one or more of the pins of the male connector are not properly aligned with the axis of the associated female socket into which it is being inserted. This can also cause damage to the socket elements. Thus, a common failure is caused by misalignment of the pin during insertion. This can cause a bending of the flexible finger at the inlet opening of the socket because the finger extends beyond, and is therefore not supported by, the surrounding metal cylindrical sleeve. The damage is exacerbated because of the shape of the fingers (i.e., semi-cylindrical) and because of the characteristics of the type of brass material from which these contacts are conventionally made. That is, they are machined from a brass alloy which is somewhat brittle so that it rather easily is deflected beyond its normal stress-deflection characteristic. When this occurs, the metal is overstressed and may even tear. In either case, it will lose its resilient characteristic; and its ability to establish reliable electrical continuity is then lost. A second problem which also results from the stiffness and shape of the semi-cylindrical fingers of the prior art construction is that they are susceptible to damage if a pin having a diameter larger than that for which the female connector is designed, is inserted into the female socket. Again, the rugged conditions of industrial applications must be borne in mind. It is not uncommon for a user to force an oversized pin into a smaller socket. If an oversized pin is attempted to be assembled to a smaller female socket, the inlet ends of both semi-circular fingers are bent outwardly and about the edge of the protecting sleeve where failure occurs if the fingers are bent with sufficient force.

"911." "What is your emergency?" "This is subway train operator 4827." "There's been an accident." "I couldn't stop the train in time, and I hit a kid." "I think he might've been pushed." "Open." "I want 'em held in isolation, no contact... not with their lawyers, not with each other... not with anybody." "This is a matter of national security." "They're terrorists?" "They look more like investment bankers to me." "Well, warden... 3 of them may be." "But one of them is the most dangerous criminal I've ever pursued." "I can hold them for 72 hours without charging them, and I fully intend to." "Then you have 72 hours." "This is Rikers, not Guantanamo." "You don't... plan on asking them any questions?" "Don't worry, Carter." "We've got the DNA evidence from New Rochelle, we got the blood from the burned car... and, thanks to you, fingerprints." "He's ours." "How did I know the federal government would be no match for you?" "As I suspect it might be compromising for you to be found with a phone, I'll be brief." "The matter is in hand, John." "We'll get you out of there." "I took too many risks." "It's my fault." "I'll handle it." "Listen to me." "I made preparations for a scenario like this." "In 72 hours, you will walk free." "What if another number comes up?" "Unfortunately, as I told you... they never stop coming." "I'll have to manage as best I can." "I sincerely hope our next conversation is under better circumstances." "I'll be in touch." "My name is Mr. Swift." "I'm your substitute teacher." "Ms. Benthem received a last-minute opportunity... to attend an all-expenses-paid teaching seminar in Maui." "I see in Ms. Benthem's lesson plan that today we're doing... addition." "That can't be right." "It's busywork, punishment." "We're supposed to add all the numbers from 1 to 100." "Math is not punishment." "You know, in the late 18th century, there was a math prodigy named Carl Friedrich Gauss... who was faced with the same... tedious problem that you are." "He figured a way around it." "1 to 100." "Who'd like to take a crack at working out Gauss' equation?" "Anybody?" "Mr..." "Phipps?" "Uh... prrrr..." "I got to be honest, "Mr. Swifty," you..." "lost me at "Friedrich." So" "I'll give you a hint." " Fusco." " Good morning, Detective." "I trust that you received my email?" "And the entire roll call for Brooklyn Science." "I need you to tell me everything you can about Caleb Phipps." "Couple run-ins with the NYPD." "Typical kid stuff." "Nothing exceptional." "I'll say. 2.6 GPA and test scores that sit squarely in the mid-range." "He spent my whole class doodling in his notebook." "Hey, you still there?" "Please continue." "1 thing did come up." "Caleb had an older brother Ryan... killed 2 years ago in a subway accident." "Kid was drunk." "Slipped on the tracks and got clipped." "Sounds awful." "Any further details?" "I'll pull the incident report." "Now Caleb lives alone with his mom." "She's an administrative assistant in Kensington." "Hey, Caleb." "You going to that party Saturday?" "Uh, no, that's not my kind of thing." "Oh." "Besides, I'm heading out of town." "Taking a trip." "*" "*" "*" "*" "They never seem to stop texting." "Beginning to feel like I'm on another planet." "Get used to it." "Their planet's gonna be running ours in about 10 years." "High schools are different nowadays." "Gang fights, drug searches, and pregnancies." "This kid could be into anything." "You weren't exaggerating about the drug problem." "Kids ain't what they used to be." "Be careful in there, pal." "I-I won't even ask." "Probably best." "Besides... we have more urgent matters to discuss." "Our friend in Rikers." "I have the situation in hand." "I don't want you crossing some kind of line to do" "This?" "Already deleted them from the network too." "*" "That line you're talking about..." "I crossed it a long time ago." "Now we have to deal with the DNA sample." "FBI keeps it in a secure lab here in New York." "I know what to do." "But I'm gonna need a couple things from you." "This is principal Lawton, reminding you that the Brooklyn School of Science Humanities closes promptly at 5 pm." "Thank you." "*" "Mr. Swift." "A word, please." "It has come to my attention that you tried to show Ms. Benthem's students how to get around one of her assignments?" "Well, the assignment seemed a bit remedial." " I was hoping to teach them" " Teaching is Ms. Benthem's job." "Your job is to ensure that her students do the work that she prepared." "Don't sweat Lawton." "She thinks schools would run better if they just got rid of the students and teachers." "Chris Beckner... computer science." "Harold Swift." " Nice to meet an idealist." " No, no, not me." "Throw all this stuff online, I say." "Let me teach in my boxers." "Run wild, man." "I believe I will." "Yes, Detective Fusco?" "Do you have some new information for me?" "Yeah, as a matter of fact, I do." "I took a look at the report of his brother's death." "Caleb was the only witness." "He was there?" "His brother died right in front of him?" "Yeah, but something's not right." "I looked at every incident report that night." "The transit cop called for a backup... to dispatch, and then canceled the request." "Why would a policeman rescind a request for backup?" "That's what I'm trying to figure out." "I'm waiting on the transcripts to find out why." "Maybe it's time I go meet Caleb's mom and find out what his home life is like." "Interesting." "Caleb's latest national aptitude test score is exactly 50%, a statistically improbable score." "Unless you try to get it." "You see, Caleb knew the answer to every question." "But he chose only to fill in every other one." "I don't get it." "He tanked on purpose?" "Why would you want to hide the fact you're a genius?" "*" "Why, indeed?" "Caleb, a word?" "I could-couldn't help but notice this." "No offense, Mr. Swift, but now you're going through the garbage?" "Pi." "Can any of you tell me what it means?" "I'll settle for an intelligent question here." " Yeah?" " My friend has a question, Mr. Swift." ""What is any of this good for, and, uh... when would we ever use it?"" "Let me show you." "Pi." "The ratio of the circumference of a circle to its diameter." "And this... is just the beginning." "It keeps on going... forever... without ever repeating." "Which means that contained within this string of decimals... is every single... other number." "Your birth date... combination to your locker... your social security number." "It's all in there, somewhere." "And if you convert... these decimals into letters... you would have every word that ever existed in every... possible combination." "The first syllable you spoke as a baby... the name of your latest crush... your entire life story from beginning to end." "Everything we ever say or do... all of the world's infinite possibilities rest within this 1... simple circle." "Now what you do with that information... what it's good for... well, that would be up to you." "Yep." "NYPD, ma'am." "We're investigating a string of burglaries in the area." "Talking to residents about things they might've seen or heard." "Mind if I come in and ask you a few questions?" "I'm running a little late." "So you, uh... you live alone?" "With my son Caleb." "We don't have a lot of room, so Caleb takes the couch." "Uh, that's work." "Just give me a sec." "So you and your son see anything suspicious lately?" "Any... strange comings and goings?" "Anyone who stands out?" "Nothing I can think of." "Cops come a few times a year." "It's domestic stuff mostly." "Some families have it rough, you know?" "Yeah." "I know exactly what you mean." "Thanks for your time." "Yes, Detective." "I planted that webcam for you." "Met Caleb's mom." "Late for work, rolling out the door with the shakes." "My guess is she's hitting the bottle." "No wonder Caleb doesn't care about his grades." "Anything new on our 2 dealers?" "Diego Velasquez and Ronnie Samms." "Used to deal for a guy by the name of Lorenzo." "Type of guy you don't wanna cross." "But now they're working for some new up-and-comer that narcotics hasn't been able to identify." "I tell you, that school's a real minefield." "Okay." "Gonna keep your mouth shut, right, Chief?" "Yeah." "Sure." "Except to say this." "The next time you decide you want to deal E to a kid who's clearly never bought in his entire life... do it in the locker room downstairs." "Because this jumpy fool... is a neon sign shouting "drugs ahoy."" "Chief." "Hmm!" " Ah!" " That's enough!" "Unless you want to settle this in the principal's office." " Are you Okay?" " I don't need your help." "Okay?" "Hacker... used to refer to... industrious coders... who... pushed the boundaries of modern computing." "Then that word... became misappropriated by those who pushed the boundaries so far... that they ended up with jail time." "Like Kevin Mitnick, back in the 1980s." "Eh, he was just trying to see how stuff worked." "Mitnick was looking for flaws in the system." "And he did so by breaking the law." "But he proved... people were the flaw, not the code." "Now they're paying him millions for the same thing that got him locked up in the first place." "Perhaps the most notorious hacker of them all was the one that got away." "Back when Uncle Sam was trying to maintain its iron grip on the budding Internet or Arpanet, as it was known then... this... hacker, this coder, hacked into the system and laid its secrets bare... ensuring... that the Internet... would become an open forum." "Plus that hacker made his mark without ever getting busted." "True." "Whoever it was... that person's still out there." "Hey, I'm checking on the boy genius." "Not you, the other one." "Turns out he's quite the little coder." "He's been coding a massive program." "In longhand, as he doesn't have a computer at home." "Then he writes it into a computer in the lab." "If the partial code I've discovered... is a snapshot of his work... what he's creating... could be groundbreaking." "Detective Fusco, can you do something for me?" "I need you to follow Diego and Ronnie." "Caleb had a run-in with them today that might lead to trouble." " Is there a history there?" " Hard to tell." "But..." "Caleb seemed to take an outsized interest in their drug dealing." "If someone's pulling their strings, I'd like to know who." "Finch, whoever this drug dealer is, he's careful." "Detective, how goes phase 1 of your plan?" "I got the package you sent over, but if I'm gonna wade in this pool, I need the right specs." "Yeah." "Sending them to you now." "Our friend in Rikers is counting on you." "*" "Okay." "Knock 'em dead, Detective." "They won't know what hit 'em." "Hm." "Wow." " Hi, I'd like to have" " The first one, on me." "How are you doing?" "Thanks, but, um..." "I'm looking for something a little more... specific." "Detective Fusco, our young man is on the move." "Give you a ride home?" "Car is right down there." "I'd like that." "I have to admit, you kind of threw me at first... asking all those questions about my background, my health." "I couldn't tell whether we were flirting'... or filling' out my medical history." "I'm a practical girl." "I like to know what I'm getting into." "H-h-hm." "So are we... getting into anything tonight?" "I am." "Ooh..." "I don't know what happened, but..." "I didn't even have that much to... drink." "Yeah." "Open wide, big fella." "I've been following this drug money all night." "Diego and Ronnie handed a bagful of it to a homeless guy, who I followed till he dumped it off at a money transfer place." "The worker there wired it to another money hub across town... where I hoofed it over there just in time... to see some other guy pick up the cash... and drop it in a PO box right here in Crown Heights." "Our mysterious drug lord is laundering his money, making it untraceable." "Well, not untraceable enough." "Whoever comes in for this cash is our guy." "Where are you anyway?" "I'm looking at you." "I thought you were following the kid." "I am." " Here you go, sir." " Thanks." "Well, I'll be damned." "Our mystery drug lord is Caleb." "Graded your quizzes." "Some of you have been paying attention." "Caleb, I expected better." "Prrrf." "*" "What did the kid do now?" "Caleb just got a message." "He's supposed to meet his supplier at 2:00." "We have to follow 'im." "Tricky little bastard, keeping his identity a secret." "He's better than most dealers twice his age." "I'll be sure and tell him how impressed you are with his criminal aptitude." "Beckman just broke into Caleb's account, Detective." "He copying a file named 17-6-21 onto a thumb drive." "Whatever Caleb's making... his teacher's interest in it... is far from academic." "Oh, Mr. Phipps!" "Look, I'm kind of on my way somewhere." "I just wanted to return something of yours." "You dropped this yesterday." "You really got to stop going through the trash, Mr. Swift." "You know, I used to do a little coding myself." "That's an elegant string you have." "But it occurs to me that if you want to implement multi-threading, you'd do better to use atomic variables." "Just a thought." "Wait, that, that works." "Yes." "That's why I suggested it." "Uh, thanks." "I hope you have your service weapon with you, Detective." "Yeah, I got you a machine gun too." "Very funny, Detective." "Let's try not to lose him." "Yo, Roman." "You here?" "Aw." "Oh, jeez." "Whoa." "That's what you came for, right?" "So tell me... why would a kid like you do something so stupid..." "like dealing at a school in my neighborhood?" "That's Lorenzo, all right." "Diego and Ronnie's old boss." "What's the plan?" "Crap." "You know, before he had his little accident here..." "Roman was telling me how you're just trying to score some bank to take a big trip." "That true?" "Yeah." "You pay back every dime you made selling to my customers, I'll let you leave town intact." "Be back here tomorrow night... 8 pm... or I'll come find you." "How do you expect me... to score that kind of cash in a day?" "Relax." "All right, I'll... rob a bank or something." "I like you." "You got brass." "But you don't show tomorrow night... break a lot more than your legs." "Kid's got it tough." "But picking a fight with a drug dealer?" "I mean... a dumb move for a genius." "Why would a young man with such potential risk it all just to get some easy drug money?" "I don't think it's about the money." "I think it's about the brother." "Dispatch transcripts from the night Ryan Phipps died." "Now the transit cop who filed the report called for backup." "Because Caleb initially reported that 2 youths got into a shoving match with Ryan... pushed him onto the tracks." "But the officer canceled the backup call and filed an accident report instead." "Why would Caleb change his story?" "Maybe he knew the killers." "Maybe he was thinking about taking care of them himself." "Diego and Ronnie?" "He's manipulating those morons." "Got 'em running drugs for him, a-and they don't even know it." "What's Beckner so absorbed in?" "That's Caleb's work." "Howard, it's Chris." "Can you still meet up tonight?" "I think you'll be impressed with what you see." "Great." "I'll see you there." "Change of plans, Detective." "Let me guess." "You need me to keep an eye on little Einstein myself tonight." "Keep me posted." "So..." "Mr. venture capital firm partner..." "Junior... partner." "Long way from the corner office." "Still have to... watch my step..." " pick my... projects carefully." " I get it." "When you see this" "Well, then, let's..." "Let's just see it..." "Chris, so I can... get back to my wife and kids." "What the hell was that?" "The Library of Congress." "What?" "235 terabytes on-on 1 thumb drive?" "The Internet's choking on streaming video." "They're gonna need a new compression algorithm to continue growing." "And I've got it." "All I need is an investment from a firm like yours to help me get it off the ground." "So... here's the thing, Chris." "I remember your code from back in college." "You were a medium talent at best." "There is no way... that that Chris Beckner designed something... this extraordinary." "Unlike our old friends..." "I didn't peak in college." "So no one else knows about this project?" "Programmers?" "Developers?" "No other entanglements?" "I can guarantee it." "Well..." "let's hope so." "Because I would hate for, uh... anyone to come between you and what I believe is... going to be a very large check." "I finally tracked down that transit cop, Murphy... the one who was first on the scene when Caleb's brother died." "Left a message for him to come down to the 8th after his shift." "Speaking of which, where's the kid now?" "He's moving money around, large amounts." "Getting the cash to pay off Lorenzo?" "No, he set up some kind of a trust, and he's pouring all his money into it." "Maybe he's thinking about taking that trip he's always talking about." "Beckner just texted Caleb." "He wants to meet at 8 tonight." "The same time he's supposed to meet Lorenzo." "And quantum physics notwithstanding, he can't be in 2 places at once." "Unless I'm right, and this kid's got a plan... time's running out on 2 fronts." "Maybe skipping town's the best thing for 'im." "Then we could focus some on getting your pal out of lockup." "Mr. Reese can take care of himself, Detective." "And right now, he's in very capable hands." "Detective Carter?" "Time is ticking away fast for our friend in Rikers." "Don't worry." "I know what to do." "*" "Here you go." "Mm." "Sorry, honey." "I'll be better tomorrow." "I promise." "Yeah." "Everything's gonna be better tomorrow, ma." "Detective Fusco." "I just want to remind you that I need your help tonight." "Caleb has 2 appointments, and we have no idea which one he intends to keep." "I'll be there." "You wanted to speak with me?" "Yeah." "Have a seat, Officer Murphy." "Like I said, I'm, uh... working on a cold case." "Commuter got pushed." "Looking for related cases, this popped up." "Ryan Phipps." "Says here you were first on the scene?" "Yeah, that's right." "Kid was 6 months shy of his 18th birthday." "Coming home with his little brother Caleb." "Ryan was horsing around, drinking a little bit." "Slipped on the tracks and got clipped." "Yeah, yeah, I remember." "It was a rough one." "Because it was a kid?" "Or because you didn't report the whole story?" "I know about the kids who pushed Ryan on the tracks." "I'm no detective, Detective." "I'm just a lowly transit cop." "I seen a lot of things in my time." "And I made a lot of decisions I regret." "This is not one of those times." "You may regret it when Caleb becomes a killer." "What are you talking about?" "You think revenge is gonna make Caleb feel better about seeing his brother die?" "You're a long ways off, Detective." "Then give me some directions." "You know, I did to the kid what you're doing to me right now." "When I asked him for descriptions of the other kids... kept changing it up." "There were no other kids." "No." "Just... 2 brothers... drinking... bored... waiting for a train to go home." "So they... dare each other to, uh... cross the tracks." "You know... how many times you can cross back and forth before a train comes?" "Well, Ryan doesn't want to lose to his little brother." "One kid makes it, the other kid doesn't." "I don't know who got the better deal." "So I told him I'd leave all that out of the report... write it up as an accident, and for him to keep it to himself." "So no matter what he had to tell his mom... or the cops, or God himself... nothing was gonna bring his brother back." "What can I tell you?" "Some things you can't fix." "Hey, I just talked to Murphy." "Brother's death was an accident, but it sounds like Caleb blames himself for it." "Well, that's a problem, Detective, because I lost Caleb." "He got on a city bus, and it left before I could catch up." "You're kidding me." "May I remind you that of the many things I'm equipped to do, pursuit would not be chief among them." "Our only option now is to wait for Caleb at the 2 places he's likeliest to turn up." "I'll stake out Beckner at the High School." "You keep an eye out for our aggrieved drug dealer." "Get everyone, and hunt that kid down!" "Our boy is a no-show, and Lorenzo wants his head." "You worry about the kid." "I'll take care of Lorenzo." "He's not here either, Detective." "I may be too late." "Swift, what are you doing here?" "I was gonna ask you the same." " I-I left some papers on" " Stop it." "I saw you break into Caleb's account and copy his files." "Is that what you're willing to stoop to?" "Stealing the work of a student and passing it off as your own?" "I am not gonna stand here and be accused of plagiarism by some substitute teacher." "Besides, why would I copy work off of a C-grade student?" "Because Caleb is anything but average." "And you know it." "That's why you took his work to your friend." "Caleb... approached me a few months ago... about this project he was working on." "I was skeptical, but when I... saw his code I couldn't believe my eyes, so I decided to help him." " By cutting him out of it." " No." "All he wanted was some money up front for this trip that he wants to take." "He said he didn't even want any credit." "Why on earth would you agree to that?" "I didn't." "Have read it for yourself." "Caleb gets all the credit." "It was just easier for me to... pitch the idea with him myself... get some capital... and then reveal the true brain behind it." "He offered me half if I put the other half in a trust that he set up for his mom." "But I'm giving him the whole thing." "All the money from 17-6-21." "17-6-21?" "It's the name he gave the program." "He said it was some kind of dedication." "Look, I am telling you, 6 months from now, Caleb is going to be the richest 18-year-old in the country." "No." "No, he won't." "Dispatch." "Officer Murphy, regarding the subway fatality." "10-80 on the backup request." "10-5, Officer." "Cancel backup request?" "Affirmative." "This seat taken?" "What are you doing here?" "You're so smart, Caleb." "Ask me something you don't know." "The thing about being reckless... taking chances... is that you make a lot of mistakes, cause a lot of grief." "Gonna start lecturing me on mistakes?" "How I need to live and learn?" "Move on?" "That's really inspiring, Mr. Swift." "I'd stand up on my desk and clap for you." "But" "No." "Your mistakes, like mine... are part of who you are now." "You can't move on... from that." "Believe me." "I've made a sizable number." "But... sometimes your mistakes can surprise you." "My biggest... mistake... for instance... brought me here... at exactly this moment... when you might need some help." "17 years, 6 months and 21 days into your life." "The age at which your brother died." "The age you've chosen to end your life... too." "17-6-21." "So, you see... maybe you and I are connected." "2 reckless people." "Yeah?" "Then what's the use?" "We're just gonna keep breaking things... over and over?" "Why not save everyone the grief?" "The thing about the world... is that it doesn't have any extra pieces." "It's like pi." "It contains everything." "You remove... a single piece... no circle." "Your recklessness, your mistakes... are the reason why, when they say "you can't change the world..."" "you won't listen." "The world is better off... with both of us in it..." "Caleb, rather than the alternative." "Yeah, you sure about that?" "Yes, and your mom is better off with you in it." "If you think money can replace you... you haven't seen the whole equation." "Take it from someone who thought that leaving... would make it easier on everyone... and then learned otherwise." "Say it to me again." "Slowly." "According to the lab results, none of the DNA we took from these 4 men matches any of the DNA in our database." "They're clean, sir." "All 4 of 'em." "I want every one of those samples sent to Quantico, reviewed through CODIS, and inspected for tampering." "They got to it." "I don't know how, but those bastards got to it." "Go." "1 more thing." "Get me Carter." "You really ought to be more careful with your code." "Thanks." "I grew up during the Cold War... when computer networks were just a gleam in the eye of the Department of Defense." "Things seemed more black and white then." "Arpanet was the new frontier." "Till a kid with a homemade computer turned the whole thing inside out." "All I'm saying is... it's a new era now, and things are about to get really weird." "So you should keep your code close to your vest." "And pick your friends wisely." "Pi." "The first... 3,000 digits." "My number's in there, somewhere." "You're smart, you'll figure it out." "Wait, uh... the hacker... the one who got away." "How'd you know he did that with a homemade computer?" "I've read all that research." "No one's ever mentioned that." "I must've heard it somewhere." "Detective Carter." "Has our friend in Rikers been released?" "Almost." "I'm going to meet 'im now." "Your DNA wasn't a match for whoever they're looking for." "We'll be processing you out momentarily." "Stop right there!" "These men have all been classified as unlawful combatants by the AUMF." "Until we can establish that they're not a threat to national security, they're not going anywhere." "Put him back." "Just the person I wanted to see." "What... is going on?" "I thought the evidence cleared these guys." "The DNA, the fingerprints, it's all too neat." "I've been burned too many times trying to bring this man to justice." "There's only 1 person that I know I can trust anymore." "You." "You've been chasing him from the beginning." "And we've only got 1 shot left at him, Detective." "If he walks out of here, we're never gonna see him again." "I know you were a senior interrogator in Iraq." "It's time to put those military skills to use." "I want you to interrogate every last one of these men, find out who they are, what they know." "Start with him."

The invention relates to an apparatus for feeding fuel from a supply container to an internal combustion engine of a motor vehicle as generically defined by the preamble to claim 1. One such apparatus is known from German Patent Disclosure DE 195 49 192. The fuel feed module described has a mushroom-shaped closing element in the bottom region of its suction container. This closing element is received in axially movable fashion. The mushroomlike part of the closing element spans an opening in the bottom of the suction container of the fuel feed module, by way of which the interior of the suction container of the fuel feed module communicates with the interior of a supply container. By its own weight, the closing element rests on the inside of the bottom of the suction container, spanning the opening, so that the opening is sealingly closed. When fuel is now introduced into the supply container, the fuel level in it rises, and as a result the static pressure acting on the underside of the closing element increases as well. This opens the valve, and fuel flows out of the supply container through the opening in the bottom of the suction container into the interior of the suction container. From the interior of the suction container, the fuel is delivered to the motor vehicle engine by means of a fuel feed module. So that fuel can be delivered to the engine by the fuel feed unit, it is therefore necessary for relatively large quantities of fuel to be introduced into the supply container, so that an adequately high static pressure can be built up to open the closing element and thus enable the fuel to flow into the interior of the suction container. A disadvantage of an initial-fill valve actuated by the static pressure is thus the relatively large quantity of fuel that must be fed into the supply container in order to actuate the initial-fill valve. It is therefore the object of the invention to create an apparatus for feeding fuel from a supply container to an internal combustion engine of a motor vehicle which in particular assures reliable initial filling of the fuel feed module after the final assembly of a motor vehicle the first time its tank is filled, or if the supply container has run empty, or only slight fuel quantities are present. This object is attained by an apparatus having the characteristics of claim 1. Expedient refinements are defined by the dependent claims. The apparatus according to the invention for feeding fuel from a supply container to an internal combustion engine of a motor vehicle. The apparatus has a fuel feed unit which on the intake side communicates with a suction container, communicating with the supply container, and on the pressure side communicates with the engine, and having a return line for feeding excess fuel into the suction container. In its bottom region the suction container has a closing element, which is movable between a first position, in which the suction container is opened relative to the supply container, and a second position, in which the suction container is closed relative to the supply container. According to the invention, the closing element has an actuating device, preferably a float body, which in particular at a low or zero fuel level in the supply container keeps the closing element in the first, open position, and which when at least enough fuel is located in the suction container so that the fuel feed unit can still furnish enough fuel to the engine, keeps the closing element in the second, closed position. One essential advantage of a closing element having an actuating device is that the sealing function and closing function of the closing element are decoupled from one another. This kind of closing element according to the invention, also known as an initial-fill valve, is connected to the actuating device in such a way that when the tank is empty, the closing element is opened. Accordingly, for actuating the initial-fill valve, there is no need for a static pressure to be built up. As a result, even when the slightest fuel quantities are introduced, an immediate inflow of fuel from the supply container into the interior of the suction container is assured. A further advantage of a closing element embodied in this way is that when the tank is empty, the initial-fill valve is kept in the open position, so that sticking effects at the sealing seat that would otherwise occur are eliminated. Especially with an actuating device that is controlled as a function of the fuel level in the supply tank, a precisely defined closing point of the closing element is settable or attainable. In one exemplary embodiment of the invention, the actuating device is embodied as a float body and is connected to the closing element. The closing element is attached to the bottom of the suction container of the fuel feed module in such a way that when no fuel is present, the closing element is located in the open position by its total mass, comprising the mass of the closing element itself and the mass of the float body, since in the absence of fuel the float body is not lent any buoyancy. The float body is dimensioned such that in the event that the float body is immersed in the fuel or surrounded by it, a buoyant force develops which is greater than the mass force exerted by the total mass of the closing element. As a result, the closing element is put in the closing position. The closing forces are greater, the larger the dimensions of the float body, because its buoyant force corresponds to the quantity of fuel positively displaced. One essential advantage of such an embodiment is also that a reliable sealing function of the closing element is thus attained, even if the sealing seat is dirty, since the buoyancy of the float body increases the sealing force, and the closing element is thus sealed off even better. The closing element is preferably embodied as a flap or umbrella valve, whose sealing function and closing function are decoupled by the fuel level-dependent positioning controlled by the float body. The term xe2x80x9cdecoupledxe2x80x9d should be understood in this context to mean on the one hand that the buildup of a static pressure from an adequately large quantity of fuel placed in the supply container does not actuate the closing element, and on the other that by the dimensioning of the float body, with the closing element already closed, as a consequence of the buoyancy of the float body located in the fuel, the sealing function of the closing element can be increased still further, if only the float body is dimensioned as large enough, thus making its buoyancy correspondingly great enough. In further exemplary embodiments, the float body is either secured directly in the closing element or is connected to the closing element via a lever, which is supported between the closing element and the float body. A substantial advantage of a float body connected directly to the closing element is that the entire closing element is structurally especially simple and thus functions reliably, especially in a failsafe manner. The substantial advantage of a closing element in which the float body is connected to the actual closing element via a lever is that by a suitable choice of the lever length and the position of the float body, which is preferably disposed displaceably on the lever in the direction of the longitudinal axis of the lever, is that the closing moment in particular and thus the sealing force of the closing element, embodied as an umbrella valve, can be designed to be settable. The closing element is preferably disposed on the bottom of the suction container in such a way that the umbrella of the umbrella valve is disposed on the outside of the bottom of the suction container, that is, the outside oriented toward the bottom of the supply container, while the float body is disposed in the interior of the suction container. However, it is also possible to dispose the closing element in the region of the bottom of the suction container, on its side wall, in which case the actuation of the closing element takes place via a float body connected to the closing element by a deflection lever. Along with the use of a size of the float body adapted to the particular location and desired sealing force of the closing element, it is also possible to provide an electromagnet, for instance, as the actuating element, the electromagnet being controlled as a function of the fuel level. For detecting the fuel level, in such a case, fuel fill level sensors of a type known per se should be provided. An actuating device of this kind has the advantage that the closing element is completely decoupled from the fuel level or from the quantity of fuel introduced.

