dwb2023/family-target-interaction-ligand-gtopdb

family_id int64 1 1.1k	family_type stringclasses 9 values	family_name stringclasses 590 values	target_id int64 1 3.29k	target_name stringlengths 3 122	interaction_id int64 1 90.9k	interaction_type stringclasses 10 values	interaction_action stringclasses 24 values	primary_target bool 2 classes	affinity_median float64 0.3 13 ⌀	affinity_units stringclasses 7 values	ligand_id int64 1 13.4k	ligand_name stringlengths 2 141	ligand_type stringclasses 6 values	ligand_approved bool 2 classes	ligand_approval_source stringclasses 439 values	pubchem_sid float64 53.8M 491M ⌀
946	catalytic_receptor	Fc epsilon receptors	2,933	Fc fragment of IgE receptor Ia	84,329	Agonist	Binding	true	10	pKd	9,557	IgE heavy chain	Peptide	false	null	336,446,943
946	catalytic_receptor	Fc epsilon receptors	2,935	Fc fragment of IgE receptor II	84,330	Agonist	Binding	true	7	pKd	9,557	IgE heavy chain	Peptide	false	null	336,446,943
314	catalytic_receptor	GDNF receptor family	1,743	GDNF family receptor α1	13,485	null	null	null	null	pKd	4,851	[<sup>125</sup>I]GDNF (rat)	Peptide	false	null	178,101,552
314	catalytic_receptor	GDNF receptor family	2,977	GDNF family receptor alpha like	89,961	Antagonist	Antagonist	false	7.13	pKd	12,844	GRASP	Peptide	false	null	483,123,392
314	catalytic_receptor	GDNF receptor family	2,977	GDNF family receptor alpha like	84,726	Agonist	Agonist	false	7.6	pKd	9,735	growth differentiation factor 15	Peptide	false	null	354,702,211
314	catalytic_receptor	GDNF receptor family	2,977	GDNF family receptor alpha like	89,959	Agonist	Agonist	false	7.26	pEC50	12,843	LY3463251	Peptide	false	null	483,123,391
314	catalytic_receptor	GDNF receptor family	2,977	GDNF family receptor alpha like	89,958	Agonist	Agonist	false	8.51	pKd	12,843	LY3463251	Peptide	false	null	483,123,391
314	catalytic_receptor	GDNF receptor family	2,977	GDNF family receptor alpha like	89,960	Agonist	Agonist	false	6.87	pEC50	12,843	LY3463251	Peptide	false	null	483,123,391
311	catalytic_receptor	IL-10 receptor family	1,904	Interferon-λ receptor 1	77,198	Agonist	Agonist	null	null	-	4,993	IFN-λ1	Peptide	false	null	178,101,690
311	catalytic_receptor	IL-10 receptor family	1,904	Interferon-λ receptor 1	77,196	Agonist	Agonist	null	null	-	4,991	IFN-λ2	Peptide	false	null	178,101,688
311	catalytic_receptor	IL-10 receptor family	1,904	Interferon-λ receptor 1	77,197	Agonist	Agonist	null	null	-	4,992	IFN-λ3	Peptide	false	null	178,101,689
311	catalytic_receptor	IL-10 receptor family	1,900	Interleukin-10 receptor	77,192	Agonist	Agonist	null	null	-	4,975	IL-10	Peptide	false	null	178,101,673
311	catalytic_receptor	IL-10 receptor family	1,901	Interleukin-20 receptor	77,193	Agonist	Agonist	null	null	-	4,984	IL-19	Peptide	false	null	178,101,681
311	catalytic_receptor	IL-10 receptor family	1,901	Interleukin-20 receptor	77,194	Agonist	Agonist	null	null	-	4,986	IL-20	Peptide	false	null	178,101,683
311	catalytic_receptor	IL-10 receptor family	1,901	Interleukin-20 receptor	77,195	Agonist	Agonist	null	null	-	4,990	IL-24	Peptide	false	null	178,101,687
311	catalytic_receptor	IL-10 receptor family	1,903	Interleukin-22α1/10β heteromer	88,934	Agonist	Agonist	false	9.92	pEC50	12,212	efmarodocokin alfa	Antibody	false	null	472,319,332
311	catalytic_receptor	IL-10 receptor family	1,903	Interleukin-22α1/10β heteromer	77,201	Agonist	Agonist	false	11.46	pEC50	4,988	IL-22	Peptide	false	null	178,101,685
311	catalytic_receptor	IL-10 receptor family	1,902	Interleukin-22α1/20β heteromer	77,199	Agonist	Agonist	null	null	-	4,986	IL-20	Peptide	false	null	178,101,683
311	catalytic_receptor	IL-10 receptor family	1,902	Interleukin-22α1/20β heteromer	77,200	Agonist	Agonist	null	null	-	4,990	IL-24	Peptide	false	null	178,101,687
311	catalytic_receptor	IL-10 receptor family	1,727	Interleukin 10 receptor, α subunit	84,288	Agonist	Agonist	false	null	pEC50	4,975	IL-10	Peptide	false	null	178,101,673
308	catalytic_receptor	IL-12 receptor family	2,292	Interleukin-12 receptor	77,186	Agonist	Agonist	null	null	-	4,977	IL-12	Peptide	false	null	178,101,675
308	catalytic_receptor	IL-12 receptor family	2,293	Interleukin-23 receptor	77,185	Agonist	Agonist	null	null	-	4,978	IL-23	Peptide	false	null	178,101,676
313	catalytic_receptor	IL-17 receptor family	2,294	Interleukin-17 receptor	77,138	Agonist	Agonist	null	null	-	4,982	IL-17A	Peptide	false	null	178,101,679