"(lNSTRUMENTS BEEPlNG)" "SAAVlK:" "Captain's Log, Stardate 81 30.3." "Starship Enterprise on training mission to Gamma Hydra," "Section 14, coordinates 22-87-4." "Approaching Neutral Zone." "All systems normal" "and functioning." "Leaving Section 14 for Section 1 5." "Stand by." "Project parabolic course to avoid entering Neutral Zone." "SULU:" "Aye, Captain." "Course change projected." "Captain, I'm getting something on the distress channel." "On speakers." "MAN:" "Imperative!" "This is the Kobayashi Maru, 19 periods out of Altair VI." "We have struck a gravitic mine and have lost all power." "(DISTORTED) Our hull is penetrated and we have sustained many causalities..." "This is the Starship Enterprise." "Your message is breaking up." "Can you give us your coordinates?" "Repeat, this is the Starship..." "Enterprise, ourposition is Gamma Hydra, Section 10." "(static) ln the Neutral Zone." "Hull penetrated, life support systems failing." "Can you assist us, Enterprise?" "Can you assist us?" "Data on Kobayashi Maru." "COMPUTER VOICE:" "Subject vessel is third class neutronic fuel carrier, crew of 81, 300 passengers." "Damn." "Mr Sulu?" "Plot an intercept course." "May I remind the Captain that if a starship enters the Zone... I'm aware of my responsibilities, Mister." "SULU:" "Estimating two minutes to intercept." "Now entering the Neutral Zone." "COMPUTER VOICE:" "Warning." "We have entered Neutral Zone." "We are now in violation of treaty, Captain." "Stand by, Transporter Room, ready to beam survivors aboard." "Captain!" "I've lost their signal." "COMPUTER VOICE:" "Alert." "Sensors indicate three Klingon cruisers, bearing 3-1-6 mark 4." "Closing fast." "Visual." "Battle stations." "Activate shields." "(ALARM blaring)" "Shields activated." "Inform the Klingons we are on a rescue mission." "They're jamming all the frequencies, Captain." "COMPUTER VOICE:" "Klingons on attack course and closing." "We're over our heads." "Mr Sulu, get us out of here." "I'll try, Captain." "COMPUTER VOICE:" "Alert." "Klingon torpedoes activated." "Alert." "Evasive action!" "(ALARM wailing)" "Engineering, damage report." "SCOTTY ON INTERCOM:" "Main energizer hit, Captain." "Engage auxiliary power." "Prepare to return fire." "(GROANS)" "Shields collapsing, Captain." "Fire all phasers." "No power to the weapons, Captain." "SCOTTY:" "Captain, it's no use." "We're dead in space." "(explosion)" "SAAVlK:" "Activate escape pods." "Send out the log buoy." "All hands abandon ship." "Repeat, all hands abandon ship." "kirk:" "All right." "Open her up." "(ALARM blaring)" "Any suggestions, Admiral?" "kirk:" "Prayer, Mr Saavik." "The Klingons don't take prisoners." "Lights." "MAN ON PA:" "Motors on." "Captain?" "Trainees, to the briefing room." "WOMAN ON PA:" "Maintenance crew, report to Bridge Simulator." "Maintenance crew, report to Bridge Simulator." ""Physician, heal thyself." -ls that all you've got to say?" "What about my performance?" "l'm not a drama critic." "Well, Mr Saavik, are you gonna stay with the sinking ship?" "Permission to speak candidly, sir?" "Granted." "SAAVlK:" "I don't believe this was a fair test of my command abilities." "And why not?" "Because there was no way to win." "A no-win situation is a possibility every commander may face." "Has that never occurred to you?" "No, sir. lt has not." "How we deal with death is at least as important as how we deal with life, wouldn't you say?" "As I indicated, Admiral, that thought had not occurred to me." "Well, now you have something new to think about." "Carry on." "WOMAN ON PA:" "Engineering cadets, assemble on C-Level." "McCOY:" "Admiral." "Wouldn't it be easier to just put an experienced crew back on the ship?" "Galloping around the cosmos is a game for the young, Doctor." "Now, what is that supposed to mean?" "Aren't you dead?" "I assume you're loitering around here to learn what efficiency rating I plan to give your cadets?" "I am understandably curious." "They destroyed the Simulator Room and you with it." "The Kobayashi Maru scenario frequently wreaks havoc with students and equipment." "As I recall, you took the test three times yourself." "Your final solution was, shall we say, unique." "It had the virtue of never having been tried." "By the way, thank you for this." "I know of your fondness for antiques." ""lt was the best of times, it was the worst of times..."" "Message, Spock?" "None that I'm conscious of." "Except, of course, happy birthday." "Surely the best of times." "WOMAN ON PA:" "Captain Spock, Captain Spock, space shuttle leaving in 15 minutes." "Where are you off to now?" "The Enterprise." "I must check in before your inspection." "And you?" "Home." "(DOORBELL dings)" "kirk:" "Why, bless me, Doctor." "What beams you into this neck of the woods?" "Beware Romulans bearing gifts." "Happy birthday, Jim." "Thanks." "Romulan ale." "Why, Bones, you know this is illegal." "I only use it for medicinal purposes." "I got a border ship that brings me in a case every now and then across the Neutral Zone." "Now, don't be a prig." "2283." "Yeah, well, it takes this stuff a while to ferment." "Here, give me." "Now, you open this one." "I'm almost afraid to." "What is it?" "Klingon aphrodisiacs?" "No." "Bones, this is charming." "For most patients your age, I usually recommend Retinax V." "l'm allergic to Retinax." "Exactly." "Cheers." "Cheers." "(EXHALES)" "Happy birthday." "l don't know what to say." "Well, you could say thank you." "Thank you." "Damn it, Jim, what the hell's the matter with you?" "Other people have birthdays." "Why are we treating yours like a funeral?" "Bones, I don't want to be lectured." "What the hell do you want?" "This is not about age and you know it." "It's about you flying a goddamn computer console when you want to be out there hopping galaxies." "Spare me your notions of poetry, please." "We all have our assigned duties." "Bull!" "You're hiding, hiding behind rules and regulations." "Who am I hiding from?" "From yourself, Admiral." "Don't mince words, Bones." "What do you really think?" "Jim, I'm your doctor and I'm your friend." "Get back your command." "Get it back before you turn into part of this collection." "Before you really do grow old." "CHEKOV:" "Starship Log, Stardate 8130.4." "Log entry by First Officer Pavel Chekov." "Starship Reliant on orbital approach to Ceti Alpha VI in connection with Project Genesis." "We are continuing our search for a lifeless planet to satisfy the requirement of a test site for the Genesis experiment." "So far, no success." "Standard orbit, please." "Mr Beach, any change in the surface scan?" "Negative." "Limited atmosphere dominated by craylon gas, sand, high-velocity winds." "incapable of supporting life forms." "Does it have to be completely lifeless?" "Don't tell me you found something." "We've picked up a minor energy flux reading on one dynoscanner." "Damn." "Are you sure?" "Maybe the scanner's out of adjustment." "I suppose it could be a particle of preanimate matter caught in the matrix." "All right." "Get on the comm-pic to Dr Marcus." "Aye, sir." "Maybe it's something we can transplant." "You know what she'll say." "CAROL:" "Let me get this straight." "Something you can transplant?" "CHEKOV:" "Yes, Doctor." "CAROL:" "Something you can transplant?" "I don't know." "TERRELL:" "But it may only be a particle of preanimate matter." "Then again, it may not." "You boys have to be clear on this." "There can't be so much as a microbe, or the show's off." "(sighs) Why don't you have a look?" "But if it is something that can be moved, I want..." "You bet, Doctor." "We're on our way." "Well, don't have kittens, Genesis is going to work." "They'll remember you in one breath with Newton, Einstein, Surak!" "Thanks a lot." "No respect from my offspring." "Par for the course." "Are you teaming up with me for bridge after dinner?" "Maybe." "What is it?" "(david sighing)" "Every time we have dealings with Starfleet, I get nervous." "We are dealing with something that could be perverted into a dreadful weapon." "Remember that overgrown Boy Scout you used to hang around with?" "That's exactly the kind of man..." "Listen, kiddo." "Jim Kirk was many things, but he was never a Boy Scout." "MAN ON RAIDO:" "Captain Terrell, stand by to beam down." "(air whooshing)" "TERRELL ON radio:" "Chekov, are you sure these are the correct coordinates?" "CHEKOV ON radio:" "Captain, this is the garden spot of Ceti Alpha VI." "(TRlCORDER BEEPlNG)" "TERRELL:" "I can barely see it." "CHEKOV:" "There's nothing here." "The tricorder must be broken." "(CHEKOV SIGHS)" "(TRlCORDER BEEPlNG FASTER)" "TERRELL:" "Chekov, overhere." "Those look like cargo carriers." "Hey, give me a hand." "(TRlCORDER BEEPlNG rapidly)" "What the hell happened?" "If they crashed, then where's the rest of the ship?" "What the hell is that?" "Botany Bay." "Botany Bay?" "Oh, no!" "We've got to get out of here now." "Damn." "What about the tricorder." "Hurry." "Never mind that." "Hurry." "Hurry!" "Chekov, what's the matter with you?" "Chekov!" "CHEKOV:" "Come on!" "Hurry!" "Starship Reliant to Captain Terrell." "This is Commander Kyle." "Will you please respond, Captain?" "Captain Terrell." "Respond, please." "Let's give them a little more time." "Khan." "I don't know you." "But you... I never forget a face." "Mr Chekov, isn't it?" "I never thought to see your face again." "Chekov, who is this man?" "A criminal, Captain." "A product of late 20th century genetic engineering." "What do you want with us?" "Sir, I demand to be..." "You are in a position to demand nothing, sir." "I, on the other hand, am in a position to grant nothing." "What you see is all that remains of the ship's company and crew of the Botany Bay, marooned here 1 5 years ago by Captain James T. Kirk." "Listen to me." "You men and women..." "Captain, Captain, Captain." "(KHAN chuckling)" "Save your strength, Captain." "These people have sworn to live and die at my command 200 years before you were born." "Do you mean he never told you the tale?" "To amuse your captain?" "No?" "Never told you how the Enterprise picked up the Botany Bay, lost in space from the year 1 996, myself and the ship's company in cryogenic freeze?" "l've never even met Admiral Kirk." "KHAN:" "Admiral?" "Admiral." "Never told you how Admiral Kirk sent 70 of us into exile on this barren sand heap, with only the contents of these cargo bays to sustain us?" "You lie!" "On Ceti Alpha V there was life!" "A fair chance." "This is Ceti Alpha V." "Ceti Alpha Vl exploded six months after we were left here." "The shock shifted the orbit of this planet and everything was laid waste." "Admiral Kirk never bothered to check on our progress." "It was only the fact of my genetically engineered intellect that allowed us to survive." "On Earth, two hundred years ago," "I was a prince with power over millions." "Captain Kirk was your host." "You repaid his hospitality by trying to steal his ship and murder him." "You didn't expect to find me." "You thought this was Ceti Alpha Vl." "Ah." "Why are you here?" "(CHEKOV gasping)" "Why?" "Allow me to introduce you to Ceti Alpha V's only remaining indigenous life form." "(CREATURE growling)" "What do you think?" "They killed 20 of my people," "including my beloved wife." "(SCREECHlNG)" "Not all at once" "and not instantly, to be sure." "(barking)" "You see, their young enter through the ears and wrap themselves around the cerebral cortex." "This has the effect of rendering the victim extremely susceptible to suggestion." "Later, as they grow, follows madness and death." "(TERRELL GRUNTlNG)" "CHEKOV:" "Khan, listen to me." "These are pets, of course." "Not quite domesticated." "Khan, Captain Kirk was only doing his duty." "TERRELL:" "No!" "(TERRELL moaning)" "(TERRELL AND CHEKOV screaming)" "(BOTH moaning)" "That's better." "Now, tell me, why are you here?" "And tell me where l may find James Kirk." "MAN ON RADIO:" "Enterprise to Admiral Kirk's shuttle." "You're cleared for docking." "Approach portside torpedo bay." "Enterprise, this is Admiral Kirk's party on final approach." "WOMAN ON radio:" "Enterprise welcomes you." "Prepare for docking." "kirk:" "I hate inspections." "I'm delighted." "Any chance to go aboard the Enterprise." "Well, I, for one, am glad to have you at the helm for three weeks." "I don't think these kids can steer." "(whistling)" "Open the airlock." "Permission to come aboard, Captain." "Welcome, Admiral." "I think you know my training crew." "Certainly they have come to know you." "Yes." "We've been through death and life together." "Mr Scott, you old space dog." "You're well?" "I had a wee bout, sir, but Dr McCoy pulled me through." "A wee bout of what?" "Shore leave, Admiral." "Oh, yes." "And who do we have here?" "Midshipman, first class, Peter Preston, engineer's mate, sir!" "First training voyage, Mr Preston?" "Yes, sir!" "l see." "Well, shall we start with the Engine Room?" "SCOTTY:" "We'll see you there, sir." "And everything is in order." "That'll be a pleasant surprise, Mr Scott." "I'll see you on the Bridge, Admiral." "Company dismissed." "(lN VULCAN)" "Well, Mr Scott, are your cadets capable of handling a minor training cruise?" "Give the word, Admiral." "Mr Scott, the word is given." "Aye, sir." "Admiral, what about the rest of the inspection?" "(MOUTHlNG)" "MAN ON RADIO:" "This is StarfIeet Operations." "Enterprise is clear for departure." "Admiral on the Bridge." "WOMAN ON RADIO:" "Pre-stage flux chillers, port." "MAN ON RADIO:" "On." "WOMAN:" "Pre-stage flux chillers, starboard." "MAN:" "On." "WOMAN:" "Main stage flux chillers, port." "MAN:" "Enabled." "SAAVlK:" "Running lights on." "WOMAN:" "Main stage flux chillers, starboard." "MAN:" "Enabled." "Very well, Mr Saavik." "You may clear all moorings." "SAAVlK:" "Aye, sir." "All moorings are clear, Captain." "Thank you." "Lieutenant?" "Have you ever piloted a starship out of space dock?" "Never, sir." "Take her out, Mr Saavik." "Aye, sir." "For everything, there is a first time, Lieutenant." "Don't you agree, Admiral?" "kirk:" "Mmm-hmm." "Aft thrusters, Mr Sulu." "SULU:" "Aft thrusters." "Would you like a tranquilliser?" "SAAVlK:" "Ahead one-quarter impulse power." "Ahead one-quarter impulse power." "We are free and clear to navigate." "Course heading, Captain?" "Captain's discretion." "Mr Sulu, you may indulge yourself." "Aye, sir." "Does that about do it?" "I don't think there's another piece of information we could squeeze into the memory banks." "Next time, we'll design a bigger one." "Who'd wanna build it?" "Dr Marcus?" "Comm-pic coming in on hyperchannel." "lt's the Starship Reliant." "On the screen, please, Jedda." "Come in, please." "This is the Reliant calling Regula I." "Repeat, this is U.S.S. Reliant." "CAROL:" "Commander, we are receiving." "This is Regula I." "Go ahead." "Dr Marcus." "Good." "We're en route to you and should be there in three days." "En route?" "Why?" "We weren't expecting you for another three months." "Has something happened?" "Nothing has happened." "Ceti Alpha VI has checked out." "Then I don't understand why you..." "We have received new orders." "Upon our arrival at Regula I, all materials of Project Genesis will be transferred to this ship for immediate testing on Ceti Alpha VI." "Who in the hell do they think they are?" "Please be quiet." "Commander Chekov, this is completely irregular." "I have my orders." "Pin him down, Mother." "Who gave the order?" "The order comes from" "Admiral James T. Kirk." "I knew it!" "I knew it!" "All along, the military's wanted to get..." "This is completely improper, Commander Chekov." "I have no intention of allowing Reliant or any other unauthorised personnel access to our work or materials." "I'm sorry that you feel that way, Doctor." "Admiral Kirk's orders are confirmed." "Please prepare to deliver Genesis to us upon our arrival." "Reliant out." "Well done, Commander." "You realise, sir, they will attempt to contact Admiral Kirk and confirm the order." "SAAVlK:" "Hold, please." "Thank you, sir." "Lieutenant, are you wearing your hair differently?" "It's still regulation, Admiral." "May I speak, sir?" "Self-expression doesn't seem to be one of your problems." "You're bothered by your performance on the Kobayashi Maru." "I failed to resolve the situation." "There's no correct resolution." "It's a test of character." "May I ask how you dealt with the test?" "You may ask." "That's a little joke." "Humour. lt is a difficult concept." "It is not logical." "We learn by doing." "Who's been holding up the damn elevator?" "Thank you, sir." "Did she change her hairstyle?" "l hadn't noticed." "Wonderful stuff, that Romulan ale." "UHURA ON INTERCOM:" "Admiral Kirk?" "Kirk here." "I have an urgent comm-pic from Space Lab Regula I for you, sir." "Dr Carol Marcus." "l'll take it in my quarters, Uhura." "UHURA:" "Aye, sir." "It never rains, but it pours." "As a physician, you of all people should appreciate the dangers of re-opening old wounds." "Sorry." "CAROL:" "Jim, can you read me?" "I can hear you, Carol." "What's wrong?" "What's the matter?" "Why are you taking Genesis away from us?" "Taking Genesis?" "Who's taking Genesis?" "Who is taking Genesis?" "I can see you, but I can't hear." "Carol..." "Jim, did you give the order?" "What order?" "Who's taking Genesis?" "Please help us, Jim." "I will not let them have Genesis without proper authorisation!" "Have Genesis?" "Who's taking..." "On whose authority can they do this?" "No one's authority!" "(DISTORTED) Jim, please..." "Uhura, what's happening?" "UHURA:" "Transmission jammed at the source, sir." "Alert Starfleet Headquarters." "UHURA:" "Aye, sir." "I want to talk to Starfleet Command." "CAROL:" "Quiet." "We must have order in here." "This has to be some sort of mistake." "david:" "Mistake!" "We're all alone here." "They waited until everyone was on leave to do this." "Reliant is supposed to be at our disposal, not vice-versa." "It seems clear Starfleet never intended..." "CAROL:" "I know that, but..." "MAN:" "David, you were right." "david:" "I tried to tell you before." "Scientists have always been pawns of the military." "Starfleet has kept the peace for 1 00 years." "I cannot and will not subscribe to your interpretation of this event." "You may be right, Doctor." "But what about Reliant?" "She's on her way." "kirk:" "We have a problem." "Something may be wrong on Regula I." "We've been ordered to investigate." "If memory serves, Regula I is a scientific research laboratory." "I told Starfleet Command all we had was a boatload of children, but we're the only ship in the quadrant." "Spock, these cadets of yours, how good are they?" "How will they respond under real pressure?" "As with all living things, each according to his gifts." "Of course, this ship is yours." "No, that won't be necessary." "Just get me to Regula I." "As a teacher on a training mission, I'm content to command the Enterprise." "If we are to go on actual duty, it is clear that the senior officer onboard must assume command." "It may be nothing." "Garbled communications." "You take the ship." "Jim." "You proceed from a false assumption." "I'm a Vulcan. I have no ego to bruise." "You're about to remind me that logic alone dictates your actions?" "I would not remind you of that which you know so well." "If I may be so bold, it was a mistake for you to accept promotion." "Commanding a starship is your first, best destiny." "Anything else is a waste of material." "I would not presume to debate you." "That is wise." "In any case, were I to invoke logic, logic clearly dictates that the needs of the many outweigh the needs of the few." "Or the one." "You are my superior officer." "You are also my friend." "I have been and always shall be yours." "Stop energizers." "SULU:" "Stop energizers." "Put me on speakers." "An emergency situation has arisen." "By order of Starfleet Command, as of now, 1 800 hours, I'm assuming command of this vessel." "Duty officer, so note in the ship's log." "Plot a new course for Space Laboratory Regula I." "Engine Room." "Mr Scott." "SCOTTY ON INTERCOM:" "Aye, sir?" "We'll be going to warp speed." "Aye, sir." "Course plotted for Regula I, Admiral." "kirk:" "Engage warp engines." "Prepare for warp speed." "Ready, sir." "I know that none of you were expecting this. I'm sorry." "I'm going to have to ask you to grow up a little bit sooner than you expected." "Warp 5, Sulu." "So much for the little training cruise." "WOMAN:" "Course to intercept Enterprise ready, sir." "KHAN:" "Excellent." "Helmsman?" "Sir, may I speak?" "We're all with you, sir." "But consider this." "We are free." "We have a ship and the means to go where we will." "We have escaped permanent exile on Ceti Alpha V." "You have proved your superior intellect and defeated the plans ofAdmiral Kirk." "You do not need to defeat him again." "He tasks me." "He tasks me and I shall have him." "I'll chase him round the moons of Nibia and round the Antares maelstrom and round perdition's flames before I give him up." "Prepare to alter course." "UHURA:" "Space Station Regula I, please come in." "Dr Marcus, please respond." "This is Enterprise... lt's no use." "There's no response from Regula I." "But no longerjammed?" "No, sir." "No nothing." "There are two possibilities." "They are unable to respond." "They are unwilling to respond." "How far?" "1 2 hours, 43 minutes, present speed." ""Give up Genesis," she said." "What in God's name does it mean?" "Give it up to whom?" "It might help my analysis if I knew what Genesis was, beyond the biblical reference." "Uhura, have Dr McCoy join us in my quarters." "UHURA:" "Aye, sir." "kirk:" "Mr Saavik?" "You have the conn." "Well, I've got Sickbay ready." "Now, will someone please tell me what's going on?" "Computer." "Request security procedure and access to Project Genesis summary." "COMPUTER VOICE:" "Identify for retina scan." "Kirk, Admiral James T." "Security Scan approved." "Summary, please?" "Project Genesis." "A proposal to the Federation." "Carol Marcus." "Yes." "What exactly is Genesis?" "Well, put simply, Genesis is life from lifelessness." "It is a process whereby molecular structure is reorganised at the subatomic level into life-generating matter of equal mass." "Stage one of our experiments was conducted in the laboratory." "Stage two of the series will be attempted in a lifeless underground." "Stage three will involve the process on a planetary scale." "It is our intention to introduce the Genesis device into a preselected area of a lifeless space body, a moon or other dead form." "The device is delivered, instantaneously causing what we call the Genesis Effect." "Matter is reorganised with life-generating results." "Instead of a dead moon, a living, breathing planet capable of sustaining whatever life forms we see fit to deposit on it." "Fascinating." "The reformed moon simulated here represents the merest fraction of the Genesis' potential, should the Federation wish to fund these experiments to their logical conclusion." "When we consider the cosmic problems of population and food supply, the usefulness of this process becomes clear." "This concludes our proposal." "Thank you for your attention." "It literally is genesis." "Power of creation." "Have they proceeded with their experiments?" "kirk:" "Well, the tape was made about a year ago, so I can only assume they've reached stage two by now." "Dear Lord, do you think we're intelligent enough to..." "Suppose..." "What if this thing were used where life already exists?" "It would destroy such life in favour of its new matrix." "Its new matrix?" "Do you have any idea what you're saying?" "I was not attempting to evaluate its moral implications, Doctor." "As a matter of cosmic history, it has always been easier to destroy than to create." "Not any more!" "Now we can do both at the same time." "According to myth, the Earth was created in six days." "Now, watch out." "Here comes Genesis." "We'll do it for you in six minutes." "Really, Dr McCoy, you must learn to govern your passions." "They will be your undoing." "Logic suggests..." "Logic?" "My God, the man's talking about logic." "We're talking about universal Armageddon." "You green-blooded, inhuman..." "SAAVIK:" "Bridge to Admiral Kirk." "Admiral, sensors indicate a vessel in our area, closing fast." "What do you make of her?" "It's one of ours, Admiral." "It's Reliant." "SPOCK:" "Reliant?" "Try the emergency channels." "Picture, Mr Saavik." "KHAN:" "Slow to one-half impulse power." "Let's be friends." "Slowing to one-half impulse power." "Reliant in our section, this quadrant, sir, and slowing." "Sir?" "May I quote General Order 1 2?" ""On the approach of any vessel" ""when communications have not been established..."" "Lieutenant." "The Admiral is well aware of the regulations." "Aye, sir." "kirk:" "is it possible their comm system has failed?" "SPOCK:" "It would explain a great many things." "They're requesting communications, sir." "Let them eat static." "joachim:" "They're still running with shields down." "Of course." "We are one big happy fleet." "(sighs LOUDLY)" "Kirk, my old friend." "Do you know the Klingon proverb that tells us," ""Revenge is a dish that is best served cold?"" "It is very cold in space." "This is damn peculiar." "Yellow alert." "Energize defence fields." "(ALARM blaring)" "I'm getting a voice message." "They say their chambers coil is overloading their comm system." "Spock?" "Scanning." "Their coil emissions are normal." "They still haven't raised their shields." "Raise ours." "Their shields are going up." "Lock phasers on target." "Locking phasers on target." "They're locking phasers." "Raise shields." "Fire!" "Sulu, get those shields up." "Trying, sir." "MAN:" "I can't breathe. I can't breathe." "(CREW CLAMOURlNG)" "MAN:" "I need air!" "I need air!" "I can't get power, sir." "Scotty?" "Uhura, turn off those damn channels!" "Mr Scott on the screen." "We're just hanging on, sir." "The main energizer's out." "KIRK:" "Try auxiliary power!" "Aye, aye, sir." "Damage report." "They knew exactly where to hit us." "Who?" "Who knew where to hit us?" "And why?" "One thing is certain." "We cannot escape on auxiliary power." "Visual." "Sulu, divert all power to phasers." "SPOCK:" "Too late." "Hang on!" "kirk:" "Scotty!" "What's left?" "SCOTTY:" "Just the batteries, sir." "I can have auxiliary power in a few minutes." "We don't have a few minutes!" "Can you give me phaser power?" "A few shots, sir." "Not enough against their shields." "Who the hell are they?" "UHURA:" "Admiral, the Commander of the Reliant is signalling." "He wishes to discuss terms of our surrender." "Put it on screen." "UHURA:" "Admiral..." "Do it!" "While we still have time." "UHURA:" "On screen, sir." "Khan." "You still remember, Admiral." "I cannot help but be touched." "I, of course, remember you." "What is the meaning of this attack?" "Where is the crew of the Reliant?" "Surely I have made my meaning plain." "I mean to avenge myself upon you, Admiral." "I've deprived your ship of power, and when I swing around, I mean to deprive you of your life." "But I wanted you to know first who it was who had beaten you." "Khan, if it's me you want, I'll have myself beamed aboard." "Spare my crew." "I make you a counterproposal." "I'll agree to your terms if, in addition to yourself, you hand over to me all data and material regarding the project called Genesis." "Genesis?" "What's that?" "Don't insult my intelligence, Kirk." "Give me some time to recall the data on our computers." "I give you 60 seconds, Admiral." "kirk:" "Clear the Bridge." "At least we know he doesn't have Genesis." "Keep nodding as though I'm still giving orders." "Mr Saavik, punch up the data charts of Reliant's command console." "Reliant's command?" "Hurry!" "45 seconds." "The prefix code?" "That's all we've got." "SAAVlK:" "The chart's up, sir." "KHAN:" "Admiral." "We're finding it." "Admiral." "kirk:" "Please." "Please, you've gotta give us time." "The Bridge is smashed." "The computer's inoperative." "Time is a luxury you don't have, Admiral." "Damn!" "Admiral?" "lt's coming through now, Khan." "Reliant's prefix number is 1 6309." "l don't understand." "You have to learn why things work on a starship." "Each ship has its own combination code to prevent an enemy from doing what we're attempting." "We're using our console to order Reliant to lower her shields." "Assuming he hasn't changed the combination." "He's quite intelligent." "Fifteen seconds, Admiral." "Khan, how do we know you'll keep your word?" "I've given you no word to keep, Admiral." "In myjudgement, you simply have no alternative." "I see your point." "Stand by to receive our transmission." "Mr Sulu, lock the phasers on target and await my command." "Phasers locked." "Time's up, Admiral." "Here it comes." "Now, Mr Spock." "(BEEPlNG)" "Sir, our shields are dropping." "Raise them." "l can't!" "Where's the override?" "The override?" "Fire." "Fire!" "Fire!" "We can't fire, sir." "Why can't you?" "They've damaged the photon control and the warp drive." "We must withdraw." "No!" "No!" "Sir, we must!" "Enterprise can wait." "She's not going anywhere." "SULU:" "Sir, you did it." "l did nothing." "Except get caught with my breeches down." "I must be getting senile." "Mr Saavik, you go right on quoting regulations." "In the meantime, let's find out how badly we've been hurt." "(DOOR opening)" "(UHURA GASPS)" "ls the word given, Admiral?" "The word is given." "Warp speed." "PRESTON:" "Aye." "(PRESTON sighing)" "(sobbing) He stayed at his post when the trainees ran." "SPOCK ON INTERCOM:" "Admiral?" "This is Spock." "Yes, Spock?" "Engine Room reports auxiliary power restored." "We can proceed at impulse power." "Best speed to Regula I." "Kirk out." "I'm sorry, Scotty." "SULU:" "Approaching Regula and Space Lab Regula I." "UHURA:" "Space Station Regula I, this is the Starship Enterprise." "Please come in." "Space Station Regula I, do you read?" "Space Station Regula I, this is Enterprise." "Please acknowledge." "This is Enterprise." "Do you read me?" "Space Station Regula I, do you read?" "Please come in." "There's no response, sir." "Sensors, Captain?" "The scanners and sensors are still inoperative." "There's no way to ascertain what's inside the station." "No way of telling if Reliant is still in the area." "Precisely." "kirk:" "What do you make of that planetoid beyond?" "SPOCK:" "Regula is Class-D." "It consists of various unremarkable ores, essentially a great rock in space." "And Reliant could be hiding behind that rock." "A distinct possibility." "Engineering." "SCOTTY:" "Aye, sir?" "Mr Scott?" "Do you have enough power for transporters?" "Barely, sir." "kirk:" "I'm going down there." "Khan could be down there." "He's been there, hasn't found what he wants." "Can you spare someone?" "There may be people hurt." "Yeah, I can spare me." "SAAVlK:" "Begging the Admiral's pardon." "General Order 1 5, "No flag officer shall beam" ""into a hazardous area without armed escort."" "There's no such regulation." "All right, join the party." "Mr Spock, the ship is yours." "Jim, be careful." "We will." "(TRlCORDER BEEPlNG) lndeterminate life signs." "Phasers on stun." "Move out." "(SOFT SCUFFLlNG)" "(GASPS)" "Jim!" "Well, rigor hasn't set in." "This couldn't have happened too long ago, Jim." "Carol." "This is Enterprise calling Space Lab Regula I." "Respond, please." "SAAVlK:" "Admiral, over here." "UHURA:" "Dr Marcus, come in, please." "Oh, my God." "Please acknowledge signal." "Please..." "SAAVIK:" "Commander Uhura, this is Lieutenant Saavik." "We're all right." "Please stand by." "Out." "Oh, sir, it was Khan." "We found him on Ceti Alpha V." "Easy." "Easy, Pav." "He put creatures in our bodies to control our minds." "McCOY:" "It's all right." "You're safe now." "Made us say lies, do things." "But we beat him." "He thought he controlled us, but he did not." "The Captain was strong." "Captain." "Where's Dr Marcus?" "Where are the Genesis materials?" "He couldn't find them." "Even the data banks were empty." "Erased?" "He tortured those people, but none of them would tell him anything." "He went wild." "He slit their throats." "He wanted to tear the place apart." "But he was late." "He had to get back to the Reliant in time to blow you to bits." "Where's Reliant's crew?" "Dead?" "Marooned on Ceti Alpha V." "He's completely mad, Admiral." "He blames you for the death of his wife." "I know what he blames me for." "The escape pods are all in place." "Where's the Transporter Room?" "Did he make it down here?" "lt was not my impression." "He spent most of his time trying to wring the information out of the people." "SAAVlK:" "Anything?" "kirk:" "The unit's been left on." "Which means nobody remained to turn it off." "Those people back there bought escape time for Genesis with their lives." "This is not logical." "These coordinates are deep inside Regula, a planetoid we know to be lifeless." "If stage two was completed, it was going to be underground." "It was going to be underground, she said." "SAAVlK:" "Stage two of what?" "Kirk to Enterprise." "SPOCK:" "Spock here." "Captain Spock, damage report." "Admiral, if we go by the book, like Lieutenant Saavik, hours could seem like days." "l read you, Captain." "Let's have it." "The situation is grave, Admiral." "We won't have main power for six days." "Auxiliary power has temporarily failed." "Restoration may be possible in two days, by the book, Admiral." "Meaning you can't even beam us back?" "Not at present." "Captain Spock. lf you don't hear from us within one hour, your orders are to restore what power you can, take the Enterprise to the nearest starbase and alert Starfleet Command as soon as you're out ofjamming range." "UHURA:" "Sir, we won't leave you behind." "Uhura, if you don't hear from us, there won't be anybody behind." "Kirk out." "Well, gentlemen, you can stay here, or... lf it's all the same, Admiral, we'd like to share the risk." "Right." "Let's go." "Saavik?" "Go?" "Where are we going?" "Where they went." "Suppose they went nowhere?" "Then this will be your big chance to get away from it all." "Admiral." "Genesis, I presume." "(RATTLlNG)" "Phasers down." "david:" "You." "Where's Dr Marcus?" "david:" "I'm Dr Marcus." "CAROL:" "Jim!" "is that David?" "Mother, he killed everybody we left behind." "Of course he didn't." "David, you're just making this harder." "I'm afraid it's even harder than you think, Doctor." "Please don't move." "Chekov." "l'm sorry, Admiral." "Your Excellency, have you been listening?" "I have indeed, Captain." "You have done well." "I knew it!" "You son of a bitch!" "(JEDDA SCREAMS)" "Don't move!" "Anybody!" "Captain?" "We are waiting." "What's the delay?" "All is well, sir." "You have the coordinates to beam up Genesis." "First things first, Captain." "Kill Admiral Kirk." "Sir, it is difficult. I..." "I try to obey, but..." "Kill him." "I... (CREATURE screeching)" "(screaming)" "Kill him, Terrell, now." "(TERRELL SCREAMS)" "(CREATURE screeching)" "(MOANlNG)" "(CHEKOV SCREAMS)" "(SCREECHlNG)" "God's sakes!" "david:" "What is it?" "(SCREECHlNG)" "Khan, you bloodsucker!" "You're gonna have to do your own dirty work now." "Do you hear me?" "Do you?" "Kirk." "Kirk, you're still alive, my old friend." "Still, old friend, you've managed to kill just about everyone else, but like a poor marksman, you keep missing the target." "Perhaps I no longer need to try, Admiral." "Oh, no." "david:" "Let go." "He can't take it!" "Khan." "Khan, you've got Genesis, but you don't have me." "You were going to kill me, Khan." "You're gonna have to come down here." "You're going to have to come down here." "I've done far worse than kill you." "I've hurt you, and I wish to go on hurting you." "I shall leave you as you left me, as you left her, marooned for all eternity in the centre of a dead planet." "Buried alive." "Buried alive." "Khan!" "Khan!" "This is Lieutenant Saavik calling Enterprise." "Can you read us?" "He's coming around." "kirk:" "Pavel?" "Can you read us?" "It's no use, Admiral." "They're still jamming all channels." "If Enterprise followed orders, she's long since gone." "If she couldn't obey, she's finished." "So are we, it looks like." "I don't understand." "Who's responsible for all this?" "Who is Khan?" "Well, it's a long story." "We appear to have plenty of time." "is there anything to eat?" "I don't know about anybody else, but I'm starved." "How can you think of food at a time like this?" "First order of business, survival." "There's food in the Genesis cave." "Enough to last a lifetime, if necessary." "We thought this was Genesis." "This?" "(SCOFFS) lt took the Starfleet Corps of Engineers 1 0 months in spacesuits to tunnel out all this." "What we did in there, we did in a day." "David, why don't you show Dr McCoy and the Lieutenant our idea of food?" "We can't just sit here." "Oh, yes, we can." "This is just to give us something to do, isn't it?" "Come on." "Admiral?" "As your teacher Mr Spock is fond of saying," ""l'd like to think that there always are possibilities."" "I did what you wanted. I stayed away." "Why didn't you tell him?" "(sighing)" "How can you ask me that?" "Were we together?" "Were we going to be?" "You had your world and I had mine, and I wanted him in mine, not chasing through the universe with his father." "Actually, he's a lot like you in many ways." "Please tell me what you're feeling." "There's a man out there I haven't seen in 1 5 years who's trying to kill me." "You show me a son that'd be happy to help him." "My son." "My life that could have been and wasn't." "What am I feeling?" "Old." "Worn out." "Let me show you something that'll make you feel young, as when the world was new." "Impulse power restored." "Excellent." "More than a match for poor Enterprise." "You did all this in a day?" "The matrix formed in a day." "The life forms grew later at a substantially accelerated rate." "McCOY:" "Jim, this is incredible!" "Have you ever seen the like?" "Can I cook or can't I?" "Where is she?" "SAAVlK:" "Sir, may I ask you a question?" "What's on your mind, Lieutenant?" "The Kobayashi Maru, sir." "Are you asking me if we're playing out that scenario now?" "On the test, sir, will you tell me what you did?" "I would really like to know." "Lieutenant, you are looking at the only Starfleet cadet who ever beat the no-win scenario." "How?" "I reprogrammed the simulation so it was possible to rescue the ship." "What?" "He cheated." "I changed the conditions of the test." "I got a commendation for original thinking." "I don't like to lose." "Then you never faced that situation, faced death?" "I don't believe in the no-win scenario." "Kirk to Spock. lt's two hours." "Are you ready?" "SPOCK:" "Right on schedule, Admiral." "Just give us your coordinates and we'll beam you aboard." "All right." "I don't like to lose." "SAAVlK: ...report, we were immobilised." "Captain Spock said it'd be two days." "kirk:" "Come, come, Lieutenant." "You of all people go by the book." "Spock!" "You know Dr Marcus." "SPOCK:" "Why, of course." "Hello, Mr Spock." "McCOY:" "I'm taking this bunch to Sickbay." "SAAVlK:" "By the book?" "By the book." "Regulation 46A. "lf transmissions are being monitored during battle..." ""No un-coded messages on an open channel."" "You lied." "l exaggerated." "Hours instead of days." "Now we have minutes instead of hours." "They're inoperative below C-Deck." "What is working around here?" "Not much, Admiral." "We have partial main power." "kirk:" "That's it?" "SPOCK:" "Best we could do in two hours." "SULU:" "Admiral on the Bridge." "Battle stations." "(ALARM wailing)" "Tactical." "Uh-oh." "SPOCK:" "She can still outrun us and outgun us, but there is the Mutara Nebula at 1 -5-3 mark 4." "kirk:" "Scotty, can we make it inside?" "The energizer's bypassed like a Christmas tree, so don't give me too many bumps." "No promises." "On your way." "Trouble with the nebula, sir, is all that static discharge and gas clouds our tactical display." "Visual won't function and shields will be useless." "Sauce for the goose, Mr Saavik." "The odds will be even." "(CREW chattering)" "There she is." "There she is." "Ah." "Not so wounded as we were led to believe." "So much the better." "Estimating nebula penetration in 2.2 minutes." "Reliant is closing." "(THUNDER rumbling) lf they go in there, we'll lose them." "KHAN:" "Explain it to them." "(explosion)" "That was close." "kirk:" "They just don't want us going in there." "One minute to nebula perimeter." "Why are we slowing?" "Daren't follow them into the nebula, sir." "Our shields would be useless." "They are reducing speed." "Uhura, patch me in." "UHURA:" "Aye, sir." "You're on, Admiral." "KIRK ON RADIO:" "This is Admiral Kirk." "We tried it once your way, Khan." "Are you game for a rematch?" "Khan, I'm laughing at the superior intellect." "Full impulse power." "No, sir." "You have Genesis." "You can have whatever you..." "Full power!" "Damn you!" "I'll say this for him, he's consistent." "We are now entering the Mutara Nebula." "kirk:" "Emergency lights." "(rumbling)" "Tactical." "inoperative." "KHAN:" "Raise the shields." "As I feared, sir, not functional." "I'm reducing speed." "(THUNDER rumbling)" "MAN:" "Target, sir." "Phaser lock inoperative, sir." "kirk:" "Best guess, Mr Sulu." "Fire when ready." "(GRUNTlNG)" "Aft torpedoes, fire!" "Hold your course." "Evasive starboard!" "Fire!" "(MEN screaming)" "KIRK:" "Damage, Mr Scott?" "Admiral, I've got to take the mains off the line." "lt's the radiation..." "Scotty." "KHAN:" "Joachim!" "Yours is superior... I shall avenge you." "Could you use another hand, Admiral?" "Man the weapons console, Mr Chekov." "Spock." "SPOCK:" "Sporadic energy readings." "Port side, aft." "Could be an impulse turn." "He won't break off now." "He followed me this far, he'll be back." "But from where?" "He's intelligent but not experienced." "His pattern indicates two-dimensional thinking." "Full stop." "Full stop, sir." "Z-minus 1 0,000 metres." "Stand by photon torpedoes." "Torpedoes ready, sir." "Look sharp." "Fire!" "Uhura, send to Commander Reliant, "Prepare to be boarded."" "UHURA:" "Aye, sir." "Commander Reliant, this is Enterprise." "Surrender and prepare to be boarded." "Enterprise to Reliant." "You are ordered to surrender your vessel." "Respond." "Reliant, come in, Reliant." "You are ordered to surrender your vessel." "Enterprise to Reliant." "You are ordered to surrender your vessel." "Respond." "No, Kirk." "The game's not over." ""To the last I will grapple with thee."" "(ringing)" "Admiral, scanning an energy source on Reliant, a pattern I've never seen before." "lt's the Genesis wave." "What?" "david:" "They're on a build-up to detonation." "How soon?" "We encoded four minutes." "We'll beam aboard and stop it." "You can't." "Scotty, I need warp speed in three minutes or we're all dead." "UHURA:" "No response, Admiral." "kirk:" "Scotty!" "Mr Sulu, get us out of here." "Best possible speed." "SULU:" "Aye, sir." "Are you out of your Vulcan mind?" "No human can tolerate the radiation that's in there." "As you are so fond of observing, Doctor, I am not human." "You're not going in there." "Perhaps you're right." "What is Mr Scott's condition?" "Well, I don't think that he... I'm sorry, Doctor." "I have no time to discuss this logically." "Remember." "Spock!" "Get out of there!" "Spock!" "Spock!" "Get out of there!" "Time from my mark?" "Two minutes, 1 0 seconds." "Engine Room, what's happening?" "Spock!" "SCOTTY:" "Spock!" "Get out of there!" "McCOY:" "Good God, man, get out of there!" "SCOTTY:" "No!" "Don't!" "Don't!" "McCOY:" "Spock!" "Spock!" "(WHOOSHlNG)" "Time?" "Three minutes, 30 seconds." "Distance from Reliant?" "4,000 kilometres." "We're not gonna make it, are we?" "No." "No, you can't get away." ""From hell's heart I stab at thee." ""For hate's sake I spit my last breath at thee."" "Sir, the mains are back online." "Bless you, Scotty." "Go, Sulu!" "My God, Carol." "Look at it." "Engine Room." "Well done, Scotty." "McCOY:" "Jim, I think you'd better get down here." "Bones?" "Better hurry." "Saavik, take the conn." "No!" "You'll flood the whole compartment." "He'll die." "Sir, he's dead already." "It's too late." "Spock!" "(HOARSELY) Ship out of danger?" "Yes." "Don't grieve, Admiral." "It is logical." "The needs of the many outweigh..." "The needs of the few." "Or the one." "I never took the Kobayashi Maru test." "Until now." "What do you think of my solution?" "Spock." "I have been, and always shall be, your friend." "Live long and prosper." "No." "kirk:" "We are assembled here today to pay final respects to our honoured dead." "And yet it should be noted that, in the midst of our sorrow, this death takes place in the shadow of new life, the sunrise of a new world, a world that our beloved comrade gave his life to protect and nourish." "He did not feel this sacrifice a vain or empty one, and we will not debate his profound wisdom at these proceedings." "Of my friend, I can only say this." "Of all the souls I have encountered in my travels," "(SOBS) his was the most" "human." "SULU:" "Honours!" "(SCOTTY playing AMAZING GRACE ON bagpipe)" "(KNOCK AT DOOR)" "Come." "I don't mean to intrude." "No, not at all. I should be on the Bridge." "Can I talk to you for a minute?" "I poured myself a drink." "Would you like it?" "Lieutenant Saavik was right." "You never have faced death." "No, not like this." "I haven't faced death." "I've cheated death." "I've tricked my way out of death and patted myself on the back for my ingenuity." "I know nothing." "You knew enough to tell Saavik that how we face death is at least as important as how we face life." "Just words." "But good words." "That's where ideas begin." "Maybe you should listen to them." "I was wrong about you and I'm sorry." "ls that what you came here to say?" "Mainly." "And also that I'm proud, very proud to be your son." "KIRK:" "Captain's Log, Stardate 8141 .6." "Starship Enterprise departing for Ceti Alpha V to pick up the crew of U.S.S. Reliant." "All is well." "And yet, I can't help wondering about the friend I leave behind." ""There are always possibilities," Spock said." "And if Genesis is indeed life from death," "I must return to this place again." "He's really not dead, as long as we remember him." ""lt's a far, far better thing I do than I have ever done before." ""A far better resting place I go to" ""than I have ever known."" "is that a poem?" "Something Spock was trying to tell me on my birthday." "You okay, Jim?" "How do you feel?" "Young." "(lNHALES) I feel young." "SPOCK:" "Space, the final frontier." "These are the continuing voyages ofthe Starship Enterprise." "Her ongoing mission, to explore strange new worlds, to seek out new life forms and new civilisations,"

1. Field of the Invention The invention relates to a connector, a set of connectors and connecting a method. 2. Description of the Related Art U.S. Pat. No. 5,476,390 discloses a lever-type connector with male and female housings. A lever is mounted rotatably on the female housing and has a cam groove that is engageable with a cam pin on the male housing. The lever initially is held at a starting position and the male housing is positioned so that the cam pin faces the entrance of the cam groove. The lever then is rotated to move the cam pin along the cam groove. As a result, the housings are pulled toward and connected with each other. Thus, the connector takes advantage of the leverage action of the lever and connects the housings with a smaller force. Some of lever-type connectors have an erroneous connection preventing means for preventing connection of the female and male housings in a wrong combination. The erroneous connection preventing means includes a rib extending in a connecting direction on one housing and a groove on the mating housing for receiving the rib. The positions of the rib and the groove differ for each pair of housings so that the male and female housings can be connected only in a correct combination. The rib is displaced from the groove if an attempt is made to connect the male and female housings in a wrong combination. Thus, the rib contacts an end surface of the mating housing to prevent the connection. A cam pin that is at the entrance to the cam groove may interfere with an edge of the cam groove and may damage the lever if an operator tries to turn the lever in a state where connection of the housings is prevented. The present invention was developed in view of the above problem and an object thereof is to provide prevent a connector from being damaged upon erroneously connecting a male and a female connector housings.

The bladder does not appear to have a dynamic secreted continuous mucous gel layer. We determined whether the nature of any protective barrier in the bladder is composed of a secreted mucous gel layer. We collected 24-hour urine samples for analysis from 8 healthy 22 to 49-year-old volunteers and 5, 19 to 59-year-old patients treated with bladder reconstruction, in addition to scrapings from 100 freshly slaughtered pig bladders. Samples were subjected to homogenization, dialysis, freeze-drying, papain digestion, gel chromatography, equilibrium density gradient centrifugation, periodic acid-Schiff assay and amino acid analysis. Normal human bladder, pig bladder, normal ileum and transposed intestinal segments were studied for the presence of a mucous layer using a new method of histological analysis. Mucin content in normal urine is 2.7 mg/24 hours, meaning that less than 0.6% of nondialyzable material in normal urine is mucin. The mucin content of urine from reconstructed bladders amounted to 86 mg/24 hours (5.2% of nondialyzable material). We observed that glycosaminoglycans accounted for 41% of the peak total elution volume of PAS positive material in normal urine. Mucin estimation in urine can be grossly overestimated if contaminating glycoconjugates are not removed. Biochemical analysis of material scraped off the pig bladder surface demonstrated that the maximum thickness of a continuous layer that could be achieved was 13.6 mum. While we could visualize an obvious mucous layer on control ileal samples and biopsies of transposed ileal segments from patients with bladder reconstruction, we were unable to note a distinct, measurable mucous layer lining the bladder surface in humans or pigs. Mucin levels in normal human and pig urine would be enough for slow turnover of a thin barrier but the large increase in mucin in the urine of patients with transposed intestinal segments demonstrates that any layer in normal bladder is much different than that lining the transposed intestinal segment. The most likely constituents of this barrier are membrane bound rather than secreted mucins along with the proteoglycan components of the glycocalix.

Web based social networking has become a popular way for people to meet other people over the Internet. Typically, social networking is implemented by websites that provide a dedicated social networking service. Social networking services are typically stand alone web-based services. To use a web-based social networking service, a user may provide information to setup an account with a social networking service. Once a user's account is configured, users can generate “profiles” of themselves. The profiles typically contain basic information about a user (such as location, occupation, hobbies, etc.). Social networking services allow users to view other user profiles, join groups with a common subject or theme, add other registered users to a contact list, and send messages to other users having an account with the particular networking service. As stand alone web services, users must generate an account and develop a “network” over time. Messages sent to other users are typically sent as text-based messages, sometimes containing formatting and other markup, and are handled entirely by the social networking system. Communication is typically limited to other users having an account with the networking service. Thus, a user may not send a message to a mail address outside the social networking service other than an invitation to join the social networking service.

DE 25 28 008 A1 shows a printing press for use in a direct printing process, and having forme cylinders which can be equipped with six printing plates in the axial direction and with two printing plates in the circumferential direction, and also having counter-pressure cylinders, on which three printing blankets can be arranged in the axial direction and one printing blanket can be arranged in the circumferential direction. Both the printing plates, which are arranged side-by-side, as well as the printing blankets, which are also arranged side-by-side, are each offset, with respect to each other, in the circumferential direction. DE 24 22 696 C2 shows a satellite printing unit of a width of six plates with offset printing groups, and having nine or ten cylinders. The two center ones of six printing formes, which are arranged side-by-side in the axial direction, are arranged offset, in the circumferential direction, with respect to the outer ones of the printing formes on the forme cylinder. A triple-wide web-fed rotary printing press, with two formers arranged on two different levels placed on top of each other, is known from DE 41 28 797 A1. A folding structure is known from U.S. Pat. No. 4,671,501. Two formers are arranged on top of each other, in which formers, following their passage through winding rollers, the webs are longitudinally cut upstream of a third former. The partial webs are turned by 90° by a third former and, after having been combined into two continuous webs, are subsequently fed to the two formers which are arranged on top of each other. A folding structure with two groups of three formers each, which two groups of formers are vertically offset with respect to each other, is known from EP 1 072 551 A2. A folding structure is known from WO 97/17 200 A2, in which cut partial webs, which are transversely offset with respect to each other, are fed to different formers. The formers, which are arranged horizontally side-by-side, are arranged partially offset with respect to each other. A longitudinal cutting arrangement for variably cut widths is known from EP 1 238 395 A2. This cutting arrangement has upper cutters which are movable in the axial direction, and a lower cutter shaft with a number of grooves exceeding the number of the upper cutters. DE 42 04 254 A1 discloses a folding structure of a printing press which is four newspaper pages wide. Two formers, which can be shifted transversely with respect to the web running direction, are arranged on a lower former level, and a single stationary former is arranged on a level above the lower former level. In one mode of operation, a newspaper with four pages is produced using the two lower formers. In another mode of operation six pages of a telephone directory are provided side-by-side by the three formers. In the latter case, the two lower formers are moved apart. EP 1 072 551 A2 shows a former arrangement with two groups of three cylinders each. The formers of one group are located on one level and overlap each other, at least viewed in their horizontal direction, in the vertical extension. It is known from DE 196 28 647 A1 to imprint a web with panorama printed pages, which panorama printed pages have printing extending over two adjacent newspaper pages, without interruption. In connection with double-width printing groups, DE 100 16 409 A1 discloses a transfer cylinder having two printing blankets situated side-by-side. Triple-width cylinders are also mentioned, in addition to single-width and double-width cylinders.

In shower units, the water from the pipe where the mixer and/or closure valve is positioned, is conveyed to a rose at the end of the unit. The rose is often bell-shaped, closed at the bottom by the nozzle where a mass of very small holes are distributed, through which water, in the form of many minute jets, is sprayed like rain on the user. The nozzle is usually made of plastic and has a cylindrical trunk shape with a hole in the middle via which it is screwed onto the rose or metallic supporting structure. With another alternative, the edge of the nozzle is rolled over and held together with the rose by a threaded ring. Lastly there are other technical alternatives wherein the nozzle is attached to the rose which feeds it with the water to be sprayed. Regardless of the type of anchorage and its particular shape, the nozzle is equipped with many minuscule holes which perforate it, in some cases having a cylindrical shape, in others having a shape that is initially a truncated cone and then cylindrical at the extreme that starts inside the rose. A nozzle structure with spray perforations made in this way facilitates the formation and accumulation of lime scale therein, and therefore the blockage of these perforations so that the unit becomes unusable. What, in fact, happens with the shower unit is, when the regulator for the water flow housed inside the pipes before the rose is turned off, not all the water comes out. A portion of the water remains in the rose due to depression in the pipe. Due to capillary and surface tension effects, the minuscule spray perforations retain water inside where it slowly evaporates due to the relatively high temperature that the rose reaches during the downflow of water which is normally heated. Lime scale and solid substances dissolved in the water and incrustations, build up particularly around the fine spray holes until they cause them to clog up. Following this, it is necessary to disassemble the nozzle and, remove it from the rose, clean it with liquid solvents capable of dissolving the lime scale or with fine needles which, when pushed into the perforations with the intention of freeing them of the lime scale, cause them to be widened and so, over time, the nozzle undergoes damage.

The limited evidence available suggests that most human cancers are likely the result of genetic transpositions. Through various rearrangements and accumulated mutations, which are now believed to occur commonly in human somatic cells, changes in activation and repression of specific genes, reflected in expression of enzymes, their isozymes and structural proteins, are considered to be the fundamental mechanisms by which the development and progression of a carcinoma are controlled. In this study, I intend to establish systematically the enzyme and isozyme differences and the differences in cell surface proteins between normal and malignant human mammary epithelial cells; the effect of mammotropic hormones on these differential expressions of isozymes and cell surface proteins; and whether this expression is useful in diagnosis and prognosis of human breast cancers. The studies are currently being carried out using a defined system to culture normal and malignant mammary epithelial cells. Work in progress suggest that normal and malignant human mammary epithelium exhibit differences in expression of certain specific enzymes and isozymes. Cell surface reactivities with specific plant lectins have also been found to distinguish normal from malignant breast tumor cells. Efforts are being made to characterize these cellular-biochemical properties unique to neoplastic human breast cells and to identify additional isozymes and cell surface proteins unique in type or amount in malignant human breast tumor cells. The possibility of using these characters as diagnostic and prognostic markers for breast cancer will be assessed.

Growers shipping their products to distant places encountered the difficulty of having the live plants arrive both alive and without damage. Damage occurs when the plants, and/or the growing medium, becomes dislodged from the containers. This is especially a problem when the shipping container becomes inverted during transportation. When inverted, the weight of the containers crushes the plants so that upon arrival the plants are no longer usable. The present solution is to offer credits and rebates for the plants damaged during shipping. Previous attempts at shipping live products have included the use of plastic overwrap. This approach has the drawback that live plants need exposure to air and sealing them with plastic does not allow respiration necessary for live plants. Another approach has been to use a plastic netting to hold the plants within their containers. Netting has proved insufficient in that plants are still able to fit within holes in the netting and become damaged. There is a need in the art for a system for shipping live plants that protects plants from becoming dislodged from their containers and prevents crushing of the plants if the container becomes inverted during shipping. It is an object of the invention to provide a system for shipping live plants. It is another object of the invention to provide a covering for plants within containers maintaining the plant within the container but allowing for respiration. It is another object of the invention to provide a shipping system preventing crushing of plants when the shipping container is inverted. It is another object of the invention to provide a shipping system for live plants minimizing the loss of plants during shipping. It is still another object of the invention to provide a shipping system which is simple and inexpensive to use. It is yet another object of the invention to provide a shipping system for live plants that safely ships a multitude of plants simultaneously. These and other objects of the invention will become apparent to one of ordinary skill in the art after reviewing the disclosure of the invention.

[Relation between the frequency of self stimulation and stimulus duration and its correlation with the duration preferred by the animal]. The effect of duration of stimulus addressed to the lateral hypothalamus on self-stimulation (SS) frequency was studied in rabbits. In the first experimental series, durations preferred by the animals were determined. Histograms of pression durations were obtained, and modal (Tm) and mean (T mean) durations were assessed. In the second series, stimuli were used of fixed duration equal to Tm, T mean and multiples to them--longer and shorter impulse bursts. Three types of distribution histograms of pression durations were obtained, which differed from each other by the form of the envelop as well as by variation coefficients of deviation of self regulated durations from the mean (T mean). These parameters were of a character of individual differences independently from localization of the stimulating electrodes tips. SS frequency was maximal when stimulation durations were 2 Tm and 1/2-1/4 T mean. Prolongation or shortening of the stimulation led to weakening of its reinforcing effect. The concept is discussed of two-component mechanism of reaction to stimulation of the SS hypothalamic zones: motivational excitation against the background of current action and positive reinforcement in post-stimulation period.

‘Saksiscopye’ originated from a hybridization of proprietary hybrid Osteospermum breeding line ‘203005’ (unpatented) and commercial hybrid Osteospermum line ‘Sunny Amanda’ (U.S. Plant Pat. No. 16,522) in Aabyhoej, Denmark. The male parent, ‘Sunny Amanda’, has a pale-yellow flower color with terracotta-brown at the flower petal apices, medium flower size and brown disc florets. The female parent, ‘203005’ has a bright-yellow flower color, medium flower size and a compact and less branching plant growth habit. In spring 2003, the two Osteospermum lines were crossed and 552 seeds were obtained. The seeds were sown and 442 plants were grown in pots for evaluation. Out of 442 F1 lines, plant number 206 was selected for its pale-yellow flowers with copper tips, medium flower size and a compact plant growth habit. In spring 2004, plant number 206 was vegetatively propagated with cuttings and re-evaluated in an open field and a greenhouse. Plant number 206 was given the code number ‘204066’. In spring 2005, plants were evaluated again in pots and in an open field. The selection ‘204066’ was named ‘Saksiscopye’ and found to retain its distinctive characteristics through successive asexual propagations.

The invention relates generally to a method and apparatus for accurately positioning a focused energy beam, and in particular to a method and apparatus for positioning a focused laser beam, very precisely and at high speed, over a complex integrated circuit surface. When integrated circuits are manufactured, many of the circuits are defective and until recently were disposed of as being uncorrectable. The ratio of the good circuits to the total number of circuits manufactured, often termed the yield of a manufacturing process, is very important to the profitability of a semiconductor manufacturing operation. The higher the yield, the greater the profitability of the operation. As circuits become more and more sophisticated, and correspondingly as the number of elements forming a semiconductor circuit increases, the likelihood of a circuit being defective increases. Consequently, the yield decreases and profitability decreases and/or the price of the more sophisticated semiconductor integrated circuits increases. Often, it is the failure of only a few of the tens or hundreds of thousands of circuit elements, that is, diodes, transistors, etc., within the integrated circuit that cause the entire circuit to be thrown away. Recently, however, with respect to very regular integrated circuits such as memories, integrated circuit manufacturers have included spare circuit elements on the semiconductor chip. Thus, when an integrated circuit is tested prior to encapsulation, a defective element can be replaced by severing the connection thereto and connecting a spare in its place. This process, called memory repair, improves the yield of complex semiconductor circuits dramatically, for example by a factor of two or three. The preferred method for severing connections in the integrated circuit is vaporization, that is, the fine conductors connecting the element to the rest of the circuit are vaporized using a focused laser beam. The conductors are usually several micrometers wide and fabricated of metal or polycrystalline silicon. The laser beam must be aimed wlth great precision at the semiconductor surface; and the focused spot must be very small, on the order of the width of the conductor being vaporized, so that adjacent conductors are not damaged. At present, the positioning accuracy and spot size required by integrated circuit manufacturers strain the capability of the equipment that is commercially available. As integrated circuit feature dimensions grow smaller, the strain upon present equipment will become even greater. In addition, the integrated circuit overall dimensions are increasing, which, as described below, yet further strain the capability of present commercial equipment. The commercially available equipment which can be employed for "repair" of the integrated circuit, to increase yield, falls into one of two general classes. In accordance with one class, the "X-Y beam positioner", a lens moves in an X-Y coordinate system over the surface of the integrated circuit. The lens must be positioned directly over the conductor to be severed during the vaporization process. A pair of mirrors are also provided. One mirror moves in one dimension (for example the X direction) only, and the other, fixed relative to the lens, moves in two dimensions (X and Y). Together, the mirrors direct a collimated beam from a fixed laser onto the movable lens. While this system provides high accuracy and small spot size, it is either relatively slow because of a high inertial weight required to minimize vibration of the moving parts; or the vibration resulting from a lower weight construction provides a limit on spot size which is insufficient for future integrated circuit repair applications (as discussed further below). A second class of commercially available equipment, designated the "galvo beam positioner", consists of a fixed lens and a pair of rotating mirrors which change the direction of the collimated light incident thereon from a fixed laser. The laser beam source is directed by the mirrors through the fixed lens toward the semiconductor surface at a designated and changeable angle controlled by the angular positions of the mirrors. The lens transforms the changing direction of light entering its optics into a changing position of a focused beam on the integrated circuit surface. In this commercial equipment, the mirrors are rotated, and hence positioned, through angles determined by the limited angular field of the lens, by galvanometer motors, often referred to as "galvos". While the galvo beam positioner is much faster than the X-Y beam positioner because it has much less inertia, and is vibration free, it does not have the necessary accuracy, spot size, or field of view required by those more sophisticated circuit configurations which have a relatively large surface area. These downside factors exist first because the angular position transducers are not accurate enough when their moment of inertia, and therefore their diameter, is small, and second, because of the demand placed upon lens design and manufacturing for a lens having a high ratio of field size to spot size, for example on the order of 1,000 to 10,000 or more. Thus, in the galvo beam positioner, small spot size conflicts with the large field of view required to cover the entire, and presently growing, size of integrated circuits. (The conflict exists because the angular position errors can be reduced by reducing lens focal length but reduced focal length conflicts with the requirement of a large field of view.) The X-Y positioner on the other hand, meets the needs of memory repair in that its field is large enough, and its spot size has adequate uniformity over the entire field. In addition, its accuracy is sufficient if the design is well engineered and the equipment is operated slowly enough to avoid positioning errors. It has however much more inertia than the galvo beam positioner and is therefore much slower in operation. Practically then, the throughput (repairs per hour) of the X-Y positioner is potentially much less than the galvo beam positioner. In order to minimize this disadvantage, the X-Y positioner is often designed to be lightweight. The lightweight design however reduces the positioner's rigidity and increases its vibration. Thus, while it becomes faster in settling within one limit of error (0.25 millimeters, for example), it becomes slower in settling within much lower limits, (for example, 0.001 millimeters), due to vibration. Thus at the lower limit, the vibration problem has the effect of limiting the effective positioning accuracy. Furthermore, vibration becomes even more of a limitation because no one has yet produced an X-Y beam positioner which is symmetric and dynamically balanced. On the other hand, it is relatively easier to mount mirrors to galvanometers so that the galvo beam positioner is dynamically balanced. The X-Y beam positioner also experiences vibration and other repeatability errors in the direction parallel to the optical axis of the lens (i.e. normal to the surface of the integrated circuit). This affects the focus of the laser on the integrated circuit surface. Thus, as the spot size at the surface becomes smaller, for a given wavelength of light, the depth of field decreases and vibration in the direction of the optical axis begins to cause variations in spot size so that the focus, in effect, varies. This sets a limit to the spot size presently obtainable with commercial X-Y beam positioners because those units now in use must be lightweight to compete, commercially (and with respect to speed), with the galvanometer systems. It furthermore turns out that the spot size limitation of commercial X-Y positioners is very close to the limit experienced by the present galvanometer beam positioners. In the galvo systems, however, the causes are completely different and include variation of spot size over the field of view. It is therefore a primary object of the invention to avoid the disadvantages of both the X-Y beam positioning system and the galvanometer beam positioning system while maintaining the advantages of both. Other objects of the invention are providing a method and apparatus for positioning a focused laser beam on an integrated circuit with very high accuracy, small spot size which is uniform over the entire field of the integrated circuit, larger field size than is presently obtainable with commercial galvanometer beam positioners, high speed, minimum vibration, and high reliability.

This invention relates to high definition televison, and in particular to the reception of signals transmitted over different types of transmission channels. The invention is particularly concerned with the reception of frequency multiplexed signals such as PAL or HD-PAL by a receiver designed for reception of time multiplexed signals such as MAC or HD-MAC. It has been recognised that the introduction of a compatible television service provided via direct broadcasting satellites or other methods of delivering uses a PAL composite method of conveying the colour signal which is not directly compatible with MAC and its derivatives. In the conventional PAL signal, luminance and colour signals are frequency multiplexed for transmission. By contrast, MAC signals are time multiplexed for transmission and, when separated, give a greater horizontal signal bandwidth than is available with PAL terrestrially broadcast signals. MAC gives an 8 MHz luminance bandwidth whereas PAL may only give 3.5 MHz useable luminance bandwidth at the output of a PAL decoder. By applying complex decoders to the PAL signal, up to 5.5 MHz may be derived. If an HD-MAC signal were to be transmitted via PAL the additional frequencies derived in the HD-MAC decoder would not be useable because there would be a large gap in the middle of the spectrum. The reason for this is that for a still picture, horizontal frequencies up to 16 MHz are coded into an effective 8 MHz bandwidth by folding them about the 8 MHz frequency. The signal is unfolded in the HD-MAC decoder, and it is vital that the full 8 MHz bandwidth is available at the HD-MAC decoder. However, if the signal is constrained in the communication path such that, for example, 3.5 MHz is available in the luminance channel of the HD-MAC decoder, the unfolded spectral components are only present from 0 to 3.5 MHz and from 12.5 MHz to 16 MHz. In this case, the higher-frequency components are of no value in enhancing the resolution of the picture because of the gap in the middle of the spectrum. Components in the band 3.5 MHz to 7 MHz would, however considerably enhance the resolution of the picture.

Project Summary/Abstract Background and preliminary data: Immuno-PET with 89Zr-labeled antibodies is a promising approach for detection, staging, and characterization of malignant tumor. Recently, we have applied this approach to imaging of PDAC using the monoclonal IgG1 antibody HMab-5B1, which potently binds on the cancer antigen (CA) 19-9. Overexpression of CA 19-9 is a well-established feature of PDAC and serum levels of CA 19-9 are commonly used in the clinic for diagnosis, risk stratification, and follow-up of pancreatic cancer. While CA 19-9 enters the circulation, its concentration in the tumor is orders of magnitude higher and leads to accumulation of HuMab-5B1 in the tumor tissue. This has been demonstrated by an ongoing phase I clinical trial at MSK that studies CA 19-9 positive malignancies with 89Zr-DFO-HuMab-5B1 PET/CT. In this trial, 89Zr-DFO-HuMab-5B1 PET/CT has shown not only known metastases, but also many sub-centimeter lesions that were not apparent on routine clinical imaging (CT, MRI). Furthermore, a significant fraction of the patients demonstrated very high and persistant uptake of 89Zr-DFO-HuMab-5B1 in the tumor tissue (SUVmax up to 101 g/ml) and tumor-to- blood ratios were higher than 10 for 50% of the lesions, suggesting that HuMab-5B1 labeled with beta-emitting radioisotopes may deliver therapeutic doses to PDAC. The goal of this application is to validate 89Zr-DFO-HuMab-5B1 PET/CT imaging findings by histopathology in patients with CA 19-9 positive pancreatic cancers scheduled to undergo surgery. Specific aims and approach: We will image 15 patients within one week before surgery and use intraoperative gamma probe measurements to precisely localize these findings in the surgical specimens. The expression of CA 19-9 will be assessed by immunohistochemistry and correlated with the tumor uptake of 89Zr on PET. Patients will undergo a diagnostic CT, optimized for pancreatic cancer imaging as part of the PET/CT study and we will test if the addition of the PET increases the staging accuracy of contrast-enhanced CT. Furthermore, we will perform quantitative autoradiography of the resected specimens in order to quantify the precise concentration of radioactivity in the tumor tissue without interfering partial volume effects. Autoradiography will also allow us to study the intratumoral distribution of 89Zr, which may affect the radiation dose that can be safely administered to the tumor tissue with systematically administered HuMab-5B1 labeled with a therapeutic radioisotope. Impact: If the study confirms our preliminary clinical findings that 89Zr-DFO-HuMab-5B1 PET/CT can detect metastatic PDAC with markedly higher sensitivity than CT alone, this would have a major impact on the selection of patients for surgery and surgical planning. Furthermore, if the degree of uptake of 89Zr-DFO- HuMab-5B1 in PDAC metastases is as high as suggested by our preliminary data, HuMab-5B1 would be a highly attractive theranostic agent for treatment of pancreatic cancer.

Prevalence of common MEFV mutations and carrier frequencies in a large cohort of Iranian populations. Familial Mediterranean fever (FMF) is a hereditary autoinflammatory disorder caused by mutations in the MEFV gene. The disease is especially common among Armenian, Turkish, Jewish and Middle East Arab populations. To identify the frequency and the spectrum of common MEFV mutations in different Iranian populations, we investigated a cohort of 208 unselected asymptomatic individuals and 743 FMF patients. Nine hundred and fifty-one samples were analysed for the presence of 12 MEFV mutations by PCR and reverse-hybridization (FMF StripAssay, ViennaLab, Vienna, Austria). Confirmatory dideoxy sequencing of all MEFV gene exons was performed for 39 patients. Fifty-seven (27.4%) healthy individual carried mutant MEFV alleles. Three hundred and ninety-one (52.6%) FMF patients were found positive for either one (172/743; 23.1%), two or three MEFV mutations. Using dideoxy sequencing, three novel variants, A66P, R202W and H300Q, could be identified. Our analysis revealed an allele frequency and carrier rate of 15.6 and 27.4%, respectively, among healthy Iranians. Still moderate compared to neighbouring Armenia, but higher than in Turkey or Iraq, these data suggest that FMF is remarkably common among Iranian populations. E148Q was most frequent in the group of healthy individuals, whereas M694V was the most common mutation among FMF patients, thereby corroborating previous studies on MEFV mutational spectra in the Middle East. Accordingly, MEFV mutations are frequent in healthy Iranian individuals across different ethnic groups. Based on this finding, the awareness for FMF and the implementation of augmented carrier screening programmes considering the multiethnic nature of the Iranian population should be promoted.