313	catalytic_receptor	IL-17 receptor family	2,294	Interleukin-17 receptor	77,140	Agonist	Agonist	null	null	-	5,874	IL-17A/IL-17F	Peptide	false	null	178,102,498
313	catalytic_receptor	IL-17 receptor family	2,294	Interleukin-17 receptor	77,139	Agonist	Agonist	null	null	-	5,873	IL-17F	Peptide	false	null	178,102,497
313	catalytic_receptor	IL-17 receptor family	2,296	Interleukin-17C receptor	77,141	Agonist	Agonist	null	null	-	5,875	IL-17C	Peptide	false	null	178,102,499
313	catalytic_receptor	IL-17 receptor family	2,295	Interleukin-25 receptor	77,143	Agonist	Agonist	null	null	-	5,877	IL-17B	Peptide	false	null	178,102,501
313	catalytic_receptor	IL-17 receptor family	2,295	Interleukin-25 receptor	77,142	Agonist	Agonist	null	null	-	5,876	IL-25	Peptide	false	null	178,102,500
313	catalytic_receptor	IL-17 receptor family	1,738	Interleukin 17 receptor A	81,834	Antibody	Binding	true	9.16	pKd	7,540	brodalumab	Antibody	true	Japan (2016), FDA (2017), EMA (2017)	187,051,841
305	catalytic_receptor	IL-2 receptor family	1,700	Interleukin-13 receptor subunit α1	88,348	Antibody	Binding	false	10.57	pKd	11,770	eblasakimab	Antibody	false	null	458,923,805
305	catalytic_receptor	IL-2 receptor family	2,302	Interleukin-15 receptor	84,436	Agonist	Agonist	false	12.3	pIC50	9,615	ALT-803	Antibody	false	null	340,590,245
305	catalytic_receptor	IL-2 receptor family	2,302	Interleukin-15 receptor	88,087	Agonist	Agonist	false	10.81	pEC50	9,615	ALT-803	Antibody	false	null	340,590,245
305	catalytic_receptor	IL-2 receptor family	2,302	Interleukin-15 receptor	77,150	Agonist	Agonist	false	11.42	pIC50	4,981	IL-15	Peptide	false	null	178,101,678
305	catalytic_receptor	IL-2 receptor family	1,702	Interleukin-15 receptor subunit α	84,440	Agonist	Agonist	false	11.42	pKd	4,981	IL-15	Peptide	false	null	178,101,678
305	catalytic_receptor	IL-2 receptor family	2,297	Interleukin-2 receptor	77,153	Antagonist	Antagonist	null	null	-	4,861	AF12198	Peptide	false	null	178,101,562
305	catalytic_receptor	IL-2 receptor family	2,297	Interleukin-2 receptor	77,152	Antagonist	Antagonist	null	null	-	5,878	IL-1 receptor antagonist	Peptide	false	null	178,102,502
305	catalytic_receptor	IL-2 receptor family	2,297	Interleukin-2 receptor	77,144	Agonist	Agonist	null	null	-	4,985	IL-2	Peptide	true	FDA (1992)	178,101,682
305	catalytic_receptor	IL-2 receptor family	2,297	Interleukin-2 receptor	77,610	Antagonist	Antagonist	false	null	-	5,052	Ro26-4550	Synthetic organic	false	null	178,101,747
305	catalytic_receptor	IL-2 receptor family	1,695	Interleukin-2 receptor subunit α	78,847	Antibody	Binding	false	null	-	6,879	basiliximab	Antibody	true	FDA (1998), EMA (1998)	178,103,461
305	catalytic_receptor	IL-2 receptor family	1,695	Interleukin-2 receptor subunit α	78,848	Antibody	Binding	true	8	pKd	6,880	daclizumab	Antibody	true	FDA FDA (1997), EMA (1999)	178,103,462
305	catalytic_receptor	IL-2 receptor family	1,696	Interleukin-2 receptor subunit β	87,060	Agonist	Agonist	false	5.75	pKd	10,659	bempegaldesleukin	Peptide	false	null	404,859,106
305	catalytic_receptor	IL-2 receptor family	2,304	Interleukin-21 receptor	77,608	Agonist	Agonist	null	null	-	4,987	IL-21	Peptide	false	null	178,101,684
305	catalytic_receptor	IL-2 receptor family	1,697	Interleukin-4 receptor subunit α	81,861	Antibody	Binding	true	11.06	pIC50	7,574	dupilumab	Antibody	true	EMA & FDA (2017)	223,365,910
305	catalytic_receptor	IL-2 receptor family	2,298	Interleukin-4 receptor type I	77,145	Agonist	Agonist	null	null	-	4,996	IL-4	Peptide	false	null	178,101,693
305	catalytic_receptor	IL-2 receptor family	2,299	Interleukin-4 receptor type II	77,147	Agonist	Agonist	null	null	-	4,980	IL-13	Peptide	false	null	178,101,677
305	catalytic_receptor	IL-2 receptor family	2,299	Interleukin-4 receptor type II	77,146	Agonist	Agonist	null	null	-	4,996	IL-4	Peptide	false	null	178,101,693
305	catalytic_receptor	IL-2 receptor family	2,300	Interleukin-7 receptor	77,148	Agonist	Agonist	null	null	-	4,999	IL-7	Peptide	false	null	178,101,696
305	catalytic_receptor	IL-2 receptor family	1,698	Interleukin-7 receptor subunit α	84,417	Antibody	Antagonist	true	11.4	pEC50	9,604	OSE-127	Antibody	false	null	340,590,234
305	catalytic_receptor	IL-2 receptor family	2,301	Interleukin-9 receptor	77,149	Agonist	Agonist	null	null	-	5,000	IL-9	Peptide	false	null	178,101,697