"[ Humming ]" "Reverend, are you interested in participating in the" "Rec Centre Children's Fundraiser For Youth Activities?" "Catchy!" "Yes, count me in." "As Jesus said, blessed be the rec centres, for in them be the open swim." "Ha." "Wonderful!" "We still need a ring announcer." "A ring announcer?" "Like a boxing ring announcer?" " Oh, is that a problem?" " Well, as a Christian" "I believe in peaceful loving solutions to every conflict." " Oh, I should have known." " But... as a man who loves boxing..." "I lo-o-ove boxing!" " Oh!" "[ Laughs ]" " Yes, I boxed in the seminary!" "Some of those guys had a lot of pent-up aggression." " We didn't do a lot of dating." " Would you consider fighting?" "Well, I suppose I could strap on the gloves and open up a can of whoop-ass." "For the kids." "Boy, that would be great!" "Now all we need is an opponent." "Well, I'm sure the Lord will provide." "Reverend." "Miss Parvy." "[ Chuckling ] Oh, you are good." "Amaar, the lovely Miss Parvy and I were talking." "Any chance you'd volunteer for the Rec Centre" "Children's..." "Fundraiser for Youth Activities." " That's the one." " It would mean a lot to the kids." " Of course!" " You're in?" "You bet!" "You name it, I'll do it!" "Well, great!" "We'll see you there." " Boxing gloves will be provided." " Whoa, boxing?" "See you in the ring, Amaar." "[ Sharp exhalations ]" "Ho!" " Ho..." " [ Forced laughter ]" "[ ♪ ]" "Season 4 Episode 9 Gloves Will Keep Us Together" "{\pos(190,180)}Jeez, Thorne, step away from the Photoshop!" " They're all over town." " God, I hope not." "Baber:" "There he is!" "Our inspiration!" "Ha." "Something tells me you're not referring to my last sermon." "{\pos(190,180)}I'm referring to the big battle." "You and Thorne," "{\pos(190,180)}mano a mano, which means man to man!" "So tough!" "[ Chuckles ]" "Mano a mano means hand to hand." "{\pos(190,180)}What?" "{\pos(190,180)}There's nothing tough about that." "{\pos(190,180)}Hand to hand?" "That sounds like a slapping contest." "No, this is the real thing." "{\pos(190,200)}It's the "Thrilla in Manila" all over again." "{\pos(190,200)}No, no." "Let's take it easy." "It's no "Rumble in the Jungle"." "This is more like "Friendly Exhibition Match" ""Between Two Men of the Cloth..." "in Mercy"!" "Yeah." "That's a terrible name!" "It is the "Punchdown in a Small Town"!" "I am much better at this than you are!" " It's nothing like that." " It's exactly like that." "[ Sigh ] You're right." "Me versus Thorne?" "Muslims versus Christians." "This is the last thing this town needs." "No, the last thing this town needs is a monorail." "The second last thing is a juice bar." "And the third last thing is... where are you going?" "[ ♪ ]" "Sarah:" "Wow." "It seems like you've been working on this wall since..." "Dinosaurs wore bell bottoms?" "Yeah." "Why is it taking so long?" "The Reverend keeps changing his mind after the work is done." " Oh, is that allowed in the contract?" " Yes, but that's okay." "Because it's nearly done." "Just a bit of paint." " Complete." "Now, all we have to do is wait." " For what?" " Well, this is all wrong." " For that." "Where's my holy fountain?" "Oh, so now there's a fountain." "With water I presume?" "Of course!" "Is there any other kind?" "It's going to be my little cascading miracle that'll take your breath away." "Wow!" "Well, it really will be a..." "[ Grunts ] miracle because the wall isn't roughed in for plumbing." "Oh." "Then I'll need that done." " But you never told me that." " Well, isn't that just assumed?" "[ Beep ]" "Reverend, Reverend!" "I can't do it!" "I can't fight you!" "It's going to send the wrong message to the community." "I understand." "What you're saying is..." " [ Chicken-like cackle ]" " Look, seriously." "Our congregations need to work together, not go head to head!" "[ Cackling ]" " Very funny." " Buk!" "Grow up!" "Oh, Amaar." "It's okay to be afraid." "I was afraid once." " Then I turned six." " And when was that, yesterday?" "Look, you can't bait me into fighting you." "[ Sigh ] So I'm learning." "Hm, you won't even fight for the youth?" "I mean, the youth is our future." " You can't guilt me either." " You really aren't Christian, are you?" "I mean guilt is our trump card." "There's nothing you can do that will make me fight you." "Never say never." "[ ♪ ]" " Coronation Street?" " Commercial!" "Oh!" "What did I miss?" "Deirdre just ordered Blanche out of her flat." "I am not ready for this." "They've been building up to it for 17 years!" "Ah, I need a caramel cup to dull the pain." "Hey!" "Quality Street?" "Granddad used to bring these back from England." "No." "He used to buy them at the drugstore on the way home from the airport." "[ Giggle ]" "But he said you could only get them in the UK." " Granddad was a liar!" " Really?" "You know he never really owned a zeppelin." "Ooh." "The show's back on!" "So Thorne... gets a... a 5% discount on the whole renovation if it's not completed by next week... his constant changes are stopping me from hitting the deadline!" "Don't take that." "Fight back!" "Good advice." "One more change and I will draw the line." "Atta girl, Blanche!" "What?" "[ "Coronation Street" theme ♪ ]" "You two are useless when "Coronation Street" is on." " Was that Dad?" " Shh!" "[ Phone ringing ] [ Clicks tongue ] Oh..." "Yasir: [ Shouting ] Can you get the phone, please!" "Hello." "Mm-hmm." "Oh hi, Reverend." "Um well, now's not really a very good t..." "Oh, fine." "Hang on, hang on." "Um..." "Don't paint the pillars." "You're good with wood." "Okay." "Yup, great." "I'll tell him!" "Bye." "You mean to say the Muslim Imam agreed to go toe-to-toe for the Youth Rec Centre and then bailed." "Now, Fred." "I'm not here to stoke controversy." "Well no, but I am." "Huh!" "So just to clarify, uh... this "Imama's" boy is afraid to take a few knocks for charity?" "Well, "afraid" is such a harsh word." " Oh." "Yellow?" " It is my favourite colour." "[ Laughing ]" "So, how will you respond to this cowardly act of non-aggression?" "Well, the important thing is that we find someone to take his place so the event can go on." " Oh, someone, uh, Muslim?" " Well, it'd be wonderful if the two communities could come together." "[ Laughing ]" "Are you issuing a challenge to any Muslim man enough to take you on?" "Well, I would never say that!" "Oh." "Is it okay if I do?" "It's your show, Fred." "[ Laughing ]" "You know frankly, I don't think any of Mohammed's minions would step into the ring with the Rev." "No, no." "They clearly prefer soft targets." "In fact, I'll tell you what." "If anyone from the mosque can go three rounds with me, for the kids, of course, my friends at This-Old-Rug Carpet Cleaning will clean all the mosque prayer rugs for an entire year!" "Whoa-ho-ho... hitting them right where they kneel." "Oh, nice." "[ Laughing ]" "You're like Jack Palance in a collar." "[ Radio clicks off ]" " Ridiculous!" " Absolutely." "Although, we could use those carpets cleaned." "Did you hear that?" "Amaar backing out of the fight?" "It's made us look like a laughingstock!" "You make us look like a laughingstock." "Salaam alaikum." "Fatima:" "Walaikum assalaam." " If you will not fight for us, who will?" " Yea..." "I didn't hear you volunteer." "I am not a soldier." "I am a general." "Who bruises a bit too easily." "[ ♪ ] ...133, 134..." "So, Reverend." "What do you think?" "Well, I'm getting there." "Oh, the pillars!" "Yes, they're beautiful." " They're a vision of vertical excellence." " Classic." "A timeless tribute to the holding up of ceilings." "Mm, and most interesting of all, they're painted!" "Oh, yeah." "They're absolutely and completely, um..." " Mm-hmm." " Why is that interesting?" "I wanted wood, Yasir." "Wood!" "No, you clearly said, "paint, Yasir!" "Paint. "" "It doesn't even sound like wood." "You see?" "It has none of the same letters, unless you spell it wrong." "And then I blame the schools." " Mm, I did say paint the wood." " Yes!" " But then I said wood was good!" " No!" "Are you calling me a liar?" "No!" "I'm saying that perhaps you misspoke." "You meant to say wood but it came out... a dirty lie!" "Well, if you look at the contract you'll see that I can change my mind as often as I like." "Yes." "In advance." "Not after the job is done." "Well, the job isn't done because this isn't the work I asked for." "Not only is the work done... but I'm done." "I'm finished." "You quit." "No, you see." "I'm not a quitter." "I'm the kind of person that leaves when the job is done, and this job is done!" "Also, I quit." "[ ♪ ]" "[ Grunts ] Eight." "Amaar:" "Ahhh." "What is this?" " Why are people taking this so seriously?" " No, no." "The question is, why aren't you?" "Have you heard what people are saying?" "We need someone to stand up and fight for us." "We need a... a hero." " I'm no hero." " Ah, but you could be." "You just need a coach." "And I am going to coach you like you have never been coached before!" " I have never been coached before." " Oh, good." "So the pressure's off me." "Yasir:" "Then he had the gall to say, "I told you all about it"!" " Can you believe it?" " Oh, the nerve of that man!" "Now, how could anyone possibly forget someone telling them wood is good?" "Why does that sound so familiar?" "So then, I said to him..." "Thank you." "I love the green ones!" "Oh, I know." "I'll get you one." "Hey..." "What's this?" " "Wood is good"?" " Oh, that's where I've seen it." "Oh!" "You have a message." "[ ♪ ]" "And now it's time now for my favourite segment," ""Fred Was Right!"" "Men: [ On tape ] ♪ Fred was right ♪" "I was right when I said that zero Muslims would go three rounds with the Punching Padre." "Sad, isn't it?" "Rev, would you say that Islam is a culture of cowardice?" "Look, Fred." "I want to make it clear that I have the utmost respect for all faiths!" " Oh." "Except for the Mormons, of course." " Yes." " All that gingham." " Mm-hmm." "I'm just saddened for the kids, the Christian kids, the Muslim kids." "This was supposed to be a charitable event." "But no event, no charity!" "And all because no Muslim had the prayer beads to step into the ring." " [ Cynical chuckle ]" " Yes." "Once again, Fred was right." "[ On tape ] ♪ Fred was right ♪" " Never get tired of hearing that." " That's good, yeah." "Wrong, Fred!" "And Reverend, you have your Muslim and you'll have your fight." "Whoa." "You know, on the one hand I love a good fight but on the other, you kind of kyboshed the name of the segment there." "[ Patting shoulder ]" "[ ♪ ]" "{ Advertisement }" "Thank you all for coming to this press conference." "What conference?" "It's just you!" "Ahem!" "Mr. Rashid?" "Zach Whitman." "Mercy Junior High "Clarion"." "Did you know that the Reverend was a seminary boxing champion?" " No!" "I did not know that!" " Nate:" "He was?" " Yeah." " Wow." "Ha!" "Reverend, are you predicting that you'll win easily?" "Oooh." "Good question." " Um..." " Tuffy Wilson: [ Whispering ]" "No, no, no." "Of course not." "He's a powerful opponent." "He's wiry, he's, um... did I mention he's wiry?" "[ Scoffs ]" "Well, look." "I'd be lying if I said I wasn't worried." "His nickname was the Minister of Justice!" "Well, Amaar is the Imam of Mercy!" "That's not my nickname." "That's my title." "Well, I was on the spot." "I've never done a press conference before, okay?" "Okay, this press conference is over." "How about some photographs?" " Oh!" " Hm?" "Nate:" "Oh yeah, oh yeah, oh yeah." " Yeah." " That's good." "[ ♪ ]" "Got a minute?" "Ah, my prodigal contractor returns." "Yeah, about that." "Funny story." "Ah, I like funny stories." " Well then you're going to love this one." " Yeah?" "See my wife, wonderful woman, she took down your message and then lost it in a box of chocolates!" "Isn't that funny!" "Only if your name's Forrest Gump." "[ Sharp exhale ]" "Now, I understand that you Christians are all about forgiveness." " That's what it says in the ads." " Hate the sin, not the sinner." "Hate the paint, not the painter." "[ Sharp exhale ]" "Hate the wall, not the..." "Well, I think you know the formula." "[ Grunts ]" "So, I gather you want to finish the job?" "Is there a stronger word than yes?" "Well, I'd be delighted to take you back." "Wonderful!" "I'll start straight away." "Great!" "Because the original deadlines are still in effect." "No." "I've lost a day." "And tomorrow's the" "Youth Centre Revival Children's Thing." " The whole town will be there." " That's what we're hoping." "But I'll never find anyone to work!" "But that's my problem." "'Cause you're busy hitting things." "[ Sharp exhalations ]" "That's it." "Left." "Left." "Left." "Left." "Left." "Keep your right up." " Why?" " To throw him off!" " [ Sighs ]" " Left." "Left." "Okay, my left arm is getting kind of sore." "We've got to build it up!" "We're going to make you the best darn southpaw in town!" "I'm not left-handed." "Okay!" "New strategy." "Let's see the right!" "What's the matter, Amaar?" "Is it 'cause he's bigger than you?" "Stronger than you?" " Are you afraid of getting hit?" " I am now." "This might help." "[ Deep exhale ] [ '80s rock ♪ ]" "What's wrong?" "You were killing him!" "That's the problem." "You know when I said I didn't want to fight Thorne?" "That wasn't true." "I do want to fight him." " I really want to fight him. [ Pounding ]" " So fight him!" "This is supposed to be a friendly little charity match." "I'm not supposed to fight out of anger." "Because someone's smug, condescending face is making me want to hit him harder, again and again [ Yelping ] and again and again and again and again!" "[ Crying ] No, no hit!" "No hit!" "No hit!" "What happens if I start punching Thorne and can't stop?" "Don't punch him." "Bob and weave for three rounds and we'll call it a win." "I can do that!" "So, what now?" "Now we turn you into a lean, mean, evading machine." "I'm sorry we're stuck here, it's all my fault." "Yes it is." "Now sand all the way up to that joist." "Joist is a funny word." "It's like it's got a built-in Brooklyn accent." ""Foist" I'll hoist the joist." "That'll build up my "thoist"!" " Yes, Sarah." "Sand, sand, sand!" " Oh." "Or we'll never finish in time." "Oh, I don't think it's going to be much of a clash." "I love Amaar, but it should be called the Mush of the Muslim." "Oh, I don't know." "I think Amaar could really land a few choice blows" " on that smug Reverend's face!" " Yeah." " Thorne:" "Ahem." " Hello!" " Hi." " Hello." " We were talking about another Reverend." " We were." " Um... not you." " No." "Reverend..." "what was his name?" " Uh..." "Joist." " Reverend Joist, yeah." "Ah!" " Back to work, dear." " Okay." "Right." "[ ♪ ]" "Fatima:" "Salaam alaikum." "Oh, walaikum assalaam, Fatima." "I have a new menu item." " The Hero Amaar Sandwich." " Oh, I'm humbled." "It's just like the regular hero sandwich." " Except flattened. [ Sniggering ]" " I'm extremely humbled." "Know that you have my full support for this fight" " and for the aftermath." " What aftermath?" "I will capably run the mosque for you during your lengthy recovery." "That's comforting." "And did you see "Million Dollar Baby"?" "If you need, I will be happy to shut off life support." "Because I care." "[ Sigh ]" "Mmm... are you ready to go?" " You're up in an hour." " Yeah." "To the death!" "If Baber ran the world." "[ Awkward laugh ]" "[ ♪ ]" "Fred:" "Well, welcome folks to Tuffy's Muscle Hut and we're moments away from the Clash of the Clerics." "A classic Achmed versus Goliath battle." "And now I'm going to turn things over to our celebrity ring announcer, the Worship herself," "Mayor Ann Popowicz." " Ooh!" " [ Applause ]" "Thank you, thank you." "I do it for the kids 'cause, you know, let's face it they'll be able to vote in a few years." " [ Scattered laughs ] - [ Fake laugh ]" "In this corner, from Mercy Mosque, weighing 157 pounds... boy, I should really consider cutting out pork..." "[ Laughter ]" "Anyway, The Imam of Mercy..." "Oh really, is that what they came up with?" "Amaar Rashi-i-id!" "[ Applause ]" "And in this corner, from Mercy Anglican, the Minister of Justice," "Reverend William Tho-o-o-o-o-orne!" "[ Applause, cheers ] [ '80s rock ♪ ]" "Fred:" "And, we're about to get things underway here, folks." "Of course, the tension, you could almost cut it with a knife, in here, it's a..." "Very, very excited crowd..." "Are you going to float like a butterfly, sting like a..." " butterfly?" " Yeah." "We're with you, Father." "[ Mixed comments, laughter ]" "Look, Reverend." "I know we've had our differences in the past" " but I think..." " May the better religion win." "[ Grunts ]" "And things are about to get going and..." "Let 'em have it!" "Ooh!" "[ Clang ]" "Fred:" "And the fight is on!" "Thorne, oh very aggressive off the top and uh, look at him, he's all over Amaar right now." "That's good, stay out of his way." "Stay." " Good, Amaar, stay out of his way!" " This is a very strange technique." "Fred:" "He's going to wear out the tread on his boots, he's moving so fast in there." "Look at him go." "Are we going to fight or are we going to dance?" "Come on, Amaar." "Come on!" "[ Sharp exhalations ]" "Ooh!" "Out of his way." "Faster." "[ Grunting ] Mrs. Wispinski:" "Hit him, Father!" " [ Squealing ] Yes!" "Yes!" " But not too hard!" "Wilson:" "Good one, Rev!" "[ Grunting ]" "Crowd: [ Gasping ]" "[ Grunting ]" "Fatima:" "Hit him, Amaar!" "[ Mixed shouts ]" "[ ♪ ]" "Wilson:" "Keep it up!" "Oh!" "[ ♪ ]" "Fred:" "What a pounding!" "Is Amaar just another Muslim on a suicide mission?" "What?" " Oh!" " Crowd: [ Gasping ]" "And..." "that should be the end of round one." "Popowicz?" "[ Laughing ] I'm doing it!" "[ Clanging ]" "Fred:" "And that'll bring the first round to a close and it does not look good for the "Imaminator" in there." "[ Laugh ] No, sir-ee." "Thorne was all over him like white on rice." "You're doing great!" "Seems like I'm evading myself right into his fists!" "Who knew that his arms were so long?" " I Know!" "Any words of advice, coach?" " Yeah, stay out of the corners, stay off the ropes and clear the centre." "Maybe I should do everyone a favour and just wait outside." "Two more rounds, and sure." "And let's get her going." "[ Clang ]" "Fred:" "And the fight is on, ladies and gentlemen." "Oh-ho-ho-ho, the punishment has already started!" "Or is Amaar just too darn scared to fight back?" "Crowd: [ Gasping ]" "Thorne is just turning him into a speed bag, ladies and gentlemen." "Hit him, Amaar!" "Hit him!" "Why isn't he hitting him?" "He has too little hate in his heart." "This is why he's not fit to lead." "My wife would punch better!" "Crowd:" "Ohhh!" "No mercy!" " What did we miss?" " This." "Yasir:" "Oooh!" "Amaar!" "You can hit him now!" "I finished the pillars!" "Hit him!" "[ Shrieking ] Hit him!" "Ooh, Ama-a-ar." "[ Grunts ]" "This is a tough one for you." "[ Grunts ]" "Maybe it'd be better if you just..." " [ Grunting ] - conceded, huh?" "Can't do that, Rev. But you go ahead and be my guest." "Ah, it's fine. 'Cause either way I win." "[ Sharp exhale ]" " How do you figure?" " Well, there's two options." "Option one: you back down now, everyone thinks I tamed the Muslim menace." " Ah!" " Oh!" "Option two:" "I knock you down in front of everyone" " and I look crushingly superior." " [ Moans ]" "Crowd:" "Oh!" "Either way, I win!" "Whoo-hoo!" "[ Grunting ]" "Oh-h!" "Look at him!" "Oh, he's waving to the crowd" "They love him here, ladies and gentlemen." " Well there was a third option, Rev." " Yeah, what's that?" "Third option is I win!" "[ Grunting ]" "Fred:" "What the heck is going on?" "Amaar is coming out of nowhere!" " Church ladies: [ Squealing ] Oh, no!" " Yes!" "Fred:" "Oh my goodness!" "Holy man down, ladies and gentlemen!" "I can't believe it!" "Yes!" "[ Laughing ]" " Two, three!" "It's over!" " Crowd: [ Shouting ]" "Fred:" "He's out!" "It's over!" "Thorne has lost the fight!" "Amaar is the winner, ladies and gentlemen!" "I don't believe it." "[ Cheering ]" "We can wait three days, he's not getting back up again." "{ Advertisement }" "Where is he?" "Amaar?" "Rayyan:" "Wow." "I can't believe you did that!" "You decked him!" " I didn't know you had it in you." " Neither did I." "So what happened to the lean mean evading machine?" "I lost my cool." "He got me angry!" "{\pos(190,200)}So you're not a machine after all." "{\pos(190,200)}You're human." "And humans make mistakes." "...forgiving us..." "[ Thump ] Ah!" "Aaah..." "The important thing is how you feel now." "{\pos(190,180)}Kind of good?" "But mostly..." "Ow!" "Subtitle by:" "Kiasuseven"

Efficacy, safety, and acceptability of thermocoagulation for treatment of cervical intraepithelial neoplasia in a hospital setting in Brazil. To analyze the acceptability, safety, and effectiveness of thermocoagulation for the treatment of histologically proven cervical intraepithelial neoplasia grade 2-3 (CIN2-3) lesions. In a retrospective study, data were obtained for women treated for CIN2-3 lesions by thermocoagulation at the Hospital de Clínicas de Porto Alegre, Brazil, between March 6, 2012, and October 29, 2013, and followed up after 1 year. The proportions of women with no evidence of disease, adverse effects, or complications were determined. Among 52 women included, 44 (85%) had no evidence of disease 1year after thermocoagulation. The rate of no disease at follow-up was similar for women treated for CIN2 (17/20 [85%]) and CIN3 (27/32 [84%]). No serious adverse effects or complications requiring hospitalization were observed during the follow-up period. Thermocoagulation is useful in the management of ectocervical CIN and should be integrated into public health services for management of cervical cancer.

Over the past several decades, substantial effort has been invested in the design and development of improved internal combustion engines. Design efforts have been, directed toward the creation of smaller, lighter engines with improved fuel efficiency and power. Engines have been characterized by their method of combustion, e.g., compression (diesel) or spark-ignited (gasoline). Further, engines are described and identified by the orientation and/or number of their pistons and cylinders, e.g., V-8, in-line 6, radial, Wankel rotary, horizontal and horizontally-opposed. Internal combustion engines with horizontally-oriented pistons and cylinders have been the subject of much research over the past several decades. Their inherent low profile offers an opportunity to reduce engine size while maintaining fuel efficiency and power. Various countries have introduced several variations of both four cylinder and six cylinder horizontally-oriented engines. A typical horizontally-oriented engine configuration includes multiple pairs of horizontal cylinders with a separate piston slidably disposed in each separate cylinder. The top or "crown" of each piston, in combination with the cylinder walls and a separate cylinder head, forms a unique, single combustion chamber. Each cylinder head, also provides a separate surface for intake and exhaust valve assemblies. In the case of spark-ignited engines, each cylinder head also provides a port for installation of some means for igniting the combustible mixture, usually a spark plug. For a typical horizontally oriented engine, each piston is connected to a common crankshaft. During operation, a mixture of air and fuel is introduced into each combustion chamber. The mixture is then combusted, by either compression (diesel engines) or a spark (gasoline engines). When combusted, the energy generated by the exothermic expansion of the combustible mixture serves to drive the piston away from the cylinder head. In so doing, the piston's linear kinetic energy is delivered to the engine's crankshaft by a connecting rod rotatably attached to the piston. The crankshaft then delivers rotational power to the power train. Several patents have offered modifications to the typical horizontally-oriented piston and cylinder configuration. Most notably, and of relevance to the present invention, is that prior art which teaches horizontally-oriented engine configurations with one combustion chamber shared between two or more pistons/cylinders. Generally, these types of engines are known as horizontally-opposed engines. For example, Henry (U.S. Pat. No. 1,533,004) teaches an internal combustion engine with a combustion chamber shared between two cylinders. The shared combustion chamber is formed by the walls of two interconnected cylinders, the crowns of two opposing pistons which slidably reciprocate within the cylinders, and a single cylinder head. In addition to acting as a wall of the shared combustion chamber, the cylinder head provides a surface for intake and exhaust ports as well as spark plug access. In Henry, the pistons simultaneously converge toward each other and then simultaneously diverge away from each other during the various engine cycles. Other patents, including most notably Feeback (U.S. Pat. No. 3,485,221), Rassey (U.S. Pat. No. 4,244,338), Johnson (U.S. Pat. No. 4,554,894) and Honkanen (U.S. Pat. No. 5,133,306) have proposed variations on the horizontally-opposed engine configuration. Each of the above include intake and exhaust valve assemblies which are located to the side of each cylinder pair. Consequently, as with Henry discussed above, these engines all require at least one separate cylinder head per cylinder pair. Other relevant prior art teaches internal combustion engines with shared combustion chambers, but whose converging pistons are not horizontally-oriented. For example, Ascari (U.S. Pat. No. 5,447,818) teaches an engine with at least four cylinders that form two separate shared combustion chambers. Two cylinders and pistons are oriented at angles of approximately ninety degrees to each other, with the crown of each piston oriented toward a shared plane of symmetry. Ascari likens his engine to a "superimposed twin V." Again, the shared combustion chamber is formed by the cylinder wall, two piston crowns and a single cylinder head. The prior art clearly evidences that the ability to reduce the overall size and weight of opposed piston engines with shared combustion chambers has been hampered by the need to include a suitable surface, i.e. a cylinder head, to accommodate the shared intake and exhaust valve assemblies. As previously indicated, in engines without shared combustion chambers, each cylinder has a cylinder head which provides a surface for the valve assemblies. Engines with shared combustion chambers have generally provided for the placement of the shared intake and exhaust valve assemblies in a separate "cylinder head-like" element that is separately bolted to the side of the cylinder blocks. The present invention advances the prior art by eliminating the need for a separate cylinder head. Although the prior art teaches reduction in the number of required cylinder heads for dual piston/cylinder engine configurations from two to one, it still struggles with valve design and placement. The intake and exhaust valve assemblies are typically located between the ends of the dual cylinders to serve a common or shared combustion chamber. Consequently, this additional space requirement frequently limited the ability to bring the ends of the cylinders, and hence, the crowns of the pistons, closely together. The patent to Rassey specifically teaches that "previous attempts to adapt poppet valves [in horizontally-opposed engines] have proven largely unsuccessful since the poppet valves cannot be positioned above the piston head as in the more conventional internal combustion engines." Accordingly, a need exists for a cylinder/piston configuration of simple and reliable design which includes a combustion chamber shared between two horizontally-opposed cylinder/piston assemblies, yet allows the use of poppet valve assemblies to service the shared combustion chamber, while eliminating the need for a separate cylinder head to house the valve assemblies, thereby minimizing the size, weight and vertical profile of the engine for equivalent power requirements and providing for smoother, more efficient and less polluting operation.

Antibodies against synthetic peptides as a tool for functional analysis of the transforming protein pp60src. To study the function of pp60src, the transforming protein encoded for by Rous sarcoma virus, we have raised antibodies against synthetic oligopeptides corresponding to the primary structure of pp60src. All eight investigated peptides were immunogenic in rabbits, and four induced pp60src-specific antibodies. We screened tumor-bearing rabbit (TBR) sera for antibodies against the peptides; this revealed that five out of six of the peptides, chosen according to a high hydrophilicity plot, were related to epitopes of native pp60src, in contrast to two peptides of low hydrophilicity, which contained a cleavage site for protease. Antibodies against three of the peptides appeared to react with the kinase-active site of pp60src, as these antibodies were phosphorylated in their heavy chain upon immune precipitation. Antibodies against two of the peptides, in contrast to the others, did not precipitate pp60src when this molecule was complexed with two cellular proteins, pp50 and pp90. This observation allows speculation about the location of the pp60src site involved in the formation of this complex.

This invention relates to drywall finishing, and more particularly to a method of reducing the time required to finish drywall joints and to a compound for sealing drywall joints. The building industry widely uses gypsum board in the construction of residential homes, commercial buildings, and other structures. The gypsum board, also known as sheetrock or drywall is usually pre-cut in flat sheets of 4xc3x978 or 4xc3x9712 foot, having a thickness of xc2xd or ⅝xe2x80x3. The sheets of the gypsum board are hung on wood or metal studs to form an interior wall of the building. Typical walls have joints between the sheetrock segments that must be covered to form a smooth surface for application of the wallpaper or paint. A conventional method of finishing the drywall comprises a number of steps. First, a drywall joint compound is deposited along the joint as a thin bead. The drywall joint compound usually has limestone, water, mica, vinyl acetate polymer and may also have talc. The limestone may be substituted by dolomite or gypsum. If the compound comes as a dry powder, it is mixed with the necessary amount of water, stirred and then applied with a six-inch joint finishing knife to the joint. Immediately after that, a drywall tape is placed over the bead of the drywall joint compound and the joint finishing knife is run over the tape to press the tape and cause it to adhere to the compound. The first coat of the compound with the tape is allowed to dry for 24 hours. Then a second coat of the joint compound is applied over the first coat to cover the tape completely and to cover the interface between the tape and the wall. The second coat is allowed to dry for 24 hours. Then a third coat is applied with a 10-inch joint finishing knife to make a wide strip of the joint compound on the wall that would entirely cover the tape as well as the first two coats. When the final coat dries, again for about 24 hours, it is sanded to remove imperfections and achieve a smooth finish. The dust is wiped off or blown off to make the wall ready for wallpaper or paint application. The disadvantage of the conventional method is that it requires 3-4 days to finish one wall, with a 24-hour drying period between joint compound applications. The drywall finisher has to come back to the same job several times before the walls are finished. The time spent on finishing the walls directly translates into the cost of the building construction. It would be therefore a considerable advantage to provide a method that would reduce the labor time in finishing the drywall and thereby reduce the overall cost of construction. The present invention contemplates provision of such a method and a novel compound for finishing a drywall that would reduce the curing time and eliminate the need for multiple joint compound applications. It is, therefore, an object of the present invention to provide a method of finishing a drywall by eliminating the number of coats necessary to finish a drywall. It is another object of the present invention to provide a drywall joint compound that has reduced curing time and is strong enough even with one application. These and other objects of the present invention are achieved through the provision of a method of finishing a drywall, which includes the steps of mixing a drywall joint compound with a predetermined amount of water and a synthetic fiber, such as Columbian fiber. An optional liquid wallpaper adhesive may be added to the mixture. The mixed compound is then applied to the joint between the drywall sheets and allowed to dry for 24 hours. No further applications of the compound are necessary. The drywall joint becomes sealed with a smooth, strong seal. The composition of the present invention contains between about 97.68% to about 98.8% of sheetrock compound, between about 0.247% to about 0.97% of water, between about 0.494% to about 0.73% of synthetic fiber, and between about 0.37% to about 0.61% by weight of the vinyl adhesive. The adhesive is selected from the family of vegetable adhesives The presence of the synthetic fiber reduces the chance of the joint cracking, making the sealed joint somewhat xe2x80x9cflexible.xe2x80x9d At the same time, the joint seal is stable, capable of withstanding settling of the house, while preserving the even, smooth surface for the application of a wallpaper or paint. The same compound may be used for repairing the drywall and covering holes or punctures in the wall. The compound of the present invention eliminates the need for mesh fabric, which is conventionally used when repairing a drywall.

Alcohol use in women 65 years of age and older. The purpose of this study was to examine the relationships between depression, codependency, self-coherence, and alcohol use and health outcomes in women 65 years of age and older. The framework is Erikson's ego-development theory. A convenience sample of 238 women was obtained from women attending flu shot clinics. This cross-sectional field study used survey methodology. Measures included the Beck Depression Inventory, Codependency Assessment Tool, Self-Coherence Survey Form C, Alcohol Use Disorders Identification Test, Alcohol Use Questionnaire, Self-Rated Health Tool, Quality of Life Visual Analogue Scale, Functional Ability Scale, Illness Prevention Screening Behaviors Checklist, and Sociodemographic Data. Results indicate a low consumption and little variation in use of alcohol. There were no significant associations between alcohol consumption and the dependent variables. Depression was significantly related to all the health outcomes; codependency was significantly related to all health outcomes except perceived quality of life; and self-coherence was significantly related to all health outcomes except illness prevention behavior. These findings have important implications for those providing care for older women.

The present invention relates to a disk array device and a technique for controlling the same and, more particularly, to a technique effectively applied to a controlling method of replication of a storage unit system that can be connected to a plurality of different kinds of networks. The inventors of the present invention have examined a conventional disk array device and a technique for controlling it and consequently understood as follows. Recently, there has been a rapid increase in quantity of data to be handled in a computer system. To efficiently utilize and manage such vast data, there has been developed a technique which connects a plurality of disk array devices (hereinafter “storage unit systems”) and an information processing apparatus to each other through a dedicated network (Storage Area Network, which is hereinafter abbreviated as “SAN”) so that high-speed and vast data access to the storage unit systems can be realized. In order to realize high-speed data transfer by connecting the storage unit systems and the information processing apparatus to each other, generally the network is built up using a communication instrument that complies with a fiber channel protocol. Meanwhile, there has been developed a network system referred to as a network attached storage (NAS), which connects a plurality of storage unit systems and an information processing apparatus to each other through a network that uses a transmission control protocol/Internet protocol (TCP/IP) so that the storage unit systems can be accessed at a file level. In the NAS, a device having a file system function is connected to the storage unit system, so that it is possible for the information processing apparatus to gain access at a file level. See Japanese Patent Laid-open No. 2002-351703.

In vivo voltage-sensitive dye imaging of the insular cortex in nerve-injured rats. The insular cortex (IC) is a pain-related brain region that receives various types of sensory input and processes the emotional aspects of pain. The present study was conducted to investigate spatiotemporal patterns related to neuroplastic changes in the IC after nerve injury using voltage-sensitive dye imaging. The tibial and sural nerves of rats were injured under pentobarbital anesthesia. To observe optical signals in the IC, rats were re-anesthetized with urethane 7days after injury, and a craniectomy was performed to allow for optical imaging. Optical signals of the IC were elicited by peripheral electrical stimulation. Neuropathic rats showed a significantly higher optical intensity following 5.0mA electrical stimulation compared to sham-injured rats. A larger area of activation was observed by 1.25 and 2.5mA electrical stimulation compared to sham-injured rats. The activated areas tended to be larger, and the peak amplitudes of optical signals increased with increasing stimulation intensity in both groups. These results suggest that the elevated responsiveness of the IC to peripheral stimulation is related to neuropathic pain, and that neuroplastic changes are likely to be involved in the IC after nerve injury.

In paging systems, subscribers receive page messages, or pages, that have been sent by users of the paging system. Generally, pages only go to the subscribers that they are intended for, and likewise, subscribers only get the pages that are intended for them. A unique use of paging systems arises when third party subscribers, or message monitoring users, wish to obtain pages that are intended for others. One example of a message monitoring user that may wish to receive another's pages is a law enforcement agency. In prior art systems, when law enforcement agencies wish to be message monitoring users, they are supplied with duplicate pagers so that when a page is sent to a user that they wish to monitor, the law enforcement agency also receives the page. This approach requires the law enforcement agency to maintain a number of operational pagers, one for each user being monitored. This also requires the law enforcement agency to be within the reception area of the target user so that the duplicate pager used for monitoring purposes can receive the monitored page. In addition to law enforcement agencies, various private users may also have the need to monitor messages intended for receipt by others. Two specific examples of potential private message monitoring users that are not currently being serviced by the paging industry are employers and parents. Many employers supply their employees with employer owned pagers for business use. The employer may need to monitor the use of these pagers to ensure that business is conducted appropriately, or to ensure that company owned pagers are not being misused. Parents or legal guardians are another example of a group of potential message monitoring users that have not been serviced by the paging industry. Parents may desire the ability to monitor the activities and pages of their children, and yet there are currently no message monitoring services available to parents. Adapting the current law enforcement solution to private parties such as parents is not entirely feasible, because parents would not be likely to carry a duplicate pager for each child. Even if parents were to carry duplicate pagers in order to monitor multiple children, with existing prior art systems the parent would have to stay within the reception area of the children in order to receive the pages. Moreover, if all of the children being monitored are not within the same reception area, the parent cannot simultaneously monitor all children. Paging systems currently known in the art lack a mechanism for a single user to conveniently monitor pages sent to multiple other users. As a result, when a message monitoring user is interested in monitoring multiple other users, the message monitoring user carries multiple duplicate pagers, and is confined to the reception area of the user being monitored. What is needed is a method and apparatus for allowing a message monitoring user to conveniently receive copies of page messages intended for multiple other users. Also what is needed is a method and apparatus which provides for a message monitoring user to conveniently specify which users are to be monitored. Also what is needed is a method and apparatus to allow a message monitoring user to receive page messages intended for others even when the message monitoring user is outside of the page delivery range of the monitored parties.

The impact of multiple sclerosis on the identity of mothers in Italy. This paper reports on one of the themes that emerged from the analysis of the study, regarding the perceived influence of multiple sclerosis (MS) on the identity of mothers in the socio-cultural context of Italy. In-depth interviews were conducted with 16 women at various stages of MS, with follow up interviews with seven of the women. Phenomenology guided the methodology and the analysis was conducted using interpretative phenomenological analysis. Through the research the value of motherhood to the women who participated emerged. The findings illustrated how many strove to maintain control of their MS, which led to some making comparisons of themselves and other mothers and feeling different. Some women described how they adjusted their roles and found strength in being mothers but others spoke of their feelings of loss. Most women described living in the moment, appreciating the present and living each day as it came. Another significant experience was fear of stigma, both realized in the form of "pity" from others, and the perceived and actual associated stigma for their families. This contributed to why some women were reluctant to disclose their condition. The mothers who took part in this study differed in how they perceived their disabled identity. Although this study was conducted in the socio-cultural setting of Italy, the findings have implications for professionals working with disabled mothers and women with MS in Italy and beyond; including recognizing the value associated with fully identifying oneself as a mother, rather than solely focusing on doing mothering tasks. Implications for Rehabilitation Professionals need to be mindful of the value of motherhood for women with multiple sclerosis. Professionals should support women who feel like they are battling with maintaining control of their multiple sclerosis, who may be adjusting their identity as mothers; recognizing that they may be influenced by the stage of their multiple sclerosis and whether they were diagnosed before or after having their children. Women can have feelings of loss related to their ability to fully participate in their children's lives and professionals should work with women to help them identify the value of their mothering role not only in physically participating in activities but also in being emotionally and physically present as a mother.

In recent years, movements of construction of a wireless communication network using a flying object such as a satellite and a balloon have been active. The wireless communication network using a flying object has an advantage that, in comparison with a communication network constructed on a surface of the ground, a base station is unlikely to encounter a disaster, for example, by constructing the base station on a flying object, and thereby disaster-resistant property is improved. Further, the wireless communication network using a flying object also has an advantage that a cost for construction such as installation of wiring facilities can be reduced. It is predicted that users of such a wireless communication network using a flying object increase, and with an increase of the users, it is supposed that frequency bands of radio waves used in the wireless communication network are tight. Therefore, as wireless communication used in the wireless communication network using a flying object, attention is paid to free space optics (FSO) using an optical frequency band expected to become markedly broadband, instead of microwaves that are currently mainstream. In order to achieve a large-capacity free space optics system, a speeding-up technique of a bit rate of a transmission signal light and a wavelength division multiplexing technique are required. Further, in a free space optics system, since a signal light is propagated for a long distance between a flying object in midair and the ground, attenuation of the signal light during the propagation is large, and therefore a high-sensitive reception device is required. For the reception device, a technique common to an optical fiber communication technique, specifically, an optical transmission/reception technique using a single mode fiber (SMF) is applied. The reason why the single mode fiber is used in a free space optics system is that an optical transmission/reception technique such as a low-noise and high-gain direct optical amplification technique, a high-sensitive digital coherent reception technique, a high bit-rate transmission/reception technique, and a dense wavelength division multiplexing (DWDM) technique can be used. In a free space optics system using a single mode fiber, it is necessary for a signal light (laser light) propagated in a free space to enter (be coupled with) a core having a small core diameter in the single mode fiber. Therefore, in a free space optics system between a flying object in midair such as an artificial satellite, and a ground station, in order to condense sufficient optical power, a reception device needs to include a telescope having a large aperture diameter. Herein, an aperture of the telescope is equal to or more than several times a spatial coherence radius of a signal light (laser light) propagated in the atmosphere, and therefore the signal light is likely to be affected by turbulence of the atmosphere such as wind. In other words, when passing through a portion where a local fluctuation of a refractive index of the atmosphere caused by a turbulence phenomenon and a thermal phenomenon occurs, a signal light is refracted and the signal light is deflected due to the refraction. Therefore, a disturbance of a beam spot of a signal light condensed by a telescope increases. In this manner, an intensity of a signal light that enters a reception device largely varies due to a disturbance of a beam spot, and therefore, in a free space optics system, a problem that stable communication is difficult occurs. In particular, when a large attenuation (fade) of a signal light due to a large intensity variation occurs, an error or lack of reception data is caused. Therefore, in a free space optics system, a problem that an overhead of forward error correction (FEC) increases and a problem that retransmission processing becomes necessary occur. Such problems cause a decrease in an effective throughput of a free space optics system. As described above, in a free space optics system, due to a disturbance of a wave-front to which a signal light is subjected during atmospheric propagation, a problem that communication becomes unstable may occur. A large number of techniques for solving such the problem have been proposed heretofore. A reception device disclosed in PTL 1 (Japanese Translation of PCT International Application Publication No. 2013-535871) includes a light condensing unit, a wavelength demultiplexer, a plurality of optical detectors, and a signal processing unit. The reception device is configured to collect light on a plurality of individual fiber end faces from the wavelength demultiplexer and converge a signal light to a single output fiber to be input to the optical detector by using a fiber bundle or the like that is gradually thinner. By such a configuration, in the reception device, stable fiber coupling is achieved even against a disturbance of a beam spot. Further, PTL 1 also discloses a configuration in which a core diameter is decreased to a diameter equal to that of a single mode fiber in a tapered shape, and thereby a coupled signal light is converged on a core of the single mode fiber and connection to an optical component adapted to a next-stage single mode fiber is made possible. A communication device that constructs a free space optics system disclosed in PTL 2 (Japanese Registered Patent Publication No. 4701454) includes a light condensing unit, a fiber bundle, a plurality of optical receivers, a plurality of optical transmitters, and a transmission/reception control unit. The communication device is configured to transmit a signal light from the same position as a light condensing position of a signal light received from an opposite device. By this configuration, regardless of deflection of a light condensing system due to an atmospheric fluctuation and a peripheral temperature change, in the opposite device side, a signal light from the communication device is condensed to a signal light emission point. NPL 1 (“Next-generation Extremely Large Optical Infrared Telescope Planning Instructions”) discloses an adaptive optics (AO) technique that measures and corrects distortion of a wave-front of a signal light. In the technique, a wave-front of a reception light distorted due to an atmospheric fluctuation is observed by a wave-front sensor and a wave-front correction element using a micro electro mechanical system (MEMS) or the like is controlled by using the observation result.