305	catalytic_receptor	IL-2 receptor family	2,305	Thymic stromal lymphopoietin receptor	77,151	Agonist	Agonist	null	null	-	5,083	thymic stromal lymphopoietin	Peptide	false	null	178,101,776
306	catalytic_receptor	IL-3 receptor family	1,707	GM-CSF receptor, α subunit	13,416	Agonist	Agonist	null	null	-	4,942	GM-CSF	Peptide	false	null	178,101,640
306	catalytic_receptor	IL-3 receptor family	1,707	GM-CSF receptor, α subunit	81,863	Antibody	Binding	true	9.86	pIC50	7,785	mavrilimumab	Antibody	false	null	223,366,117
306	catalytic_receptor	IL-3 receptor family	2,309	Granulocyte macrophage colony-stimulating factor receptor	77,612	Agonist	Agonist	null	null	-	4,934	G-CSF	Peptide	true	null	178,101,632
306	catalytic_receptor	IL-3 receptor family	2,309	Granulocyte macrophage colony-stimulating factor receptor	77,176	Agonist	Agonist	null	null	-	4,942	GM-CSF	Peptide	false	null	178,101,640
306	catalytic_receptor	IL-3 receptor family	2,307	Interleukin-3 receptor	77,174	Agonist	Agonist	null	null	-	4,994	IL-3	Peptide	false	null	178,101,691
306	catalytic_receptor	IL-3 receptor family	2,308	Interleukin-5 receptor	77,175	Agonist	Agonist	null	null	-	4,997	IL-5	Peptide	false	null	178,101,694
306	catalytic_receptor	IL-3 receptor family	2,308	Interleukin-5 receptor	77,611	Antagonist	Antagonist	null	null	-	5,090	YM90709	Synthetic organic	false	null	178,101,783
306	catalytic_receptor	IL-3 receptor family	1,705	Interleukin 3 receptor, α subunit	13,414	Agonist	Agonist	null	null	-	4,994	IL-3	Peptide	false	null	178,101,691
306	catalytic_receptor	IL-3 receptor family	1,706	Interleukin 5 receptor, α subunit	80,175	Antibody	Binding	false	8.67	pKd	7,674	benralizumab	Antibody	true	FDA (2017), EMA (2018)	223,366,009
306	catalytic_receptor	IL-3 receptor family	1,706	Interleukin 5 receptor, α subunit	13,415	Agonist	Agonist	null	null	-	4,997	IL-5	Peptide	false	null	178,101,694
307	catalytic_receptor	IL-6 receptor family	2,313	Ciliary neutrophic factor receptor	77,180	Agonist	Agonist	null	null	-	4,897	ciliary neurotrophic factor	Peptide	false	null	178,101,597
307	catalytic_receptor	IL-6 receptor family	2,313	Ciliary neutrophic factor receptor	77,613	Agonist	Agonist	null	null	-	6,150	CRCF1/CLCF1 heterodimer	Peptide	false	null	178,102,771
307	catalytic_receptor	IL-6 receptor family	2,311	Interleukin-11 receptor	77,178	Agonist	Agonist	null	null	-	4,976	IL-11	Peptide	false	null	178,101,674
307	catalytic_receptor	IL-6 receptor family	2,311	Interleukin-11 receptor	79,029	Agonist	Full agonist	true	null	-	6,971	oprelvekin	Peptide	true	FDA (1997)	178,103,550
307	catalytic_receptor	IL-6 receptor family	2,316	Interleukin-27 receptor	77,617	Agonist	Agonist	null	null	-	6,151	IL-27	Peptide	false	null	178,102,772
307	catalytic_receptor	IL-6 receptor family	2,312	Interleukin-31 receptor	77,179	Agonist	Agonist	null	null	-	4,995	IL-31	Peptide	false	null	178,101,692
307	catalytic_receptor	IL-6 receptor family	1,710	Interleukin-31 receptor, α subunit	82,661	Antibody	Binding	true	8.7	pKd	8,720	nemolizumab	Antibody	true	Japan (2022)	252,827,378
307	catalytic_receptor	IL-6 receptor family	2,310	Interleukin-6 receptor	77,177	Agonist	Agonist	true	9.36	pKd	4,998	IL-6	Peptide	false	null	178,101,695
307	catalytic_receptor	IL-6 receptor family	2,310	Interleukin-6 receptor	83,487	Antibody	Binding	true	8.85	pKd	9,093	satralizumab	Antibody	true	Canada, Japan and FDA (2020), EMA (2021)	315,661,178
307	catalytic_receptor	IL-6 receptor family	2,310	Interleukin-6 receptor	78,849	Antibody	Binding	true	8.6	pKd	6,881	tocilizumab	Antibody	true	Japan (2005), EMA (2009), FDA (2010)	178,103,463
307	catalytic_receptor	IL-6 receptor family	2,310	Interleukin-6 receptor	83,486	Antibody	Binding	true	12.72	pKd	8,363	vobarilizumab	Antibody	false	null	252,166,575
307	catalytic_receptor	IL-6 receptor family	1,708	Interleukin-6 receptor, α subunit	83,712	Agonist	Agonist	true	9.36	pKd	4,998	IL-6	Peptide	false	null	178,101,695
307	catalytic_receptor	IL-6 receptor family	1,708	Interleukin-6 receptor, α subunit	81,886	Antibody	Binding	true	null	pKd	7,999	sarilumab	Antibody	true	EMA & FDA (2017)	249,565,679
307	catalytic_receptor	IL-6 receptor family	1,712	Leptin receptor	13,421	Agonist	Agonist	false	10.19	pKd	5,015	leptin	Peptide	false	null	178,101,712
307	catalytic_receptor	IL-6 receptor family	2,314	Leukemia inhibitory factor receptor	77,181	Agonist	Agonist	null	null	-	4,906	cardiotrophin-1	Peptide	false	null	178,101,605