"'Previously on "Hannibal"...'" "I can't be with you." "You're becoming." "The dragon is your higher self." "There's a family out there who don't know he's coming." "They're not my family, and I'm not letting them die." "You are." " What did you say to him?" " "Save yourself." "Kill them all."" "Then I gave him your home address." "How's the wife?" "I look at my wife and I see her dead." "I see Mrs Leeds and Mrs Jacobi lying where Molly should be." "Do you see yourself killing her?" "Yes." "Over and over." "It's hard to predict when brittle materials will break." "Hannibal gave you three years to build a family, confident that he would find a way to take them from you." "And he has." "What's he going to take from you?" "Is it important to you that he take something from me?" "Hannibal has agency in the world." "Hannibal has no intention of seeing me dead by any other hand than his own." "And only then, if he can eat me." "He's in no position to eat me now." "If you play you pay." "You have paid dearly." "It excites him to know that you are marked in this particular way." " Why?" " Why do you think?" "Bluebeard's wife." "Secrets you're not to know, yet sworn to keep." "If I'm to be Bluebeard's wife," "I would have preferred to be the last." "Is Hannibal in love with me?" "Could he daily feel a stab of hunger for you and find nourishment at the very sight of you?" "Yes." "But do you ache for him?" "Will's thoughts are no more bound by fear or kindness than Milton's were by physics." "He is both free and damned to imagine anything." "Now that he's imagined the worst." "Like ducklings, we imprint on those ideas that grab our attention." "What's got your attention, Doctor?" "God, the Devil and the Great Red Dragon?" "Lest we forget the Lamb." "Will is the Lamb of God?" "Hide us from the wrath of the Lamb." "Who's "us"?" "You, me and the Great Red Dragon." "The Lamb's wrath touches everyone who errs." "His retribution is even more deadly than the Dragon's." "It is for you." "The seals are being opened, Jack." "The lamb is becoming a lion." ""For the great day of his wrath is come;" "and who shall be able to stand?"" "I'll still be standing." "Is your conscience clear?" "As clear as yours." "Righteousness is what you and Will have in common." ""In righteousness, the Lamb doth judge and make war."" "War against the Great Red Dragon." "He's not the Dragon, you are." "The Devil himself bound in the pit." "Then that makes you God, Jack." "Yes, it does." "All gods demand sacrifices." "We don't have anything else." "Eight people dead in a month." "We can't play the long game." "You know and I know it's the best way to bait him." "Got me on the hook, now you're dangling me to catch a bigger fish." "It was your suggestion." "And you're thrilled you didn't have to make it." "You once fooled yourselves into believing you were in control of what was happening." "Are you still under that delusion?" "The Dragon has a certain abstract curiosity about me." "All psychopaths are narcissists, they love to read about themselves." "If you were smart, Jack, you would use Freddie Lounds." "She will need to interview you, Will." "Take your picture." "I'm in it now." "Can't go home as long as he's loose." "So, I really bad-mouth the Red Dragon in TattleCrime." "Give him a shot at me." "It's gotta be a really good shot." "What about the set-up?" "Something open." "Someplace where he can get close to me." "It feels like a trap to me." "And it'll feel like a trap to him." "Unless you have a professional voice who will legitimise what you're saying." "Someone to hide the wire of the snare?" "Are you volunteering?" "No." "I'd have to be a fool." "Since your commitment, you have written some brilliant articles for The Northern Medical Journal of Psychiatry." "Thank you, Frederick." "I just finished your most recent piece." "Extraordinary stuff!" " A particularly good one." " It may be my favourite." "I have seen a lot of hostility." "But this was quantifiably bitchy!" "Do you think I am your nemesis?" "No." "Nemesis?" "No." " You refuted my entire book." " It didn't hold up to scrutiny." "Of course it didn't, I was lying!" "On your behalf!" "To save your life!" "You refuted your insanity defence." "I went out on a limb for you and you climbed up there and sawed it off!" ""Wood burns because it has the proper stuff in it;" ""and a man becomes famous because he has the proper stuff in him."" "You don't have the proper stuff, Frederick." "I am a best-selling author." "The journals only still publish your writing for the freak value of your by-line." "The attention given to you is dwindling since you have been overshadowed by another creature." "That book is writing itself." "I think I'll call it The Dragon Slayer." "All I need is the ending." "Fate has a habit of not letting us choose our own endings, Frederick." "This is the ending fate has chosen for you." "Your teeth will go and your strength." "Nobody will be afraid of you anymore." "After Dr Bloom's reign, you will be out in the ward." "The young ones will push you around and use you for sex." "All you'll get to read is what you write on the wall." "You have seen the old ones." "They cry when they do not like the stewed apricots." "Oh..." "I'm just going to leave an extra copy of my book right over here." "Thank you, Frederick." "I've personalised it for you." "Are you here to remonstrate me with "I told you so"?" "That's not why I'm here." "She's here because we need someone who's less concerned about the truth than the best story." "Dr Chilton, lay out your theories and Will will aggravate them for the record." "You're making statements no investigator would ever make and no straight newspaper would credit." "You're not a straight newspaper." "You sell T-shirts that say:" ""The Tooth Fairy Is A One-Night Stand."" "I can get you one, if you like." "You small or medium?" "Small, I bet." "They aren't selling so well since you started calling him "The Dragon"." "The killer's objection to the name "The Tooth Fairy" is likely grounded in the homosexual implication of the word "fairy"." "Tedious, I know, but if you really want to piss him off, that's what you should call him." "Very well. "Tooth Fairy" it is." "The Tooth Fairy's actions indicate a projective delusion compensating for intolerable feelings of inadequacy." "Smashing mirrors ties these feelings to his appearance..." "And not only is the Tooth Fairy insane, he is ugly and impotent." "There's a strong bonding of aggressive and sexual drives that occurs in sadists at an early age..." "He's a vicious, perverted, sexual failure." "An animal." "The savage acts aimed primarily at the women, performed in the presence of families, are clearly strikes at a maternal figure..." "The Tooth Fairy is the product of an incestuous home." "This is the child of a nightmare." "Will, I think we need a key shot of you here in your "Washington hideaway"." "I'd love something of you in a bathrobe, sitting at a desk, poring over this artist's conception of the Fairy." "I'll stand by the window." "Make sure you can see the fountain and the Capitol dome." "The Red Dragon needs to be able to find this place, if he wants to." "Frederick, would you like to be in the photograph?" "One for the dust jacket." "That's it, up." "There." "This whole procedure is way too passive for my taste." "We are playing games in the dark of the moon." "He thinks he can do anything." "Maybe he thinks he can stop." "If he can hold off until we catch him, maybe we can help him make it stop." "He almost killed your wife and son." "Hannibal almost killed them." "All right, pedestrian traffic falls off around 7:15." "You should go for a walk, say 8:30 or so." "He'll have to cross open ground to get close." " He'll want to get close." " I've got snipers on the roofs." "You'll be wearing body armour." "Seven out of eleven times, he's gone for the headshot, Jack." "Yeah..." "That's absurd." "That's not what I said at all." "Dr Lecter gave misleading answers in my interviews." "I will refute his refutations in my new book, "Blood And Chocolate"." "Supermarket tabloids love Hannibal Lecter more than alien abductions." "That is his demographic now." "We know who his fans are..." "Would you like a blanket?" "I'll get you a blanket." "Oh, my back hurts." "Oh, my skin." "Oh, did I get burned?" "Did I... did I get burned?" "Hope, dear God, I am not burned." "Burned?" "Burned..." "Burned." "No." "You just rest there." "What am I doing here?" "Atoning, Dr Chilton." "I have not seen your face." "I could not..." "I could not identify you." "I do not know what you look like." "Do you know who I am?" "No." "No." "I do not want to know, believe me." "According to you," "I'm a vicious, perverted, sexual failure." "An animal." "You know now, don't you?" "Yes." "Why did you lie, Dr Chilton?" "Do you understand what I'm doing?" "No." "No!" "But I think I have an opportunity to understand." "Then all my readers could understand, too." "Do you feel privileged?" "It is a privilege." "But I have to tell you, I am scared." "Man to man, I am scared." "And it is... it is very hard to, er... to concentrate when you are scared." "If you have got a great idea, you do not need to scare me for me to be impressed, OK?" ""Man to man."" "You use that phrase to imply frankness." "But you see, I am not a man." "I have become Other and More than a man." "Do you think God is in attendance here?" "Are you praying to him now?" "We pray to God mostly when we are scared." "And does God help you?" "No." "I don't know, I don't know." "I do not know." "I do..." "I do..." "I ought..." "I do not think about it after." " I ought to." " You ought to." "I ought to." "There are so many things that you ought to understand." "And in a little while, I will help you understand." "No, I do not want to see your face!" "When you turn around, you will open your eyes and look at me." "Or I will staple your eyelids to your forehead." "D?" "It's me." "If you make a sound, I will kill her." "I don't like surprises." "I bet you don't, either." "I tried to call you." "May I come in?" "I won't be long." "I asked my taxi to wait." "How are you feeling?" "OK." " Your office said you were sick." " The flu." "You shouldn't be here." "I brought you soup." "I..." "I didn't come just to give you soup, D." "I guess I'm guilty of liking you." "Demonstrably guilty." "And I know you like me, too." "I do." "I've learned that withdrawal can be a strategy to avoid pain." "I have a deep vein of cripple's anger in me." "While I can't get rid of it, I've made it work for me." "It's fuelled my independence." "I'm not so scarred by life that I'm incapable of love." "I hope you aren't, either." "Enjoy the soup." "Do you want to know what I am?" "More than anything." "I was afraid to ask." "Look." " Do you see now?" " Yes." " Do you see?" " Yes." "Do you see?" " Do you see?" " Yes." "Do you see?" "Yes!" "Do you... see?" "Yes!" "Do... you... see?" "God!" "Do you see?" "Please!" "No!" " No what?" " Not me." "Are you going to tell more lies about me, Dr Chilton?" " No, no, no..." " Why did you tell lies, Dr Chilton?" "It was the police who told me to." "They... they said it." "You quote Will Graham." "Graham... told the lies." "Graham!" "Will you tell the truth now about me?" "About my work?" "My Becoming?" "My Art, Dr Chilton?" "Is... this..." "Art?" "Art." "You said that I, who see more than you, am insane." "I, who has pushed the world so much further than you, am insane." "I have dared more than you." "I am the Dragon and you call me insane?" "Before me, you are a slug in the sun." "You are privy to a great Becoming, and you recognise nothing!" "It is in your nature to do one thing correctly, and before me you tremble." "Fear is not what you owe me." "You owe me... awe!" "For your journey home." "Ice." "You will need that." "But before we go," "I think we should tape for a little while." "Look straight down the lens." "Repeat after me." "Dr Chilton, you did very well." "You will let me go now?" "I will." "Although there is one way that I can help you better understand and remember." "I want to understand." "And I've got a very good memory." "Hand delivered." " May I open it privately?" " You may not." "Dr Chilton often offended me, so I certainly understand the sentiment." "Where's the other one?" "This one can provide you anything the other one can." "I'm sorry, Jack." "The tragedy of what's happened to Frederick has put me in an excellent humour." "Dr Chilton disappeared yesterday, under armed escort." "You pretended to burn Freddie Lounds in a wheelchair to flush me out." "What were you pretending to do with Frederick Chilton?" "He profiled the Dragon." "For Freddie Lounds." "We wanted to enrage him." "Congratulations." "You could've provided anything Dr Chilton could." "That would've been your lip I was tasting." "Again." "You publicly discredited Dr Chilton." "By refuting him, you orchestrated his end by proxy." "You orchestrated his end, Alana." "You saw the hole and let him roll right into it." "That's professional discourtesy." "'I have had a great privilege." "'I have seen with wonder and awe 'the strength of the Great Red Dragon." "'All that I said was lies from Will Graham." "'I have blasphemed against the Dragon." "'Even so, the Dragon is merciful." "'Because I was forced to lie, 'he will be more merciful to me than to you, Will Graham." "'Reach behind you and feel 'the small knobs on the top of your pelvis." "'Feel your spine between them." "'That is the precise spot where the Dragon will snap your spine." "'There is much for you to dread." "'From my own lips, you will learn a little more to dread.'" "Would you like to talk about what happened with Frederick Chilton?" "The divine punishment of a sinner mirrors the sin being punished." "Contrapasso." "You play, you pay." "Chilton languished, unrecognised, until "Hannibal the Cannibal."" "He wanted the world to know his face." "And now he doesn't have one." "Damned if I'll feel." "We are all making our way through the Inferno." "Dante's pilgrims." "No, we're not pilgrims." "We are pets." "And the Great Red Dragon kills pets first." "You put your hand on Dr Chilton's shoulder in the photograph." "Touch gives the world an emotional context." "The touch of others makes us who we are." "It builds trust." "I put my hand on his shoulder for authenticity." "To establish that he really told you those insults about the Dragon?" "Or maybe you wanted to put Dr Chilton at risk?" "Just a little?" "I wonder." "Do you have to wonder?" "No." "What did you think the Great Red Dragon would do?" "You were curious what would happen, that's apparent." "Is this what you were expecting?" "I can't say I am surprised." "Then you may as well have struck the match." "That's participation." "Hannibal Lecter does have agency in the world." "He has you." "He's trashed." "He did Chilton like it looked like you did Freddie Lounds." "Hannibal said he would in his own way." "Hannibal told him to." " You OK?" " Yeah, I'm OK." "I had the SWAT team." "Chilton said your name when they brought him into the ER." "He's trashed." "You ought to get ready for this." "Frederick, it's Will Graham." "I'm sorry this happened to you." "Can you understand what he's saying?" "He said..." ""You set me up." "You knew it." ""You put your hand on me in the picture like a pet."" "Did you see anything?" ""A black woman." "She's blind."" ""Reba." The Dragon said her name when he called Lecter." "We're here." "If I untie you and let you sit up, will you be good?" "I didn't know you cared this much about me." "I'm glad you feel that way, but you scared me with this." "I never hurt you." "I never wanted to." "Let's just be friends and have a good time and forget about this..." "Shut up." "I'm going to tell you something." "The most important thing that you will ever hear." ""Sermon-on-the-Mount" important." ""Ten-Commandments" important." "Got it?" " Yes, D. I don't..." " Shut up." "Some remarkable events have happened in Chicago and Buffalo." "Do you know what I'm talking about?" "No." "It's been on the news a lot." "Two groups of people were changed." "Leeds and Jacobi." "The police think that they were murdered." "You know now?" "Do you know what they call the Being that visited those people?" " The Tooth F..." " Think." "Answer correctly." "It's..." "Dragon something." "Dragon..." "Red Dragon." "I am the Dragon."

The drive system for a rotating apparatus (such as a centrifuge instrument) typically includes a shaft attached at one end to a motive force (e. g., an electric motor). The shaft supports a load somewhere along its length. One inherent property of such a drive system is load imbalance. Even a very small imbalance in the otherwise symmetrical mass distribution about the drive shaft can cause damaging vibrations. The magnitude of the imbalance places a load on the bearings. This problem can be addressed by providing a degree of flexibility to the drive shaft. However, as this rotating apparatus accelerates to its operating speed the system passes through several critical speeds. A thin, elongate shaft rotating about its longitudinal axis possesses certain natural frequencies of vibration that become apparent at these critical speeds. Passage through a critical speed thus causes the drive system to vibrate, which in turn magnifies the load imposed on the bearings. This increase in load can significantly reduce the life of the bearing. In the example of a centrifuge instrument the vibration may also have a detrimental effect on the sample that is being processed within the rotor of the instrument. Several methods have been proposed in the art to solve the problem of vibration generated during passage of a drive system of a rotating apparatus through a critical rotational speed. One solution is to attempt to damp the vibrations imposed on the system. U.S. Pat. No. 5,026,341 (Giebeler) is an example of a rotating system for use in a centrifuge instrument that restricts the deflection of the shaft, thus damping vibration. Another solution, exemplified by the arrangement disclosed in U.S. Pat. No. 4,236,426 (Meinke et al.), is to alter the physical properties of the drive system in a speed-dependent fashion. As a result, for a first portion of the speed regime of the apparatus, the stiffness of the system is such that the critical speed lies well beyond a predetermined speed threshold. However, once the speed threshold is crossed the stiffness of the system is dynamically altered such that the critical speed of the modified drive lies at a speed that is well below the predetermined threshold. Thus, as the apparatus accelerates through its fill speed regime to its operating speed the critical speeds associated with both the original and the modified drives are avoided. In an arrangement as shown in the Meinke et al. patent, springs, dampers and/or masses are actively coupled and uncoupled in response to the changes in the deflection of the shaft. This coupling and uncoupling has the effect of altering the critical rotational speeds. Implementation of either of the above-described expedients usually requires a complex mechanism to effect the interaction between rotating and non-rotating parts of the drive system. In either case, technical difficulties can result. Therefore, in view of the foregoing it is believed advantageous to provide an arrangement of the type which dynamically alters the stiffness of the drive system, yet which does so without undue mechanical complexity.

Ability of lactoferrin to promote the growth of Bifidobacterium spp. in vitro is independent of receptor binding capacity and iron saturation level. Lactoferrin (Lf) is an iron-binding protein which has been shown to inhibit the growth of various bacterial pathogens and promote the growth of anaerobic bacteria of the genus Bifidobacterium in vitro. The present study was designed to investigate whether the bifidobacteria growth promotion activity of Lf is correlated with either the binding of Lf to bifidobacterial cells or the iron saturation of Lf. Bovine Lf (bLf) from mature milk increased the growth of B. infantis and B. breve in vitro in a dose-dependent fashion, while much less growth promotion activity was found for B. bifidum. In contrast, human Lf (huLf) from mature milk promoted the growth of B. bifidum and was inactive for B. infantis and B. breve, while bLf from colostrum was devoid of bifidobacteria growth promotion activity. Changes in the iron content of Lf did not alter the bifidobacteria growth promotion activity of either bLf or huLf preparations. Competitive binding studies with biotinylated milk bLf showed that binding of bLf was inhibited by unlabelled bLf and huLf but not by beta-lactoglobulin, alpha-lactalbumin or transferrin. Binding of bLf to B. bifidum and B. breve was c. 40-fold higher than binding to Escherichia coli. Colostrum bLf was also found to bind to B. bifidum and B. breve, despite a lack of in-vitro growth promotion activity. Collectively, these results demonstrate that the ability of Lf to promote the growth of Bifidobacterium spp. in vitro is independent of the iron saturation level for Lf and suggest that binding of Lf to bifidobacteria cells may be involved but is not sufficient for stimulation of bifidobacterial growth.

[Try to improve journal quality by improving standards and editing process]. The quality of medical journals depends on several factors involving 3 groups of people with their independent but relevant roles: the authors, the reviewers and the editors. Peer review and editing is the key factor to improve the quality of medical publications and journals. Shanghai Journal of Stomatology (SJS) has been regarded as a leading journal for publishing high-quality work in the field of stomatology in China. In October 2003, it was accepted by the National Library of Medicine, USA, to be indexed and included in Index Medicus and MEDLINE. To further improve the journal's overall quality, the Editorial Agency led by Professor Zheng Jia-wei has made great efforts to formulate its essential requirements in paper style, bilingual abstract writing and statistical analysis for the manuscripts submitted for possible publication. Strict independent peer review system has been adopted to assess the quality of the manuscripts received since it was founded in 1992. The reviewer is required to address detailed aspects of the paper under review and to resend his or her opinion on the paper. The editorial management is a crucial part of the publishing process. The editors begin action with the receipt of the manuscript, direct the various steps of evaluation, correction and re-submission, until a decision is made to accept or reject the paper at the regular meeting of Decision Making Group on Manuscripts of SJS led by the Editor-in-Chief. Once a paper is accepted and carefully revised, the editors will make necessary text and layout editing. Due consideration is given to the statistical, bilingual and ethical aspects as well as to the overall uniformity of the terminology, nomenclatures and style throughout the volume as a whole in the promotion of standards. The journal has not been cited by Science Citation Index (SCI) till now, further steps should be taken to make this journal better known throughout the World, to improve the quality of the publications and reduce the delay between the initial receipt and the final publication of manuscripts.

Many restaurants, and especially fast food restaurants, prepare food in advance so that they can meet the daily fluctuations in demand that occur around breakfast time, lunch time, or dinner time. Food prepared in advance must be stored safely until it is delivered to the consumer. For many food products this means keeping the food product above a certain minimum threshold temperature to prevent spoilage. For other food products, it means keeping the food frozen or chilled. Either way, the food products need to be heated and held at an elevated temperature before being served to consumers. Although many systems exist to warm or heat food, many of these suffer from a number of drawbacks. For example, infrared (IR) heat lamps not only heat the food, but they also heat the surrounding environment. This can result in increased air conditioning costs for the restaurant. This problem may be exacerbated when the food products are in metal foil packaging since the metal foil may have a tendency to reflect the IR radiation away from the food product and into the surrounding environment. Furthermore, IR lamps tend to become quite hot, which poses a burn risk to restaurant employees and/or customers. Although warm air convection systems do not have many of the problems associated with IR lamps, warm air convection systems often cause food products to dry out. Both IR and warm air convection systems tend to steadily consume power regardless of how many food products are currently being heated. It would be desirable to provide an improved system for warming food that is energy efficient, safe, and effective. In one embodiment described herein, an induction heating system is used to warm food. The food may be packaged in food packaging that includes a current conducting material. The food packaging may be capable of being inductively heated to a temperature sufficient to warm the food.

A conventional technique for coating a phosphor on an LED, as shown in FIG. 1, includes directly applying a polymer material 20 such as epoxy, etc., into which the phosphor is mixed, onto an LED 10, and then, curing the polymer material 20. The conventional method of coating a phosphor on an LED has a problem that the polymer material 20 including the phosphor cannot be easily patterned. Therefore, in the conventional phosphor coating method, the phosphor must be applied to the entire surface after completion of wire bonding. In this case, when the LED to which the phosphor is applied cannot have desired performance (for example, in color, uniformity of color, etc.), the LED, which is expensive due to the wire bonding, is wasted, and thus, the overall manufacturing cost increases. In addition, the conventional method of coating a phosphor on the LED 10 is not appropriate for mass production. More specifically, in the conventional phosphor coating method, since the polymer material 20 including the phosphor must be separately coated onto each LED, the coating is expensive. Further, the conventional method of coating a phosphor on the LED 10 has a problem in that the thickness of the polymer material 20 including the phosphor cannot be easily adjusted. When the thickness of the polymer material 20 including the phosphor increases, intensity of light having a frequency varied by the phosphor increases, and when the thickness of the polymer material 20 including the phosphor decreases, intensity of light having a frequency varied by the phosphor decreases. Therefore, since the thickness of the polymer material 20 including the phosphor is an important factor for determining colors finally obtained from the LED 10, the thickness must be precisely controlled. In particular, since the light is emitted from side surfaces of the LED 10 as well as an upper surface thereof, the thickness of the polymer material 20 including the phosphor disposed on the side surfaces of the LED 10 as well as the thickness of the polymer material 20 including the phosphor disposed on the upper surface of the LED 10 must be precisely controlled. Furthermore, since the polymer material 20 including the phosphor is applied onto the LED 10 to a non-uniform thickness in the conventional method of coating a phosphor on the LED 10, uniform colors cannot be obtained. For example, when a white light is obtained by mixing a blue light emitted from a blue LED 10 and a yellow light obtained by a yellow phosphor, the white light with yellow color is transmitted to an observer 1 of FIG. 1 since the thickness of the polymer material 20 including the phosphor is large, and the white light with blue color is transmitted to an observer 2 of FIG. 1 since the thickness of the polymer material 20 including the phosphor is small.

Alterations of tau and VASP during microcystin-LR-induced cytoskeletal reorganization in a human liver cell line. Previously, we have reported alterations to HSP27 during Microcystin-LR (MC-LR)-induced cytoskeletal reorganization in the human liver cell line HL7702. To further elucidate the detailed mechanism of MC-LR-induced cytoskeletal assembly, we focused on two cytoskeletal-related proteins, Tau and VASP. These two proteins phosphorylated status influences their ability to bind and stabilize cytoskeleton. We found that MC-LR markedly increased the level of Tau phosphorylation with the dissociation of phosphorylated Tau from the cytoskeleton. Furthermore, the phosphorylation of Tau induced by MC-LR was suppressed by an activator of PP2A and by an inhibitor of p38 MAPK. VASP was also hyperphosphorylated upon MC-LR exposure; however, its phosphorylation appeared to regulate its cellular localization rather than cytoskeletal dynamics, and its phosphorylation was unaffected by the PP2A activator. These data suggest that phosphorylated Tau is regulated by p38 MAPK, possibly as a consequence of PP2A inhibition. Tau hyperphosphorylation is likely an important factor leading to the cytoskeletal destabilization triggered by MC-LR and the role of VASP alteration upon MC-LR exposure needs to be studied further. To our knowledge, the finding that Tau is implicated in cytoskeletal destabilization in MC-LR-treated hepatocytes and MC-LR-induced VASP's alteration has not been reported previously.

Short- and mid-term outcomes of robotic-assisted total mesorectal excision for the treatment of rectal cancer. Our experience after 198 consecutive cases. Robot-assisted total mesorectal excision is a safe alternative for rectal cancer treatment. Nevertheless, substantial data is still missing. Our aim was to assess the perioperative and oncological outcomes of the routine use of the robotic-assisted approach for rectal cancer treatment. 198 Consecutive robotic rectal resections were performed between January 2011 and April 2015 in patients with stage I-IV disease. We prospectively evaluated peri and postoperative data, pathological findings and mid-term oncological outcomes. 36 Abdominoperineal Amputations, 28 High Anterior Resections, 131 Low Anterior Resections and 3 Hartmann operations were performed. Mean age, ASA, BMI and distance form anal verge were respectively 67.5 years, ASA II, 26.95 kg/m(2) and 5.9 cm. 71.2% Patients received neoadjuvant therapy. Mean OR time was 294 minutes. Conversion occurred in 4.5%. Mean postoperative stay was 8 days. 36 Patients required blood transfusion with a mean of 162 ml. Complications Clavien III-IV were 12.1%. 8 complete responses were observed, 50 UICC class I, 84 class II, 51 class III and 13 class IV. Mean lymph node harvested were 11.7. Mean distal margin was 3.3 cm. 11 Circumferential margins were affected in UICC class III-IV patients. Postoperative mortality was 0.5%. Local recurrence was observed in 5% patients. Median follow-up was 27.6 months. Single institution descriptive study. The routine use of robotic assisted laparoscopic surgery may help to achieve lower conversion rates with lower ventral hernia rates and similar oncological outcomes using a minimally invasive approach in a non-selected group of patients with non-selected rectal tumours.

1. Field of the Invention The present invention relates generally to the field of disposable devices for anchoring bodily mounted drainage tubes such as urinary catheters and the like and, more particularly to a prefabricated device especially configured to facilitate its attachment to the drainage tube, or the like, and to the skin of a patient. 2. Discussion of the Related Art During the course of certain medical procedures, and particularly, after surgery, it is necessary to place drainage devices to prevent accumulation of fluids in various bodily cavities or organs. One of the most common of these, of course, is the urinary catheter which is generally routed through the patient's urethral opening or superpubic ostomy site. It is important to anchor the catheter device so that there is little movement with respect to the insertion site to minimize irritation. In the case of the urinary catheter the tube normally has a very long length and is hooked to a rather large bag, so it is quite easy to catch the catheter and bag which may result in dislodgement of the catheter, which, in turn, causes great pain to the patient and possibly actual physical damage. One common practice associated with immobilizing such things as catheter tubes has been to simply use several sections of adhesive tape to secure the tubing to the patient's body at a convenient spot between the insertion site and the collection bag. An alternative practice with respect to the urinary catheter has been to use a cloth retainer which fastens around the leg and has some form of cloth or plastic catheter holding device attached to it. Both of these approaches, of course, have drawbacks. In the case of the tape, it is cumbersome to use and remove and also, because it is rigid, it does not move with the compliance modulus of the skin. The cloth wrapped around the leg has a tendency to slide downward as the leg naturally narrows from the proximal to the distal approaching the knee. This requires multiple adjustments to keep the leg band in position. In addition, the system does not provide for fixing the catheter tube in place and it tends to slip through the cloth loop and can possibly detach completely with a light pull. This is especially true in view of the fact that to reduce friction between the tube and the tissue it engages at the insertion site, the tube is normally made of reduced friction material such as a silicone plastic or the like or possibly, in the alternative, is coated with a hydrophilic material which causes the material to exhibit a non-stick surface. These developments represent progress with respect to the insertion of the catheter tube into the body in terms of ease and comfort to the patient. However, they also cause difficulties with respect to anchoring the tube because of the increased likelihood of slipping of the catheter tube with respect to the tape or cloth anchor device. The need still exists for a more positive support which retains the quality of being gentle to the patient. Additional devices have also been proposed. A one-piece catheter anchoring tube or holder is disclosed by Johnson in U.S. Pat. No. 4,165,748, in which a piece of material has adhesive on one surface and is in the shape of a narrow bridge of the material that connects two larger spaced rectangular skin addressing segments. The device has two larger segments designed to adhere to the skin of the patient and the narrow or bridge portion uses the adhesive on the skin side directed to adhere to itself, forming a double fold layer. The double layer, in turn, wraps around the tube to be secured and is further provided with fasteners such as snap fasteners or Velcro.RTM. for securing the double thickness loop to itself after encircling the tube. The tube can be released and resecured but must rely on the friction of the tube encircling loop alone to anchor the tube longitudinally once fixed in position. Thus, the tube can be easily dislodged in the directional parallel to its length and slidably displaced while secured in the loop. A further device is shown in U.S. Pat. No. 3,677,250 to Thomas that discloses embodiments in which anchoring or skin adhering sections or patches are provided with integral tabs which are designed to wrap about the tubes to be secured, fixing them tangentially or parallel to the skin against the upper side of the skin anchoring patch. The tabs may permanently adhere to the surface of the tube in a non-reusable manner or, as in one embodiment, a pair of opposing tabs are provided which removably adhere to each other and slidably retain the tube or tubes therebeneath. This one-piece arrangement either does not allow for removal, replacement or adjustment of the tube or, in the case of the removable, readherable embodiment, suffers from the same ease of slidable tube displacement associated with other prior devices.

Challenges in defining predictive markers for response to endocrine therapy in breast cancer. Endocrine therapy is a major treatment modality for hormone-dependent breast cancer. It has a relatively low morbidity, and there is evidence that antihormonal treatments have had a significant effect in reducing mortality for breast cancer. Despite this, resistance to endocrine therapy, either primary or acquired during treatment, occurs in the majority of patients, and is a major obstacle to optimal clinical management. There is therefore an urgent need to identify, on an individual basis, those tumors that are most likely to respond to endocrine therapy (so sparing patients with resistant tumors the needless side effects of ineffective therapy), and the mechanisms of resistance in tumors that are nonresponsive to treatment (so these can be bypassed). These needs are the focus of this review, which discusses the particular issues encountered when investigating the potential of multigene expression signatures as predictive factors for response to aromatase inhibitors, which have recently become front-line endocrine therapies for postmenopausal patients with breast cancer.

1. Field of the Invention The present invention relates to a steel sheet for use in applications requiring electric conduction, such as grounding, supply of electricity or electric welding, which is endowed with both an electrical conductivity as one feature of a steel sheet and an excellent corrosion resistance, and specifically to a precoated steel sheet which is used as the casings of electric or electronic appliances and office automation appliances, and which is free of blocking in piling (shearing of plates to the required dimensions) or coiling and has a corrosion resistance, an electrical conductivity and an electromagnetic wave shielding effect. 2. Description of the Related Art Steel sheets have many features and are used in a wide range of applications. Among such many features, electrical conductivity is one of the important features. Thus, steel sheets have many fields of utilization in grounding, supply of electricity, electric welding, etc. However, they always involve a problem of rusting. The use of a steel sheet without any treatment for the purpose of securing electrical conductivity does not meet the requirement of corrosion resistance. The method of using a conductive coating (see, for example, Japanese Patent Laid-Open No. 189,843/1982) involves insufficiency of electric conductivity and high cost due to an expensive conductive coating. In a method of using other metal sheets such as an aluminum sheet instead of a steel sheet, the electrical conductivity of such a metal sheet is considerably poor as compared with that of a steel sheet, and other properties such as strength are also inferior. There has recently arisen a problem that electromagnetic waves generated in an electric or electronic appliance or an office automation appliance bring about malfunction or noise generation of other electric or electronic appliance or office automation appliance (this phenomenon is called electromagnetic interference, hereinafter referred to briefly as EMI). This problem can be solved if the appliance is wholly covered with a conductive substance to ground the same. However, plastics as insulating substances and precoated steel sheets having insulating coatings formed on both sides thereof have recently been increasingly used particularly in casings of appliances, so that there has been an increasing demand for a countermeasure against the problem of EMI. As for plastics, there has been proposed various methods as the EMI countermeasures including spray coating of a metal, vacuum evaporation and deposition of a metal, coating of the surface of a plastic with a paint containing a conductive pigment (see, for example, Japanese Patent Laid-Open No. 207,938/1984), and incorporation of a conductive substance into a plastic (see, for example, Japanese Patent Laid-Open No. 102,953/1984). However, any of these methods has disadvantages that the electrical conductivity is insufficient, a technical difficulty is involved, and the cost is increased. As for precoated steel sheets, there have been proposed no particular EMI countermeasures as yet. Thus, a countermeasure is taken by leaving one side of a steel sheet untreated or subjecting the same to only chemical treatment or conversion coating, or by shaving off part of a coating from a precoated steel sheet. However, these methods involve a problem of a decrease in corrosion resistance in the exposed portion of the steel sheet. Particularly in the method of leaving one side of a steel sheet untreated or subjecting the same to only chemical treatment, there occurs, blocking, that is, injury of a decorative side (coated side) of a steel sheet by an untreated or chemically treated side thereof in piling or coiling. The method of shaving off part of a coating has a defect of an increase in the number of steps of manufacturing. As the method of imparting an electrical conductivity to a precoated steel sheet, there has been proposed one in which a steel sheet is coated with a coating containing a metallic powder incorporated thereinto for imparting an electrical conductivity as described above. Also in this case, blocking is caused by the protruded portions of metal particles incorporated into the coating in piling or coiling just like the method of leaving one side of a steel sheet untreated or subjecting the same to only chemical treatment. Further, the electrical conductivity is insufficient for the EMI countermeasure.

Short-term fasting and lipolytic activity in rat adipocytes. The aim of this experiment was to study the influence of 18-hour food deprivation on basal and stimulated lipolysis in adipocytes obtained from young male Wistar rats. Fat cells from fed and fasted rats were isolated from the epididymal adipose tissue by collagenase digestion. Adipocytes were incubated in Krebs-Ringer buffer (pH 7.4, 37 degrees C) without agents affecting lipolysis and with different lipolytic stimulators (epinephrine, forskolin, dibutyryl-cAMP, theophylline, DPCPX, amrinone) or inhibitors (PIA, H-89, insulin). After 60 min of incubation, glycerol and, in some cases, also fatty acids released from adipocytes to the incubation medium were determined. Basal lipolysis was substantially potentiated in cells of fasted rats in comparison to adipocytes isolated from fed animals. The inhibition of protein kinase A activity by H-89 partially suppressed lipolysis in both groups of adipocytes, but did not eliminate this difference. The agonist of adenosine A (1) receptor also did not suppress fasting-enhanced basal lipolysis. The epinephrine-induced triglyceride breakdown was also enhanced by fasting. Similarly, the direct activation of adenylyl cyclase by forskolin or protein kinase A by dibutyryl-cAMP resulted in a higher lipolytic response in cells derived from fasted animals. These results indicate that the fasting-induced rise in lipolysis results predominantly from changes in the lipolytic cascade downstream from protein kinase A. The antagonism of the adenosine A (1) receptor and the inhibition of cAMP phosphodiesterase also induced lipolysis, which was potentiated by food deprivation. Moreover, the rise in basal and epinephrine-stimulated lipolysis in adipocytes of fasted rats was shown to be associated with a diminished non-esterified fatty acids/glycerol molar ratio. This effect was presumably due to increased re-esterification of triglyceride-derived fatty acids in cells of fasted rats. Comparing fed and fasted rats for the antilipolytic effect of insulin in adipocytes revealed that short-term food deprivation resulted in a substantial deterioration of the ability of insulin to suppress epinephrine-induced lipolysis.

Echocardiographic prediction of volume responsiveness in critically ill patients with spontaneously breathing activity. In hemodynamically unstable patients with spontaneous breathing activity, predicting volume responsiveness is a difficult challenge since the respiratory variation in arterial pressure cannot be used. Our objective was to test whether volume responsiveness can be predicted by the response of stroke volume measured with transthoracic echocardiography to passive leg raising in patients with spontaneous breathing activity. We also examined whether common echocardiographic indices of cardiac filling status are valuable to predict volume responsiveness in this category of patients. Prospective study in the medical intensive care unit of a university hospital. 24 patients with spontaneously breathing activity considered for volume expansion. We measured the response of the echocardiographic stroke volume to passive leg raising and to saline infusion (500 ml over 15 min). The left ventricular end-diastolic area and the ratio of mitral inflow E wave velocity to early diastolic mitral annulus velocity (E/Ea) were also measured before and after saline infusion. A passive leg raising induced increase in stroke volume of 12.5% or more predicted an increase in stroke volume of 15% or more after volume expansion with a sensitivity of 77% and a specificity of 100%. Neither left ventricular end-diastolic area nor E/Ea predicted volume responsiveness. In our critically ill patients with spontaneous breathing activity the response of echocardiographic stroke volume to passive leg raising was a good predictor of volume responsiveness. On the other hand, the common echocardiographic markers of cardiac filling status were not valuable for this purpose.

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The RCMI-supported core shared research facilities at the Center for Study of Gene Structure and Function at Hunter College provide essential services to support the first-class research of our scientists. It is imperative that we improve the strengths of the facilities by constantly updating the equipment and expertise of the managers and users. The facilities also allow us to compete for topnotch scientists, highly qualified graduate students and post-doctoral researchers who contribute to our research output. An environment where researchers compete successfully for outside funding is critical to our overall aims, and with the addition of new and planned facilities we will be able to better address the problem of health disparities in the United States. In the next grant period, we plan to hire essential personnel and to upgrade the equipment in the following facilities: Bioimaging, Animal Care, Genomics, Internet2 and the Gene Center Local Area Network (LAN). Our plans include improving these core shared research facilities as well as the Fluorescence Activated Cell Sorting (FACS), the Nuclear Magnetic Resonance (NMR) and the X-Ray Diffraction Facilities. These improvements require the following: (a) supporting service contracts with grant funds and users'fees;(b) upgrading the skills of facilities'managers through advanced training, continuing education, external collaborations and professional certifications;and (c) upgrading standard operating procedures, record-keeping, manuals, and websites. Improving our core facilities will help us to maximize our scientific output and attain the goals of the RCMI Program.

Identification and differentiation between colored pencils. With pencils of any color, the first step certainly involves visual examination to distinguish between the color tints and to study the quality of the stroke itself. In many instances by this step alone, 2 pencils can be distinguished if they are the product of 2 different manufacturers. In other words, the most useful of all tests is the visual examination. In the case of red pencils, infrared luminescence reveals significant information and should be resorted to in those instances where two questioned strokes are extremely similar. Study under ultraviolet radiation may also help to establish similarities or differences which are not readily discernible by visual examination. However, reflected infrared examination and study with dichroic filters have no particular value when dealing with red pencil although chemical spot testing may be of some assistance. In the case of blue pencils, a number of brands absorbs infrared radiation to a different extent and some give off distinctive infrared luminescence, so that these 2 tests can assist in distinguishing between certain similar colors or tints. Also, study through dichroic filters has value. Thus, the combination of these 3 tests can be of some advantage, but in most instances, particularly with dark blues, examination under ultraviolet radiation is not particularly helpful. Chemical spot testing has some limited advantages but generally only in combination with all other tests. In the case of green pencils, the same pattern of testing may be used as with blues. Many of the greens absorb infrared rays and some have bright infrared luminescence. Ultraviolet radiation can cause certain greens to fluoresce in a distinctive way. Thus, with each color studied, differences can be revealed and similarities established. Colored pencils are a distinct group of writing instruments. Within any color classification, there is a variety of shades or tints. Although it is not psosible to determine the make of pencil used in any particular writing, it is possible under many circumstances to distinguish between the work of different makes and grades of red, blue and green pencils, as well as other colors which have not been covered by this paper. While visual examination will separate the many different makes, other tests are described which will further assist in grouping or separating colored writing strokes. For a number of reasons, and particularly because of manufacturing procedures of different companies, not every make of pencil is distinctive, but there has been found to be a definite variety within each color group, and many makes are distinguishable.

The invention relates to a contact-free plate conveyor particularly for glass plates. In the float glass production, the glass web which has been formed and solidified on a liquid metal bath is carried away in a well-known manner by plate conveyors which are generally roller conveyors on which the glass web is moved with its bath side disposed on the rollers. During movement, the finished glass web is cut longitudinally and transversely into glass plates of the desired format and these glass plates are also moved by plate conveyors to stacking station where the plates are removed from the conveyor. By its contact with the rollers during its movement over the rollers, small traces remain on the support side of the glass. These traces are normally not noticeable but are objectionable for some applications and therefore detrimentally affect the quality of the glass surface. It is the object of the present invention to provide a conveyor by which such traces inflicted by the mechanical contact between the glass surface and conveyor elements is avoided.

Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells. Despite increasing evidence that high levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis, the regulation of its expression is not well characterized. We observe that IL-17 production is increased in response to the recently described cytokine IL-23. We present evidence that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion. IL-23 also induced expression of the related cytokine IL-17F. IL-23 is a heterodimeric cytokine and shares a subunit, p40, with IL-12. In contrast to IL-23, IL-12 had only marginal effects on IL-17 production. These data suggest that during a secondary immune response, IL-23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.

The importance of early treatment of the anaemia of chronic kidney disease. The beneficial effects of treating the anaemia of dialysis-dependent patients with erythropoietin on the improvement of cardiac status, exercise capacity, cognitive function and quality of life are well established. Equally, if not more important is the reduction in morbidity and mortality that accompanies the treatment of anaemia with epoietin. These documented improvements in outcomes of care notwithstanding, mortality and morbidity due to cardiovascular disease (CVD) remain high in dialysis patients. Recent epidemiological evidence indicates that: (i) the prevalence of CVD is very high in patients at the start of dialysis; (ii) pre-existing CVD is the major risk factor for mortality and morbidity on dialysis; (iii) CVD begins early in the course of kidney disease, shows an inverse relationship to kidney function and increases in prevalence and severity with progression of kidney disease; and (iv) corrective measures, which take 3-5 years to show a favourable effect, must be instituted well before the initiation of dialysis. Hypertension and anaemia, which develop in the course of progressive reduction in kidney function, are the principal risk factors for the prevalence of left ventricular hypertrophy (LVH) in those with chronic kidney disease, and their treatment has been shown to arrest or reverse LVH in these individuals. Whereas the treatment of hypertension early in the course of kidney disease has been incorporated into clinical practice, there has been reluctance in the treatment of anaemia because of the possibility of worsening kidney function with epoietin, as shown in rats. There is now convincing evidence that epoietin has no potential adverse effect on kidney function in humans. While the most compelling reason for the early treatment of the anaemia of kidney disease is its beneficial effect on cardiovascular function, other documented potential benefits are improvements in exercise capacity, cognitive function and quality of life.

Integrative teaching in radiology - a survey. To survey integrative teaching in radiology at German universities. A questionnaire about radiological education was sent electronically to all 37 chairpersons of university radiology departments in Germany. The questions included the course type, teaching methods, concept, perception, and advantages and disadvantages of integrative teaching. Statistical analysis was performed with nonparametric statistics and chi-square test. The survey was considered representative with a return rate of 68 %. Integrative teaching is established at 4/5 of all departments. Integrative teaching is well accepted with an acceptance rate that is significantly higher in so-called "Modellstudiengängen" [model courses of study] (100 %) compared to conventional courses of study (72 %). The advantages of integrative teaching include linking of content (92 %) and preparation for interdisciplinary work (76 %). The disadvantages include high effort (75 %) and time (67 %) for organization. Furthermore, there is a risk that basic radiological facts and knowledge cannot be conveyed and that the visibility of radiology as an independent discipline is lost. Conventional radiological teaching has a similarly high acceptance (84 %) compared to integrative courses (76 %). Integrative teaching has a high acceptance among chairpersons in radiology in Germany despite the greater effort. A good interdisciplinary collaboration is essential for integrative teaching and at the same time this can be conveyed to the students. However, the visibility of radiology as a discipline and the possibility to cover basic radiological content must be ensured. Therefore, both conventional courses and integrative teaching seems reasonable, especially in cross-disciplinary subjects such as radiology. Both integrative teaching and conventional radiological teaching are highly accepted. The advantages include the linking of multidisciplinary content and the preparation for interdisciplinary cooperation. The disadvantages include more time and effort for organization and reduced visibility of cross-disciplinary subjects.

Fecal testosterone is elevated in high ranking female ibexes (Capra nubiana) and associated with increased aggression and a preponderance of male offspring. We monitored fecal testosterone and progesterone levels in 26 adult ibexes (17 males, 9 females) in a captive herd Nubian ibex held on 250 ha tract to test if testosterone is associated with dominance. The ibexes were observed over a 20-month period, and including two mating seasons, during which time we collected fecal samples twice during early gestation and postpartum intervals and once during lactation and pre-rut season intervals. The social hierarchy was linear with age in adult males and nearly linear in adult females. High ranking males were in solitude, but females were aggregated with the kids in the presence of a dominant female. The testosterone concentration in the males in the pre-rut (211+/-12 ng/g; N=13; dominant male 296 ng/g) was significant higher than other seasons (P<0.05). High testosterone in dominant male at pre-rut was associated with a decrease in confrontations. The individuals with the highest average testosterone concentrations were the dominant male and female (166+/-82 ng/g; 130+/-32 ng/g, N=6, respectively). In females, testosterone was highest in during the post-partum interval and was associated with an increase in aggression. The three highest fertile ranking females had higher testosterone (119+/-14 ng/g vs. 92+/-18 ng/g, P<0.05) than the four subordinate females. The sex ratio of the offspring was 8M/3F for the three older females and 5M/7F for the younger females. In early gestation period, females with only male fetuses had higher testosterone than other gravidities (119+/-14 ng/g, N=6 vs. 91+/-18 ng/g, N=7, P<0.01). Progesterone was significantly higher in the eight multiparous pregnancies than in those with the five singletons (210+/-19 ng/g vs. 186+/-12 ng/g, P<0.02). We conclude that high testosterone in females is associated with an increase in aggressive confrontations in early- and mid-lactation. In contrast, increased testosterone during pre-rut in males is associated with fewer confrontations. In addition, the data support the hypothesis that higher ranking, older dimorphic female ungulates have higher testosterone concentrations and have more male births than subordinate females.

The inventive concept relates generally to electronic data storage technologies. More particularly, the inventive concept relates to data storage devices and related methods of operation. The information age has produced an explosive increase in the demand for personal data storage. With this increasing demand, various types of personal data storage devices have proliferated. For example, hard disk drives (HDDs) have been widely used due to various attractive features such as high recording density, high speed of data transmission, fast data access time, and low cost. Unfortunately, an HDD can be damaged by even slight shock and vibration due to its use of a platter and complex mechanical parts. In recent years, solid-state disks or drives (SSDs) have been developed to replace HDDs. An SSD is a data storage device that uses a solid-state semiconductor memory as a main form of data storage. Unlike HDDs, SSDs do not include a platter and related mechanical parts. As a result, SSDs tend to have lower mechanical driving time and latency, and faster read/write times compared with HDDs. They also tend to have fewer errors due to latency and mechanical friction compared with HDDs, so their reliability in performing read/write operations tends to be better than that of HDDs. Moreover, SSDs generate relatively little heat and noise during operation, and they can withstand physical shock, which makes them increasingly more attractive than HDDs. Due to the increasing popularity of SSDs, researchers are currently devoting great efforts to improving numerous aspects of their performance, including read/write speed, storage capacity, power consumption, reliability, durability, and many others.

"Commander." "We're getting a reading." " Eagle 1 in orbit and holding." " Twenty seconds visual contact." "We have linkup with on-board computer." " Fifteen seconds to visual contact." " Eagle 1 holding." "Eagle 1 breaking orbit now." "Punch in long-range cameras." " Vital signs normal." " Alpha to Eagle 1. do you copy?" " Alpha to Eagle 1. do you copy?" " Keep trying." "Paul." "Eagle 1. are you receiving?" "Come in." "Eagle 1." "Preliminary results from on-board computer coming through." "Good." "Terra Nova." "New Earth." "Mm." "Just what we're looking for. isn't it?" "'Resources to sustain human life... unlimited.'" " Looks good." " Mm-hmm." "'Eagle 1 to Alpha." "You won't believe it but I think we made it this time.'" "I've seen rivers and trees." "Lakes. mountains. valleys..." "It's just like Earth!" " 'Any intelligent life?" "'" " That's it..." "'The planet seems empty." "It's just waiting for us.'" "No!" "Eagle 1. this is Alpha." "Do you copy?" "Are you receiving me?" "Come in." "Eagle 1." "Contact lost." "Commander." " Vital life signs?" " Not registering." "Eagle 1. this is Alpha." "Do you copy?" "Are you receiving me?" "Eagle 1. come in." "Commander. flight pattern shows Eagle 1 on course and closing." " Systems functioning." " Vital signs normal." "Emergency touchdown procedure." "Yellow alert." "Eagle 1 on final approach." " Flight pattern?" " Normal." "Still on automatic." "Emergency red." "Set?" " They're alive." " John!" "I thought this was only a two-man crew." "It was." "What is it?" "It's my husband." "You're absolutely certain it's him?" "Yes." "It doesn't make any sense." "No. it doesn't make any sense." "But John." "I know my own husband." "He's been dead five years." "Yes. he has. he's been presumed dead." "We'll be in Dr Russell's quarters." "If there's any change. let us know." "Yes." "Commander." "Wasn't he on the Astro 7 mission?" "The Astro 7. yes." "The mission failed." "What?" "They got locked in orbit around Jupiter." "Something like that." "They lost contact." "As I remember. it was radiation." "The ship burned up." "I" " I don't know. they just lost contact around Jupiter." "Helena. we're billions of miles from Jupiter." "John. we may be billions of miles from Jupiter. but Lee is here." "He is here." "Many things have happened since we broke away from our solar system." "Unexplainable things." "But this time." "We might get some answers." " If he is..." " 'Dr Russell.'" " Yes?" " 'Something strange." "'Could you come to the care unit straight away?" "'" "Yes." " Checked the equipment?" " Yes." "It's functioning perfectly but it's still not recording his vital signs." " How is he?" " Normal." "Then why aren't the instruments recording?" "I don't know." "Let's find out." "Kano. what does the computer have on Russell?" "Checks out." "It's him." "Commander." "Ah. just a minute." "John..." "The only information we have on Russell comes from his wife's file." "Now. that's too limited." "Analysis of the data does suggest that the planet is just right for us." "Commander. the accident to the probe pilot puts phase two behind schedule." "Paul. how much time do we have for phase two?" " Twenty hours." " Phase three?" "A total evacuation of Moonbase Alpha will take 48 hours." "Kano. if we cut phase two in half." "How will that leave us?" "We could do it sir. but only just." "We'll postpone phase two by 10 hours to give us time to check out Russell." "People are wondering why phase two is not taking place now." "Captain." "I'm not gonna jump the gun on this." "I'm not going to endanger the lives of any more pilots." "Sir. it can't be Russell." "It just can't be!" "I repeat. until we know what's going on. we do not go down on that planet." "Lee?" "Lee. can you hear me?" "Uh. are..." "Are... you..." "Helena?" "Yes. it's me." "Lee." "What... is this... place?" "Lee. you're in a hospital room." "We're on Moonbase Alpha." "Helena." "I came... to... you." "I came... because..." "Victor. what do you think of it?" "I don't know." " But I'll have a guess." " What?" "Our instruments are designed to respond to human biological stimuli as we know them." "But assuming Russell was on Terra Nova for five years." "Then perhaps some aspect of that planet's environment caused him to adapt in some way which our instruments can't record." "Victor. that's good. but it doesn't answer my immediate questions." "How did he get onto that Eagle?" "Did he have any affect on our pilots?" "Can he be of help to us?" "What does he know about that planet?" "You want me to bring him out of it with metrazene?" "I must talk to him." "There are things about his condition that we don't understand." "Can it wait?" " Wait?" " A little longer. at least." "In three days. we'll be out of range." "Every hour that passes lessens our chance of finding a decent home." "There are 300 lives." "Helena." "Can you or I deny them that chance?" "All right." "That's the maximum. sir." "I can't give him any more." "I'm Commander Koenig." "I've got to speak to you." "Helena." "It's all right." "Lee." "I'm right here." "Commander Koenig is a friend." "He's going to ask you some questions." "I must speak... to Helena." "It's important to all of us." "How did you get on that planet?" "Planet..." "What's there?" "Think." "Try to remember." "Helena... called me." "The planet. is it safe?" "Only..." "Helena..." "It hasn't worked." "Helena. you try." "I'm sorry." "John." "He's got to rest." "All right. but you stay with him." "Lee?" "This place." "Helena." "Tell me." "Tell you what?" "This place..." "Where is it?" "We're on Moonbase Alpha." "Lee." "There was an accident." "The moon was blown out of Earth's orbit." "What do you want?" "We think we've found what we want." "A new world. someplace to live." "Your planet." "We're going to colonise it." "We could be together." "Kano. what's the latest time prediction on phase two?" "Hasn't changed." "We've peaked your optimum take-off time." "In two hours we must abandon phase two." " You said we had an emergency" " Did I?" "I must have been mistaken." "Sandra. no bad news for me yet?" "Nothing." "Almost too good to be true." "That's nice." "Oh." "Commander." "We are going down. aren't we?" "What's going to stop us?" "'Commander. could you come to Dr Russell's quarters. please?" "'" "Yes." "What happened?" "I found her on the floor of the care unit." " You all right?" " Oh." "I'm fine." "I've checked her over." "There's no damage." "Thank you." "Doctor." "I must have passed out." "Helena. it's not like you to just pass out." "Now. what's wrong?" "I don't know." "Lee and I were talking..." "What?" "He talked?" " Yes. a little." " What did he say?" "Not much." "It was just before I fainted." "Did he talk about the planet?" "I don't remember." "No." "I'm sure he didn't." "I would remember." "Helena. you're sure." "Really sure he's your husband?" "Yes." "I'm sure of that." "It just doesn't make sense." "I mean..." "How do you feel?" "Just a little tired. that's all." "John. we are going down there." "Aren't we?" "When we're sure it's safe to do so." "These are some thermographic scans I did of Lee Russell." "Normally. they'd have been passed to Helena for analysis." "But Mathias was worried that they might upset her." "You'll see why in a moment." "Now. as you know. these plates respond to body heat." "There you are." "Lee Russell." "And from this." "He seems to be perfectly normal." "You can see the areas of body heat - brain. vital organs." "And the cold areas. yellows." "All just as it should be." "Oh. that hand at the bottom of the picture. that's Helena's." "But now. look at this." "I don't get it." "Victor." " It's not a living being." " Exactly. nothing there." "No body heat. no reds at all." "Just yellow." "And yet. when this scan was taken. he was breathing. his heart was beating." "And now. look at this." "See. normal again." "Is Lee Russell dead or alive?" "I don't know." "According to that picture. he's alive." "And that one says he'd dead." "Take your choice." "Course. this may be a symptom of his adaptation to living on that planet." "I don't go for that." "Victor." "He was on that planet five years." "It takes billions of years for a human being to adapt that radically." "So we've always thought. on Earth." "But we're a long way from home." "We'll have to start thinking differently if we're to come to terms with space." "Victor. where was Helena for the second scan?" "Not in the care unit." "So she's with him for the first and the last scan." "And they're normal." "Then she leaves him..." "and this happens." "That's right." "Very strange. isn't it?" "Whatever life force sustains him." "He's drawing it from some outside source." "From Helena." "Helena..." "Mr Russell. please." "You should be in bed." "I... want..." "Helena." " You're not well." " I want Helena!" " Yes. in a moment." " No!" "Lee Russell." "Stop him!" "Lee!" "Lee. it's all right." "It's time we talked." "Take him to my office." "Lee. try to help us." "Help us to understand." "Helena. stay away from him." " But why?" " Stay away." "I know why you brought me here." " Good." " Then will you help us?" "That's why I'm here." "To help you." " Where's Helena?" " It's best not to see her." "What are you doing on Alpha?" "I... had to come." "Where did you come from." "Mr Russell?" " The planet." " How did you get there?" " That's not important." " How?" "Commander." "I don't know how I got there. how long I've been there." " How'd you board our ship?" " You're wasting time." "Then help us." "Mr Russell." "Tell us what you know." "I... know... you're in danger. all of you." " From what?" " Is the planet inhabited?" "No." "Yes." "Not in the way you think." "You must not go near that planet." "Mr Russell. we're marooned." " We can't survive indefinitely." " You cannot go down there." "That's our decision to make." "You face power beyond your understanding." "It will destroy you." "What is this power. this danger?" "Your... opposite." "It will annihilate you." "Our calculations show that planet is perfectly suitable for human life." "You... don't believe... do you?" "What can we believe?" "You appear. and we don't know how." "You seem to be human. but are you?" "You'll... go... to that planet whatever I say." "Isn't that so?" "Helena." "Mathias." "He's dead." "Victor. we're running out of time." "At least wait till we find out why Russell died." "'Commander Koenig." "'Essential we have flight coordinates for phase two probe.'" "Not yet available." "Stay on standby." " 'We're cutting it very fine. sir.'" " I know how fine." "Kano. thank you!" "Victor. we've gotta go." "We've gotta find out about Russell." "For the sake of the mission." "We must wait." "Mathias'll rush the autopsy." "But I'm not waiting for the results." "I'm starting phase two." " OK. but let me have an hour." " For what?" "To run some skin tests on Russell." " Well. all right." " John..." "Has Helena been told?" "She knows." " 'Helena.'" " Come in." "Helena." "I..." "I've already said it all to myself." "John." "I don't blame anyone." "My interrogation could have something to do with it." "Could have." "We simply don't know." "The autopsy should give us some of the answers." "As a doctor. of course." "I'm interested." "As Lee's wife." "I'd rather forget." "The first time I lost Lee." "I thought I'd never survive it." "Now that it's happened again." "I'm just numb." "I guess I never really had him back." "I'm all right." "Reconnaissance section reports Eagle 2 on standby. equipment checked." "Planetary data programmed into on-board computer." " Fine." "Kano?" " Yes." " Have you made a new flight plan?" " We must leave in 30 minutes." "Though it will cut our surface operating time to zero minimum." "We need a definite time for phase two launch." "Commander." "John..." "Victor." "I've made my decision." "This is about Lee Russell." " Lee Russell is dead." " The skin tests..." "Whatever he was. wherever he came from doesn't matter." "His influence on us has gone." "Don't you agree?" "In that sense I'd have to." "But please. listen." "But nothing stops us from going?" "John. just hear me out." "I put the skin data through the particle analyser." "Now. his skin structure was normal while he was alive." "But since his death. the atomic structure of his body is changing." "There are signs of reversed polarity." "And it's becoming more pronounced." "More complete." "Reversed polarity?" "That's just speculation." "Yes. but reversed polarity is the first step towards anti-matter." "As soon as that process is complete." "It means annihilation." " It's just a theory." " Yes. a theory so far." "But if..." "Sorry. it's not enough." "That's your decision." "Yes. it is." " Alan." " Sir?" "Phase two Eagle lift-off. 15 minutes." "Right." "Commander." "Paul. activate Operation Exodus." "Maximum alert." "If phase two works." "I want evacuation in minutes." "They'll be ready." "Yes. we're going down to Terra Nova." "Now. we don't know what we'll find there." "There's an awful lot about the planet we don't understand." "At best. it's a calculated risk." "But there's a chance." "A chance to find a place to live." "To raise families. to start again." "Now. the landing party." "Many of you qualify." "But this is my choice." "Captain Carter. we need a pilot." "Paul Morrow." "Analyst Sandra Benes." "Dr Russell. will you come?" "Yes." "The landing party is under my command." "We will rendezvous at assembly point three at 13:25 lunar time." "Thank you." "Victor." "Victor." "I'd like you to stay back here." "For any reason." "If things don't go too well." "I'd like you to take over my command." "All right." "Good luck." "John." "All pre-flight checks complete." "Countdown continuing." "20 seconds to take-off." "'John. something very serious.'" " Eighteen seconds." " 'The autopsy on Lee Russell.'" " What's happened?" " Sixteen seconds." " 'His body's vanished.'" " Vanished?" " 'John. abort the mission.'" " On what grounds?" " 'Lee Russell's warning.'" " Seven seconds." "'Anti-matter - the risks are tremendous." "Five seconds." "What do we do." "Commander?" "'John. please." "Reconsider.'" "Sorry." "Victor. we'll just have to face those risks." "All right." "Captain. lift off." " It looks good." " Mm-hmm." "Yes. it looks good." "The computer agrees." "Atmosphere 22 parts oxygen." "71 parts nitrogen." "Outside temperature 23 degrees." "Gravity similar to Earth." "Please don't approach animal life." "No matter how harmless it appears." "Don't eat any vegetation without carrying out the appropriate tests." "Paul. you and Sandra cover this hilly area to the right." "Helena and I will take this wooded area to the left." "Carter. you stay on the ship." "Leave it under no circumstances." "The rest of us will rendezvous here at 18:00 hours." "If we're not back." "It means we're in trouble." "Right." "As long as you keep your locator beams on. we'll find you." "Well. here we go." " The breeze." " The flowers." " Hey." "Commander." "Good luck." " Thank you." "Carter." "Commander..." "Water?" "Let's find out." " No impurities." " Data readout normal so far." "'Have a drink on me." "John.'" " Will you join me?" " I'd be delighted." "'Clear. fresh water.'" "Edible!" "'Sorry. that's it." "We'll call you back in ten minutes.'" "All right." "I haven't enjoyed a picture that much for a long time." "Main Mission standing by." "Paul. how are you doing?" "'We're fine." "No dangerous elements so far.'" "OK." "Paul. keep in touch." " Come in." "Alpha." " 'John. we've got trouble." "'Atmosphere seals are weakening.'" " All the seals?" " 'All of them." "'Including the plastics on your Eagle." "'Get Carter to check it out.'" "Carter?" " 'Yes. sir.'" " What's your situation?" "'Well. the insulation's beginning to act up a bit." "'Doesn't seem serious.'" "Maybe not. but I'm recalling the landing party." " Get ready for lift-off." " 'Yes.'" "Helena. we're going back to the Eagle." "What's wrong?" " Paul?" " 'Yes. sir?" "'" " You two get to the Eagle." " 'But. sir.'" " Do as I say." " 'Yes. sir.'" "'It's worse than we thought." "John." "The plastic seals are melting." "'Atmosphere screens are burning up.'" " We could use another Eagle." " 'Difficult." "Can't vouch for them.'" "Carter." "'Commander?" "I got smoke pouring from the instrument panels." "'All the seals on the ship are melting.'" "Punch in on-board camera." "Carter. get out of there!" "'I can't get out!" "All the systems have failed!" "'" "Carter!" "We're on our way." "Let's go." "Paul." "Sandra. quickly!" "Sandra!" "His laser exploded." "Let's get rid of it." "Easy." "Easy." "Paul." "He's dead." "Come on. come on." "Here we go." "OK. it's all right." "It's OK." "I cannot see." "Helena. you stay with her." "I'm blind!" "Come in." "Alpha. this is Koenig." "Moonbase Alpha. come in." "Alpha!" "'The situation is deteriorating... '..have gone in various areas... '..evacuated..." "'We have many unaccountable technical troubles...'" "John!" "John!" "Hold on!" "Helena!" "Helena. where's Sandra?" "Are you all right?" "Where's Sandra?" "Sandra!" " Sandra!" " Sandra!" "Sandra!" "Helena." "We..." "We almost made it." "You... and I." "Helena." "Helena." "Lee." "You?" "I tried to stop you coming here." "Help me. please." "Lee." "How is this possible?" "The Astro 7 mission." "You remember?" "We were drawn into close orbit around Jupiter." "Our heat shields burned up." "We were affected by an unknown form of radiation." "I suppose." "It transformed us." "Scattered us into deep space." "And I became... what I am now." "Ended up here. on this planet." "But you died." "No. nobody dies." "Matter never dies." "It only changes its form." "There are many forms of life in space and many forms of death. too." "I'm... the image and mirror." "The opposite of myself." "Anti-matter?" "If you like." "But I couldn't survive in your world." "And you can't survive in mine." "That's why you must leave. now." "You've seen what can happen here." "It will get worse. much worse!" " You must leave. now." " How?" "I'll give you the strength." "See what you want to see." "We cannot stay here." "John." "'Paul and Sandra are waiting in the Eagle. as instructed.'" "Stand by." "'Fifteen minutes to lift-off." "John." "'Operation Exodus ready when you give the word.'" "Cancel Operation Exodus." "Commander. you know those feasibility programs we've been running?" "Yes?" "What about them?" "Our present trajectory will take us past about ten million planets." "It means we should pass near to 3.600 Earth-type planets." "Statistically. that's ten Earth-type planets for everyone on Alpha." "And how much older will you be by the time we reach the first?" "Not very much." "Relatively speaking. that is." "More to the point. how much older will you be when we reach the last?" "2.543 years old. to be exact. sir." " Just thought you'd like to know." " Thank you." "Kano."

GALVESTON, Texas (KTRK) -- A man has been arrested after police say he damaged several headstones, some beyond repair, at a historic Galveston cemetery.Corey Johnson, 40, is charged with felony criminal mischief.Galveston police say officers started to receive calls Saturday morning about someone throwing concrete and other debris at drivers in the 4100 block of Broadway.Police increased patrols in the area and found Johnson around 3 p.m., shortly after concrete, wood and pieces of headstones were discovered across several lanes of Broadway.Johnson was taken into custody on an unrelated charge of drinking in public while Galveston police investigated.Staff from the City of Galveston Parks Department, the group that runs the historic cemetery, told authorities they've found some 80 headstones damaged over the past month.He was then connected to the cemetery damage. Johnson's bond was set at $80,000.Some of the damaged headstones date back to Galveston's antebellum period. The damage is estimated at $13,300.

Such operation is characterized by the production in the anode circuit of water, nitrogen diffusing through the membrane separating the anode compartment from the cathode compartment, as well as possibly impurities initially present in the hydrogen and which tend to concentrate. So as to maintain optimum operating conditions, water, nitrogen and impurities are eliminated by proceeding generally to regular purges of the hydrogen circuit. The frequency of the necessary purges depends on the characteristics of the cell as well as the operating cycles and can range from several seconds to several minutes. One of the operating characteristic of such cells is also to leave, at the outlet of the anode circuit, a residual quantity of unconsumed hydrogen which is thus lost if the elimination of water, nitrogen and impurities is carried out by periodic purges. So as to avoid a loss of hydrogen, the prior art ensured a recirculation of the mixture from the outlet of the anode compartment to reinject it at the inlet of the same compartment of the cell. Such a reinjection ensures continued mixing of the gases and improves the operation in the presence of impurities and nitrogen but however does not solve the problem of recovery of the water which is to be recovered so as to promote the hydraulic balance of the operation, particularly to ensure moistening and/or cooling of the cells. The choice of proceeding with recirculation of the mixture requires using particular technical means and, particularly, the presence of a circulator which constitutes a rotary machine that is relatively complicated and subject to sensitive operating conditions, particularly in the presence of liquid water. Such a rotary machine constitutes costly equipment, requiring substantial maintenance and, as a result, substantially increasing the purchase price as well as the operating cost of a fuel cell. Moreover, it has been noted that the recirculation of mixture does not always improve the conditions effective to eliminate water, particularly when the speed of the principal gaseous mixture is not sufficient. This drawback could be overcome at least in part by subjecting the mixture to more rapid recirculation, but then the problems inherent in the presence of the circulator proportionately increase. No matter what the operational conditions described above, it is moreover always necessary to have a particularly effective phase separator so as to be able to ensure the separation of the water. However, such a separator constitutes a relatively burdensome accessory, occupying a substantial volume and giving rise to problems of inertia in the case of stopping or starting the operation of a fuel cell.

This invention relates to lubricant compositions, and more particularly to lubricant compositions containing a synergistic mixture of a hydrocarbyl-substituted mono and bis succinimide having polyamine chain linked hydroxacyl radicals and a neopentyl polyol derivative as a detergent and/or dispersant. Internal combustion engines operate under a wide range of temperatures including low temperature, stop and go service as well as high temperature conditions produced by continuous high speed driving. Stop-and-go driving, particularly during cold, damp weather conditions, leads to the formation of a sludge in the crankcase and in the oil passages of a gasoline or a diesel engine. This sludge seriously limits the ability of the crankcase oil to lubricate the engine. In addition, the sludge with its enrapped water tends to contribute to rust formation in the engine. The noted problems tend to be compounded by standard lubrication service recommendations for extended oil drain intervals. With the introduction of four cylinder internal combustion engines which must operate at high speeds to produce the required torque output, it has become increasingly difficult to provide a satisfactory dispersant lubricating oil composition. The high temperature operating conditions increase the oil's propensity for oxidation. Oxidized oil thickens when cooled and will not afford satisfactory lubrication. Certain mineral oil based stocks are more prone to oxidation than others. The base stocks used in many European lubricating oils have been found to have a higher propensity for oxidation than base stocks used in the United States. Further, lubricant compositions need to be compatible with the elastomer seals used in internal combustion engines, such as Viton seals. Many oil additives have been found to be aggressive towards the seals causing their deterioration. Previously, nitrogen containing compounds which act as dispersants and/or detergents have been used in the formulation of lubricant compositions. Many of these dispersant and/or detergent compounds are based on the reaction of an alkenylsuccinic acid anhydride with amine or polyamine to produce an alkylsuccinimide or an alkylsuccinic acid as determined by the conditions of reaction. Such products contain a high level of nitrogen in order to provide improve dispersency in a crank case lubricant composition. One such class of compounds which are excellent dispersants and/or detergents is set forth in coassigned U.S. Pat. No. 4,482,464, whose disclosure is incorporated herein by reference. Other useful detergent and/or dispersant additives for a lubricant composition are based on derivatives of neopentyl polyols and polyolefinic-P.sub.2 S.sub.5 products. A preferred class of such compounds are set forth coassigned U.S. Pat. No. 3,281,359 whose disclosure is incorporated herein by reference. However, it is been found that with many lubricating oils particularly those containing European base stocks neither of these two class of detergents and/or dispersants have been found to be entirely satisfactory under all operating conditions.

Identification and characterization of a canine highly similar to retinoic acid receptor alpha. A canine highly similar to retinoic acid receptor alpha (canine HS-RARa) cDNA was isolated from the spleen tissue. A database search and the alignment revealed that the canine cDNA was most similar to highly similar type of human RARa and was named canine HS-RARa. The expression of the genes encoding RARa in the dog was the highest in the testis and moderate in the blood, lymph node, mammary gland, pancreas, salivary gland, spleen, thyroid gland, tonsil and uterus. The nucleotide sequence encoded the 462-amino acid containing the conserved sequence motif of RARa. Though the amino acid sequences were well-conserved among species, some unique arrangements were observed within each class. In the phylogenetic analysis, each species separated according to their class. In the branch of mammals, the dog is in the cluster of humans, mice and western wild mice. However, hamsters and rats formed another branch.