307	catalytic_receptor	IL-6 receptor family	2,314	Leukemia inhibitory factor receptor	77,182	Agonist	Agonist	null	null	-	5,016	LIF	Peptide	false	null	178,101,713
307	catalytic_receptor	IL-6 receptor family	2,314	Leukemia inhibitory factor receptor	77,183	Agonist	Agonist	null	null	-	5,035	oncostatin M	Peptide	false	null	178,101,731
307	catalytic_receptor	IL-6 receptor family	2,315	Oncostatin-M receptor	77,184	Agonist	Agonist	null	null	-	5,035	oncostatin M	Peptide	false	null	178,101,731
953	catalytic_receptor	Immune checkpoint catalytic receptors	1,874	CD40	13,549	null	null	null	null	-	5,077	CD40 ligand	Peptide	false	null	178,101,770
953	catalytic_receptor	Immune checkpoint catalytic receptors	1,874	CD40	84,845	Antibody	Binding	true	9.16	pKd	9,802	CFZ533	Antibody	false	null	354,702,274
953	catalytic_receptor	Immune checkpoint catalytic receptors	1,887	herpes virus entry mediator	13,565	null	null	null	null	-	4,891	B and T lymphocyte attenuator	Peptide	false	null	178,101,591
953	catalytic_receptor	Immune checkpoint catalytic receptors	1,887	herpes virus entry mediator	13,563	null	null	null	null	-	5,070	LIGHT	Peptide	false	null	178,101,763
953	catalytic_receptor	Immune checkpoint catalytic receptors	1,887	herpes virus entry mediator	13,564	null	null	null	null	-	5,064	lymphotoxin-α	Peptide	false	null	178,101,757
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,736	Interleukin-1 receptor-like 2	84,575	Antibody	Antagonist	true	10.62	pKd	9,665	MAB92	Antibody	false	null	348,353,624
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,736	Interleukin-1 receptor-like 2	88,895	Antibody	Binding	false	10.52	pKd	12,169	spesolimab	Antibody	true	FDA and EMA (2022)	472,319,291
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,905	Interleukin-1 receptor, type I	77,164	Antagonist	Antagonist	null	null	-	4,861	AF12198	Peptide	false	null	178,101,562
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,905	Interleukin-1 receptor, type I	79,033	Inhibitor	Inhibition	true	7.82	pKd	6,972	anakinra	Peptide	true	FDA (no history prior to 2001), EMA (2002)	178,103,551
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,905	Interleukin-1 receptor, type I	77,163	Antagonist	Antagonist	null	null	-	5,878	IL-1 receptor antagonist	Peptide	false	null	178,102,502
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,905	Interleukin-1 receptor, type I	77,165	Agonist	Agonist	null	null	-	4,973	IL-1α	Peptide	false	null	178,101,671
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,905	Interleukin-1 receptor, type I	77,166	Agonist	Agonist	null	null	-	4,974	IL-1β	Peptide	false	null	178,101,672
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,905	Interleukin-1 receptor, type I	84,664	Inhibitor	Inhibition	true	10.52	pKd	9,704	isunakinra	Peptide	false	null	348,353,663
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,908	Interleukin-18 receptor	77,173	Agonist	Agonist	null	null	-	4,983	IL-18	Peptide	false	null	178,101,680
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,908	Interleukin-18 receptor	77,609	Agonist	Agonist	null	null	-	6,149	IL-37	Peptide	false	null	178,102,770
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,906	Interleukin-33 receptor	77,167	Agonist	Agonist	null	null	-	5,880	IL-33	Peptide	false	null	178,102,504
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,907	Interleukin-36 receptor	77,170	Antagonist	Antagonist	false	null	-	5,879	IL-36 receptor antagonist	Peptide	false	null	178,102,503
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,907	Interleukin-36 receptor	77,168	Agonist	Agonist	null	null	-	5,881	IL-36α	Peptide	false	null	178,102,505
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,907	Interleukin-36 receptor	77,169	Agonist	Agonist	null	null	-	5,882	IL-36β	Peptide	false	null	178,102,506
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	1,907	Interleukin-36 receptor	77,172	Agonist	Agonist	null	null	-	5,883	IL-36γ	Peptide	false	null	178,102,507
312	catalytic_receptor	Immunoglobulin-like family of IL-1 receptors	2,969	single Ig and TIR domain containing	84,672	Agonist	Agonist	false	null	-	6,149	IL-37	Peptide	false	null	178,102,770
760	catalytic_receptor	Integrins	2,577	integrin α1β1	78,536	Inhibitor	Inhibition	null	9.1	pIC50	6,581	obtustatin	Peptide	false	null	178,103,195

946

catalytic_receptor

Fc epsilon receptors

2,933

Fc fragment of IgE receptor Ia

84,329

Agonist

Binding

true

10

pKd

9,557

IgE heavy chain

Peptide

false

null

336,446,943

946

catalytic_receptor

Fc epsilon receptors

2,935

Fc fragment of IgE receptor II

84,330

Agonist

Binding

true

7

pKd

9,557

IgE heavy chain

Peptide

false

null

336,446,943

314

catalytic_receptor

GDNF receptor family

1,743

GDNF family receptor α1

13,485

null

pKd

4,851

[<sup>125</sup>I]GDNF (rat)

Peptide

false

null

178,101,552

314

catalytic_receptor

GDNF receptor family

2,977

GDNF family receptor alpha like

89,961

Antagonist

false

7.13

pKd

12,844

GRASP

Peptide

false

null

483,123,392

314

catalytic_receptor

GDNF receptor family

2,977

GDNF family receptor alpha like

84,726

Agonist

false

7.6

pKd

9,735

growth differentiation factor 15

Peptide

false

null

354,702,211

314

catalytic_receptor

GDNF receptor family

2,977

GDNF family receptor alpha like

89,959

Agonist

false

7.26

pEC50

12,843

LY3463251

Peptide

false

null

483,123,391

314

catalytic_receptor

GDNF receptor family

2,977

GDNF family receptor alpha like

89,958

Agonist

false

8.51

pKd

12,843

LY3463251

Peptide

false

null

483,123,391

314

catalytic_receptor

GDNF receptor family

2,977

GDNF family receptor alpha like

89,960

Agonist

false

6.87

pEC50

12,843

LY3463251

Peptide

false

null

483,123,391

311

catalytic_receptor

IL-10 receptor family

1,904

Interferon-λ receptor 1

77,198

Agonist

null

-

4,993

IFN-λ1

Peptide

false

null

178,101,690

311

catalytic_receptor

IL-10 receptor family

1,904

Interferon-λ receptor 1

77,196

Agonist

null

-

4,991

IFN-λ2

Peptide

false

null

178,101,688

311

catalytic_receptor

IL-10 receptor family

1,904

Interferon-λ receptor 1

77,197

Agonist

null

-

4,992

IFN-λ3

Peptide

false

null

178,101,689

311

catalytic_receptor

IL-10 receptor family

1,900

Interleukin-10 receptor

77,192

Agonist

null

-

4,975

IL-10

Peptide

false

null

178,101,673

311

catalytic_receptor

IL-10 receptor family

1,901

Interleukin-20 receptor

77,193

Agonist

null

-

4,984

IL-19

Peptide

false

null

178,101,681

311

catalytic_receptor

IL-10 receptor family

1,901

Interleukin-20 receptor

77,194

Agonist

null

-

4,986

IL-20

Peptide

false

null

178,101,683

311

catalytic_receptor

IL-10 receptor family

1,901

Interleukin-20 receptor

77,195

Agonist

null

-

4,990

IL-24

Peptide

false

null

178,101,687

311

catalytic_receptor

IL-10 receptor family

1,903

Interleukin-22α1/10β heteromer

88,934

Agonist

false

9.92

pEC50

12,212

efmarodocokin alfa

Antibody

false

null

472,319,332

311

catalytic_receptor

IL-10 receptor family

1,903

Interleukin-22α1/10β heteromer

77,201

Agonist

false

11.46

pEC50

4,988

IL-22

Peptide

false

null

178,101,685

311

catalytic_receptor

IL-10 receptor family

1,902

Interleukin-22α1/20β heteromer

77,199

Agonist

null

-

4,986

IL-20

Peptide

false

null

178,101,683

311

catalytic_receptor

IL-10 receptor family

1,902

Interleukin-22α1/20β heteromer

77,200

Agonist

null

-

4,990

IL-24

Peptide

false

null

178,101,687

311

catalytic_receptor

IL-10 receptor family

1,727

Interleukin 10 receptor, α subunit

84,288

Agonist

false

null

pEC50

4,975

IL-10

Peptide

false

null

178,101,673

308

catalytic_receptor

IL-12 receptor family

2,292

Interleukin-12 receptor

77,186

Agonist

null

-

4,977

IL-12

Peptide

false

null

178,101,675

308

catalytic_receptor

IL-12 receptor family

2,293

Interleukin-23 receptor

77,185

Agonist

null

-

4,978