This invention relates to the identification and use of cis acting nucleic acid elements that bind to nucleic acid binding factors to regulate genetic activities of nucleic acids. All living creatures store information in nucleic acid molecules called DNA or RNA that encode structural and regulatory proteins. The collective behavior of nucleic acids and proteins constitutes and controls normal cell and organismal life cycles. Nucleic acids and proteins also act as causative agents in, or response factors to, pathological conditions. Transcription of DNA into RNA, translation of RNA into proteins and other genetic events such as nucleic acid synthesis, sorting, processing, repair and degradation, are regulated by a variety of specialized nucleic acid binding factors. Nucleic acid binding factors bind to specific sequences present on the nucleic acid molecules they regulate, called cis acting nucleic acid elements. These nucleic acid binding factors, bound to their specific cis acting nucleic acid elements, are able to interact with other cellular factors to modulate specific genetic events. The binding of a nucleic acid binding factor to a cis acting nucleic acid element, or its ability to interact with other factors that mediate genetic events, or both, can be regulated in response to signals transmitted into the cell from the cell exterior. As an example, regulatory proteins called xe2x80x9ctranscription factorsxe2x80x9d bind to cis acting nucleic acid elements on genomic DNA at sites known as xe2x80x9cpromotersxe2x80x9d and xe2x80x9cenhancersxe2x80x9d present at variable distances from the site of initiation of transcription of the genes they regulate. The enhancer sequences and adjacent nucleic acid sequences, together with their bound transcription factors, are able to bend to contact the transcriptional complex bound to the promoter. Such contact can either enhance or reduce expression of the regulated gene. The human genome, which stores the genetic information of a human cell as DNA, is estimated to contain about 100,000 genes. Each of these genes and the RNAs they encode is likely to have multiple cis acting nucleic acid elements that bind to corresponding nucleic acid binding factors to regulate gene expression. These cis acting nucleic acid elements, and the factors that bind them, are potential targets for therapeutic drugs that could be used to modulate gene expression. Determining which cis acting nucleic acid elements are bound under different conditions can also be used to characterize and monitor the genetic responses of a cell under normal, pathological or experimental conditions. Current methods of identifying cis acting nucleic acid elements have several disadvantages. Most of these methods require prior identification of either the nucleic acid that is regulated, or the corresponding regulatory nucleic acid binding factor, or both. For example, once a nucleic acid has been identified, adjacent sequences, which are predicted to contain cis acting nucleic acid elements, can be isolated and subsequences therefrom are tested for cis activities. Alternatively, once a nucleic acid binding factor has been isolated, the sequences to which it binds can be identified. Other methods, which are limited to identifying transcriptional enhancer elements, involve cloning random nucleic acid sequences upstream of a reporter gene and observing expression of the reporter gene product. At present, however, there is no broadly applicable method to identify cis acting nucleic acid elements without prior identification of the regulated nucleic acid or of the regulatory nucleic acid binding factor. There is also no rapid and efficient method to simultaneously identify a plurality of cis acting nucleic acid elements. Thus, there exists a need for a method of rapidly and efficiently identifying cis acting nucleic acid elements. The present invention satisfies this need and provides related advantages as well. The invention provides a method of identifying nucleic acids containing cis acting nucleic acid elements. The method consists of contacting a diverse population of nucleic acid binding factors with a diverse population of isolated nucleic acid molecules under conditions that allow the nucleic acid binding factors to selectively bind the nucleic acids. The nucleic acids that bind the nucleic acid binding factors are identified and are characterized as nucleic acids containing cis acting nucleic acid elements. The method simultaneously provides for the isolation of nucleic acid binding factors that selectively bind the isolated nucleic acid molecules. The invention also provides methods of identifying compounds that are cis acting nucleic acid element analogs, compounds that are nucleic acid binding factor analogs, and compounds that selectively bind cis acting nucleic acid elements. The invention further provides methods to identify compounds that selectively displace binding between a nucleic acid binding factor and a cis acting nucleic acid element or between nucleic acid binding factors. The invention further provides a plurality of isolated nucleic acid molecules that each contain one or more cis acting nucleic acid elements. Also provided is a plurality of isolated cis acting nucleic acid element analogs. The isolated nucleic acid molecules containing cis acting nucleic acid elements and the isolated cis acting nucleic acid element analogs in the pluralities can be bound to nucleic acid binding factors. A plurality of isolated nucleic acid binding factors is also provided. The invention also provides a method of determining a binding state of a nucleic acid. The method consists of contacting a nucleic acid with a plurality of isolated cis acting nucleic acid elements under conditions that allow nucleic acid binding factors bound to the nucleic acid to bind to the isolated cis acting nucleic acid elements. The isolated cis acting nucleic acid elements that bind the nucleic acid binding factors are identified and characterize the binding state of the nucleic acid. The invention further provides a method of treating a pathological condition in an individual. The method consists of administering to the individual an effective amount of a therapeutic agent that selectively alters the ability of a cis acting nucleic acid element to regulate a genetic activity of a nucleic acid involved in the pathological condition. Also provided is a method of treating a pathological condition in an individual by contacting a cell of the individual with an effective amount of a targeting construct that includes a cis acting nucleic acid element and targeting sequences. The targeting construct is taken up by the cell and inserted by homologous recombination into a nucleic acid involved in the pathological condition so as to alter a genetic activity of the nucleic acid.

The present invention relates to defensive weapons and more particularly to a spring whip which can be conveniently carried by a user and can be easily placed in its whipping position. With the increased amount of crime, and especially attacks on individuals, there is a great need for defensive weapons which can be used to inflict a limited amount of pain so as to act as a deterrent. The weapon should be of a type which can be conveniently carried by an individual, and at the same time be available for immediate operation should an emergency situation arise. Numerous such defensive weapons are currently available. However, most of them require a great amount of time to place into operation. Such time delay can frequently result in harm to the individual before he has an opportunity to even assemble the defensive weapon. Other prior art devices are extremely dangerous and provide hazards to the individual carrying them and are therefore generally avoided. Still other devices are only available for summoning aid by sounding alarms, but do not provide an immediate weapon which can inflict pain and ward off an attacker. A useful self-defense weapon has been described in my U.S. Pat. No. 3,554,546. In that patent there is described a spring whip which can be utilized as a defensive weapon, and which is formed of interconnected lengths of springs, wherein the selected diameter of the springs provide a compact, telescoped arrangement which attributes to the convenience of carrying the device. The conventional spring construction which consists of a succession of helical turns permits interconnecting of the spring lengths in their extended operative position by merely providing variations in the diameters of cooperating helical turns which produce a wedging engagement between adjacent spring lengths. The lengths of springs are stored in a housing which also serves as a hand grip. In order to facilitate the movement of the springs from their storage to their projected position extending from the housing, a number of weights are movably disposed within the hollow interior of one of the springs and are confined within that spring by bending respective opposite ends of the spring. As the spring whip is projected from the housing, the plural weights move within that spring and roll toward the remote end of the spring to aid in the projection of the springs into their extended position. While such spring whips have been found quite useful, numerous problems have presented themselves with such devices to detract from their most efficient operation. For example, the lengths of spring did not have an arrangement for restraining their movement within the housing, and accordingly there was a tendency for the springs to loosen from the housing and accidentally move into their extended position. Furthermore, the movement of the weights provided an awkward arrangement in the projection of the lengths of springs, since they had a tendency to roll and move within the spring and continuously provided a source of annoying noise and disturbance. Furthermore, because the ends of the smallest spring were bent to retain the plural weights, the remote end of the housing had a sharp pointed edge, which had a tendency to cut and harm the individual carrying the weapon even when the weapon was not being used. These and other various problems provided an inconvenience and shortcoming to the spring whip described in the aforementioned patent.

Cerebellar atrophy diagnosed by computed tomography and clinical data. The diagnostic relevance of computed tomography (CT) in the classification of cerebellar atrophy or degeneration is unclear. Twenty-one patients with cerebellar atrophy at CT were studied and the findings were correlated to clinical data. Based upon such data the material was divided into two groups. In the first group (12 patients), with signs of cerebellar deficiency, 6 cases presented familial hereditary ataxia, and olivopontocerebellar atrophy of the Menzl type, 3 ataxia telangiectasia (Louis-Bar syndrome), 2 olivopontocerebellar atrophy of the sporadic type, and 1 adrenoleukodystrophy. In the second group (9 patients), without cerebellar deficit, cerebellar atrophy was found only occasionally. In all of them, there was cerebral atrophy. Clinically manifest cerebellar deficiency and cerebellar atrophy as evident at CT was mainly found in patients with familial genetic disorders. Cerebellar and/or vermian atrophy without clinical signs of cerebellar deficiency were observed only occasionally and were not specific.

On the other hand, sometimes you see other peoples or any person you know suffering from a bad situation or may be treated badly and wants to take the stand and raise for himself or herself, but he or she can't in that case if you think you can take stand for her/him then go for it, don't just step back.You know what, just remain silent all the time is not enough. Ok, sometimes you need to be silent when it needed in any particular situation. But when it needed to take the stand and raise voice then you have to go for it. sometimes, if you see other people need help then you have to raise voice and take the stand for himself/herself.That's the way you should live the life. that's the way you can solve the problem. because if you want to get out of something unfair or bad circumstances, you have to do by taking the stand, and this is one of the effective wayAll and all just take stand every time you think you have to then just go for it maybe for you, maybe for another person that you don't know. don't be hesitate, so when situations call for you just take the stand and raise voice don't step back.Thank youHave a nice dayFollow us

High-power, cascaded random Raman fiber laser with near complete conversion over wide wavelength and power tuning. Cascaded Raman fiber lasers based on random distributed feedback (RDFB) are proven to be wavelength agile, enabling high powers outside rare-earth doped emission windows. In these systems, by simply adjusting the input pump power and wavelength, high-power lasers can be achieved at any wavelength within the transmission window of optical fibers. However, there are two primary limitations associated with these systems, which in turn limits further power scaling and applicability. Firstly, the degree of wavelength conversion or spectral purity (percentage of output power in the desired wavelength band) that can be achieved is limited. This is attributed to intensity noise transfer of input pump source to Raman Stokes orders, which causes incomplete power transfer reducing the spectral purity. Secondly, the output power range over which the high degree of wavelength conversion is maintained is limited. This is due to unwanted Raman conversion to the next Stokes order with increasing power. Here, we demonstrate a high-power, cascaded Raman fiber laser with near complete wavelength conversion over a wide wavelength and power range. We achieve this by culmination of two recent developments in this field. We utilize our recently proposed filtered feedback mechanism to terminate Raman conversion at arbitrary wavelengths, and we use the recently demonstrated technique (by J Dong and associates) of low-intensity noise pump sources (Fiber ASE sources) to achieve high-purity Raman conversion. Pump-limited output powers >34W and wavelength conversions >97% (highest till date) were achieved over a broad - 1.1μm to 1.5μm tuning range. In addition, high spectral purity (>90%) was maintained over a broad output power range (>15%), indicating the robustness of this laser against input power variations.

[Treatment of defects of soft tissue and sternum, as postoperative complications of A-C bypass, case report]. Medial sternotomy is optimal approach for great number of heart surgery. Deep infection of sternum and mediastinis are very rear, but very dangerous complications followed by high rate of morbidity and mortality. Factors which can be responsible for these complications are numerous: post operation bleedings, surgery reinterventions, extended mechanical ventilation, liver chronic diseases, older age, diabetes, previous irradiation therapy, respiratory obstructions and use of steroids. Clinical signs for these complications are: red skin around the surgical wound, leaking, dehiscence, increased body temperature and instability of sternum. Early diagnosis, adequate antimicrobial therapy, and aggressive surgical and multidisciplinary approach in initial phase, are base for successful treatment. Surgical treatment most often assumes use of flaps. Our main objective in this work was to present treatment of defect of sternum and soft tissues, after triple aorto-coronary bypass. After the surgery patients got slack of sternum's ficsation and reficsation. With satisfactory respiratory function, corrections of defect was achieved by omentum and bipedicular myocutan flaps. (m. pectoralis major flap). There was no complications.

Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this patient react with proteins from viruses of the HTLV-I subgroup, but type-specific antisera to HTLV-I do not precipitate proteins of the new isolate. The virus from this patient has been transmitted into cord blood lymphocytes, and the virus produced by these cells is similar to the original isolate. From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.

Children enjoy toys that can captivate their attention. A toy ball is a particular play item that has endured the test of time and remained a favorite with children of all ages (infants, toddlers, etc.). However, as with any child's toy, some intrinsic dangers must be avoided. According to the U.S. Consumer Product Safety Commission, small objects can easily be lodged in the airway of young children, creating a choking hazard. Thus, it is imperative to create toy balls that are increasingly safe for use by children. Furthermore, a toy ball is often constructed from more than one base component (e.g., two half-spherical (hemispherical) shells that may be attached together to form a substantially spherical shell) in order to form a spherical structure. If these components that are used to construct the toy balls also contain small parts, they may create additional choking hazards to children in the event they come free during use. Thus, the particular construction of the components making up the toy ball must be considered so as to ensure safe use by children. In addition, ancillary entertainment features are often incorporated into toy balls (e.g., figurines, rattling elements, fluids, etc.) in order to further captivate and hold a child's attention. Such ancillary features are intended to be stimulating and aesthetically pleasing so as to maintain the attention span of most children. It should be noted, however, that some of these ancillary entertainment features may be sufficiently small in size so as to pose a potential choking hazard to children. Children sometimes play in rough manner. Thus, toys should generally be constructed so as to minimize the risk of damage during the normal course of play. In the instant case, a toy ball is sometimes subjected to rough play. A toy ball is subject to a plethora of physical activities (e.g., being thrown, rolled, dropped, hit, batted, etc.). Should a toy ball be broken apart in the course of play, the contents within the ball would be exposed/set free and, as such, the freed contents may constitute a risk to the safety of children playing with the toy. Additionally, the broken toy would be rendered unfit for future use. Prior art toy balls typically are constructed from two shell halves mated together to form a seam along an equator of the toy ball. Such prior art toy balls are illustrated in U.S. Design Pat. No. 274,070 to Ma, U.S. Design Pat. No. 190,036 to Lakin, U.S. Design Pat. No. 314,598 to Capper et al. (illustrated in FIG. 1), U.S. Pat. No. 4,272,911 to Strauss, U.S. Pat. No. 2,519,248 to Hulbert, and U.S. Pat. No. 2,351,762 to Hoover. The method of affixing one shell half to another can include but are not limited to cementing, heat-sealing, ultrasonic welding, and dielectric welding. Still other toys have a substantially formed sphere, with an opening to insert an additional entertainment item, and are then capped to encapsulate the item within the sphere. An example of such a prior art toy ball is illustrated in U.S. Pat. No. 4,601,675 to Robinson. During rough play, the toy balls have an increased risk of breaking open. The toy balls found in the prior art are not inherently resistant to forces acting perpendicular to the seam running along the ball's equator. More specifically, the equatorial seam provides little resistance to a shearing force applied at the seam or to tensile forces acting on the two shells perpendicular to the seam. Thus, it would be desirable to provide toy balls with a greater factor of safety for children. In particular, it would be desirable to provide a toy ball that possesses additional strength to withstand shearing forces acting on the seam of the toy ball. Additionally, it would be desirable to provide a toy ball that possesses additional strength to withstand tensile forces acting on the two shells perpendicular to the seam. Such additional strength would enhance the intrinsic value of a toy by providing an additional level of safety for children. Furthermore, while the addition of an element to structurally strengthen the toy ball is desired, any such element should not detract from the aesthetically pleasing nature of the toy ball to a child. Thus, there exists a need for providing a toy ball that has a construction that adds strength to the ball's seam in order to prevent the toy ball from breaking open and exposing its contents to the child playing with the ball. Furthermore, any additional element incorporated into the construction of the toy ball should be generally aesthetically pleasing to a child. Providing such an arrangement that both increases the toy's safety and makes the toy more aesthetically desirable not only increases a child's enjoyment, but also increases the attractiveness of the toy to anyone concerned with the safety of children. This invention is directed generally to a toy ball with additional strength to resist forces in a tensile direction or shearing forces applied to a main seam. More specifically, this invention is directed to a toy ball having two shells (hemispherical or unequal in size) fused together forming a seam, the toy ball also having opposing end caps, each end cap capturing a portion of each shell to resist both shearing and tensile forces acting on the seam.

Under 35 U.S.C. xc2xa7 119, this application claims the benefit of German Application No. 10023158.6, filed May 12, 2000, and entitled xe2x80x9cProcess and Means for the Production of a Radiation Device for Carrying Out an Intensity-Modulated Radiotherapy as well as Radiation Device,xe2x80x9d which is incorporated herein by reference. This invention relates to systems and methods for planning radiation therapy for a patient. Radiation therapy involves delivering a high, curative dose of radiation to a tumor, while minimizing the dose delivered to surrounding healthy tissues and adjacent healthy organs. Therapeutic radiation doses typically are supplied by a charged particle accelerator that is configured to generate a high-energy electron beam. The electron beam may be applied directly to one or more therapy sites on a patient, or it may be used to generate a photon (e.g., X-ray) beam, which is applied to the patient. With a multi-leaf collimator, the shape of the radiation beam at the therapy site may be controlled by multiple leaves (or finger projections) that are positioned to block selected portions of the radiation beam. The multiple leaves may be programmed to contain the radiation beam within the boundaries of the therapy site and, thereby, prevent healthy tissues and organs located beyond the boundaries of the therapy site from being exposed to the radiation beam. A typical radiation therapy plan calls for the delivery of series of radiation treatment fractions to the patient over the course of a several days or weeks. Each treatment fraction consists of a sequence of radiation segments with a prescribed cumulative dose intensity profile. Each segment generally has a different intensity profile and, therefore, requires a different leaf arrangement. The time required to deliver a treatment fraction primarily depends on the prescribed cumulative dose and the number of segments to be delivered to the patient. In order to reduce the discomfort patients experience during the delivery of a treatment fraction, efforts have been made to reduce the time needed to deliver treatment fractions to the patient. For example, U.S. Pat. No. 5,663,999 describes a scheme for optimizing the delivery of an intensity modulated radiation beam by selectively combining segments in a single treatment fraction to reduce the total number of segments in the treatment fraction. The invention features systems and methods of planning a radiation therapy comprising of a series of radiation treatment fractions each comprising a sequence of radiation segments with a prescribed cumulative dose intensity profile to be delivered to a therapy site on a patient. In one aspect of the invention, a pair of consecutive radiation treatment fractions is generated, wherein each treatment fraction comprises a different set of radiation segments. Embodiments may include one or more of the following features. Common radiation segments of two consecutive prescribed radiation treatment fractions may be combined to reduce the total number of radiation segments applied to the patient. The resulting intensity profiles of the two consecutive radiation treatment fractions may be different. The intensity profiles of the two consecutive radiation treatment fractions may be generated from an initial common intensity profile. The common cumulative dose intensity profile may be divided into a series of layers each corresponding to a predetermined dosage level. The layers preferably are re-assigned to a respective one of the two consecutive radiation treatment fractions. The layers may be re-assigned to the consecutive radiation treatment fractions so that the intensity profiles of the two consecutive radiation treatment fractions are approximately the same. Adjacent layers of the series of layers may be assigned to a different one of the two consecutive radiation treatment fractions. The remaining radiation treatment fractions may be grouped into fraction pairs, wherein the fractions of each pair each has a respective intensity profile generated from layers of a common intensity profile. The treatment fractions of each pair may have different intensity profiles. The two consecutive radiation treatment fractions may be normalized. For example, the two consecutive radiation treatment fractions may be normalized by increasing the predetermined dosage level of each layer by the same amount to achieve a cumulative radiation dose for each treatment fraction that is substantially the same as the cumulative radiation dose of the common intensity profile. In one embodiment, the radiation treatment fractions may be normalized by substantially doubling the predetermined dosage level of each layer. In one embodiment, the total number of radiation segments applied to the patient may be reduced further. In this embodiment, the intensity profile of a selected one of the two consecutive radiation treatment fractions may be divided into a plurality of radiation segments. Divided out radiation segments preferably are combined to reduce the total number of radiation segments in the selected treatment fraction. The invention also features a system, a computer program, and a computer-readable medium carrying instructions for planning the application of a series of radiation treatment fractions, each fraction comprising a sequence of radiation segments with a prescribed cumulative dose intensity profile to be delivered to a therapy site on a patient. The system, computer program, and computer-readable medium each are operable to combine common radiation segments of two radiation treatment fractions to reduce the total number of radiation segments applied to the patient. Among the advantages of the invention are the following. The invention combines common radiation segments across the series of the radiation treatment fractions in the overall treatment plan to reduce the total number of segments in each treatment fraction. In accordance with this inventive scheme, the treatment time may be reduced without substantially changing the overall, curative biological effect of the treatment plan.

Synthesis of two storage proteins during larval development of the tobacco hornworm, Manduca sexta. Studies of synthesis and accumulation of the two storage proteins arylphorin and female-specific protein (FSP) during the final two larval instars of the tobacco hornworm showed both stage and temporal specificity. Arylphorin was present in both stages, but its synthesis ceased during the molt, during starvation, and at the wandering stage, and then resumed about 24 hr after the onset of feeding. During the larval molt about 25% of injected iodinated arylphorin was incorporated into the newly forming fifth instar cuticle. The cessation of arylphorin synthesis was mimicked by exposure of the fat body to 1 microgram/ml 20-hydroxyecdysone (20HE) in complete Grace's medium or to dilutions of Grace's medium greater than 50%. Lower concentrations of 20HE were ineffective, indicating that the cessation of synthesis in vivo was likely due to a combination of lack of excess nutrients and the hormonal milieu. The female-specific protein was not synthesized until the final larval instar, appearing first in females on Day 2 and later in males at the time of wandering, with synthesis continuing throughout the prepupal period. In vitro studies showed that this protein was synthesized as a 620-kDa protein, and then during secretion a 730-kDa immunoreactive form also appeared. Synthesis of FSP was inhibited by exposure of Day 2 fat body to 1 microgram/ml 20HE for 24 hr. Ligation followed by 20HE infusion showed that the disappearance of FSP from the hemolymph during the prepupal period was controlled by the rising ecdysteroid titer.

Competitive enzyme-linked immunoassay for sialoglycoprotein of edible bird's nest in food and cosmetics. The proliferation of fake and inferior edible bird's nest (EBN) products has recently become an increasingly serious concern. To identify and classify EBN products, a competitive enzyme-linked immunoassay (ELISA) was developed to quantitate sialoglycoprotein in EBN used in food and cosmetic applications. The characteristic sialoglycoprotein in EBN was found, extracted, purified, and analyzed. Sialoglycoprotein, considered the main carrier of sialic acid in EBN, consisted of 106 and 128 kDa proteins. A monoclonal antibody that could recognize both proteins was prepared. The heat-treated process did not change the affinity of sialoglycoprotein with the antibody. An optimized ELISA method was established with a cross-reactivity of less than 0.1% and an IC(50) of 3.3 μg/mL. On the basis of different food and cosmetic samples, the limits of detection (LOD) were 10-18 μg/g. Recoveries of fortified samples at levels of 20 and 80 μg/g ranged from 81.5 to 96.5%, respectively. The coefficients of variation were less than 8.0%.

Health-related quality of life and its determinants in children and adolescents born with oesophageal atresia. Following surgical correction in the neonatal period, patients born with oesophageal atresia have significant co-morbidity, particularly in childhood. This study evaluates health-related quality of life and its determinants such as concomitant anomalies and the presence of respiratory and/or gastro-intestinal symptoms 6-18 years after repair of oesophageal atresia. Parents of 24 patients with oesophageal atresia completed the child health questionnaire for parents and 37 patients completed the child form. Gastro-intestinal symptoms were assessed by a validated standardized reflux questionnaire. Results were compared with a healthy reference population. Parents as well as patients themselves scored significantly lower on the domain general health perception. According to parents, general health perception was negatively affected by age at follow-up and concomitant anomalies. Patients reported that reflux symptoms reduced general health perception. In this first study describing health-related quality of life in children and adolescents born with oesophageal atresia, we demonstrated that general health remains impaired because of a high incidence of concomitant anomalies and gastrointestinal symptoms in patients with oesophageal atresia when compared with the healthy reference population.

The present application finds particular application in parking brake systems in vehicles, particularly involving pneumatic parking brake systems. However, it will be appreciated that the described technique may also find application in other brake control systems, other valve actuation systems, or other pneumatic control systems. Conventional single-motion parking brake release mechanisms suffer from many drawbacks, including unintentional parking brake release, which can cause a vehicle to roll unexpectedly and cause injury and/or property damage. For instance, such systems typically employ a plunger knob that an operator pulls outward to actuate the parking brake system. When the operator wants to release the parking brake, the operator pushes the plunger knob inward to a released position, which permits air to be supplied to a parking brake system and causes the parking brake to be deactivated. However, using such an arrangement increases the occurrence of inadvertent or accidental brake release. For instance, an operator or occupant may inadvertently depress the knob into a released position; a pet that travels with the operator in the cab of his truck may depress the knob into a released position when looking out through the windshield, etc. In these cases, if the release of the parking brake is not immediately noticed, the vehicle can roll away and cause damage to property or worse, injury to people. The present innovation provides a new and improved parking brake release system, which overcomes the above-referenced problems and others.

Aortic depressor nerve unmyelinated fibers in spontaneously hypertensive rats. The objective of the present study was to compare the morphology of the unmyelinated fibers in the aortic depressor nerves (ADN) of spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY). In anesthetized rats, the ADN was identified by its spontaneous activity synchronous with the arterial pulses. Thin sections of the proximal and distal segments of the ADN were analyzed by electron microscopy, and a morphometric study of the unmyelinated fibers and Schwann cells was performed. The proximal segments of WKY and SHR ADN contain an average of 335 +/- 68 and 130 +/- 14 unmyelinated fibers, respectively (P < 0.05), and the distal segments contain an average of 337 +/- 46 and 242 +/- 77 unmyelinated fibers, respectively (P < 0.05). The distribution of the diameters of unmyelinated fibers was unimodal for both strains, with the histogram from the SHR significantly shifted to the left. Because the unmyelinated fibers play a role in the tonic inhibition of the medullary vasomotor centers, especially in the presence of hypertension, the morphological differences observed in the ADN from SHR may account, at least in part, for the blunted baroreflex of SHR.

Effects of phacoemulsification with versus without viscoelastic devices on surgical outcomes. The aim of this study is to report surgical outcomes in patients undergoing phacoemulsification surgery (PE) with versus without ophthalmic viscosurgical devices (OVDs). This is a comparative case series study. In total, 145 patients who performed PE with OVDs in 68 eyes (Group 1) and without OVD in 77 eyes (Group 2) were enrolled. A comprehensive ophthalmological examination was performed including slit-lamp, fundus examination. Best-corrected visual acuity (BCVA), intraocular pressure (IOP) specular endothelial microscopy (SM), and ultrasound pachymetry (UP) were also measured before surgery and at four-time points postoperatively. The differences in baseline characteristics as well as in outcomes were compared between the two groups. The mean BCVA was 0.41 ± 0.26 logMAR in Group 1 and 0.54 ± 0.34 in Group 2 at postoperative first day, with a significant difference (p < 0.01). The mean BCVA, IOP, and UP at 6 months did not differ between the groups. The mean baseline and postoperative SMs were 2063 and 1910 cells/mm2, respectively, and the endothelial cell loss (ECL) was 153.89 ± 189 in Group 1. The mean baseline and postoperative SMs were 2153 and 1948 cells/mm2, respectively, and the ECL was 205 ± 200 in Group 2. The difference between the groups was not statistically significant (p = 0.105). The ECL seemed to be higher in the Group 2, but the difference was not significant. The final clinical outcomes were similar between the groups. In selected cases, PE without OVD may be preferable to reduce the cost of surgery in places with low economic status and to prevent side-effects of these devices.

Interrelations between carbohydrates, lipids, and the hemostatic system in relation to the risk of thrombotic and cardiovascular disease. Metabolic diseases, such as obesity, impaired glucose tolerance, type I and type II diabetes, hypercholesterolemia, and hypertriglyceridemia, are among the main risk factors for the development of atherothrombosis. Various abnormalities of the hemostatic system (platelet hyperaggregability, hypercoagulability, and hypofibrinolysis) have been described in all these situations. The individual effect of each of these disease on the hemostatic system is difficult to evaluate because these states are often associated in the same patient and the treatment of one can benefit the others. Therefore it may be queried if a common abnormality of these pathologic states might explain their impact on the cardiovascular system. We have been interested by hyperinsulinemia, which is observed in obesity, impaired glucose tolerance, type II diabetes, and hypertriglyceridemia, and we have shown a very strong correlation between plasma insulin, body mass index, triglyceride levels, and one of the main inhibitors of the fibrinolytic system, plasminogen activator inhibitor-1. Partial correlation analysis showed that only the correlation between insulin and plasminogen activator inhibitor-1 was independent. Therefore a high plasma insulin level could be responsible for elevated levels of plasminogen activator inhibitor-1, which by inducing an hypofibrinolysis, could play a role in the deposition of fibrin and the development of atherothrombosis. The description of some interrelations between metabolic diseases and hemostasis is satisfactory but does not exclude specific effects of these diseases on hemostasis, such as glycation of the coagulation and fibrinolytic factors in diabetes or toxic action of lipoprotein on endothelial cells in hyperlipoproteinemia.