IL-23

Peptide

false

null

178,101,676

313

catalytic_receptor

IL-17 receptor family

2,294

Interleukin-17 receptor

77,138

Agonist

null

-

4,982

IL-17A

Peptide

false

null

178,101,679

313

catalytic_receptor

IL-17 receptor family

2,294

Interleukin-17 receptor

77,140

Agonist

null

-

5,874

IL-17A/IL-17F

Peptide

false

null

178,102,498

313

catalytic_receptor

IL-17 receptor family

2,294

Interleukin-17 receptor

77,139

Agonist

null

-

5,873

IL-17F

Peptide

false

null

178,102,497

313

catalytic_receptor

IL-17 receptor family

2,296

Interleukin-17C receptor

77,141

Agonist

null

-

5,875

IL-17C

Peptide

false

null

178,102,499

313

catalytic_receptor

IL-17 receptor family

2,295

Interleukin-25 receptor

77,143

Agonist

null

-

5,877

IL-17B

Peptide

false

null

178,102,501

313

catalytic_receptor

IL-17 receptor family

2,295

Interleukin-25 receptor

77,142

Agonist

null

-

5,876

IL-25

Peptide

false

null

178,102,500

313

catalytic_receptor

IL-17 receptor family

1,738

Interleukin 17 receptor A

81,834

Antibody

Binding

true

9.16

pKd

7,540

brodalumab

Antibody

true

Japan (2016), FDA (2017), EMA (2017)

187,051,841

305

catalytic_receptor

IL-2 receptor family

1,700

Interleukin-13 receptor subunit α1

88,348

Antibody

Binding

false

10.57

pKd

11,770

eblasakimab

Antibody

false

null

458,923,805

305

catalytic_receptor

IL-2 receptor family

2,302

Interleukin-15 receptor

84,436

Agonist

false

12.3

pIC50

9,615

ALT-803

Antibody

false

null

340,590,245

305

catalytic_receptor

IL-2 receptor family

2,302

Interleukin-15 receptor

88,087

Agonist

false

10.81

pEC50

9,615

ALT-803

Antibody

false

null

340,590,245

305

catalytic_receptor

IL-2 receptor family

2,302

Interleukin-15 receptor

77,150

Agonist

false

11.42

pIC50

4,981

IL-15

Peptide

false

null

178,101,678

305

catalytic_receptor

IL-2 receptor family

1,702

Interleukin-15 receptor subunit α

84,440

Agonist

false

11.42

pKd

4,981

IL-15

Peptide

false

null

178,101,678

305

catalytic_receptor

IL-2 receptor family

2,297

Interleukin-2 receptor

77,153

Antagonist

null

-

4,861

AF12198

Peptide

false

null

178,101,562

305

catalytic_receptor

IL-2 receptor family

2,297

Interleukin-2 receptor

77,152

Antagonist

null

-

5,878

IL-1 receptor antagonist

Peptide

false

null

178,102,502

305

catalytic_receptor

IL-2 receptor family

2,297

Interleukin-2 receptor

77,144

Agonist

null

-

4,985

IL-2

Peptide

true

FDA (1992)

178,101,682

305

catalytic_receptor

IL-2 receptor family

2,297

Interleukin-2 receptor

77,610

Antagonist

false

null

-

5,052

Ro26-4550

Synthetic organic

false

null

178,101,747

305

catalytic_receptor

IL-2 receptor family

1,695

Interleukin-2 receptor subunit α

78,847

Antibody

Binding

false

null

-

6,879

basiliximab

Antibody

true

FDA (1998), EMA (1998)

178,103,461

305

catalytic_receptor

IL-2 receptor family

1,695

Interleukin-2 receptor subunit α

78,848

Antibody

Binding

true

8

pKd

6,880

daclizumab

Antibody

true

FDA FDA (1997), EMA (1999)

178,103,462

305

catalytic_receptor

IL-2 receptor family

1,696

Interleukin-2 receptor subunit β

87,060

Agonist

false

5.75

pKd

10,659

bempegaldesleukin

Peptide

false

null

404,859,106

305

catalytic_receptor

IL-2 receptor family

2,304

Interleukin-21 receptor

77,608

Agonist

null

-

4,987

IL-21

Peptide

false

null

178,101,684

305

catalytic_receptor

IL-2 receptor family

1,697

Interleukin-4 receptor subunit α

81,861

Antibody

Binding

true

11.06

pIC50

7,574

dupilumab

Antibody

true

EMA & FDA (2017)

223,365,910

305

catalytic_receptor

IL-2 receptor family

2,298

Interleukin-4 receptor type I

77,145

Agonist

null

-

4,996

IL-4

Peptide

false

null

178,101,693

305

catalytic_receptor

IL-2 receptor family

2,299

Interleukin-4 receptor type II

77,147

Agonist

null

-

4,980

IL-13

Peptide

false

null

178,101,677

305

catalytic_receptor

IL-2 receptor family

2,299

Interleukin-4 receptor type II

77,146

Agonist

null

-

4,996

IL-4

Peptide

false

null

178,101,693

305

catalytic_receptor

IL-2 receptor family

2,300

Interleukin-7 receptor

77,148

Agonist

null

-

4,999

IL-7

Peptide

false

null

178,101,696

305

catalytic_receptor

IL-2 receptor family

1,698

Interleukin-7 receptor subunit α

84,417

Antibody

Antagonist

true

11.4

pEC50

9,604

OSE-127

Antibody

false

null

340,590,234

305

catalytic_receptor

IL-2 receptor family

2,301

Interleukin-9 receptor

77,149

Agonist

null

-

5,000

IL-9

Peptide

false

null

178,101,697

305

catalytic_receptor

IL-2 receptor family

2,305

Thymic stromal lymphopoietin receptor

77,151

Agonist

null

-

5,083

thymic stromal lymphopoietin

Peptide

false

null

178,101,776

306

catalytic_receptor

IL-3 receptor family

1,707

GM-CSF receptor, α subunit

13,416

Agonist

null

-

4,942

GM-CSF

Peptide

false

null

178,101,640

306

catalytic_receptor

IL-3 receptor family

1,707

GM-CSF receptor, α subunit

81,863

Antibody

Binding

true

9.86

pIC50

7,785

mavrilimumab

Antibody

false

null

223,366,117

306

catalytic_receptor

IL-3 receptor family

2,309

Granulocyte macrophage colony-stimulating factor receptor

77,612

Agonist

null

-

4,934

G-CSF

Peptide

true

null

178,101,632

306

catalytic_receptor

IL-3 receptor family

2,309

Granulocyte macrophage colony-stimulating factor receptor

77,176

Agonist

null

-

4,942

GM-CSF

Peptide

false

null

178,101,640

306

catalytic_receptor

IL-3 receptor family

2,307

Interleukin-3 receptor

77,174

Agonist

null

-

4,994

IL-3

Peptide

false

null

178,101,691

306

catalytic_receptor

IL-3 receptor family

2,308

Interleukin-5 receptor

77,175

Agonist

null

-

4,997

IL-5

Peptide

false

null

178,101,694

306

catalytic_receptor

IL-3 receptor family

2,308

Interleukin-5 receptor

77,611

Antagonist

null

-

5,090

YM90709

Synthetic organic

false

null

178,101,783

306

catalytic_receptor

IL-3 receptor family

1,705

Interleukin 3 receptor, α subunit

13,414

Agonist

null

-

4,994

IL-3

Peptide

false

null

178,101,691

306

catalytic_receptor

IL-3 receptor family

1,706

Interleukin 5 receptor, α subunit

80,175

Antibody

Binding

false

8.67

pKd

7,674

benralizumab

Antibody

true

FDA (2017), EMA (2018)

223,366,009

306

catalytic_receptor

IL-3 receptor family

1,706

Interleukin 5 receptor, α subunit

13,415

Agonist

null

-

4,997

IL-5

Peptide

false

null

178,101,694

307

catalytic_receptor

IL-6 receptor family

2,313

Ciliary neutrophic factor receptor

77,180

Agonist

null

-

4,897

ciliary neurotrophic factor

Peptide

false

null

178,101,597

307

catalytic_receptor

IL-6 receptor family

2,313

Ciliary neutrophic factor receptor

77,613

Agonist

null

-

6,150

CRCF1/CLCF1 heterodimer

Peptide

false

null

178,102,771

307

catalytic_receptor

IL-6 receptor family

2,311

Interleukin-11 receptor

77,178

Agonist

null

-

4,976

IL-11

Peptide

false

null

178,101,674

307

catalytic_receptor

IL-6 receptor family

2,311

Interleukin-11 receptor

79,029

Agonist

Full agonist

true

null

-

6,971

oprelvekin

Peptide

true

FDA (1997)

178,103,550

307

catalytic_receptor

IL-6 receptor family

2,316

Interleukin-27 receptor

77,617

Agonist

null

-

6,151

IL-27

Peptide

false

null

178,102,772

307

catalytic_receptor

IL-6 receptor family

2,312

Interleukin-31 receptor

77,179

Agonist

null

-

4,995

IL-31

Peptide

false

null

178,101,692

307

catalytic_receptor

IL-6 receptor family

1,710

Interleukin-31 receptor, α subunit

82,661

Antibody

Binding

true

8.7

pKd

8,720

nemolizumab

Antibody

true

Japan (2022)

252,827,378

307

catalytic_receptor

IL-6 receptor family

2,310

Interleukin-6 receptor

77,177

Agonist

true

9.36

pKd

4,998

IL-6

Peptide

false

null

178,101,695

307

catalytic_receptor

IL-6 receptor family

2,310

Interleukin-6 receptor

83,487

Antibody

Binding

true

8.85

pKd

9,093

satralizumab

Antibody

true

Canada, Japan and FDA (2020), EMA (2021)

315,661,178

307

catalytic_receptor

IL-6 receptor family

2,310

Interleukin-6 receptor

78,849

Antibody

Binding

true

8.6

pKd

6,881

tocilizumab

Antibody

true

Japan (2005), EMA (2009), FDA (2010)