"Bible?" "Paris!" "Help me!" "Help me!" "Please!" "Hey you!" "I'll kill you, stop!" "thief!" "Miss!" "Miss..." "Miss..." "Miss!" "The bets have been placed!" "Paris." "Twelve thousand..." "She's very beautiful... and you don't have a blonde." "Three hundred." "Three hundred... and fifty with the shoe." "That's a bonus!" "Get out!" "Get Out!" "Ask her... what she's doing in Yuck Yen!" "She's not talking!" "Idiot!" "How can she?" "Tell us about yourself, Miss..." "If you need help..." "I'll be glad to help." "Answer!" "Idiot!" "Escaped from where?" "From a convent to find her father." "What's a convent?" "Convent?" ""Convent: boarding school where girls are instructed by Catholic nuns"." "In Chinese!" "Nice... the story about seeing her father..." "In a dream!" "And having a premonition of the danger he's in!" "Translate!" "Translate!" "I don't know how to say 'premonition'." "Amateur!" "Go away!" "Let's see if she's made like a Chinese girl..." "Watch out!" "I don't give a shit about the stuff in the crates." "Or about the bastard who tried to kill me." "But I do give a shit when you screw me around." "Now, if you pay me back like a good boy, I might forget it." "Because I'm not the vindictive type." "Hurry up!" "I want to see your hand moving." "That's right." "You understand me when you choose to." "That's for your staffing costs." "Oh, bugger." "I'm Gwendoline." "He owed me $859." "Here." "Look in her hand!" "She killed them all!" "Run!" "Miss!" "Those filthy scoundrels dared to lay their hands on you." "My dress is all torn." " This is awful." " Can you mend it?" "It was from Mother." "Of course, Miss." "I shouldn't have helped you make this journey." "You were nearly killed." "Yes." "He was wonderful!" "His big, blue eyes, his strong, soft hands..." " Put that money back." " We have to search for your father." "How else will we survive in this godforsaken backwater?" " We are not stealing this!" " Very well, but it won't be easy." "Your fine principles will be the death of you." "And me." "Hide!" "They were here!" " Beth!" "Beth, it's him." " Alright." " You're going to lose again, Willard." " I'm not, I feel lucky tonight." "Help us!" "They're after us!" "Tell them we didn't kill their friends." "I don't help people." "Everything on seven." "Seven." "That's it." "Excuse me." "I won." "Just because Yuki was unwell, there's no need to upset me." "I'm playing." " I'm so grateful." " You just made me lose $60." "Beat it." "Or else..." "Or else I'll stuff you in that bag." "We need you." "Don't desert us." "Run along home." "Mummy will be worried about you." "This dress belonged to her, but she never had a chance to wear it." " Really?" " That's enough!" "This girl came more than 4,000 miles in a filthy cargo hold to find her father." " And what does her father do?" " He's a butterfly collector." "Well, you're in luck." "This is Inspector Kataceo, the chief of police." "Him?" "Inspector, please protect us!" "Hey, that's enough." "Stop it!" "What are you doing?" "Let's have a little dance up on stage and I'll see what I can do for you." "Let go of her, or else..." " Or else what?" " You monster!" "Leave me alone!" "If it's black, you help us;" "if it's red, you never see us again." "Go ahead." "We won!" "Get your hands off me!" "We lost." "Let her go." "I said,"We lost"." "Let her go." "Here's a present for you." "Let's go." "Hi, Shirku." "I've brought you some guests." "See?" "You're not disturbing him at all." "He's listening." " We're looking for a man who..." " Collects butterflies." "Yes, I know him." "Have you seen him recently?" "He wanted me to go with him on his expedition." "I told him what he would be up against." "It was like talking about syphilis to a virgin." "Going off to risk his life for some shitty little butterfly." "But he's devoted his life to this." "If he finds this butterfly, it will be named after him..." "I know, I know." "I'll tell you where to find this insect of yours in need of a name." "This is Eastern Katiwan." " We're in Yuk Yen..." " Yuk Yen." " Next there's jungle and swamp..." " Swamp." " then the River Chu Chi Yu..." " Chu Chi Yu." "on which you sometimes see very mysterious junks." "And then there's nothing." "The Yek Yeik." "All of this is the Yek Yeik." "This is a great map of the Yek Yeik." "There's nothing on it." "Just a few squiggles going nowhere to let you know that you're lost." "No one has ever gone there." "No one has ever gone there and no one will ever come back." "Sometimes a wind blows from the south." "It's the Kalibidu, a supernatural force." "This wind is lethal." "I'm sorry, but I can't help it... if your butterfly chooses to live in the Yek Yeik desert." "In the Yek Yeik, is there a huge crack in the ground... where there are explosions that rock the earth?" "So people say." "But that's just a legend, the Legend of Pikaho." "That's what I saw in my dream." " I have to go there." " Bon voyage, Miss." "The last time I saw your father, he was in Tacoma." "Right, take us to Tacoma." "What?" "No." "No way." "Sorry." " Bye, Shirku." " Ciao." "I'm taking you in." "We've found traces of the virus that killed Yuki." "And the girls don't have passports." " Ow!" " Be careful!" " So you're playing it nasty?" " I've got a bit of a sore cheek." "What?" "Are you scared of dirtying your strong, soft hands?" "Thank you." "So much for all your fine words." "Let her go!" "That's enough messing about!" "Let go!" "What are you waiting for?" "Aren't you going to scream?" " More!" " Hit me!" "Defend yourself!" " More!" " More?" "Scream, for Christ's sake." "What an idiot!" "There you go." "I'll never forget what you've done." "If you ever cross my path again, you're for it." "Didn't you hear me?" "Get lost!" "I'm sorry, but you can't just abandon us here." "Take them to the port..." "OK?" "Come with me." "There's a nice ship that's going to take you back to Europe." "There you go." "Bon voyage, kiddo." "It's better this way, believe me." "Got a light, Willard?" "Scottie wants to see you." "I don't want to see him." "Tell him yourself." "You wanted to see me?" " Another little racket?" " I've got 20 of these." "They may be small, but they're worth a fortune." "You'll find an old junk as you come out of Ogao." "No messing around, Willard." "They're worth a fortune." "What will you pay me to deliver them?" " Two?" " Four." "Let's say three." " Three and a quarter." " Right." "When is it for?" "We'll get it to you tomorrow morning." " You know where to find me?" " The whole world knows." " What the hell...?" " My father's in danger." "With you as a daughter, it's hardly surprising." " Can you swim?" " No!" "It doesn't take long to learn." "Bon voyage." "Right, let's make a start on Lesson Two." " Off you go!" " Help!" " Off with you!" " Get your dirty great hands off me!" "Nobody tells me what to do." "Oh, I forgot to tell you." "Two gentlemen came this morning with your packages, but you were asleep." "I told them to be quiet so as not to wake you, but don't worry, I've got the packages." "Thank you." "That's very kind of you." "If you're still there when I get back, I'll throw you a rubber ring." "That's awfully kind, but there's a slight problem." "I can't..." "I can't remember where I put the packages." "I've got an idea." "Beth, once we're out of the water and we've found my father, we might make a real effort to remember where we put them." "Otherwise this poor boy might never be able to go back to Yuk Yen, which would be a real shame." "Did the packages you hid look like this?" "Yes." "It's obvious you've done this before." "Let me give you some advice." "Keep your heads down." "Otherwise once we've found Daddy, you're on your own." "Willard?" "Is there anything I can do for you?" "Yes, if you know how to fight." "I want it back in the same condition as it is now." "Understand?" " Ready to die?" " When I'm with you, I feel safe." "That's funny." "When I'm with you, I feel the opposite." "Maybe they won't come." "They're already there." "Hiding." "Watching." "I'm sorry we're causing you so much trouble." "Will you forget about yesterday when you kissed me?" "It was my first ever kiss." "I don't know what came over me." "If something happened to one of us, I couldn't bear it." "Love will always find a way." "If a man came out with crap like that, I'd smack his face in." "Now you go off and have a little nap until Daddy calls you for supper." "Don't move." "Here they come." "Your junk sure looks loaded down..." "What's wrong with it?" "I want... everybody on your junk's deck!" "Don't you trust me?" "That'll do, Taouto." "You know the place is teeming with pirates." "Get everyone on deck, or the deal's off." "Everybody out!" "Two men will be enough." " Only two?" " Yes, two." "OK, two of you go check the bags!" "Get a move on!" "Quick!" "What's with this need to check up?" "Don't you trust me?" "It seems there are pirates around here!" "Hey!" "Catch!" "This might speed you up a bit." "Go and get him!" "Kill him!" "Don't move!" "I'll never forget this, Willard!" "Nice work." "Perfect." "You're hired." " Willard?" " Yes, Miss?" " What's that?" " What do you think?" "It's Tacoma." "Catch!" "Tell Tom that Willard just blew in." "If your father came this way, Tom will have seen him." "He always knows what's going on." "If he's not here, that's that." "End of journey." "I've repaid my debt." "What does your father look like?" "When he's out on expeditions, he always wears a white jacket, white trousers and a brown hat." "On his last expedition..." "Willard, you old bugger!" " No!" " No!" "Oh, Miss!" "Help me." "Where did you find those clothes, Tom?" "We found his body tangled up in some roots along by the river." "Judging by the state he was in," "I would say he had ventured out as far as the Kiops." "Unfortunately for him, the Kalibidu was very strong that night." "There's no doubt in my mind that he was a victim of their superstition." "What do you mean?" "It's not a pretty story." "You tell them." " No." " Tell us." "The Kalibidu is a poisonous desert wind." "It makes you retch, it makes you puke, it can kill you." "The Kiops are terrified of it and believe they can appease its fury with human sacrifices." "They sacrificed my father to appease the spirits?" "The bizarre thing is that the Kiops sacrifice only men to their gods." "They tie them up live to a sort of web they weave and then the Kalibidu comes along and the bodies disappear." "The bodies disappear." "Without trace." "End of story." "But what was most surprising was that your father's body had a gunshot wound in it." "The Kiops don't have any firearms." " Could it have been a trafficker?" " I know my stuff." "No one trades with them." "They don't have money." "What I find hard to understand is why a white man would go all that way just for a butterfly." "I wouldn't do it for $1,000." "What about $2,000?" "$2,000 all in one go?" "There's no such thing." "That's enough, Willard." "We leave tomorrow." " Where for?" " The Yek Yeik." "Why?" "Your father is dead." "It's pointless." "I'm going to find the butterfly and name it after my father." " I'm going to pursue his dream." " Well, you can count me out." " Are you scared?" " Are you paying?" "You'll get it tomorrow morning." "Tom, I need to speak to you." "And you can go and wash." "You stink." "But where is she going to find all that money?" "If Willard finds out about this, I'm done for." "Think about it." "You'll make a big profit." "I'll have to keep out of the way of Scottie's pals, or that's me done for again." "What a fascinating job yours is." "I hate to see all that money wasted for the sake of a mere butterfly." "Consider it carefully." "No one has ever come back from the Yek Yeik alive." "What do you want those labels for?" "That's more like it." "I suppose this will be enough for all my kit." "Such a pretty girl." "You did that on purpose." "I could have lost." "Get up and let's go." "This is neither the time northe place to count it, but it's all there." "Where did this spring from?" "If you knew, you wouldn't be happy." "I don't like waiting." "Gentlemen." "Sorry, boys." "I'll do anything for science." "Willard!" "Where are you?" "Got one!" " Got it!" " You're lagging." "There!" "I'm in training forthe great butterfly hunt." "I just can't do it." "Willard, stop!" "You're going too fast." "You're doing it on purpose." "While you're down there, you might as well fill this up." "I might need it for my bath tonight." "Well, here we are, the gates of hell." "Your very own hell." "I don't suppose you were thinking of giving up, because I was..." "No?" " You really want to go on?" "OK." " Oh, just stop it." " What's up?" "Come on." " You're not very funny." "I thought we were rationing the water." "Gwendoline!" "Don't move." "Don't move your foot." "Beth, the flask." "Sapricus Orantis, rose of the desert." "It lives 30 years on three drops of water." "What's got into you?" "Have you gone crazy, or what?" "Look, if we haven't found your bloody butterfly by the time our flasks are empty, we're going home." "You're a bastard, Willard." "That's why I hired you." "You have to help me." "We have a contract." "Isn't that word a bit stupid in our current situation?" "I order you to go on." "What's more, you're going to carry Beth." "And, when I'm tired, you're going to carry me." " No, there's no need." "Don't do that!" " Goodbye and good luck!" "What do I care about your insects and your family problems?" "I'm not risking my life in a godforsaken uncharted desert with a hysterical girl, a useless maid and a bloody butterfly net!" " Wasn't your father's death enough?" " Come back!" "You can't desert us!" "Willard, you're going to come with us because I'm telling you to." "You're nothing but a swindler, a dirty, opportunistic nobody." " He's going!" " I don't like goodbyes." "Come back, Willard!" "Maybe now is the time to count your money." "You never know." "Shit!" "You'll get your money." "Don't get worked up." "If you're a good boy, you'll be paid when we get back." "Let's go, Beth." "Miss." "Good work, Willard." "This will speed us up." "With each swing of the machete, I'm picturing it slicing your head off." "Don't move." " Somebody's been this way." " Could it have been my father?" "No, it's too recent." "Don't mess with us." "We're not in the mood." " Is that a boa?" " Of course not." "It's a goldfish." " Are you sure this is the way?" " I don't know." "Ask him, he's local." "Hey!" "Where are you?" "Wait for me!" "What's he doing?" "Is he ill?" "Take your clothes off!" "Quickly!" " I told you to get undressed!" " He's mad." "We'll catch our deaths." "Would you rather die of thirst?" "Come on." "Do as I'm doing." "You're useless!" "Go and fetch me some wood." "We have to make a fire." "Hurry up!" "We're doing our best." "Here." " Where is this from?" " I can't remember." "Why?" "Try to remember." "There." "I've seen crates like these before." "I don't think we're alone." "Let's keep going anyway." "Stand up!" "That's more like it." "Willard!" "Willard!" "Haven't you ever been in love?" "Yes." "With every woman in the world except you." "I won't have you telling me how to live my life." "I decide." " That's not what I was asking you." " Really?" "No!" "No!" "The first time I saw you, I was reminded of a panther I once found." "She was beautiful, with magnificent eyes." "She followed me everywhere, slept in my bed." "One day, she was killed by a hunter, and I cried." "Jesus!" "How totally ridiculous!" " Willard?" " Shh." "Be quiet." "I can hear something." "It sounds like a waterfall." "I said, "Be quiet"." " Yes, it's water." " Come back!" " Ow!" "What are you doing?" " Don't move!" "Stop it!" "But..." "Goodness!" "How did you guess?" "Instinct." "I'm infallible." " Come on." " Let's get out of here." "Shit!" "The Kiops." "Pretty, aren't they?" " Are those your father's binoculars?" " Yes." "My mother gave them to him." " For his last expedition." " I see." "Look at his tattoo." "Isn't that your stupid butterfly?" "All I know is that we're nearing our goal." "Great." "Now we can die in peace." " Are you OK?" " Yes." "Are they going to kill us?" "The Kiops don't actually kill." "Tonight, they'll stir up their dogs and tomorrow they'll turn you out and you'll have to run." "If you can outrun the dogs, you might just see my money again." "Feel free to send it my love." " What will they do with you?" " Tie me to one of their webs." "By sacrificing me to the Kalibidu, they save one of their warriors." "When you're running away from the dogs tomorrow, if they haven't caught you after 300 yards, run in zigzags." "They'll get disorientated and tire more quickly." "Do we have any chance at all?" "None at all." "Willard..." "Forgive me." "Oh, please." "Whatever you want, but not that." "It's my last night on earth." "I want a good night's sleep." "Oh, brilliant." "Don't you think it's a bit late to start blubbing?" "What did you expect?" "A walk in the park?" "A picnic?" "Maybe you'll feel differently about butterflies when the dogs are feeding on your entrails." "Keep your comments to yourself." "You'll never be a hero without being paid." "Gwendoline..." "Let me tell you something." "If I were your father, looking down from heaven, I'd be so proud of you." "If we ever get out of here, I promise you we'll find your butterfly." "It will be the most beautiful butterfly in the world, and it will be named after you." "Willard, I feel so guilty." "Gwendoline..." "Have you ever made love?" "No." "No?" "You can't die without having made love." "Come closerto me." "You mustn't feel ashamed." "Imagine your body against mine." "You're trembling." "I'm kissing you, burying my face in your neck." "You close your eyes." "You can feel my kisses on your skin." "Oh, your lips are so soft." "I'm stroking your hair." "You can feel my hands in your hair." "I'm running my hands down your body." "You can feel my hands on your breasts." "You shiver." "You're beautiful." "Let yourself go." "I'm in your mouth." "I'm stroking yourthighs," "I'm stroking your stomach..." "Let yourself go." "Don't be ashamed of what you're feeling." "I want to come inside you." "I want you." "You can feel my skin against yours." "You can feel how much I want you." "Gently, gently..." "I'm coming into you..." "Slowly." "I'm coming." "I'm inside you." "I can feel you." "I can feel you." "Feel me." "It feels good." "Feel it!" "Beth!" "I've done it." "Oh, no!" "I've had enough." "Enough, enough, enough!" "Enough of walking, running, falling, swimming, dying..." "I just want to catch this stupid butterfly and go home." "So if one of you little savages raises a finger to stop us leaving, he'll pay." "Why can't we be left to walk through the jungle in peace?" "I won't have it!" "Right, let's go." "I can't take any more." "She's right, you know." "You're beginning to get on my tits." "Oh, shit." " This way." " Quick!" " Hurry up!" " We've done it." "We've escaped." "Yes." "It's odd, though, isn't it?" "Well, we've reached the Yek Yeik, anyway." "Of course!" "That's why they didn't follow us." "I should have known." "It's the Kalibidu." "Lie down!" "Come on, lie down." "Lie down flat." "Breathe as little as possible." "Lie down." "Lie down and don't breathe!" "Do as I say." "Cover up your mouth, otherwise you'll die." " How long will it last?" " I don't know." "Alright, guys?" "Are you still alive?" "If you know someone who likes solitude and wide open spaces, this is the place for him." "Yes." "Yes, this is it." "It's here." "I'm sure of it." "The footsteps in the sand." "The bodies in my dream..." "The butterfly is in the chasm ahead." "This is fantastic!" "Wait!" "What's she doing?" " This is it!" " What's up with her?" "It's exactly like in my dream." "Come on!" " Does this mean it's all over?" " Come on!" " The Kalibidu has gone to her head." " Maybe." "Nice place." "This is it." "We'll catch the butterfly and go home." " You think your bug is down there?" " Of course." "Throw something down..." "Not my cap!" " What are we waiting for?" " Have you got the net?" " I'm so happy." " Can I go down first?" " Excuse me." " Go ahead." " Willard, have you been to Paris?" " What?" " We could go there." " Hang on." "This is my kind of place." "If you try to force me to go to Paris, I'll smash your face in." "I see, because we had a romantic moment last night, we have to print the wedding invites" "I see." "What happened last night was just a game for you." " I'm down!" " You're horrible." "I don't need you any more, Willard." "You're dismissed." "I've got it!" "I've got it!" "It's beautiful." "Come on down!" "No!" "No, no." "It's wonderful!" "Beth!" "Beth!" "Beth, what's happening?" "Beth, Beth!" "We have to do something." " Yes, but what?" " I don't know." "Climb the wall." "There must be a way through." "Beth!" "Well done." "That was subtle." " Nobody's perfect." " Let's go." " We killed her." " We'll say the butterfly killed her." "You didn't tell me the end of your dream." "There's a tunnel over there." "Let's go." "There are only women." "No men at all." "What are we going to do to find Beth?" "What?" "What?" " No!" " Oh, yes." "This is ridiculous." "They'll realise at once." "They've all got huge breasts." "Relax." "Even with your beard, you look stunning." "Right, I've had enough." "I'm throwing you overthe wall." "You can find Beth and carry on your childish games elsewhere." "Go ahead." "What are you waiting for?" "It won't help you, though." "You'll never see your money again." "You know how I got the money?" "I sold your packages to Tom." "I always knew Tom was a shit." "Really?" "Well, there's no reason he should look up to you." "You're a coward, Willard." "You're afraid of feelings." " Oh, yeah?" "Feelings are for wimps." " Really?" "You're never going to find anyone who loves you for what you are because you lack the courage to say, "I love you"." "Goodbye." "Don't cry over me." "I'm not worth it." "Fine." "Let go, then." "But it's your name I'll cry out as I hit the ground." "I belong to you, body and soul." "Are you joking?" "Gwendoline!" "Let me go!" "I don't know how to say those kinds of things." "Jesus Christ!" "Gwendoline, I love you!" "I hope that was genuine." "Let's go." "Look!" "Idiot!" "Come on." " What's that?" "Are those diamonds?" " Come on." "I'm sure of it, look at the pipes, the machinery, the buckets..." "It's diamonds!" "I love your butterfly." "Pikaho is real." "Let's find Beth and go." "We'll be rich!" "Let him go." "You'll suffocate him." "That way!" "Quick!" "Come on." "The Kiops." "The Kiops, the storm..." "The storm..." "It was real." "I don't believe it." "The bodies in my dream were theirs..." "I can't leave you alone for five minutes." "I'm doubling my fee." "Behind you!" "I don't believe it." "Beth!" "Don't bother with me." "Have you lost something, Gwendoline?" "Oh, you're beautiful." "Come over here." "Welcome." "We're not used to visitors." "This is a quiet spot." "Let Beth go, now!" "Ah, Beth." "From now on, she's U89." "Your friend has been punished, Gwendoline." "We were just having a quiet chat when suddenly she killed herself." "Such a pity." "I have so little chance to practise your charming language." "I'm surrounded by idiots here." " What have you come here for?" " Just to catch a butterfly." " And who is with you?" " Nobody." "I hate lies." "The kingdom needs discipline." "These girls tried to bring a man into the building without my permission." "I find disobedience loathsome." "Take her away and untie the other one." " Ah, there you are." " Superb." "You're superb." "I never know how to introduce you, Darcy." "Just call me Darcy, as usual." "What do you think of her?" "Superb." " She's superb." " That'll do, Darcy." "What about me?" "What do you think of me?" "You're superb." "I'm most honoured." "Welcome." "You're hopeless, Daroy." "I've told you before, you don't kiss a girl's hand." "You must excuse him, Gwendoline." "He was dragged up." "But he's right." "You really are superb." "It's stupid of you to refuse my friendship." "It's your only chance." "Right, that's enough." "Stop your stupid games!" "Gwendoline's coming with me." "We've got a lot to do." "Mr Willard, I presume." "You're not in a position to make demands." " Is he, Darcy?" " You're superb." "Right, you're going to let her go and we'll leave now and forget everything." "Gwendoline, could you forget everything?" " You're hunting a butterfly?" " Yes." "My father's." "Ah, yes." "The old gentleman who also claimed to be hunting the butterfly." " Do you remember, Darcy?" " I never forget what you make me do." "Bring him to me." "Smile, Gwendoline." "I hate sulky people." "There." "Are you sure you don't know the Legend of Pikaho, Gwendoline?" " Willard?" " Never heard of it." "I'm sure you could tell it beautifully." "I'd be surprised." "Let me help you out." "In the 12th Century, a volcano, extinct for 10,000 years, started to spew out diamonds." "The earth split open, the volcano was swallowed up and Pikaho was never heard of again." "According to the legend, no one survived, but it seems some bastards are still profiting from the situation." "Beautiful, Willard." "I love educated people, don't I, Darcy?" "Very educated." "The legend also says that the volcano takes vengeance on those who rob it." "So be careful, your alchemical games might blow up in your face." "Impossible." "Everything is precisely tuned." "So, you came to hunt the butterfly?" "Yes." "I'm under contract to the young lady." " What do you think of him?" " Superb." "He's superb." "You've lost, Willard, but I'm not vindictive, so I'll let you into my legend." "When the earth split open, nature went awry and few survived." "Most were women." "Such men, as there were died off mysteriously." "I need men like you, Willard, to keep my civilisation alive." "Darcy will set up a trial to find out which of my top girls will have you." "You'll give her a child." "I want a male." "Really?" "Why not get your odd-jobber to make you one?" "Fortunately for him, that's not on his list of duties." "Because here, you have to pass exams before you're allowed to make love?" "If I accept, will you let Gwendoline go?" "Oh, you can do whatever you want afterwards." " But you'll be worn out by then." " Don't insult me." "I could repopulate this place single-handed." "You're wrong to boast, young man." "I wouldn't like to be in your shoes." " No one asked you, Darcy." " I said nothing." "You're superb." "Just give in." "Here, we hope to be able to love." "You have nothing left to defend or protect." " Forget the man who was with you." " Willard?" "Why?" "Here, all men die after mating." "When nature transformed the mountain, the natural order also changed." "We live like insects." "The female kills during her climax." "I don't want him to die." " You're mad." "You'll never get to him." " I must try." "It's my fault he's here." " No." "It's too dangerous." " Let me go!" "Beth!" "Sorry, Beth." "Willard, these are my top warriors." "They're prepared to fight to the death to make love to you." " Choose four of them." " I don't want to." "Perfect." "Willard!" " Willard!" " Coming!" "Kill her!" "You must kill her, you stupid, pathetic idiots!" "Give me the reins." " Let's find Beth, find an exit and go." " Have you seen an exit?" "No." "This is serious..." "No, let me speak." "We'll be fine." "Not a word!" "It's horrible." "Willard, be serious." "You're in danger." "If you ever make love..." "Willard!" "Here, when a man makes love, he dies." "What?" " Beth!" " Put on her helmet, quickly." "Now Gwendoline is going to kill Gwendoline off." "If you take her place, you can join the fight and save Willard." " But I don't know how to fight." " Shh!" "Be brave." " No!" " Poor, poor Gwendoline." "I saw the fight." "It was fantastic." "Unbelievable." "Amazing." " Mind your own business, Darcy." " Bad luck." "Willard, that child had no class." "Don't cry over her." "You won't miss her." "You don't understand." "You're already dead." "You're a coward, numb to all feeling." " You'll never say, "I love you"." " That's for wimps." "Well, maybe I am a wimp." "But now I've lost everything." "Everything!" "You won't get anything out of me." "You're no queen, you're a joke!" " Darcy, I forbid you to laugh!" " You're superb." "I'll blow up your mountain!" "I'll kill you, you joke of a queen!" "Darcy, go and prepare the trial." "I want everything perfect, as usual." "Farewell, Gwendoline." "Those girls are perfectly trained." "You don't stand a chance." "Drop this mad idea and come with me." "I'll blow up the city so we can escape." "Otherwise the Queen will kill you for real." "You killed my father." "You crawl in front of that mad woman." "You're vile..." "Superb." "She was superb." "All the men were mad about her and I was a little physicist with nothing." "I wanted her so much that, to win her, I set out to find her famous Pikaho." "She used my love to turn me into what I've become, to foroe me to do things that go against nature." "But I can harness the energy of the volcano and turn its fury against her." "I can dominate the Queen." "I shall crush her in one of her horrible machines and go back to a normal world, where the power of money is different." "Go on, then." "What are you waiting for?" "Courage." "Be my courage." "Forget this nightmare, forget your butterflies." "Don't touch me!" "These are precise instruments." "When I press that button, the volcano will spew out its fortune." "When I press this one, the earth will close over again." "The legend will become nothing but a legend once again." " I can help you." " You disgust me." " Can't you knock?" " Thanks for reminding me." "I found this." "Deal with it." "Make it spectacular." "I will." " Arsehole." " What?" " Superb." "You're superb." " Good." "What?" "What have you done with Willard?" "How inventive." "Naughty bird." "These girls will fight to the death for you in a contest without rules." "You'll get the winner." "Do me the honour of starting them." "Go!" "Come on!" "That one doesn't stand a chance, does she?" "More chance than you'd stand against me." " Shall we bet on a colour?" " I don't give a shit about your bets." "But just to make a fool of you, I bet the one who's losing will win." "You're making a mistake, Willard." " You're losing." "Green is going down." " I'll kill you anyway." "Don't be so positive." "It's annoying." "You're not one of us!" "Who are you?" "Take off your helmet so that the Queen can see your face." "No!" "No!" " Stop this carnage, you swine!" " I can't go against the Queen." "I'm bored." "This isn't interesting." "Yes, it is." "But all you like is violence." "It will be your downfall." "I hope the next part is more original and picturesque, Darcy." "I think you'll find it traditional, but to yourtaste." " Who are these butterflies?" " That's a surprise." " Beth?" " Don't talk." "I'll shield you." "You're going to win." "You have to." " Don't get involved." " Too late." "Now we're together, we'll win." "Come on." "Ready..." "Go!" "Look out!" " Beth, I can't go on any longer." " You have to." " I can't." " You have no choice." "Look out!" "Bring her over here." "My luck is turning." "Green is superb..." "Yellow is superb!" "You're going to die!" "Go on!" "Look." "She's going to die." "Winning the bet doesn't change things." "You have to be the champion tonight." "Pick her up." "Take off her mask." "Leave it on for the ceremony." "It will add to the mystery." "Well done, Darcy." "You're coming on." "I know you love surprises." "You're mad!" "You're risking your life." "That doesn't matter." "I just had to see you one last time." "You've been amazing." "I'll never forget you." "I don't know what will become of me, but I'll try to be as brave as you've been." "I wish I could help you." "I'm so scared." "But you're going to get together with Willard and you'll be free." "Come on, now." "This isn't the moment to lose heart." " I'm afraid, Beth." " After all you've done?" "I don't know how to make love." "Let me tell you, it's a lot easier than fighting with your hands tied behind your back." "How?" "You remember that night with the Kiops?" "No, that's not..." "Well, Willard..." "No..." "It's the same thing..." "Well, not quite..." "But I'm afraid." "I'm afraid I won't know what to do." "Your helmet!" "Quick!" "Gwendoline, the Queen will see through your scheme and you'll die." "I can win, if you have an ounce of feeling for me." "I have." "I've come to fetch you and take you outside." "You'll be free." "You've always betrayed everyone." "Leave me alone." "All you care about is getting out of Pikaho with your diamonds." "The butterflies have started circling and I've sped the process up." "I'll make a fine lady of you." "You'll have all you could want." "All the diamonds of Pikaho will never make me forget the place." "Gwendoline, I'm begging you." "I want to love you." "There's nothing I can do for you." "The Queen wants me destroyed, but I still have the same desires as other men." "Leave me alone, I tell you." "Please, Gwendoline." "Quickly." " Or I'll tell the Queen everything." " Pig!" "Where's Darcy?" "Do I have to do everything?" "What is this charade?" "I'm beginning to get tired of it." "You can't just make love like anyone else." "Oh, no." "You need whips, torture, contests." "You know, your head is full of shit, Your Majesty." "Come here and I can sort it out for you." "Nice and clean." "Don't be vulgar." "And keep your criticisms for later." "You'll need them." "You're a joke." "I'm not making love to anyone." "I knew you'd be reluctant, but I'm prepared." "You won't even give me an erection." "They've been training for years." "Failure is not an option." "You're sick." "I didn't want to hurt you, so I haven't yet told you everything." "That's good, girls." "Keep it up." " I see it's having an effect." " Jesus!" "It's time to share with you what was amusing Darcy." "Here, men can only make love once." "They die immediately afterwards." " That's the law of Pikaho." " No!" "Bring her in." "No!" "No!" " You'll be a fine lady." " You're pathetic." " Wait." "This is important." " What?" " Untie me first." " I'm listening." "Everything's going to blow up." "I've set the timer." "I can't stop it." "Everything will be swallowed up." "Nothing will be left." "Nothing!" "Just dust and lava." " Pikaho will become a legend again." " How long have we got?" "No!" "Willard." " Gwendoline?" " What's he saying?" "Yes, Willard." "Gwendoline." "Come on, come on." "Darcy is totally useless." "I can't see a bloody thing." "That wasn't in the plan." "What's that imbecile Daroy up to?" "That'll do." "Take off your mask." "Willard must die face to face with his executioner." "No!" "Gwendoline has destroyed your power." "Now the volcano will avenge itself." "You're going to die." "You've lost." "Lost everything, you joker queen." "Willard, Gwendoline!" "Darcy has opened the security gates." "Everything's going to blow up any minute now." "Hurry up!" "Completely crazy." "Joker queen!" "I'm a queen." "I'm the Queen, I'm the Queen!" "Not that way." "Quick!" " Go ahead." "I'll catch up." " Don't go in: it's hell." "I need something to make up for the bad memories." "Don't be like Darcy." "Come on!" "We don't need the diamonds." "Willard!" "Willard!" "Hurry up!" "Quick!" "I don't believe it." "Willard!" "Willard!" "Stop!" "You owe me $2,000." "My butterfly!" "Just Jaeckin especially thanks Claude Renard and Françoise Schuiten... for their original designs for the costumes and set decoration."

Sizing strategy is a major determinant of postoperative pressure gradients in commonly implanted stented tissue valves. We compared the haemodynamic performance of two pericardial aortic prostheses with the stent either on the outside (Perimount), or the inside (Mitroflow) of the valve cusps, with regard to sizing strategies and valve dimensions. We analysed discharge echoes from all patients who received an isolated Perimount (n = 537) or Mitroflow (n = 164) between January 2007 and November 2010. We obtained outer valve diameters from the manufacturers, and measured sizer dimensions. We compared pressure gradients (ΔP) and maximum velocity across the valve (V(max)). The majority of implanted valves had a size label 23 (39.7% of the Perimount; 56.1% of the Mitroflow). The metric outer diameter for size label 23 was 31 mm for Perimount, and 26 mm for Mitroflow. Despite the smaller outer diameter of the Mitroflow compared with the Perimount, peak gradients were lowest in the Mitroflow (ΔP mmHg: 22.3 ± 7.8 for Mitroflow vs 23.9 ± 7.3 for Perimount, n.s.), suggesting a design advantage for the Mitroflow. However, the 23 Mitroflow sizer was 26 mm and the 21 sizer was 23 mm. In contrast, the 23 Perimount sizer was indeed 23 mm. Thus, an intrannular sizing strategy for a patient with a 23 mm annulus most likely results in the selection of 21 Mitroflow and 23 Perimount. Haemodynamic comparison of the 21 Mitroflow with the 23 Perimount reversed the above- described difference (ΔP mmHg: 26.0 ± 10.2 for Mitroflow vs 23.9 ± 7.3 for Perimount, P < 0.05). Multivariate analysis identified a 21 valve as a predictor of high pressure gradients, but found no differences between both valve types. The potential haemodynamic advantage of the Mitroflow is lost due to the different sizing strategy. The results underscore the importance of an optimal sizing strategy, possibly by replica sizing.

[Diet and lifesyle of a cohort of primary school children]. The obesity is the disease of the new millennium, because it affects about 300 million people in the world, and especially it has a high prevalence in children. Obesity is a significant risk factor for cardiovascular disease, diabetes mellitus type II, hypertension, problems of adaptation and relationship with other, lower self-esteem and depression. The objective of our study is to identify children at risk of overweight/obesity in order to primary prevention. We have organized meetings with children, families and school's members where we discussed the results of our investigation about the importance of healthy diet and lifestyle. The study was carried out on 545 children (282F, 263M), age 6.-10 years, of two primary schools in Catanzaro, from 2008 to 2010. The valuation parameters were: gender, age, weight, height, blood pressure and waist circumference. To children were also administered a questionnaire about dietary habits and lifestyle. Fisher's test. We had that 62% of children was normal weight, 27% overweight, 11% obese. A particularly relevant datum is that the percentage of overweight-obese boys of 8 and 9 years old was higher (56%) than that of normal weight. We found cases of hypertension only in obese children. 98% of obese, 80% of overweight and 24% of normal weight children had a high waist circumference. We did not find differences in food quality among normal weight and overweight/obese children. Instead, we found significant differences in behavior between children: 90% of obese, 64% of overweight and 53% of normal weight children passed more than 2 hours in the afternoon watching television, playing computer and video games. 70% of normal weight, 82% of overweight and 95% of obese children practiced physical activity. Our study shows a alarming fact about the increase of the obesity in children. In particular the most important problem is that this condition could predispose to cardio-metabolic, endocrine, respiratory, musculoskeletal and psychological consequence. So it is important that everybody who lives with children, especially parents and school's members, educates children to have healthy lifestyles. These attentions may slow the worryng epidemic of obesity.

Changes occurring in chloroplasts of Phaseolus following infection by Sclerotinia: a cytochemical study. Dramatic changes occur in the ultrastructure of chloroplasts within host tissues during the infection of Phaseolus by the plant pathogenic fungus Sclerotinia. Electron-opaque deposits develop initially in the peripheral region of the chloroplast stroma, in cells in advance of the hyphal front. As infection continues, the amount and intensity of deposition increases and spreads throughout the chloroplast. The deposits possess a high degree of structural integrity in the form of a crystalline square lattice with 10 nm periodicity. Enzyme digestion studies have been used to show that the deposits are proteinaceous. Similar deposits are also induced by treatment with oxalic and citric acids, but not by the potassium salts of these acids buffered at pH 7.2. It is suggested that a pH change within the chloroplasts, resulting from oxalic acid secretion by the fungus, is responsible for induction of protein deposition. The likelihood that the deposits are ribulose, 1,5-bisphosphate carboxylase-oxygenase is discussed.

Results of a survey of owners of miniature swine to characterize husbandry practices affecting risks of foreign animal disease. To characterize husbandry practices that could affect the risks of foreign animal disease in miniature swine. Survey study. 106 owners of miniature swine. An online survey of owners of miniature swine was conducted to obtain information about miniature pig and owner demographics; pig husbandry; movements of pigs; and pig contacts with humans, other miniature swine, and livestock. 12 states, 106 premises, and 317 miniature swine were represented in the survey. More than a third (35%) of miniature swine owners also owned other livestock species. Regular contact with livestock species at other premises was reported by 13% of owners. More than a third of owners visited shows or fairs (39%) and club or association events (37%) where miniature swine were present. More than 40% of owners fed food waste to miniature swine. Approximately half (48%) of the veterinarians providing health care for miniature swine were in mixed-animal practice. Results of this study indicated that miniature swine kept as pets can be exposed, directly and indirectly, to feed and other livestock, potentially introducing, establishing, or spreading a foreign animal disease such as foot-and-mouth disease. In addition, the veterinary services and carcass disposal methods used by miniature swine owners may reduce the likelihood of sick or dead pigs undergoing ante- or postmortem examination by a veterinarian.

The case for dissemination research in health promotion and disease prevention. The case for dissemination research stems from the major imbalance in research funds available for preventive medicine, relative to needs. For examples, in the United States in 1992 prevention research was only 0.32% of the health care budget and dissemination research was a small proportion of prevention research. The Canadian Heart Health Initiative is an excellent example of successful dissemination research, based on needs assessment and evaluation of widespread demonstration projects. Other examples include the California Tobacco Tax Initiative, community projects and practitioner training. Continued professional and public education are needed to counter the prevalent philosophy favouring curative medicine; such policy documents as the Victoria Declaration for Heart Health and the Catalonia Declaration Investing in Heart Health are steps in this direction. The dissemination research agenda is broad, including replication of success in different geographic and cultural setting. The final goal is to hasten technology transfer of useful health promotion methods throughout the world.

The Botanical Core will facilitate the work of all three Research Projects, the Animal Core and the Pilot Research Programs by performing the following tasks: Greenhouse-based cultivation of source plants and optimization of bioactives production, Production of botanical therapeutics for the Center's research, pre-clinical and clinical studies and pilot research programs, Activity guided isolation of bioactives and characterization of their interactions, Analytical and structural chemistry support for the research activities and pre-clinical and clinical studies, Quality control and botanical authentication. The Botanical Core will also perform research activities dedicated to discovering novel botanical therapeutics, which will be studied by the Pilot Research Programs. The Botanical Core will be located and led from Rutgers University (Dr. Raskin - Core Leader) with some work subcontracted to Louisiana State University Agricultural Center (Dr. Liu - Core Co-Leader). The Core will utilize recently developed methods for the discovery, characterization, standardization and production of bioactives proven successful in developing novel botanicals that are currently in clinical trials. It will effectively leverage resources, expertise, equipment and greenhouse facilities available at Dr. Raskin's laboratory as a result of industry-supported programs and NTH-NSF-USDA-funded International Cooperative Biodiversity Groups (ICBG) grant for natural product bioprospecting.

Assessment of the need for care 15 years after onset of a Dutch cohort of patients with schizophrenia, and an international comparison. Assessment of needs for care is crucial in the evaluation of ongoing changes from institutional care to various forms of day- and outpatient treatment. Do patients really do better in the community and are they adequately cared for? The 15-year follow-up of a Dutch incidence cohort of patients with schizophrenia and other functional non-affective psychoses showed that 47 (out of 63) patients had positive ratings of symptoms and disabilities. They were assessed by means of the Needs for Care Assessment Schedule, which articulates the problems and corresponding interventions resulting in a judgement of met or unmet need for treatment or assessment. There was a mean of 2.1 clinical problems and 2.1 social problems per patient. Few problems were considered to generate unmet needs: 14% of the clinical problems and only 7% of the social problems. Nevertheless, 32% of the patients had one or more unmet needs. These results were compared with data from six research centres in the United Kingdom (Camberwell, Oxford and South Glamorgan), Canada (Montreal), Italy (Verona) and Finland (Tampere). Despite differences in health care settings in the four countries, the ratio of met to unmet needs (about 4-5 to 1) among chronic, mostly schizophrenic patients is more or less the same with the exception of an apparently underserved hostel population in Oxford and the Finnish patient population probably due to high expectations with respect to independent community living.

Detection thresholds for four different fatty stimuli are associated with increased dietary intake of processed high-caloric food. BMI-specific differences in food choice and energy intake have been suggested to modulate taste perception. However, associations between body composition and fat taste sensitivity are controversial. The objective of this study was to examine the association between body composition, dietary intake and detection thresholds of four fatty stimuli (oleic acid, paraffin oil, canola oil, and canola oil spiked with oleic acid) that could be perceived via gustatory and/or textural cues. In 30 participants, fat detection thresholds were determined in a repeated measurements design over twelve days. Weight status was examined by measuring the participants' BMI, waist circumference and waist-to-hip ratio. The habitual food intake was assessed via several questionnaires and twelve, non-consecutive 24-hour food diaries. In this study, a negative correlation was found between fat detection thresholds and the intake of food rich in vitamins and fibre. Moreover, a positive correlation was identified between the intake of high-fat food and fat detection thresholds. No differences in fat detection thresholds were observed due to variations in BMI or waist-to-hip ratio. These findings indicate that a regular intake of fatty foods might decrease an individuals' perceptual response to fats which might lead to excess fat intake on the long term.