178,103,463

307

catalytic_receptor

IL-6 receptor family

2,310

Interleukin-6 receptor

83,486

Antibody

Binding

true

12.72

pKd

8,363

vobarilizumab

Antibody

false

null

252,166,575

307

catalytic_receptor

IL-6 receptor family

1,708

Interleukin-6 receptor, α subunit

83,712

Agonist

true

9.36

pKd

4,998

IL-6

Peptide

false

null

178,101,695

307

catalytic_receptor

IL-6 receptor family

1,708

Interleukin-6 receptor, α subunit

81,886

Antibody

Binding

true

null

pKd

7,999

sarilumab

Antibody

true

EMA & FDA (2017)

249,565,679

307

catalytic_receptor

IL-6 receptor family

1,712

Leptin receptor

13,421

Agonist

false

10.19

pKd

5,015

leptin

Peptide

false

null

178,101,712

307

catalytic_receptor

IL-6 receptor family

2,314

Leukemia inhibitory factor receptor

77,181

Agonist

null

-

4,906

cardiotrophin-1

Peptide

false

null

178,101,605

307

catalytic_receptor

IL-6 receptor family

2,314

Leukemia inhibitory factor receptor

77,182

Agonist

null

-

5,016

LIF

Peptide

false

null

178,101,713

307

catalytic_receptor

IL-6 receptor family

2,314

Leukemia inhibitory factor receptor

77,183

Agonist

null

-

5,035

oncostatin M

Peptide

false

null

178,101,731

307

catalytic_receptor

IL-6 receptor family

2,315

Oncostatin-M receptor

77,184

Agonist

null

-

5,035

oncostatin M

Peptide

false

null

178,101,731

953

catalytic_receptor

Immune checkpoint catalytic receptors

1,874

CD40

13,549

null

-

5,077

CD40 ligand

Peptide

false

null

178,101,770

953

catalytic_receptor

Immune checkpoint catalytic receptors

1,874

CD40

84,845

Antibody

Binding

true

9.16

pKd

9,802

CFZ533

Antibody

false

null

354,702,274

953

catalytic_receptor

Immune checkpoint catalytic receptors

1,887

herpes virus entry mediator

13,565

null

-

4,891

B and T lymphocyte attenuator

Peptide

false

null

178,101,591

953

catalytic_receptor

Immune checkpoint catalytic receptors

1,887

herpes virus entry mediator

13,563

null

-

5,070

LIGHT

Peptide

false

null

178,101,763

953

catalytic_receptor

Immune checkpoint catalytic receptors

1,887

herpes virus entry mediator

13,564

null

-

5,064

lymphotoxin-α

Peptide

false

null

178,101,757

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,736

Interleukin-1 receptor-like 2

84,575

Antibody

Antagonist

true

10.62

pKd

9,665

MAB92

Antibody

false

null

348,353,624

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,736

Interleukin-1 receptor-like 2

88,895

Antibody

Binding

false

10.52

pKd

12,169

spesolimab

Antibody

true

FDA and EMA (2022)

472,319,291

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,905

Interleukin-1 receptor, type I

77,164

Antagonist

null

-

4,861

AF12198

Peptide

false

null

178,101,562

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,905

Interleukin-1 receptor, type I

79,033

Inhibitor

Inhibition

true

7.82

pKd

6,972

anakinra

Peptide

true

FDA (no history prior to 2001), EMA (2002)

178,103,551

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,905

Interleukin-1 receptor, type I

77,163

Antagonist

null

-

5,878

IL-1 receptor antagonist

Peptide

false

null

178,102,502

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,905

Interleukin-1 receptor, type I

77,165

Agonist

null

-

4,973

IL-1α

Peptide

false

null

178,101,671

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,905

Interleukin-1 receptor, type I

77,166

Agonist

null

-

4,974

IL-1β

Peptide

false

null

178,101,672

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,905

Interleukin-1 receptor, type I

84,664

Inhibitor

Inhibition

true

10.52

pKd

9,704

isunakinra

Peptide

false

null

348,353,663

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,908

Interleukin-18 receptor

77,173

Agonist

null

-

4,983

IL-18

Peptide

false

null

178,101,680

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,908

Interleukin-18 receptor

77,609

Agonist

null

-

6,149

IL-37

Peptide

false

null

178,102,770

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,906

Interleukin-33 receptor

77,167

Agonist

null

-

5,880

IL-33

Peptide

false

null

178,102,504

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,907

Interleukin-36 receptor

77,170

Antagonist

false

null

-

5,879

IL-36 receptor antagonist

Peptide

false

null

178,102,503

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,907

Interleukin-36 receptor

77,168

Agonist

null

-

5,881

IL-36α

Peptide

false

null

178,102,505

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,907

Interleukin-36 receptor

77,169

Agonist

null

-

5,882

IL-36β

Peptide

false

null

178,102,506

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

1,907

Interleukin-36 receptor

77,172

Agonist

null

-

5,883

IL-36γ

Peptide

false

null

178,102,507

312

catalytic_receptor

Immunoglobulin-like family of IL-1 receptors

2,969

single Ig and TIR domain containing

84,672

Agonist

false

null

-

6,149

IL-37

Peptide

false

null

178,102,770

760

catalytic_receptor

Integrins

2,577

integrin α1β1

78,536

Inhibitor

Inhibition

null

9.1

pIC50

6,581

obtustatin

Peptide

false

null

178,103,195